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Protein

Zinc finger protein 175

Gene

ZNF175

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30123C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Antiviral defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 175
Alternative name(s):
Zinc finger protein OTK18
Gene namesi
Name:ZNF175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12964. ZNF175.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37546.

Polymorphism and mutation databases

BioMutaiZNF175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Zinc finger protein 175PRO_0000047440Add
BLAST

Proteomic databases

MaxQBiQ9Y473.
PaxDbiQ9Y473.
PRIDEiQ9Y473.

2D gel databases

REPRODUCTION-2DPAGEQ9Y473.

PTM databases

PhosphoSiteiQ9Y473.

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

By HIV-1 infection.

Gene expression databases

BgeeiQ9Y473.
CleanExiHS_ZNF175.
ExpressionAtlasiQ9Y473. baseline and differential.
GenevisibleiQ9Y473. HS.

Organism-specific databases

HPAiHPA002717.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131963EBI-3438881,EBI-3905054
KRTAP10-7P604093EBI-3438881,EBI-10172290
PSTPIP1O435863EBI-3438881,EBI-1050964
ZNF250P15622-33EBI-3438881,EBI-10177272
ZNF264Q14C613EBI-3438881,EBI-2826570

Protein-protein interaction databases

BioGridi113517. 8 interactions.
IntActiQ9Y473. 7 interactions.
STRINGi9606.ENSP00000262259.

Structurei

3D structure databases

ProteinModelPortaliQ9Y473.
SMRiQ9Y473. Positions 22-69, 230-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872KRABPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi359 – 3624Nuclear localization signalSequence analysis

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30123C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128369.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y473.
KOiK09228.
OMAiFNGRSNF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y473.
TreeFamiTF350810.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC
60 70 80 90 100
LYRDVMLELY SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER
110 120 130 140 150
EFGLEIPQKE ISKKASFQKD MVGEFTRDGS WCSILEELRL DADRTKKDEQ
160 170 180 190 200
NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK MIRTRPHLAS SQKQPQKCCL
210 220 230 240 250
FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA CSKNIHTGET
260 270 280 290 300
FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI
310 320 330 340 350
HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL
360 370 380 390 400
LTHQKTHTRK KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF
410 420 430 440 450
SQNSTLIIHQ KIHTGERQYA CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI
460 470 480 490 500
ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC GKSFISKSQL DIHHRIHTGE
510 520 530 540 550
KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF NQKSILSMHQ
560 570 580 590 600
RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS
610 620 630 640 650
NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK
660 670 680 690 700
SFSKKPQLKV HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK
710
CSYSVKGFTK Q
Length:711
Mass (Da):81,609
Last modified:November 1, 1999 - v1
Checksum:i43FB8ACD1B3094A2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti363 – 3631Y → N.
Corresponds to variant rs60097262 [ dbSNP | Ensembl ].
VAR_061938
Natural varianti505 – 5051C → R.
Corresponds to variant rs3764548 [ dbSNP | Ensembl ].
VAR_052789

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50419 mRNA. Translation: BAA23362.1.
AK292687 mRNA. Translation: BAF85376.1.
AC018755 Genomic DNA. Translation: AAF87843.1.
CH471135 Genomic DNA. Translation: EAW72030.1.
BC052997 mRNA. Translation: AAH52997.1.
CCDSiCCDS12837.1.
RefSeqiNP_009078.1. NM_007147.2.
UniGeneiHs.119014.

Genome annotation databases

EnsembliENST00000262259; ENSP00000262259; ENSG00000105497.
GeneIDi7728.
KEGGihsa:7728.
UCSCiuc002pxb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50419 mRNA. Translation: BAA23362.1.
AK292687 mRNA. Translation: BAF85376.1.
AC018755 Genomic DNA. Translation: AAF87843.1.
CH471135 Genomic DNA. Translation: EAW72030.1.
BC052997 mRNA. Translation: AAH52997.1.
CCDSiCCDS12837.1.
RefSeqiNP_009078.1. NM_007147.2.
UniGeneiHs.119014.

3D structure databases

ProteinModelPortaliQ9Y473.
SMRiQ9Y473. Positions 22-69, 230-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113517. 8 interactions.
IntActiQ9Y473. 7 interactions.
STRINGi9606.ENSP00000262259.

PTM databases

PhosphoSiteiQ9Y473.

Polymorphism and mutation databases

BioMutaiZNF175.

2D gel databases

REPRODUCTION-2DPAGEQ9Y473.

Proteomic databases

MaxQBiQ9Y473.
PaxDbiQ9Y473.
PRIDEiQ9Y473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262259; ENSP00000262259; ENSG00000105497.
GeneIDi7728.
KEGGihsa:7728.
UCSCiuc002pxb.4. human.

Organism-specific databases

CTDi7728.
GeneCardsiZNF175.
HGNCiHGNC:12964. ZNF175.
HPAiHPA002717.
MIMi601139. gene.
neXtProtiNX_Q9Y473.
PharmGKBiPA37546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128369.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y473.
KOiK09228.
OMAiFNGRSNF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y473.
TreeFamiTF350810.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF175. human.
GenomeRNAii7728.
NextBioi29930.
PROiQ9Y473.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y473.
CleanExiHS_ZNF175.
ExpressionAtlasiQ9Y473. baseline and differential.
GenevisibleiQ9Y473. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures."
    Saito H., Fujiwara T., Takahashi E., Shin S., Okui K., Nakamura Y.
    Genomics 31:376-379(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  6. "Molecular characterization of a putative antiretroviral transcriptional factor, OTK18."
    Carlson K.A., Leisman G., Limoges J., Pohlman G.D., Horiba M., Buescher J., Gendelman H.E., Ikezu T.
    J. Immunol. 172:381-391(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, FUNCTION AS AN ANTIRETROVIRAL PROTEIN.

Entry informationi

Entry nameiZN175_HUMAN
AccessioniPrimary (citable) accession number: Q9Y473
Secondary accession number(s): A8K9H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.