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Q9Y496

- KIF3A_HUMAN

UniProt

Q9Y496 - KIF3A_HUMAN

Protein

Kinesin-like protein KIF3A

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi100 – 1078ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. plus-end-directed microtubule motor activity Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. spectrin binding Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    3. blood coagulation Source: Reactome
    4. cilium assembly Source: UniProtKB
    5. determination of left/right symmetry Source: Ensembl
    6. dorsal/ventral neural tube patterning Source: Ensembl
    7. heart development Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. kidney development Source: Ensembl
    10. membrane organization Source: Reactome
    11. metabolic process Source: GOC
    12. microtubule-based movement Source: Reactome
    13. organelle organization Source: ProtInc
    14. plus-end-directed vesicle transport along microtubule Source: BHF-UCL
    15. positive regulation of receptor-mediated endocytosis Source: Ensembl
    16. smoothened signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_25201. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF3A
    Alternative name(s):
    Microtubule plus end-directed kinesin motor 3A
    Gene namesi
    Name:KIF3A
    Synonyms:KIF3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6319. KIF3A.

    Subcellular locationi

    Cytoplasmcytoskeleton Curated. Cell projectioncilium By similarity

    GO - Cellular componenti

    1. centrosome Source: BHF-UCL
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. kinesin II complex Source: BHF-UCL
    5. microtubule Source: UniProtKB-KW
    6. microtubule cytoskeleton Source: BHF-UCL
    7. neuron projection Source: Ensembl
    8. photoreceptor connecting cilium Source: Ensembl
    9. primary cilium Source: UniProtKB
    10. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 699699Kinesin-like protein KIF3APRO_0000125393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei687 – 6871Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y496.
    PaxDbiQ9Y496.
    PRIDEiQ9Y496.

    PTM databases

    PhosphoSiteiQ9Y496.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y496.
    BgeeiQ9Y496.
    CleanExiHS_KIF3A.
    GenevestigatoriQ9Y496.

    Organism-specific databases

    HPAiCAB037085.

    Interactioni

    Subunit structurei

    Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DISC1Q9NRI53EBI-1104844,EBI-529989
    KIFAP3Q928453EBI-1104844,EBI-954040

    Protein-protein interaction databases

    BioGridi116300. 19 interactions.
    DIPiDIP-33237N.
    IntActiQ9Y496. 11 interactions.
    STRINGi9606.ENSP00000368020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y496.
    SMRiQ9Y496. Positions 13-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 345332Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni697 – 6993Globular

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili355 – 590236Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000116164.
    HOVERGENiHBG052255.
    KOiK10394.
    OrthoDBiEOG7WX086.
    PhylomeDBiQ9Y496.
    TreeFamiTF105223.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y496-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK    50
    TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG 100
    QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL 150
    EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT 200
    LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD 250
    LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 300
    KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR 350
    INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE 400
    DGEKRKKRRG KKKVSPDKMI EMQAKIDEER KALETKLDME EEERNKARAE 450
    LEKREKDLLK AQQEHQSLLE KLSALEKKVI VGGVDLLAKA EEQEKLLEES 500
    NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ GKTKKLKKVW 550
    TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY 600
    QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH 650
    VYLAYTEESL RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ 699
    Length:699
    Mass (Da):80,041
    Last modified:May 18, 2010 - v4
    Checksum:iA0BF5BB1F699DF12
    GO

    Sequence cautioni

    The sequence BAD93017.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAC04475.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511E → G in AAH45542. (PubMed:15489334)Curated
    Sequence conflicti170 – 1701E → A in AAC72294. (PubMed:10548469)Curated
    Sequence conflicti409 – 4091R → RDQA in BAD93017. 1 PublicationCurated
    Sequence conflicti409 – 4091R → RDQT in AAH45542. (PubMed:15489334)Curated
    Sequence conflicti409 – 4091R → RIQI in AAC72294. (PubMed:10548469)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti172 – 1721K → I.1 Publication
    Corresponds to variant rs17854353 [ dbSNP | Ensembl ].
    VAR_055319

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041853 mRNA. Translation: AAC72294.1.
    AB209780 mRNA. Translation: BAD93017.1. Different initiation.
    AC004039 Genomic DNA. No translation available.
    AC004237 Genomic DNA. Translation: AAC04475.1. Sequence problems.
    BC045542 mRNA. Translation: AAH45542.1.
    CCDSiCCDS34235.1.
    RefSeqiNP_008985.3. NM_007054.5.
    UniGeneiHs.43670.

    Genome annotation databases

    EnsembliENST00000378746; ENSP00000368020; ENSG00000131437.
    GeneIDi11127.
    KEGGihsa:11127.
    UCSCiuc003kxo.3. human.

    Polymorphism databases

    DMDMi296439481.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041853 mRNA. Translation: AAC72294.1 .
    AB209780 mRNA. Translation: BAD93017.1 . Different initiation.
    AC004039 Genomic DNA. No translation available.
    AC004237 Genomic DNA. Translation: AAC04475.1 . Sequence problems.
    BC045542 mRNA. Translation: AAH45542.1 .
    CCDSi CCDS34235.1.
    RefSeqi NP_008985.3. NM_007054.5.
    UniGenei Hs.43670.

    3D structure databases

    ProteinModelPortali Q9Y496.
    SMRi Q9Y496. Positions 13-391.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116300. 19 interactions.
    DIPi DIP-33237N.
    IntActi Q9Y496. 11 interactions.
    STRINGi 9606.ENSP00000368020.

    Chemistry

    ChEMBLi CHEMBL5544.

    PTM databases

    PhosphoSitei Q9Y496.

    Polymorphism databases

    DMDMi 296439481.

    Proteomic databases

    MaxQBi Q9Y496.
    PaxDbi Q9Y496.
    PRIDEi Q9Y496.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378746 ; ENSP00000368020 ; ENSG00000131437 .
    GeneIDi 11127.
    KEGGi hsa:11127.
    UCSCi uc003kxo.3. human.

    Organism-specific databases

    CTDi 11127.
    GeneCardsi GC05M132059.
    H-InvDB HIX0024788.
    HGNCi HGNC:6319. KIF3A.
    HPAi CAB037085.
    MIMi 604683. gene.
    neXtProti NX_Q9Y496.
    PharmGKBi PA30102.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000116164.
    HOVERGENi HBG052255.
    KOi K10394.
    OrthoDBi EOG7WX086.
    PhylomeDBi Q9Y496.
    TreeFami TF105223.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_25201. Kinesins.

    Miscellaneous databases

    ChiTaRSi KIF3A. human.
    GeneWikii KIF3A.
    GenomeRNAii 11127.
    NextBioi 42288.
    PROi Q9Y496.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y496.
    Bgeei Q9Y496.
    CleanExi HS_KIF3A.
    Genevestigatori Q9Y496.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina."
      Whitehead J.L., Wang S.Y., Bost-Usinger L., Hoang E., Frazer K.A., Burnside B.
      Exp. Eye Res. 69:491-503(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-172.
      Tissue: Testis.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: INTERACTION WITH PIFO.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments."
      Uusi-Rauva K., Kyttala A., van der Kant R., Vesa J., Tanhuanpaa K., Neefjes J., Olkkonen V.M., Jalanko A.
      Cell. Mol. Life Sci. 69:2075-2089(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLN3.

    Entry informationi

    Entry nameiKIF3A_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y496
    Secondary accession number(s): A8MSW9
    , Q59EN1, Q86XE9, Q9Y6V4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3