ID   JERKL_HUMAN             Reviewed;         524 AA.
AC   Q9Y4A0; A8K3G4; B2RAJ3; Q32MC2;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   24-JAN-2024, entry version 157.
DE   RecName: Full=Jerky protein homolog-like;
DE   AltName: Full=Human homolog of mouse jerky gene protein;
DE            Short=HHMJG;
GN   Name=JRKL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.
RX   PubMed=9240447; DOI=10.1006/bbrc.1997.6935;
RA   Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K.,
RA   Carter K.C., Li Y.;
RT   "Cloning, mapping, and tissue distribution of a human homologue of the
RT   mouse jerky gene product.";
RL   Biochem. Biophys. Res. Commun. 236:389-395(1997).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC       ECO:0000255|PROSITE-ProRule:PRU00583}.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in the majority of tissues
CC       examined, including brain and skeletal muscle.
CC   -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB65833.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK290579; BAF83268.1; -; mRNA.
DR   EMBL; AK314216; BAG36890.1; -; mRNA.
DR   EMBL; AP003781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471065; EAW66986.1; -; Genomic_DNA.
DR   EMBL; BC109202; AAI09203.1; -; mRNA.
DR   EMBL; AF004715; AAB65833.1; ALT_INIT; mRNA.
DR   CCDS; CCDS8308.1; -.
DR   PIR; JC5594; JC5594.
DR   RefSeq; NP_001248762.1; NM_001261833.1.
DR   RefSeq; NP_003763.2; NM_003772.3.
DR   AlphaFoldDB; Q9Y4A0; -.
DR   SMR; Q9Y4A0; -.
DR   BioGRID; 114237; 7.
DR   IntAct; Q9Y4A0; 7.
DR   STRING; 9606.ENSP00000333350; -.
DR   iPTMnet; Q9Y4A0; -.
DR   PhosphoSitePlus; Q9Y4A0; -.
DR   BioMuta; JRKL; -.
DR   DMDM; 254763306; -.
DR   EPD; Q9Y4A0; -.
DR   jPOST; Q9Y4A0; -.
DR   MassIVE; Q9Y4A0; -.
DR   MaxQB; Q9Y4A0; -.
DR   PaxDb; 9606-ENSP00000333350; -.
DR   PeptideAtlas; Q9Y4A0; -.
DR   ProteomicsDB; 86140; -.
DR   Pumba; Q9Y4A0; -.
DR   Antibodypedia; 31694; 135 antibodies from 19 providers.
DR   DNASU; 8690; -.
DR   Ensembl; ENST00000332349.5; ENSP00000333350.4; ENSG00000183340.7.
DR   GeneID; 8690; -.
DR   KEGG; hsa:8690; -.
DR   MANE-Select; ENST00000332349.5; ENSP00000333350.4; NM_001261833.2; NP_001248762.1.
DR   UCSC; uc009ywu.5; human.
DR   AGR; HGNC:6200; -.
DR   CTD; 8690; -.
DR   GeneCards; JRKL; -.
DR   HGNC; HGNC:6200; JRKL.
DR   HPA; ENSG00000183340; Low tissue specificity.
DR   MIM; 603211; gene.
DR   neXtProt; NX_Q9Y4A0; -.
DR   OpenTargets; ENSG00000183340; -.
DR   PharmGKB; PA30002; -.
DR   VEuPathDB; HostDB:ENSG00000183340; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   GeneTree; ENSGT00940000161513; -.
DR   HOGENOM; CLU_018294_1_1_1; -.
DR   InParanoid; Q9Y4A0; -.
DR   OMA; SRAWKQI; -.
DR   OrthoDB; 2967227at2759; -.
DR   PhylomeDB; Q9Y4A0; -.
DR   TreeFam; TF101131; -.
DR   PathwayCommons; Q9Y4A0; -.
DR   SignaLink; Q9Y4A0; -.
DR   BioGRID-ORCS; 8690; 13 hits in 1164 CRISPR screens.
DR   GenomeRNAi; 8690; -.
DR   Pharos; Q9Y4A0; Tdark.
DR   PRO; PR:Q9Y4A0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9Y4A0; Protein.
DR   Bgee; ENSG00000183340; Expressed in buccal mucosa cell and 199 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   InterPro; IPR007889; HTH_Psq.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR19303:SF16; JERKY PROTEIN HOMOLOG-LIKE; 1.
DR   PANTHER; PTHR19303; TRANSPOSON; 1.
DR   Pfam; PF04218; CENP-B_N; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
DR   PROSITE; PS50960; HTH_PSQ; 1.
DR   Genevisible; Q9Y4A0; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..524
FT                   /note="Jerky protein homolog-like"
FT                   /id="PRO_0000126130"
FT   DOMAIN          1..52
FT                   /note="HTH psq-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT   DOMAIN          67..139
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   DOMAIN          168..385
FT                   /note="DDE-1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        28..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   DNA_BIND        100..132
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        59
FT                   /note="S -> F (in Ref. 1; BAF83268)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        109
FT                   /note="F -> S (in Ref. 1; BAG36890)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        380
FT                   /note="T -> I (in Ref. 1; BAG36890)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        433
FT                   /note="E -> K (in Ref. 1; BAG36890)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   524 AA;  59912 MW;  81FEC7468DCBBF47 CRC64;
     MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD
     STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN
     PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG
     LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST
     DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
     NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL
     TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL
     ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA
     ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ
//