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Q9Y4A8 (NF2L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear factor erythroid 2-related factor 3

Short name=NF-E2-related factor 3
Short name=NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene names
Name:NFE2L3
Synonyms:NRF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length694 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates erythroid-specific, globin gene expression.

Subunit structure

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).

Subcellular location

Nucleus By similarity.

Tissue specificity

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas. Ref.5

Sequence similarities

Belongs to the bZIP family. CNC subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence caution

The sequence AAP22344.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAA76288.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription from RNA polymerase II promoter

Traceable author statement Ref.5. Source: ProtInc

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.5. Source: ProtInc

transcription coactivator activity

Traceable author statement Ref.5. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 694694Nuclear factor erythroid 2-related factor 3
PRO_0000076452

Regions

Domain578 – 64164bZIP
Region580 – 59920Basic motif By similarity
Region606 – 62015Leucine-zipper By similarity
Compositional bias14 – 4936Leu-rich

Natural variations

Natural variant4411V → E.
Corresponds to variant rs2072129 [ dbSNP | Ensembl ].
VAR_055562

Experimental info

Sequence conflict2861P → L in AAH68455. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9Y4A8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DAD6D883FCCBA982

FASTA69476,154
        10         20         30         40         50         60 
MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG GPASSAYALS 

        70         80         90        100        110        120 
PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV PFVPRTSVDA WLVHSVAAGS 

       130        140        150        160        170        180 
ADEAHGLLGA AAASSTGGAG ASVDGGSQAV QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ 

       190        200        210        220        230        240 
VPDAGGCASE ENGVLREKHE AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE 

       250        260        270        280        290        300 
AEKTTESRNE RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH 

       310        320        330        340        350        360 
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT NPEQTLPGTN 

       370        380        390        400        410        420 
LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE DNFDPIDVSQ LFDEPDSDSG 

       430        440        450        460        470        480 
LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ 

       490        500        510        520        530        540 
SDSDFHGDLT FQHVFHNHTY HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ 

       550        560        570        580        590        600 
RAKALHIPFS VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL 

       610        620        630        640        650        660 
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR DDQGRPVNPN 

       670        680        690 
HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK 

« Hide

References

« Hide 'large scale' references
[1]"NRF3, a basic leucine zipper protein interacting with MAFG."
Blank V., Andrews N.C.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAFG.
[2]Stoesz S.P., Liu S., Pickett C.B.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney, Lymph and Placenta.
[5]"Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH MAFK, TISSUE SPECIFICITY.
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133059 mRNA. Translation: AAG43275.1.
AF134891 mRNA. Translation: AAF61404.1.
AF135116 Genomic DNA. Translation: AAF61415.1.
AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems.
BC049219 mRNA. Translation: AAH49219.1.
BC056142 mRNA. Translation: AAH56142.1.
BC068455 mRNA. Translation: AAH68455.1.
AB010812 mRNA. Translation: BAA76288.1. Different initiation.
RefSeqNP_004280.5. NM_004289.6.
UniGeneHs.404741.
Hs.712898.

3D structure databases

ProteinModelPortalQ9Y4A8.
SMRQ9Y4A8. Positions 491-641.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114967. 10 interactions.
STRING9606.ENSP00000056233.

PTM databases

PhosphoSiteQ9Y4A8.

Polymorphism databases

DMDM56404677.

Proteomic databases

PaxDbQ9Y4A8.
PRIDEQ9Y4A8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000056233; ENSP00000056233; ENSG00000050344.
GeneID9603.
KEGGhsa:9603.
UCSCuc003sxq.3. human.

Organism-specific databases

CTD9603.
GeneCardsGC07P026158.
H-InvDBHIX0033872.
HGNCHGNC:7783. NFE2L3.
HPAHPA055889.
MIM604135. gene.
neXtProtNX_Q9Y4A8.
PharmGKBPA31589.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278006.
HOGENOMHOG000234410.
HOVERGENHBG052609.
InParanoidQ9Y4A8.
KOK09040.
OMAEIVRMPV.
OrthoDBEOG715Q3N.
PhylomeDBQ9Y4A8.
TreeFamTF337360.

Gene expression databases

BgeeQ9Y4A8.
CleanExHS_NFE2L3.
GenevestigatorQ9Y4A8.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
InterProIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNFE2L3.
GenomeRNAi9603.
NextBio36023.
PROQ9Y4A8.
SOURCESearch...

Entry information

Entry nameNF2L3_HUMAN
AccessionPrimary (citable) accession number: Q9Y4A8
Secondary accession number(s): Q6NUS0 expand/collapse secondary AC list , Q7Z498, Q86UJ4, Q86VR5, Q9UQA4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM