Q9Y4A8 (NF2L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name=NF-E2-related factor 3
Short name=NFE2-related factor 3

Alternative name(s):
Nuclear factor, erythroid derived 2, like 3

Gene names

Name:	NFE2L3
Synonyms:	NRF3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	694 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activates erythroid-specific, globin gene expression.
Subunit structure	Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
Subcellular location	Nucleus By similarity.
Tissue specificity	Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas. Ref.5
Sequence similarities	Belongs to the bZIP family. CNC subfamily. Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution	The sequence AAP22344.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA76288.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription from RNA polymerase II promoter Traceable author statement Ref.5. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.5. Source: ProtInc transcription coactivator activity Traceable author statement Ref.5. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 694	694	Nuclear factor erythroid 2-related factor 3		PRO_0000076452
Regions
	Domain	578 – 641	64	bZIP
	Region	580 – 599	20	Basic motif By similarity
	Region	606 – 620	15	Leucine-zipper By similarity
	Compositional bias	14 – 49	36	Leu-rich
Natural variations
	Natural variant	441	1	V → E. Corresponds to variant rs2072129 [ dbSNP | Ensembl ].		VAR_055562
Experimental info
	Sequence conflict	286	1	P → L in AAH68455. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9Y4A8 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: DAD6D883FCCBA982	FASTA	694	76,154
	10 20 30 40 50 60 MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG GPASSAYALS 70 80 90 100 110 120 PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV PFVPRTSVDA WLVHSVAAGS 130 140 150 160 170 180 ADEAHGLLGA AAASSTGGAG ASVDGGSQAV QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ 190 200 210 220 230 240 VPDAGGCASE ENGVLREKHE AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE 250 260 270 280 290 300 AEKTTESRNE RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH 310 320 330 340 350 360 YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT NPEQTLPGTN 370 380 390 400 410 420 LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE DNFDPIDVSQ LFDEPDSDSG 430 440 450 460 470 480 LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ 490 500 510 520 530 540 SDSDFHGDLT FQHVFHNHTY HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ 550 560 570 580 590 600 RAKALHIPFS VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL 610 620 630 640 650 660 DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR DDQGRPVNPN 670 680 690 HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NRF3, a basic leucine zipper protein interacting with MAFG." Blank V., Andrews N.C. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAFG.
[2]	Stoesz S.P., Liu S., Pickett C.B. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney, Lymph and Placenta.
[5]	"Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3." Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M. J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH MAFK, TISSUE SPECIFICITY. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF133059 mRNA. Translation: AAG43275.1. AF134891 mRNA. Translation: AAF61404.1. AF135116 Genomic DNA. Translation: AAF61415.1. AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems. BC049219 mRNA. Translation: AAH49219.1. BC056142 mRNA. Translation: AAH56142.1. BC068455 mRNA. Translation: AAH68455.1. AB010812 mRNA. Translation: BAA76288.1. Different initiation.
IPI	IPI00009207.
RefSeq	NP_004280.5. NM_004289.6.
UniGene	Hs.404741. Hs.712898.
3D structure databases
ProteinModelPortal	Q9Y4A8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000056233.
PTM databases
PhosphoSite	Q9Y4A8.
Polymorphism databases
DMDM	56404677.
Proteomic databases
PaxDb	Q9Y4A8.
PRIDE	Q9Y4A8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000056233; ENSP00000056233; ENSG00000050344.
GeneID	9603.
KEGG	hsa:9603.
UCSC	uc003sxq.3. human.
Organism-specific databases
CTD	9603.
GeneCards	GC07P026158.
H-InvDB	HIX0033872.
HGNC	HGNC:7783. NFE2L3.
HPA	HPA055889.
MIM	604135. gene.
neXtProt	NX_Q9Y4A8.
PharmGKB	PA31589.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278006.
HOGENOM	HOG000234410.
HOVERGEN	HBG052609.
InParanoid	Q9Y4A8.
KO	K09040.
OMA	RTRVDAW.
OrthoDB	EOG44J2HM.
PhylomeDB	Q9Y4A8.
Gene expression databases
Bgee	Q9Y4A8.
CleanEx	HS_NFE2L3.
Genevestigator	Q9Y4A8.
GermOnline	ENSG00000050344. Homo sapiens.
Family and domain databases
Gene3D	1.10.880.10. 1 hit.
InterPro	IPR004827. bZIP. IPR008917. Euk_TF_DNA-bd. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
SUPFAM	SSF47454. Euk_transcr_DNA. 1 hit.
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9603.
NextBio	36023.
SOURCE	Search...

Entry information

Entry name

NF2L3_HUMAN

Accession

Primary (citable) accession number: Q9Y4A8
Secondary accession number(s): Q6NUS0 , Q7Z498, Q86UJ4, Q86VR5, Q9UQA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.