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Q9Y4A8

- NF2L3_HUMAN

UniProt

Q9Y4A8 - NF2L3_HUMAN

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Protein

Nuclear factor erythroid 2-related factor 3

Gene
NFE2L3, NRF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:NFE2L3
Synonyms:NRF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7783. NFE2L3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Nuclear factor erythroid 2-related factor 3PRO_0000076452Add
BLAST

Proteomic databases

PaxDbiQ9Y4A8.
PRIDEiQ9Y4A8.

PTM databases

PhosphoSiteiQ9Y4A8.

Expressioni

Tissue specificityi

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ9Y4A8.
CleanExiHS_NFE2L3.
GenevestigatoriQ9Y4A8.

Organism-specific databases

HPAiHPA055889.

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).

Protein-protein interaction databases

BioGridi114967. 10 interactions.
STRINGi9606.ENSP00000056233.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A8.
SMRiQ9Y4A8. Positions 536-638.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini578 – 64164bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni580 – 59920Basic motif By similarityAdd
BLAST
Regioni606 – 62015Leucine-zipper By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 4936Leu-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.

Phylogenomic databases

eggNOGiNOG278006.
HOGENOMiHOG000234410.
HOVERGENiHBG052609.
InParanoidiQ9Y4A8.
KOiK09040.
OMAiEIVRMPV.
OrthoDBiEOG715Q3N.
PhylomeDBiQ9Y4A8.
TreeFamiTF337360.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4A8-1 [UniParc]FASTAAdd to Basket

« Hide

MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG    50
GPASSAYALS PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV 100
PFVPRTSVDA WLVHSVAAGS ADEAHGLLGA AAASSTGGAG ASVDGGSQAV 150
QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ VPDAGGCASE ENGVLREKHE 200
AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE AEKTTESRNE 250
RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH 300
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT 350
NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE 400
DNFDPIDVSQ LFDEPDSDSG LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC 450
TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ SDSDFHGDLT FQHVFHNHTY 500
HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ RAKALHIPFS 550
VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL 600
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR 650
DDQGRPVNPN HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK 694
Length:694
Mass (Da):76,154
Last modified:November 1, 1999 - v1
Checksum:iDAD6D883FCCBA982
GO

Sequence cautioni

The sequence BAA76288.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAP22344.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti441 – 4411V → E.
Corresponds to variant rs2072129 [ dbSNP | Ensembl ].
VAR_055562

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861P → L in AAH68455. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133059 mRNA. Translation: AAG43275.1.
AF134891 mRNA. Translation: AAF61404.1.
AF135116 Genomic DNA. Translation: AAF61415.1.
AC004520 Genomic DNA. Translation: AAP22344.1. Sequence problems.
BC049219 mRNA. Translation: AAH49219.1.
BC056142 mRNA. Translation: AAH56142.1.
BC068455 mRNA. Translation: AAH68455.1.
AB010812 mRNA. Translation: BAA76288.1. Different initiation.
CCDSiCCDS5396.1.
RefSeqiNP_004280.5. NM_004289.6.
UniGeneiHs.404741.
Hs.712898.

Genome annotation databases

EnsembliENST00000056233; ENSP00000056233; ENSG00000050344.
GeneIDi9603.
KEGGihsa:9603.
UCSCiuc003sxq.3. human.

Polymorphism databases

DMDMi56404677.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF133059 mRNA. Translation: AAG43275.1 .
AF134891 mRNA. Translation: AAF61404.1 .
AF135116 Genomic DNA. Translation: AAF61415.1 .
AC004520 Genomic DNA. Translation: AAP22344.1 . Sequence problems.
BC049219 mRNA. Translation: AAH49219.1 .
BC056142 mRNA. Translation: AAH56142.1 .
BC068455 mRNA. Translation: AAH68455.1 .
AB010812 mRNA. Translation: BAA76288.1 . Different initiation.
CCDSi CCDS5396.1.
RefSeqi NP_004280.5. NM_004289.6.
UniGenei Hs.404741.
Hs.712898.

3D structure databases

ProteinModelPortali Q9Y4A8.
SMRi Q9Y4A8. Positions 536-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114967. 10 interactions.
STRINGi 9606.ENSP00000056233.

PTM databases

PhosphoSitei Q9Y4A8.

Polymorphism databases

DMDMi 56404677.

Proteomic databases

PaxDbi Q9Y4A8.
PRIDEi Q9Y4A8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000056233 ; ENSP00000056233 ; ENSG00000050344 .
GeneIDi 9603.
KEGGi hsa:9603.
UCSCi uc003sxq.3. human.

Organism-specific databases

CTDi 9603.
GeneCardsi GC07P026158.
H-InvDB HIX0033872.
HGNCi HGNC:7783. NFE2L3.
HPAi HPA055889.
MIMi 604135. gene.
neXtProti NX_Q9Y4A8.
PharmGKBi PA31589.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278006.
HOGENOMi HOG000234410.
HOVERGENi HBG052609.
InParanoidi Q9Y4A8.
KOi K09040.
OMAi EIVRMPV.
OrthoDBi EOG715Q3N.
PhylomeDBi Q9Y4A8.
TreeFami TF337360.

Miscellaneous databases

GeneWikii NFE2L3.
GenomeRNAii 9603.
NextBioi 36023.
PROi Q9Y4A8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4A8.
CleanExi HS_NFE2L3.
Genevestigatori Q9Y4A8.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF03131. bZIP_Maf. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NRF3, a basic leucine zipper protein interacting with MAFG."
    Blank V., Andrews N.C.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MAFG.
  2. Stoesz S.P., Liu S., Pickett C.B.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney, Lymph and Placenta.
  5. "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3."
    Kobayashi A., Ito E., Toki T., Kogame K., Takahashi S., Igarashi K., Hayashi N., Yamamoto M.
    J. Biol. Chem. 274:6443-6452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-694, CHARACTERIZATION, INTERACTION WITH MAFK, TISSUE SPECIFICITY.
    Tissue: Placenta.

Entry informationi

Entry nameiNF2L3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A8
Secondary accession number(s): Q6NUS0
, Q7Z498, Q86UJ4, Q86VR5, Q9UQA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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