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Q9Y4A0

- JERKL_HUMAN

UniProt

Q9Y4A0 - JERKL_HUMAN

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Protein

Jerky protein homolog-like

Gene

JRKL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 4821H-T-H motifBy similarityAdd
BLAST
DNA bindingi100 – 13233H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. central nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homolog-like
Alternative name(s):
Human homolog of mouse jerky gene protein
Short name:
HHMJG
Gene namesi
Name:JRKL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6200. JRKL.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30002.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Jerky protein homolog-likePRO_0000126130Add
BLAST

Proteomic databases

MaxQBiQ9Y4A0.
PaxDbiQ9Y4A0.
PRIDEiQ9Y4A0.

PTM databases

PhosphoSiteiQ9Y4A0.

Expressioni

Tissue specificityi

Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.

Gene expression databases

BgeeiQ9Y4A0.
CleanExiHS_JRKL.
GenevestigatoriQ9Y4A0.

Organism-specific databases

HPAiHPA046184.

Interactioni

Protein-protein interaction databases

IntActiQ9Y4A0. 1 interaction.
STRINGi9606.ENSP00000333350.

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A0.
SMRiQ9Y4A0. Positions 6-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5252HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini67 – 13973HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini168 – 385218DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG71546.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000130798.
HOVERGENiHBG101551.
InParanoidiQ9Y4A0.
OMAiKGAWMDL.
OrthoDBiEOG7GBFWK.
PhylomeDBiQ9Y4A0.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y4A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE
60 70 80 90 100
KIITYASSSD STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP
110 120 130 140 150
ICAKRAEFFF YALGMDGDFN PSAGWLTRFK QRHSIREINI RNERLNGDET
160 170 180 190 200
AVEDFCNNFR DFIERENLQP EQIYNADETG LFWKCLPSRI SVIKGKCTVP
210 220 230 240 250
GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST DTLNLPVSYF
260 270 280 290 300
SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
310 320 330 340 350
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG
360 370 380 390 400
NDLKSFWKKL TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF
410 420 430 440 450
DVEDISVATV AAILQHTKGL ENVTTENLEK WLEVDSTEPG YEVLTDSEII
460 470 480 490 500
RRAQGQADES SENEEEEIEL IPEKHINHAA ALQWTENLLD YLEQQGDMIL
510 520
PDRLVIRKLR ATIRNKQKMT KSSQ
Length:524
Mass (Da):59,912
Last modified:July 28, 2009 - v2
Checksum:i81FEC7468DCBBF47
GO

Sequence cautioni

The sequence AAB65833.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591S → F in BAF83268. (PubMed:14702039)Curated
Sequence conflicti109 – 1091F → S in BAG36890. (PubMed:14702039)Curated
Sequence conflicti380 – 3801T → I in BAG36890. (PubMed:14702039)Curated
Sequence conflicti433 – 4331E → K in BAG36890. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290579 mRNA. Translation: BAF83268.1.
AK314216 mRNA. Translation: BAG36890.1.
AP003781 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66986.1.
BC109202 mRNA. Translation: AAI09203.1.
AF004715 mRNA. Translation: AAB65833.1. Different initiation.
CCDSiCCDS8308.1.
PIRiJC5594.
RefSeqiNP_001248762.1. NM_001261833.1.
NP_003763.2. NM_003772.3.
UniGeneiHs.105940.
Hs.745352.

Genome annotation databases

EnsembliENST00000332349; ENSP00000333350; ENSG00000183340.
GeneIDi8690.
KEGGihsa:8690.
UCSCiuc001pfy.2. human.

Polymorphism databases

DMDMi254763306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290579 mRNA. Translation: BAF83268.1 .
AK314216 mRNA. Translation: BAG36890.1 .
AP003781 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66986.1 .
BC109202 mRNA. Translation: AAI09203.1 .
AF004715 mRNA. Translation: AAB65833.1 . Different initiation.
CCDSi CCDS8308.1.
PIRi JC5594.
RefSeqi NP_001248762.1. NM_001261833.1.
NP_003763.2. NM_003772.3.
UniGenei Hs.105940.
Hs.745352.

3D structure databases

ProteinModelPortali Q9Y4A0.
SMRi Q9Y4A0. Positions 6-134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Y4A0. 1 interaction.
STRINGi 9606.ENSP00000333350.

PTM databases

PhosphoSitei Q9Y4A0.

Polymorphism databases

DMDMi 254763306.

Proteomic databases

MaxQBi Q9Y4A0.
PaxDbi Q9Y4A0.
PRIDEi Q9Y4A0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332349 ; ENSP00000333350 ; ENSG00000183340 .
GeneIDi 8690.
KEGGi hsa:8690.
UCSCi uc001pfy.2. human.

Organism-specific databases

CTDi 8690.
GeneCardsi GC11P096123.
H-InvDB HIX0035846.
HGNCi HGNC:6200. JRKL.
HPAi HPA046184.
MIMi 603211. gene.
neXtProti NX_Q9Y4A0.
PharmGKBi PA30002.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71546.
GeneTreei ENSGT00760000119149.
HOGENOMi HOG000130798.
HOVERGENi HBG101551.
InParanoidi Q9Y4A0.
OMAi KGAWMDL.
OrthoDBi EOG7GBFWK.
PhylomeDBi Q9Y4A0.
TreeFami TF101131.

Miscellaneous databases

GenomeRNAii 8690.
NextBioi 32591.
PROi Q9Y4A0.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y4A0.
CleanExi HS_JRKL.
Genevestigatori Q9Y4A0.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product."
    Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K., Carter K.C., Li Y.
    Biochem. Biophys. Res. Commun. 236:389-395(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.

Entry informationi

Entry nameiJERKL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A0
Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3