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Protein

Kinesin-like protein KIF3A

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: BHF-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL
  • spectrin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131437-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5610787. Hedgehog 'off' state.
R-HSA-5620924. Intraflagellar transport.
R-HSA-5635838. Activation of SMO.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.
SIGNORiQ9Y496.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3A
Alternative name(s):
Microtubule plus end-directed kinesin motor 3A
Gene namesi
Name:KIF3A
Synonyms:KIF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6319. KIF3A.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: BHF-UCL
  • ciliary tip Source: Reactome
  • cilium Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • kinesin II complex Source: BHF-UCL
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi11127.
OpenTargetsiENSG00000131437.
PharmGKBiPA30102.

Chemistry databases

ChEMBLiCHEMBL5544.

Polymorphism and mutation databases

BioMutaiKIF3A.
DMDMi296439481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253931 – 699Kinesin-like protein KIF3AAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei687PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y496.
MaxQBiQ9Y496.
PaxDbiQ9Y496.
PeptideAtlasiQ9Y496.
PRIDEiQ9Y496.

PTM databases

iPTMnetiQ9Y496.
PhosphoSitePlusiQ9Y496.

Expressioni

Gene expression databases

BgeeiENSG00000131437.
CleanExiHS_KIF3A.
ExpressionAtlasiQ9Y496. baseline and differential.
GenevisibleiQ9Y496. HS.

Organism-specific databases

HPAiCAB037085.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with CLN3 (PubMed:22261744). Interacts with DCTN1 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DISC1Q9NRI53EBI-1104844,EBI-529989
KIFAP3Q928456EBI-1104844,EBI-954040
RAB11FIP5Q9BXF62EBI-1104844,EBI-1387068

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL
  • spectrin binding Source: MGI

Protein-protein interaction databases

BioGridi116300. 67 interactors.
DIPiDIP-33237N.
IntActiQ9Y496. 25 interactors.
STRINGi9606.ENSP00000368020.

Chemistry databases

BindingDBiQ9Y496.

Structurei

3D structure databases

ProteinModelPortaliQ9Y496.
SMRiQ9Y496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 345Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni697 – 699Globular3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 590Sequence analysisAdd BLAST236

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiQ9Y496.
KOiK10394.
PhylomeDBiQ9Y496.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE
410 420 430 440 450
DGEKRKKRRG KKKVSPDKMI EMQAKIDEER KALETKLDME EEERNKARAE
460 470 480 490 500
LEKREKDLLK AQQEHQSLLE KLSALEKKVI VGGVDLLAKA EEQEKLLEES
510 520 530 540 550
NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ GKTKKLKKVW
560 570 580 590 600
TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY
610 620 630 640 650
QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH
660 670 680 690
VYLAYTEESL RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ
Length:699
Mass (Da):80,041
Last modified:May 18, 2010 - v4
Checksum:iA0BF5BB1F699DF12
GO

Sequence cautioni

The sequence AAC04475 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD93017 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151E → G in AAH45542 (PubMed:15489334).Curated1
Sequence conflicti170E → A in AAC72294 (PubMed:10548469).Curated1
Sequence conflicti409R → RDQA in BAD93017 (Ref. 2) Curated1
Sequence conflicti409R → RDQT in AAH45542 (PubMed:15489334).Curated1
Sequence conflicti409R → RIQI in AAC72294 (PubMed:10548469).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055319172K → I.1 PublicationCorresponds to variant rs17854353dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041853 mRNA. Translation: AAC72294.1.
AB209780 mRNA. Translation: BAD93017.1. Different initiation.
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. Translation: AAC04475.1. Sequence problems.
BC045542 mRNA. Translation: AAH45542.1.
CCDSiCCDS34235.1.
RefSeqiNP_001287720.1. NM_001300791.1.
NP_001287721.1. NM_001300792.1.
NP_008985.3. NM_007054.6.
UniGeneiHs.43670.

Genome annotation databases

EnsembliENST00000378746; ENSP00000368020; ENSG00000131437.
GeneIDi11127.
KEGGihsa:11127.
UCSCiuc003kxo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041853 mRNA. Translation: AAC72294.1.
AB209780 mRNA. Translation: BAD93017.1. Different initiation.
AC004039 Genomic DNA. No translation available.
AC004237 Genomic DNA. Translation: AAC04475.1. Sequence problems.
BC045542 mRNA. Translation: AAH45542.1.
CCDSiCCDS34235.1.
RefSeqiNP_001287720.1. NM_001300791.1.
NP_001287721.1. NM_001300792.1.
NP_008985.3. NM_007054.6.
UniGeneiHs.43670.

3D structure databases

ProteinModelPortaliQ9Y496.
SMRiQ9Y496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116300. 67 interactors.
DIPiDIP-33237N.
IntActiQ9Y496. 25 interactors.
STRINGi9606.ENSP00000368020.

Chemistry databases

BindingDBiQ9Y496.
ChEMBLiCHEMBL5544.

PTM databases

iPTMnetiQ9Y496.
PhosphoSitePlusiQ9Y496.

Polymorphism and mutation databases

BioMutaiKIF3A.
DMDMi296439481.

Proteomic databases

EPDiQ9Y496.
MaxQBiQ9Y496.
PaxDbiQ9Y496.
PeptideAtlasiQ9Y496.
PRIDEiQ9Y496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378746; ENSP00000368020; ENSG00000131437.
GeneIDi11127.
KEGGihsa:11127.
UCSCiuc003kxo.4. human.

Organism-specific databases

CTDi11127.
DisGeNETi11127.
GeneCardsiKIF3A.
H-InvDBHIX0024788.
HGNCiHGNC:6319. KIF3A.
HPAiCAB037085.
MIMi604683. gene.
neXtProtiNX_Q9Y496.
OpenTargetsiENSG00000131437.
PharmGKBiPA30102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiQ9Y496.
KOiK10394.
PhylomeDBiQ9Y496.
TreeFamiTF105223.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131437-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-5610787. Hedgehog 'off' state.
R-HSA-5620924. Intraflagellar transport.
R-HSA-5635838. Activation of SMO.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.
SIGNORiQ9Y496.

Miscellaneous databases

ChiTaRSiKIF3A. human.
GeneWikiiKIF3A.
GenomeRNAii11127.
PROiQ9Y496.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131437.
CleanExiHS_KIF3A.
ExpressionAtlasiQ9Y496. baseline and differential.
GenevisibleiQ9Y496. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y496
Secondary accession number(s): A8MSW9
, Q59EN1, Q86XE9, Q9Y6V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.