Q9Y493 (ZAN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zonadhesin

Gene names

Name:

ZAN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2812 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Subunit structure	Probably forms covalent oligomers.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Note: Exclusively on the apical region of the sperm head By similarity.
Tissue specificity	In testis, primarily in haploid spermatids.
Domain	The MAM domains probably mediate sperm adhesion to the zona pellucida. During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus. The VWFD domain 2 may mediate covalent oligomerization By similarity.
Sequence similarities	Contains 1 EGF-like domain. Contains 3 MAM domains. Contains 4 TIL (trypsin inhibitory-like) domains. Contains 5 VWFC domains. Contains 4 VWFD domains.
Sequence caution	The sequence AAC78790.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76487.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76488.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76489.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76490.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76491.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAW76492.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	binding of sperm to zona pellucida Non-traceable author statement Ref.7. Source: UniProtKB cell-cell adhesion Non-traceable author statement Ref.7. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Non-traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9Y493-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9Y493-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2724: HGVSSRYHIS...NPCQNDGQCR → YAILCQEAGA...PFLAGQQLSD
     2725-2812: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2 (identifier: Q9Y493-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2689: HGVSSRYHIS...SSRILLCEPF → YAILCQEAGA...ASTTSWAAAF
     2690-2812: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9Y493-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2624: HGVSSRYHISELYDTLPSILCQPGRPRG → YAILCQEAGAALAGWRDRTLCAGQQLSD
     2625-2812: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 5 (identifier: Q9Y493-5)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2601: HGVSS → WAAAF
     2602-2812: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q9Y493-6)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2617: HGVSSRYHISELYDTLPSILC → YAILCQEAGAALAGWRDRTLC
     2618-2708: Missing.

Isoform 7 (identifier: Q9Y493-7)

The sequence of this isoform differs from the canonical sequence as follows:
     2597-2636: HGVSSRYHIS...GPLRGRLRQH → YAILCQEAGA...EGPCVEGCAD
     2663-2666: LGSS → VRAGSRRPWGAEAPRRARPGMELERLLLALPFLAGQQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 2812	2795	Zonadhesin		PRO_0000007783
Regions
	Topological domain	18 – 2757	2740	Extracellular Potential
	Transmembrane	2758 – 2778	21	Helical; Potential
	Topological domain	2779 – 2812	34	Cytoplasmic Potential
	Domain	39 – 204	166	MAM 1
	Domain	209 – 368	160	MAM 2
	Domain	371 – 536	166	MAM 3
	Domain	1044 – 1093	50	TIL 1
	Domain	1103 – 1148	46	VWFC 1
	Domain	1155 – 1371	217	VWFD 1
	Domain	1426 – 1479	54	TIL 2
	Domain	1480 – 1535	56	VWFC 2
	Domain	1541 – 1758	218	VWFD 2
	Domain	1812 – 1867	56	TIL 3
	Domain	1868 – 1924	57	VWFC 3
	Domain	1930 – 2144	215	VWFD 3
	Domain	2211 – 2267	57	TIL 4
	Domain	2268 – 2329	62	VWFC 4
	Domain	2330 – 2537	208	VWFD 4
	Domain	2652 – 2797	146	VWFC 5
	Domain	2708 – 2744	37	EGF-like
	Region	573 – 1041	469	66 X heptapeptide repeats (approximate) (mucin-like domain)
Amino acid modifications
	Glycosylation	333	1	N-linked (GlcNAc...) Potential
	Glycosylation	493	1	N-linked (GlcNAc...) Potential
	Glycosylation	1112	1	N-linked (GlcNAc...) Potential
	Glycosylation	1188	1	N-linked (GlcNAc...) Potential
	Glycosylation	1685	1	N-linked (GlcNAc...) Potential
	Glycosylation	1804	1	N-linked (GlcNAc...) Potential
	Glycosylation	1900	1	N-linked (GlcNAc...) Potential
	Glycosylation	1946	1	N-linked (GlcNAc...) Potential
	Glycosylation	2203	1	N-linked (GlcNAc...) Potential
	Glycosylation	2542	1	N-linked (GlcNAc...) Potential
	Glycosylation	2701	1	N-linked (GlcNAc...) Potential
	Disulfide bond	2712 ↔ 2723		By similarity
	Disulfide bond	2717 ↔ 2732		By similarity
	Disulfide bond	2734 ↔ 2743		By similarity
Natural variations
	Alternative sequence	2597 – 2724	128	HGVSS…DGQCR → YAILCQEAGAALAGWRDRTL CAMECPAGTIYQSCMTPCPA SCANLADPGDCEGPCVEGCA SIPGYAYSGTQSLPWLTVAA PAMASTTRSELAAGGPGEQR RQGEPDQGWNWNVSSWPFPF LAGQQLSD in isoform 1.		VSP_001430
	Alternative sequence	2597 – 2689	93	HGVSS…LCEPF → YAILCQEAGAALAGWRDRTL CAMECPAGTIYQSCMTPCPA SCANLADPGDCEGPCVEGCA SIPGYAYSGTQSLPWLTVAA PAMASTTSWAAAF in isoform 2.		VSP_001428
	Alternative sequence	2597 – 2636	40	HGVSS…RLRQH → YAILCQEAGAALAGWRDRTL CAMECPAGTIYQSCMTPCPA SCANLADPGDCEGPCVEGCA D in isoform 7.		VSP_001426
	Alternative sequence	2597 – 2624	28	HGVSS…GRPRG → YAILCQEAGAALAGWRDRTL CAGQQLSD in isoform 4.		VSP_001424
	Alternative sequence	2597 – 2617	21	HGVSS…PSILC → YAILCQEAGAALAGWRDRTL C in isoform 6.		VSP_001422
	Alternative sequence	2597 – 2601	5	HGVSS → WAAAF in isoform 5.		VSP_001420
	Alternative sequence	2602 – 2812	211	Missing in isoform 5.		VSP_001421
	Alternative sequence	2618 – 2708	91	Missing in isoform 6.		VSP_001423
	Alternative sequence	2625 – 2812	188	Missing in isoform 4.		VSP_001425
	Alternative sequence	2663 – 2666	4	LGSS → VRAGSRRPWGAEAPRRARPG MELERLLLALPFLAGQQ in isoform 7.		VSP_001427
	Alternative sequence	2690 – 2812	123	Missing in isoform 2.		VSP_001429
	Alternative sequence	2725 – 2812	88	Missing in isoform 1.		VSP_001431
	Natural variant	16	1	L → F. Corresponds to variant rs12673246 [ dbSNP | Ensembl ].		VAR_064584
	Natural variant	113	1	G → A. Corresponds to variant rs34828430 [ dbSNP | Ensembl ].		VAR_061162
	Natural variant	412	1	G → S. Corresponds to variant rs17162408 [ dbSNP | Ensembl ].		VAR_055785
	Natural variant	430	1	Q → H. Ref.2 Ref.5 Corresponds to variant rs221833 [ dbSNP | Ensembl ].		VAR_064585
	Natural variant	690	1	S → T. Corresponds to variant rs13241461 [ dbSNP | Ensembl ].		VAR_055786
	Natural variant	1012	1	L → R. Corresponds to variant rs6942733 [ dbSNP | Ensembl ].		VAR_055787
	Natural variant	1096	1	F → C. Corresponds to variant rs221823 [ dbSNP | Ensembl ].		VAR_055788
	Natural variant	1375	1	A → T. Corresponds to variant rs2293767 [ dbSNP | Ensembl ].		VAR_055789
	Natural variant	1674	1	G → C. Corresponds to variant rs10953303 [ dbSNP | Ensembl ].		VAR_055790
	Natural variant	1698	1	L → P. Corresponds to variant rs10247980 [ dbSNP | Ensembl ].		VAR_055791
	Natural variant	1742	1	C → R. Corresponds to variant rs17147735 [ dbSNP | Ensembl ].		VAR_055792
	Natural variant	1878	1	P → S. Corresponds to variant rs314298 [ dbSNP | Ensembl ].		VAR_055793
	Natural variant	1903	1	C → Y. Corresponds to variant rs12673041 [ dbSNP | Ensembl ].		VAR_055794
	Natural variant	1922	1	R → C. Corresponds to variant rs314299 [ dbSNP | Ensembl ].		VAR_064586
	Natural variant	1969	1	F → L. Ref.2 Ref.5 Ref.6 Corresponds to variant rs542137 [ dbSNP | Ensembl ].		VAR_064587
	Natural variant	1995	1	I → M. Ref.5 Corresponds to variant rs541275 [ dbSNP | Ensembl ].		VAR_059278
	Natural variant	2035	1	S → T. Ref.2 Ref.5 Ref.6 Corresponds to variant rs539445 [ dbSNP | Ensembl ].		VAR_064588
	Natural variant	2073	1	N → S. Corresponds to variant rs314300 [ dbSNP | Ensembl ].		VAR_059279
	Natural variant	2111	1	L → P. Ref.2 Ref.5 Ref.6 Corresponds to variant rs531503 [ dbSNP | Ensembl ].		VAR_064589
	Natural variant	2334	1	Y → S. Corresponds to variant rs60783739 [ dbSNP | Ensembl ].		VAR_061163
	Natural variant	2349	1	L → F. Corresponds to variant rs59541653 [ dbSNP | Ensembl ].		VAR_061164
	Natural variant	2527	1	T → M. Corresponds to variant rs3847059 [ dbSNP | Ensembl ].		VAR_059280
	Natural variant	2643	1	W → R. Corresponds to variant rs314339 [ dbSNP | Ensembl ].		VAR_059281
Experimental info
	Sequence conflict	1922	1	R → H in AAL04410. Ref.2
	Sequence conflict	1922	1	R → H in AAL04411. Ref.2
	Sequence conflict	1922	1	R → H in AAL04412. Ref.2
	Sequence conflict	1922	1	R → H in AAL04413. Ref.2
	Sequence conflict	1922	1	R → H in AAL04414. Ref.2
	Sequence conflict	1922	1	R → H in AAL04415. Ref.2
	Sequence conflict	1922	1	R → H in ABJ98522. Ref.2
	Sequence conflict	1922	1	R → H in AAC78790. Ref.5
	Sequence conflict	1922	1	R → H in AAK21011. Ref.6
	Sequence conflict	2430	1	W → R in AAL04410. Ref.2
	Sequence conflict	2430	1	W → R in AAL04411. Ref.2
	Sequence conflict	2430	1	W → R in AAL04412. Ref.2
	Sequence conflict	2430	1	W → R in AAL04413. Ref.2
	Sequence conflict	2430	1	W → R in AAL04414. Ref.2
	Sequence conflict	2430	1	W → R in AAL04415. Ref.2
	Sequence conflict	2430	1	W → R in ABJ98522. Ref.2
	Sequence conflict	2430	1	W → R in AAK21011. Ref.6
	Sequence conflict	2430	1	W → R in AAC51208. Ref.7
	Sequence conflict	2555	1	G → A in AAC51208. Ref.7
	Sequence conflict	2565	1	A → P in AAC51208. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified March 8, 2011. Version 4. Checksum: 912FBE459AFC3302	FASTA	2,812	305,663
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGHGVS SRYHISELYD TLPSILCQPG RPRGLRGPLR GRLRQHPRLC 2650 2660 2670 2680 2690 2700 LQWHPEPPLA DCGCTSNGIY YQLGSSFLTE DCSQRCTCAS SRILLCEPFS CRAGEVCTLG 2710 2720 2730 2740 2750 2760 NHTQGCFPES PCLQNPCQND GQCREQGATF TCECEVGYGG GLCMEPRDAP PPRKPASNLV 2770 2780 2790 2800 2810 AVLLGLLVPV VVVLLAVTRE CIYRTRRKRE KTQEGDRLAR LVDTDTVLDC AC
	Isoform 1 [UniParc]. Checksum: 74016809A5DF2331	FASTA	2,724	295,261
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGYAIL CQEAGAALAG WRDRTLCAME CPAGTIYQSC MTPCPASCAN 2650 2660 2670 2680 2690 2700 LADPGDCEGP CVEGCASIPG YAYSGTQSLP WLTVAAPAMA STTRSELAAG GPGEQRRQGE 2710 2720 PDQGWNWNVS SWPFPFLAGQ QLSD
	Isoform 2 [UniParc]. Checksum: 7E12C3343BFD408C	FASTA	2,689	291,356
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGYAIL CQEAGAALAG WRDRTLCAME CPAGTIYQSC MTPCPASCAN 2650 2660 2670 2680 LADPGDCEGP CVEGCASIPG YAYSGTQSLP WLTVAAPAMA STTSWAAAF
	Isoform 4 [UniParc]. Checksum: 1ABB2256CC5A2BA3	FASTA	2,624	284,848
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 QDPREQEELR CQVLSGYAIL CQEAGAALAG WRDRTLCAGQ QLSD
	Isoform 5 [UniParc]. Checksum: 6B97B524C67AABF4	FASTA	2,601	282,431
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 QDPREQEELR CQVLSGWAAA F
	Isoform 6 [UniParc]. Checksum: 142E9CBF3D404EC3	FASTA	2,721	295,509
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGYAIL CQEAGAALAG WRDRTLCESP CLQNPCQNDG QCREQGATFT 2650 2660 2670 2680 2690 2700 CECEVGYGGG LCMEPRDAPP PRKPASNLVA VLLGLLVPVV VVLLAVTREC IYRTRRKREK 2710 2720 TQEGDRLARL VDTDTVLDCA C
	Isoform 7 [UniParc]. Checksum: C31893BFC621EF6C	FASTA	2,866	311,094
	10 20 30 40 50 60 MVPPVWTLLL LVGAALFRKE KPPDQKLVVR SSRDNYVLTQ CDFEDDAKPL CDWSQVSADD 70 80 90 100 110 120 EDWVRASGPS PTGSTGAPGG YPNGEGSYLH MESNSFHRGG VARLLSPDLW EQGPLCVHFA 130 140 150 160 170 180 HHMFGLSWGA QLRLLLLSGE EGRRPDVLWK HWNTQRPSWM LTTVTVPAGF TLPTRLMFEG 190 200 210 220 230 240 TRGSTAYLDI ALDALSIRRG SCNRVCMMQT CSFDIPNDLC DWTWIPTASG AKWTQKKGSS 250 260 270 280 290 300 GKPGVGPDGD FSSPGSGCYM LLDPKNARPG QKAVLLSPVS LSSGCLSFSF HYILRGQSPG 310 320 330 340 350 360 AALHIYASVL GSIRKHTLFS GQPGPNWQAV SVNYTAVGRI QFAVVGVFGK TPEPAVAVDA 370 380 390 400 410 420 TSIAPCGEGF PQCDFEDNAH PFCDWVQTSG DGGHWALGHK NGPVHGMGPA GGFPNAGGHY 430 440 450 460 470 480 IYLEADEFSQ AGQSVRLVSR PFCAPGDICV EFAYHMYGLG EGTMLELLLG SPAGSPPIPL 490 500 510 520 530 540 WKRVGSQRPY WQNTSVTVPS GHQQPMQLIF KGIQGSNTAS VVAMGFILIN PGTCPVKVLP 550 560 570 580 590 600 ELPPVSPVSS TGPSETTGLT ENPTISTKKP TVSIEKPSVT TEKPTVPKEK PTIPTEKPTI 610 620 630 640 650 660 STEKPTIPSE KPNMPSEKPT IPSEKPTILT EKPTIPSEKP TIPSEKPTIS TEKPTVPTEE 670 680 690 700 710 720 PTTPTEETTT SMEEPVIPTE KPSIPTEKPS IPTEKPTISM EETIISTEKP TISPEKPTIP 730 740 750 760 770 780 TEKPTIPTEK STISPEKPTT PTEKPTIPTE KPTISPEKPT TPTEKPTISP EKLTIPTEKP 790 800 810 820 830 840 TIPTEKPTIP TEKPTISTEE PTTPTEETTI STEKPSIPME KPTLPTEETT TSVEETTIST 850 860 870 880 890 900 EKLTIPMEKP TISTEKPTIP TEKPTISPEK LTIPTEKLTI PTEKPTIPIE ETTISTEKLT 910 920 930 940 950 960 IPTEKPTISP EKPTISTEKP TIPTEKPTIP TEETTISTEK LTIPTEKPTI SPEKLTIPTE 970 980 990 1000 1010 1020 KPTISTEKPT IPTEKLTIPT EKPTIPTEKP TIPTEKLTAL RPPHPSPTAT GLAALVMSPH 1030 1040 1050 1060 1070 1080 APSTPMTSVI LGTTTTSRSS TERCPPNARY ESCACPASCK SPRPSCGPLC REGCVCNPGF 1090 1100 1110 1120 1130 1140 LFSDNHCIQA SSCNCFYNND YYEPGAEWFS PNCTEHCRCW PGSRVECQIS QCGTHTVCQL 1150 1160 1170 1180 1190 1200 KNGQYGCHPY AGTATCLVYG DPHYVTFDGR HFGFMGKCTY ILAQPCGNST DPFFRVTAKN 1210 1220 1230 1240 1250 1260 EEQGQEGVSC LSKVYVTLPE STVTLLKGRR TLVGGQQVTL PAIPSKGVFL GASGRFVELQ 1270 1280 1290 1300 1310 1320 TEFGLRVRWD GDQQLYVTVS STYSGKLCGL CGNYDGNSDN DHLKLDGSPA GDKEELGNSW 1330 1340 1350 1360 1370 1380 QTDQDEDQEC QKYQVVNSPS CDSSLQSSMS GPGFCGRLVD THGPFETCLL HVKAASFFDS 1390 1400 1410 1420 1430 1440 CMLDMCGFQG LQHLLCTHMS TMTTTCQDAG HAVKPWREPH FCPMACPPNS KYSLCAKPCP 1450 1460 1470 1480 1490 1500 DTCHSGFSGM FCSDRCVEAC ECNPGFVLSG LECIPRSQCG CLHPAGSYFK VGERWYKPGC 1510 1520 1530 1540 1550 1560 KELCVCESNN RIRCQPWRCR AQEFCGQQDG IYGCHAQGAA TCTASGDPHY LTFDGALHHF 1570 1580 1590 1600 1610 1620 MGTCTYVLTR PCWSRSQDSY FVVSATNENR GGILEVSYIK AVHVTVFDLS ISLLRGCKVM 1630 1640 1650 1660 1670 1680 LNGHRVALPV WLAQGRVTIR LSSNLVLLYT NFGLQVRYDG SHLVEVTVPS SYGGQLCGLC 1690 1700 1710 1720 1730 1740 GNYNNNSLDD NLRPDRKLAG DSMQLGAAWK LPESSEPGCF LVGGKPSSCQ ENSMADAWNK 1750 1760 1770 1780 1790 1800 NCAILINPQG PFSQCHQVVP PQSSFASCVH GQCGTKGDTT ALCRSLQAYA SLCAQAGQAP 1810 1820 1830 1840 1850 1860 AWRNRTFCPM RCPPGSSYSP CSSPCPDTCS SINNPRDCPK ALPCAESCEC QKGHILSGTS 1870 1880 1890 1900 1910 1920 CVPLGQCGCT DPAGSYHPVG ERWYTENTCT RLCTCSVHNN ITCFQSTCKP NQICWALDGL 1930 1940 1950 1960 1970 1980 LRCRASGVGV CQLPGESHYV SFDGSNHSIP DACTLVLVKV CHPAMALPFF KISAKHEKEE 1990 2000 2010 2020 2030 2040 GGTEAFRLHE VYIDIYDAQV TLQKGHRVLI NSKQVTLPAI SQIPGVSVKS SSIYSIVNIK 2050 2060 2070 2080 2090 2100 IGVQVKFDGN HLLEIEIPTT YYGKVCGMCG NFNDEEEDEL MMPSDEVANS DSEFVNSWKD 2110 2120 2130 2140 2150 2160 KDIDPSCQSL LVDEQQIPAE QQENPSGNCR AADLRRAREK CEAALRAPVW AQCASRIDLT 2170 2180 2190 2200 2210 2220 PFLVDCANTL CEFGGLYQAL CQALQAFGAT CQSQGLKPPL WRNSSFCPLE CPAYSSYTNC 2230 2240 2250 2260 2270 2280 LPSCSPSCWD LDGRCEGAKV PSACAEGCIC QPGYVLSEDK CVPRSQCGCK DAHGGSIPLG 2290 2300 2310 2320 2330 2340 KSWVSSGCTE KCVCTGGAIQ CGDFRCPSGS HCQLTSDNSN SNCVSDKSEQ CSVYGDPRYL 2350 2360 2370 2380 2390 2400 TFDGFSYRLQ GRMTYVLIKT VDVLPEGVEP LLVEGRNKMD PPRSSIFLQE VITTVYGYKV 2410 2420 2430 2440 2450 2460 QLQAGLELVV NNQKMAVPYR PNEHLRVTLW GQRLYLVTDF ELVVSFGGRK NAVISLPSMY 2470 2480 2490 2500 2510 2520 EGLVSGLCGN YDKNRKNDMM LPSGALTQNL NTFGNSWEVK TEDALLRFPR AIPAEEEGQG 2530 2540 2550 2560 2570 2580 AELGLRTGLQ VSECSPEQLA SNSTQACRVL ADPQGPFAAC HQTVAPEPFQ EHCVLDLCSA 2590 2600 2610 2620 2630 2640 QDPREQEELR CQVLSGYAIL CQEAGAALAG WRDRTLCAME CPAGTIYQSC MTPCPASCAN 2650 2660 2670 2680 2690 2700 LADPGDCEGP CVEGCADPRL CLQWHPEPPL ADCGCTSNGI YYQVRAGSRR PWGAEAPRRA 2710 2720 2730 2740 2750 2760 RPGMELERLL LALPFLAGQQ FLTEDCSQRC TCASSRILLC EPFSCRAGEV CTLGNHTQGC 2770 2780 2790 2800 2810 2820 FPESPCLQNP CQNDGQCREQ GATFTCECEV GYGGGLCMEP RDAPPPRKPA SNLVAVLLGL 2830 2840 2850 2860 LVPVVVVLLA VTRECIYRTR RKREKTQEGD RLARLVDTDT VLDCAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple intra-species variants of human zonadhesin." Cheung T.L., Wassler M.J., Cornwall G.A., Hardy D.M. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6). Tissue: Testis.
[2]	"Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution." Gasper J., Swanson W.J. Am. J. Hum. Genet. 79:820-830(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-430; LEU-1969; THR-2035 AND PRO-2111.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes." Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A. Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-430; LEU-1969; MET-1995; THR-2035 AND PRO-2111.
[6]	"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F. Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1810-2812 (ISOFORM 1), VARIANTS LEU-1969; THR-2035 AND PRO-2111.
[7]	"Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN)." Gao Z., Harumi T., Garbers D.L. Genomics 41:119-122(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2375-2683 (ISOFORM 7). Tissue: Testis.
[8]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF332975 mRNA. Translation: AAK01431.1. AF332976 mRNA. Translation: AAK01432.1. AF332977 mRNA. Translation: AAK01433.1. AF332978 mRNA. Translation: AAK01434.1. AF332979 mRNA. Translation: AAK01435.1. AF332980 mRNA. Translation: AAK01436.1. EF025894 Genomic DNA. Translation: ABJ98522.1. AY046055 Genomic DNA. Translation: AAL04410.1. AY046055 Genomic DNA. Translation: AAL04411.1. AY046055 Genomic DNA. Translation: AAL04412.1. AY046055 Genomic DNA. Translation: AAL04413.1. AY046055 Genomic DNA. Translation: AAL04414.1. AY046055 Genomic DNA. Translation: AAL04415.1. AC009488 Genomic DNA. No translation available. AC011895 Genomic DNA. No translation available. CH471091 Genomic DNA. Translation: EAW76487.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76488.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76489.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76490.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76491.1. Sequence problems. CH471091 Genomic DNA. Translation: EAW76492.1. Sequence problems. AF053356 Genomic DNA. Translation: AAC78790.1. Sequence problems. AF312032 Genomic DNA. Translation: AAK21011.1. U83191 mRNA. Translation: AAC51208.1.
IPI	IPI00000454. IPI00220092. IPI00220093. IPI00220094. IPI00220095. IPI00220096. IPI00220097.
RefSeq	NP_003377.1. NM_003386.1. NP_775082.1. NM_173059.1.
UniGene	Hs.307004.
3D structure databases
ProteinModelPortal	Q9Y493.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4658080.
PTM databases
PhosphoSite	Q9Y493.
Polymorphism databases
DMDM	27924006.
Proteomic databases
PRIDE	Q9Y493.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000348028; ENSP00000423579; ENSG00000146839. ENST00000349350; ENSP00000422387; ENSG00000146839. ENST00000421100; ENSP00000425454; ENSG00000146839. ENST00000427578; ENSP00000425200; ENSG00000146839. ENST00000443370; ENSP00000421245; ENSG00000146839. ENST00000449052; ENSP00000422208; ENSG00000146839.
GeneID	7455.
KEGG	hsa:7455.
UCSC	uc003uwj.3. human. uc003uwk.3. human.
Organism-specific databases
CTD	7455.
GeneCards	GC07P100333.
HGNC	HGNC:12857. ZAN.
MIM	602372. gene.
neXtProt	NX_Q9Y493.
PharmGKB	PA37446.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG000375.
InParanoid	Q9Y493.
Gene expression databases
ArrayExpress	Q9Y493.
Bgee	Q9Y493.
Genevestigator	Q9Y493.
GermOnline	ENSG00000146839. Homo sapiens.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR000998. MAM_dom. IPR002919. TIL_dom. IPR025615. TILa_dom. IPR014853. Unchr_dom_Cys-rich. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF08742. C8. 4 hits. PF00008. EGF. 1 hit. PF00629. MAM. 3 hits. PF01826. TIL. 4 hits. PF12714. TILa. 5 hits. PF00094. VWD. 4 hits. [Graphical view]
SMART	SM00832. C8. 4 hits. SM00181. EGF. 1 hit. SM00137. MAM. 3 hits. SM00214. VWC. 3 hits. SM00216. VWD. 4 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 3 hits. SSF57567. Cysrich_TIL. 4 hits.
PROSITE	PS00022. EGF_1. 1 hit. PS01186. EGF_2. 4 hits. PS50026. EGF_3. 1 hit. PS00740. MAM_1. 1 hit. PS50060. MAM_2. 3 hits. PS01208. VWFC_1. False negative. PS50184. VWFC_2. False negative. PS51233. VWFD. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7455.
NextBio	29192.
SOURCE	Search...

Entry information

Entry name

ZAN_HUMAN

Accession

Primary (citable) accession number: Q9Y493
Secondary accession number(s): A0FKC8 , D6W5W4, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 8, 2011
Last modified:	May 29, 2013
This is version 117 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.