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Q9Y4A8

- NF2L3_HUMAN

UniProt

Q9Y4A8 - NF2L3_HUMAN

Protein

Nuclear factor erythroid 2-related factor 3

Gene

NFE2L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Activates erythroid-specific, globin gene expression.

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear factor erythroid 2-related factor 3
    Short name:
    NF-E2-related factor 3
    Short name:
    NFE2-related factor 3
    Alternative name(s):
    Nuclear factor, erythroid derived 2, like 3
    Gene namesi
    Name:NFE2L3
    Synonyms:NRF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7783. NFE2L3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31589.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Nuclear factor erythroid 2-related factor 3PRO_0000076452Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y4A8.
    PRIDEiQ9Y4A8.

    PTM databases

    PhosphoSiteiQ9Y4A8.

    Expressioni

    Tissue specificityi

    Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.1 Publication

    Gene expression databases

    BgeeiQ9Y4A8.
    CleanExiHS_NFE2L3.
    GenevestigatoriQ9Y4A8.

    Organism-specific databases

    HPAiHPA055889.

    Interactioni

    Subunit structurei

    Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).2 Publications

    Protein-protein interaction databases

    BioGridi114967. 10 interactions.
    STRINGi9606.ENSP00000056233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4A8.
    SMRiQ9Y4A8. Positions 536-638.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini578 – 64164bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni580 – 59920Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni606 – 62015Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 4936Leu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. CNC subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278006.
    HOGENOMiHOG000234410.
    HOVERGENiHBG052609.
    InParanoidiQ9Y4A8.
    KOiK09040.
    OMAiEIVRMPV.
    OrthoDBiEOG715Q3N.
    PhylomeDBiQ9Y4A8.
    TreeFamiTF337360.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y4A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG    50
    GPASSAYALS PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV 100
    PFVPRTSVDA WLVHSVAAGS ADEAHGLLGA AAASSTGGAG ASVDGGSQAV 150
    QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ VPDAGGCASE ENGVLREKHE 200
    AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE AEKTTESRNE 250
    RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH 300
    YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT 350
    NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE 400
    DNFDPIDVSQ LFDEPDSDSG LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC 450
    TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ SDSDFHGDLT FQHVFHNHTY 500
    HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ RAKALHIPFS 550
    VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL 600
    DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR 650
    DDQGRPVNPN HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK 694
    Length:694
    Mass (Da):76,154
    Last modified:November 1, 1999 - v1
    Checksum:iDAD6D883FCCBA982
    GO

    Sequence cautioni

    The sequence BAA76288.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAP22344.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti286 – 2861P → L in AAH68455. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti441 – 4411V → E.
    Corresponds to variant rs2072129 [ dbSNP | Ensembl ].
    VAR_055562

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133059 mRNA. Translation: AAG43275.1.
    AF134891 mRNA. Translation: AAF61404.1.
    AF135116 Genomic DNA. Translation: AAF61415.1.
    AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems.
    BC049219 mRNA. Translation: AAH49219.1.
    BC056142 mRNA. Translation: AAH56142.1.
    BC068455 mRNA. Translation: AAH68455.1.
    AB010812 mRNA. Translation: BAA76288.1. Different initiation.
    CCDSiCCDS5396.1.
    RefSeqiNP_004280.5. NM_004289.6.
    UniGeneiHs.404741.
    Hs.712898.

    Genome annotation databases

    EnsembliENST00000056233; ENSP00000056233; ENSG00000050344.
    GeneIDi9603.
    KEGGihsa:9603.
    UCSCiuc003sxq.3. human.

    Polymorphism databases

    DMDMi56404677.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133059 mRNA. Translation: AAG43275.1 .
    AF134891 mRNA. Translation: AAF61404.1 .
    AF135116 Genomic DNA. Translation: AAF61415.1 .
    AC004520 Genomic DNA. Translation: AAP22344.1 . Sequence problems.
    BC049219 mRNA. Translation: AAH49219.1 .
    BC056142 mRNA. Translation: AAH56142.1 .
    BC068455 mRNA. Translation: AAH68455.1 .
    AB010812 mRNA. Translation: BAA76288.1 . Different initiation.
    CCDSi CCDS5396.1.
    RefSeqi NP_004280.5. NM_004289.6.
    UniGenei Hs.404741.
    Hs.712898.

    3D structure databases

    ProteinModelPortali Q9Y4A8.
    SMRi Q9Y4A8. Positions 536-638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114967. 10 interactions.
    STRINGi 9606.ENSP00000056233.

    PTM databases

    PhosphoSitei Q9Y4A8.

    Polymorphism databases

    DMDMi 56404677.

    Proteomic databases

    PaxDbi Q9Y4A8.
    PRIDEi Q9Y4A8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000056233 ; ENSP00000056233 ; ENSG00000050344 .
    GeneIDi 9603.
    KEGGi hsa:9603.
    UCSCi uc003sxq.3. human.

    Organism-specific databases

    CTDi 9603.
    GeneCardsi GC07P026158.
    H-InvDB HIX0033872.
    HGNCi HGNC:7783. NFE2L3.
    HPAi HPA055889.
    MIMi 604135. gene.
    neXtProti NX_Q9Y4A8.
    PharmGKBi PA31589.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278006.
    HOGENOMi HOG000234410.
    HOVERGENi HBG052609.
    InParanoidi Q9Y4A8.
    KOi K09040.
    OMAi EIVRMPV.
    OrthoDBi EOG715Q3N.
    PhylomeDBi Q9Y4A8.
    TreeFami TF337360.

    Miscellaneous databases

    GeneWikii NFE2L3.
    GenomeRNAii 9603.
    NextBioi 36023.
    PROi Q9Y4A8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4A8.
    CleanExi HS_NFE2L3.
    Genevestigatori Q9Y4A8.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NRF3, a basic leucine zipper protein interacting with MAFG."
      Blank V., Andrews N.C.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAFG.
    2. Stoesz S.P., Liu S., Pickett C.B.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney, Lymph and Placenta.
    5. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
      Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
      J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH MAFK, TISSUE SPECIFICITY.
      Tissue: Placenta.

    Entry informationi

    Entry nameiNF2L3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4A8
    Secondary accession number(s): Q6NUS0
    , Q7Z498, Q86UJ4, Q86VR5, Q9UQA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3