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Q9Y4A0 (JERKL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Jerky protein homolog-like
Alternative name(s):
Human homolog of mouse jerky gene protein
Short name=HHMJG
Gene names
Name:JRKL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length524 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.

Sequence similarities

Belongs to the tigger transposable element derived protein family.

Contains 1 DDE domain.

Contains 1 HTH CENPB-type DNA-binding domain.

Contains 1 HTH psq-type DNA-binding domain.

Sequence caution

The sequence AAB65833.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentral nervous system development

Traceable author statement Ref.5. Source: ProtInc

   Cellular_componentnucleus

Traceable author statement Ref.5. Source: ProtInc

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 524524Jerky protein homolog-like
PRO_0000126130

Regions

Domain1 – 5252HTH psq-type
Domain67 – 13973HTH CENPB-type
Domain168 – 385218DDE
DNA binding28 – 4821H-T-H motif By similarity
DNA binding100 – 13233H-T-H motif By similarity

Experimental info

Sequence conflict591S → F in BAF83268. Ref.1
Sequence conflict1091F → S in BAG36890. Ref.1
Sequence conflict3801T → I in BAG36890. Ref.1
Sequence conflict4331E → K in BAG36890. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y4A0 [UniParc].

Last modified July 28, 2009. Version 2.
Checksum: 81FEC7468DCBBF47

FASTA52459,912
        10         20         30         40         50         60 
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD 

        70         80         90        100        110        120 
STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN 

       130        140        150        160        170        180 
PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG 

       190        200        210        220        230        240 
LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST 

       250        260        270        280        290        300 
DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE 

       310        320        330        340        350        360 
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL 

       370        380        390        400        410        420 
TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL 

       430        440        450        460        470        480 
ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA 

       490        500        510        520 
ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product."
Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K., Carter K.C., Li Y.
Biochem. Biophys. Res. Commun. 236:389-395(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK290579 mRNA. Translation: BAF83268.1.
AK314216 mRNA. Translation: BAG36890.1.
AP003781 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66986.1.
BC109202 mRNA. Translation: AAI09203.1.
AF004715 mRNA. Translation: AAB65833.1. Different initiation.
PIRJC5594.
RefSeqNP_001248762.1. NM_001261833.1.
NP_003763.2. NM_003772.3.
UniGeneHs.105940.
Hs.745352.

3D structure databases

ProteinModelPortalQ9Y4A0.
SMRQ9Y4A0. Positions 6-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Y4A0. 1 interaction.
STRING9606.ENSP00000333350.

PTM databases

PhosphoSiteQ9Y4A0.

Polymorphism databases

DMDM254763306.

Proteomic databases

PaxDbQ9Y4A0.
PRIDEQ9Y4A0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332349; ENSP00000333350; ENSG00000183340.
ENST00000458427; ENSP00000389989; ENSG00000183340.
GeneID8690.
KEGGhsa:8690.
UCSCuc001pfy.2. human.

Organism-specific databases

CTD8690.
GeneCardsGC11P096123.
H-InvDBHIX0035846.
HGNCHGNC:6200. JRKL.
HPAHPA046184.
MIM603211. gene.
neXtProtNX_Q9Y4A0.
PharmGKBPA30002.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71546.
HOGENOMHOG000130798.
HOVERGENHBG101551.
InParanoidQ9Y4A0.
OMAKGAWMDL.
OrthoDBEOG7GBFWK.
PhylomeDBQ9Y4A0.
TreeFamTF101131.

Gene expression databases

BgeeQ9Y4A0.
CleanExHS_JRKL.
GenevestigatorQ9Y4A0.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8690.
NextBio32591.
PROQ9Y4A0.
SOURCESearch...

Entry information

Entry nameJERKL_HUMAN
AccessionPrimary (citable) accession number: Q9Y4A0
Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM