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Q9Y4A0

- JERKL_HUMAN

UniProt

Q9Y4A0 - JERKL_HUMAN

Protein

Jerky protein homolog-like

Gene

JRKL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi28 – 4821H-T-H motifBy similarityAdd
    BLAST
    DNA bindingi100 – 13233H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. central nervous system development Source: ProtInc

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Jerky protein homolog-like
    Alternative name(s):
    Human homolog of mouse jerky gene protein
    Short name:
    HHMJG
    Gene namesi
    Name:JRKL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6200. JRKL.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Jerky protein homolog-likePRO_0000126130Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y4A0.
    PaxDbiQ9Y4A0.
    PRIDEiQ9Y4A0.

    PTM databases

    PhosphoSiteiQ9Y4A0.

    Expressioni

    Tissue specificityi

    Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.

    Gene expression databases

    BgeeiQ9Y4A0.
    CleanExiHS_JRKL.
    GenevestigatoriQ9Y4A0.

    Organism-specific databases

    HPAiHPA046184.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Y4A0. 1 interaction.
    STRINGi9606.ENSP00000333350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y4A0.
    SMRiQ9Y4A0. Positions 6-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5252HTH psq-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini67 – 13973HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 385218DDEAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG71546.
    HOGENOMiHOG000130798.
    HOVERGENiHBG101551.
    InParanoidiQ9Y4A0.
    OMAiKGAWMDL.
    OrthoDBiEOG7GBFWK.
    PhylomeDBiQ9Y4A0.
    TreeFamiTF101131.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view]
    PfamiPF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y4A0-1 [UniParc]FASTAAdd to Basket

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    MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE    50
    KIITYASSSD STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP 100
    ICAKRAEFFF YALGMDGDFN PSAGWLTRFK QRHSIREINI RNERLNGDET 150
    AVEDFCNNFR DFIERENLQP EQIYNADETG LFWKCLPSRI SVIKGKCTVP 200
    GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST DTLNLPVSYF 250
    SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE 300
    NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG 350
    NDLKSFWKKL TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF 400
    DVEDISVATV AAILQHTKGL ENVTTENLEK WLEVDSTEPG YEVLTDSEII 450
    RRAQGQADES SENEEEEIEL IPEKHINHAA ALQWTENLLD YLEQQGDMIL 500
    PDRLVIRKLR ATIRNKQKMT KSSQ 524
    Length:524
    Mass (Da):59,912
    Last modified:July 28, 2009 - v2
    Checksum:i81FEC7468DCBBF47
    GO

    Sequence cautioni

    The sequence AAB65833.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591S → F in BAF83268. (PubMed:14702039)Curated
    Sequence conflicti109 – 1091F → S in BAG36890. (PubMed:14702039)Curated
    Sequence conflicti380 – 3801T → I in BAG36890. (PubMed:14702039)Curated
    Sequence conflicti433 – 4331E → K in BAG36890. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290579 mRNA. Translation: BAF83268.1.
    AK314216 mRNA. Translation: BAG36890.1.
    AP003781 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW66986.1.
    BC109202 mRNA. Translation: AAI09203.1.
    AF004715 mRNA. Translation: AAB65833.1. Different initiation.
    CCDSiCCDS8308.1.
    PIRiJC5594.
    RefSeqiNP_001248762.1. NM_001261833.1.
    NP_003763.2. NM_003772.3.
    UniGeneiHs.105940.
    Hs.745352.

    Genome annotation databases

    EnsembliENST00000332349; ENSP00000333350; ENSG00000183340.
    GeneIDi8690.
    KEGGihsa:8690.
    UCSCiuc001pfy.2. human.

    Polymorphism databases

    DMDMi254763306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK290579 mRNA. Translation: BAF83268.1 .
    AK314216 mRNA. Translation: BAG36890.1 .
    AP003781 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW66986.1 .
    BC109202 mRNA. Translation: AAI09203.1 .
    AF004715 mRNA. Translation: AAB65833.1 . Different initiation.
    CCDSi CCDS8308.1.
    PIRi JC5594.
    RefSeqi NP_001248762.1. NM_001261833.1.
    NP_003763.2. NM_003772.3.
    UniGenei Hs.105940.
    Hs.745352.

    3D structure databases

    ProteinModelPortali Q9Y4A0.
    SMRi Q9Y4A0. Positions 6-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Y4A0. 1 interaction.
    STRINGi 9606.ENSP00000333350.

    PTM databases

    PhosphoSitei Q9Y4A0.

    Polymorphism databases

    DMDMi 254763306.

    Proteomic databases

    MaxQBi Q9Y4A0.
    PaxDbi Q9Y4A0.
    PRIDEi Q9Y4A0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332349 ; ENSP00000333350 ; ENSG00000183340 .
    GeneIDi 8690.
    KEGGi hsa:8690.
    UCSCi uc001pfy.2. human.

    Organism-specific databases

    CTDi 8690.
    GeneCardsi GC11P096123.
    H-InvDB HIX0035846.
    HGNCi HGNC:6200. JRKL.
    HPAi HPA046184.
    MIMi 603211. gene.
    neXtProti NX_Q9Y4A0.
    PharmGKBi PA30002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71546.
    HOGENOMi HOG000130798.
    HOVERGENi HBG101551.
    InParanoidi Q9Y4A0.
    OMAi KGAWMDL.
    OrthoDBi EOG7GBFWK.
    PhylomeDBi Q9Y4A0.
    TreeFami TF101131.

    Miscellaneous databases

    GenomeRNAii 8690.
    NextBioi 32591.
    PROi Q9Y4A0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y4A0.
    CleanExi HS_JRKL.
    Genevestigatori Q9Y4A0.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view ]
    Pfami PF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product."
      Zeng Z., Kyaw H., Gakenheimer K.R., Augustus M., Fan P., Zhang X., Su K., Carter K.C., Li Y.
      Biochem. Biophys. Res. Commun. 236:389-395(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-524.

    Entry informationi

    Entry nameiJERKL_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y4A0
    Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3