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Q9Y496

- KIF3A_HUMAN

UniProt

Q9Y496 - KIF3A_HUMAN

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Protein
Kinesin-like protein KIF3A
Gene
KIF3A, KIF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. plus-end-directed microtubule motor activity Source: BHF-UCL
  3. protein binding Source: UniProtKB
  4. spectrin binding Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  3. blood coagulation Source: Reactome
  4. cilium assembly Source: UniProtKB
  5. determination of left/right symmetry Source: Ensembl
  6. dorsal/ventral neural tube patterning Source: Ensembl
  7. heart development Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. kidney development Source: Ensembl
  10. membrane organization Source: Reactome
  11. metabolic process Source: GOC
  12. microtubule-based movement Source: Reactome
  13. organelle organization Source: ProtInc
  14. plus-end-directed vesicle transport along microtubule Source: BHF-UCL
  15. positive regulation of receptor-mediated endocytosis Source: Ensembl
  16. smoothened signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3A
Alternative name(s):
Microtubule plus end-directed kinesin motor 3A
Gene namesi
Name:KIF3A
Synonyms:KIF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6319. KIF3A.

Subcellular locationi

Cytoplasmcytoskeleton Inferred. Cell projectioncilium By similarity

GO - Cellular componenti

  1. centrosome Source: BHF-UCL
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. kinesin II complex Source: BHF-UCL
  5. microtubule Source: UniProtKB-KW
  6. microtubule cytoskeleton Source: BHF-UCL
  7. neuron projection Source: Ensembl
  8. photoreceptor connecting cilium Source: Ensembl
  9. primary cilium Source: UniProtKB
  10. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Kinesin-like protein KIF3A
PRO_0000125393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei687 – 6871Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y496.
PaxDbiQ9Y496.
PRIDEiQ9Y496.

PTM databases

PhosphoSiteiQ9Y496.

Expressioni

Gene expression databases

ArrayExpressiQ9Y496.
BgeeiQ9Y496.
CleanExiHS_KIF3A.
GenevestigatoriQ9Y496.

Organism-specific databases

HPAiCAB037085.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B. Interacts with PIFO. Interacts with CLN3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-1104844,EBI-529989

Protein-protein interaction databases

BioGridi116300. 19 interactions.
DIPiDIP-33237N.
IntActiQ9Y496. 10 interactions.
STRINGi9606.ENSP00000368020.

Structurei

3D structure databases

ProteinModelPortaliQ9Y496.
SMRiQ9Y496. Positions 13-391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 345332Kinesin motor
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni697 – 6993Globular

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili355 – 590236 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
KOiK10394.
OrthoDBiEOG7WX086.
PhylomeDBiQ9Y496.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y496-1 [UniParc]FASTAAdd to Basket

« Hide

MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK    50
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG 100
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL 150
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT 200
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD 250
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 300
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR 350
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE 400
DGEKRKKRRG KKKVSPDKMI EMQAKIDEER KALETKLDME EEERNKARAE 450
LEKREKDLLK AQQEHQSLLE KLSALEKKVI VGGVDLLAKA EEQEKLLEES 500
NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ GKTKKLKKVW 550
TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY 600
QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH 650
VYLAYTEESL RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ 699
Length:699
Mass (Da):80,041
Last modified:May 18, 2010 - v4
Checksum:iA0BF5BB1F699DF12
GO

Sequence cautioni

The sequence BAD93017.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAC04475.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721K → I.1 Publication
Corresponds to variant rs17854353 [ dbSNP | Ensembl ].
VAR_055319

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511E → G in AAH45542. 1 Publication
Sequence conflicti170 – 1701E → A in AAC72294. 1 Publication
Sequence conflicti409 – 4091R → RDQA in BAD93017. 1 Publication
Sequence conflicti409 – 4091R → RDQT in AAH45542. 1 Publication
Sequence conflicti409 – 4091R → RIQI in AAC72294. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041853 mRNA. Translation: AAC72294.1.
AB209780 mRNA. Translation: BAD93017.1. Different initiation.
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. Translation: AAC04475.1. Sequence problems.
BC045542 mRNA. Translation: AAH45542.1.
CCDSiCCDS34235.1.
RefSeqiNP_008985.3. NM_007054.5.
UniGeneiHs.43670.

Genome annotation databases

EnsembliENST00000378746; ENSP00000368020; ENSG00000131437.
GeneIDi11127.
KEGGihsa:11127.
UCSCiuc003kxo.3. human.

Polymorphism databases

DMDMi296439481.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041853 mRNA. Translation: AAC72294.1 .
AB209780 mRNA. Translation: BAD93017.1 . Different initiation.
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. Translation: AAC04475.1 . Sequence problems.
BC045542 mRNA. Translation: AAH45542.1 .
CCDSi CCDS34235.1.
RefSeqi NP_008985.3. NM_007054.5.
UniGenei Hs.43670.

3D structure databases

ProteinModelPortali Q9Y496.
SMRi Q9Y496. Positions 13-391.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116300. 19 interactions.
DIPi DIP-33237N.
IntActi Q9Y496. 10 interactions.
STRINGi 9606.ENSP00000368020.

Chemistry

ChEMBLi CHEMBL5544.

PTM databases

PhosphoSitei Q9Y496.

Polymorphism databases

DMDMi 296439481.

Proteomic databases

MaxQBi Q9Y496.
PaxDbi Q9Y496.
PRIDEi Q9Y496.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378746 ; ENSP00000368020 ; ENSG00000131437 .
GeneIDi 11127.
KEGGi hsa:11127.
UCSCi uc003kxo.3. human.

Organism-specific databases

CTDi 11127.
GeneCardsi GC05M132059.
H-InvDB HIX0024788.
HGNCi HGNC:6319. KIF3A.
HPAi CAB037085.
MIMi 604683. gene.
neXtProti NX_Q9Y496.
PharmGKBi PA30102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000116164.
HOVERGENi HBG052255.
KOi K10394.
OrthoDBi EOG7WX086.
PhylomeDBi Q9Y496.
TreeFami TF105223.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_25201. Kinesins.

Miscellaneous databases

ChiTaRSi KIF3A. human.
GeneWikii KIF3A.
GenomeRNAii 11127.
NextBioi 42288.
PROi Q9Y496.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y496.
Bgeei Q9Y496.
CleanExi HS_KIF3A.
Genevestigatori Q9Y496.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina."
    Whitehead J.L., Wang S.Y., Bost-Usinger L., Hoang E., Frazer K.A., Burnside B.
    Exp. Eye Res. 69:491-503(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-172.
    Tissue: Testis.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: INTERACTION WITH PIFO.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-687, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments."
    Uusi-Rauva K., Kyttala A., van der Kant R., Vesa J., Tanhuanpaa K., Neefjes J., Olkkonen V.M., Jalanko A.
    Cell. Mol. Life Sci. 69:2075-2089(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLN3.

Entry informationi

Entry nameiKIF3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y496
Secondary accession number(s): A8MSW9
, Q59EN1, Q86XE9, Q9Y6V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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