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Protein

Nuclear factor erythroid 2-related factor 3

Gene

NFE2L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:NFE2L3
Synonyms:NRF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7783. NFE2L3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Nuclear factor erythroid 2-related factor 3PRO_0000076452Add
BLAST

Proteomic databases

PaxDbiQ9Y4A8.
PRIDEiQ9Y4A8.

PTM databases

PhosphoSiteiQ9Y4A8.

Expressioni

Tissue specificityi

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ9Y4A8.
CleanExiHS_NFE2L3.
ExpressionAtlasiQ9Y4A8. baseline and differential.
GenevestigatoriQ9Y4A8.

Organism-specific databases

HPAiHPA055889.

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).2 Publications

Protein-protein interaction databases

BioGridi114967. 11 interactions.
STRINGi9606.ENSP00000056233.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A8.
SMRiQ9Y4A8. Positions 536-604.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini578 – 64164bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 59920Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni606 – 62015Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 4936Leu-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278006.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9Y4A8.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9Y4A8.
TreeFamiTF337360.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029854. NF2L3.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF8. PTHR24411:SF8. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG
60 70 80 90 100
GPASSAYALS PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV
110 120 130 140 150
PFVPRTSVDA WLVHSVAAGS ADEAHGLLGA AAASSTGGAG ASVDGGSQAV
160 170 180 190 200
QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ VPDAGGCASE ENGVLREKHE
210 220 230 240 250
AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE AEKTTESRNE
260 270 280 290 300
RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH
310 320 330 340 350
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT
360 370 380 390 400
NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE
410 420 430 440 450
DNFDPIDVSQ LFDEPDSDSG LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC
460 470 480 490 500
TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ SDSDFHGDLT FQHVFHNHTY
510 520 530 540 550
HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ RAKALHIPFS
560 570 580 590 600
VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL
610 620 630 640 650
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR
660 670 680 690
DDQGRPVNPN HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK
Length:694
Mass (Da):76,154
Last modified:November 1, 1999 - v1
Checksum:iDAD6D883FCCBA982
GO

Sequence cautioni

The sequence AAP22344.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA76288.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861P → L in AAH68455 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti441 – 4411V → E.
Corresponds to variant rs2072129 [ dbSNP | Ensembl ].
VAR_055562

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133059 mRNA. Translation: AAG43275.1.
AF134891 mRNA. Translation: AAF61404.1.
AF135116 Genomic DNA. Translation: AAF61415.1.
AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems.
BC049219 mRNA. Translation: AAH49219.1.
BC056142 mRNA. Translation: AAH56142.1.
BC068455 mRNA. Translation: AAH68455.1.
AB010812 mRNA. Translation: BAA76288.1. Different initiation.
CCDSiCCDS5396.1.
RefSeqiNP_004280.5. NM_004289.6.
UniGeneiHs.404741.
Hs.712898.

Genome annotation databases

EnsembliENST00000056233; ENSP00000056233; ENSG00000050344.
GeneIDi9603.
KEGGihsa:9603.
UCSCiuc003sxq.3. human.

Polymorphism databases

DMDMi56404677.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133059 mRNA. Translation: AAG43275.1.
AF134891 mRNA. Translation: AAF61404.1.
AF135116 Genomic DNA. Translation: AAF61415.1.
AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems.
BC049219 mRNA. Translation: AAH49219.1.
BC056142 mRNA. Translation: AAH56142.1.
BC068455 mRNA. Translation: AAH68455.1.
AB010812 mRNA. Translation: BAA76288.1. Different initiation.
CCDSiCCDS5396.1.
RefSeqiNP_004280.5. NM_004289.6.
UniGeneiHs.404741.
Hs.712898.

3D structure databases

ProteinModelPortaliQ9Y4A8.
SMRiQ9Y4A8. Positions 536-604.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114967. 11 interactions.
STRINGi9606.ENSP00000056233.

PTM databases

PhosphoSiteiQ9Y4A8.

Polymorphism databases

DMDMi56404677.

Proteomic databases

PaxDbiQ9Y4A8.
PRIDEiQ9Y4A8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000056233; ENSP00000056233; ENSG00000050344.
GeneIDi9603.
KEGGihsa:9603.
UCSCiuc003sxq.3. human.

Organism-specific databases

CTDi9603.
GeneCardsiGC07P026191.
H-InvDBHIX0033872.
HGNCiHGNC:7783. NFE2L3.
HPAiHPA055889.
MIMi604135. gene.
neXtProtiNX_Q9Y4A8.
PharmGKBiPA31589.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278006.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9Y4A8.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9Y4A8.
TreeFamiTF337360.

Miscellaneous databases

GeneWikiiNFE2L3.
GenomeRNAii9603.
NextBioi36023.
PROiQ9Y4A8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y4A8.
CleanExiHS_NFE2L3.
ExpressionAtlasiQ9Y4A8. baseline and differential.
GenevestigatoriQ9Y4A8.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029854. NF2L3.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF8. PTHR24411:SF8. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NRF3, a basic leucine zipper protein interacting with MAFG."
    Blank V., Andrews N.C.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAFG.
  2. Stoesz S.P., Liu S., Pickett C.B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Lymph and Placenta.
  5. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH MAFK, TISSUE SPECIFICITY.
    Tissue: Placenta.

Entry informationi

Entry nameiNF2L3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A8
Secondary accession number(s): Q6NUS0
, Q7Z498, Q86UJ4, Q86VR5, Q9UQA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: March 4, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.