Q9Y4A0 (JERKL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Jerky protein homolog-like

Alternative name(s):
Human homolog of mouse jerky gene protein
Short name=HHMJG

Gene names

Name:

JRKL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.
Sequence similarities	Belongs to the tigger transposable element derived protein family. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain.
Sequence caution	The sequence AAB65833.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	central nervous system development Traceable author statement Ref.5. Source: ProtInc
Cellular_component	nucleus Traceable author statement Ref.5. Source: ProtInc
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Jerky protein homolog-like		PRO_0000126130
Regions
	Domain	1 – 52	52	HTH psq-type
	Domain	67 – 139	73	HTH CENPB-type
	Domain	168 – 385	218	DDE
	DNA binding	28 – 48	21	H-T-H motif By similarity
	DNA binding	100 – 132	33	H-T-H motif By similarity
Experimental info
	Sequence conflict	59	1	S → F in BAF83268. Ref.1
	Sequence conflict	109	1	F → S in BAG36890. Ref.1
	Sequence conflict	380	1	T → I in BAG36890. Ref.1
	Sequence conflict	433	1	E → K in BAG36890. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y4A0 [UniParc]. Last modified July 28, 2009. Version 2. Checksum: 81FEC7468DCBBF47	FASTA	524	59,912
	10 20 30 40 50 60 MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD 70 80 90 100 110 120 STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN 130 140 150 160 170 180 PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG 190 200 210 220 230 240 LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST 250 260 270 280 290 300 DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE 310 320 330 340 350 360 NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL 370 380 390 400 410 420 TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL 430 440 450 460 470 480 ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA 490 500 510 520 ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product." Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K., Carter K.C., Li Y. Biochem. Biophys. Res. Commun. 236:389-395(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK290579 mRNA. Translation: BAF83268.1. AK314216 mRNA. Translation: BAG36890.1. AP003781 Genomic DNA. No translation available. CH471065 Genomic DNA. Translation: EAW66986.1. BC109202 mRNA. Translation: AAI09203.1. AF004715 mRNA. Translation: AAB65833.1. Different initiation.
IPI	IPI00216634.
PIR	JC5594.
RefSeq	NP_001248762.1. NM_001261833.1. NP_003763.2. NM_003772.3.
UniGene	Hs.105940. Hs.722414.
3D structure databases
ProteinModelPortal	Q9Y4A0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y4A0. 1 interaction.
STRING	9606.ENSP00000333350.
PTM databases
PhosphoSite	Q9Y4A0.
Polymorphism databases
DMDM	254763306.
Proteomic databases
PaxDb	Q9Y4A0.
PRIDE	Q9Y4A0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332349; ENSP00000333350; ENSG00000183340. ENST00000458427; ENSP00000389989; ENSG00000183340.
GeneID	8690.
KEGG	hsa:8690.
UCSC	uc001pfy.2. human.
Organism-specific databases
CTD	8690.
GeneCards	GC11P096123.
H-InvDB	HIX0035846.
HGNC	HGNC:6200. JRKL.
HPA	HPA046184.
MIM	603211. gene.
neXtProt	NX_Q9Y4A0.
PharmGKB	PA30002.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG71546.
HOGENOM	HOG000130798.
HOVERGEN	HBG101551.
InParanoid	Q9Y4A0.
OMA	ALQWTEN.
OrthoDB	EOG444KK2.
PhylomeDB	Q9Y4A0.
Gene expression databases
Bgee	Q9Y4A0.
CleanEx	HS_JRKL.
Genevestigator	Q9Y4A0.
GermOnline	ENSG00000183340. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 2 hits.
InterPro	IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR006600. HTH_CenpB_DNA-bd_dom. IPR007889. HTH_Psq. [Graphical view]
Pfam	PF04218. CENP-B_N. 1 hit. PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view]
SMART	SM00674. CENPB. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS51253. HTH_CENPB. 1 hit. PS50960. HTH_PSQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8690.
NextBio	32591.
SOURCE	Search...

Entry information

Entry name

JERKL_HUMAN

Accession

Primary (citable) accession number: Q9Y4A0
Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.