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Protein

Zinc finger protein 175

Gene

ZNF175

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • defense response to virus Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processAntiviral defense, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 175
Alternative name(s):
Zinc finger protein OTK18
Gene namesi
Name:ZNF175
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105497.7
HGNCiHGNC:12964 ZNF175
MIMi601139 gene
neXtProtiNX_Q9Y473

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7728
OpenTargetsiENSG00000105497
PharmGKBiPA37546

Polymorphism and mutation databases

BioMutaiZNF175

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474401 – 711Zinc finger protein 175Add BLAST711

Proteomic databases

MaxQBiQ9Y473
PaxDbiQ9Y473
PeptideAtlasiQ9Y473
PRIDEiQ9Y473

2D gel databases

REPRODUCTION-2DPAGEiQ9Y473

PTM databases

iPTMnetiQ9Y473
PhosphoSitePlusiQ9Y473

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

By HIV-1 infection.

Gene expression databases

BgeeiENSG00000105497
CleanExiHS_ZNF175
ExpressionAtlasiQ9Y473 baseline and differential
GenevisibleiQ9Y473 HS

Organism-specific databases

HPAiHPA002717

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113517, 8 interactors
IntActiQ9Y473, 8 interactors
STRINGi9606.ENSP00000262259

Structurei

3D structure databases

ProteinModelPortaliQ9Y473
SMRiQ9Y473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi359 – 362Nuclear localization signalSequence analysis4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri671 – 693C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137993
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9Y473
KOiK09228
OMAiFNGRSNF
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y473
TreeFamiTF350810

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q9Y473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC
60 70 80 90 100
LYRDVMLELY SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER
110 120 130 140 150
EFGLEIPQKE ISKKASFQKD MVGEFTRDGS WCSILEELRL DADRTKKDEQ
160 170 180 190 200
NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK MIRTRPHLAS SQKQPQKCCL
210 220 230 240 250
FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA CSKNIHTGET
260 270 280 290 300
FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI
310 320 330 340 350
HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL
360 370 380 390 400
LTHQKTHTRK KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF
410 420 430 440 450
SQNSTLIIHQ KIHTGERQYA CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI
460 470 480 490 500
ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC GKSFISKSQL DIHHRIHTGE
510 520 530 540 550
KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF NQKSILSMHQ
560 570 580 590 600
RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS
610 620 630 640 650
NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK
660 670 680 690 700
SFSKKPQLKV HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK
710
CSYSVKGFTK Q
Length:711
Mass (Da):81,609
Last modified:November 1, 1999 - v1
Checksum:i43FB8ACD1B3094A2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061938363Y → N. Corresponds to variant dbSNP:rs60097262Ensembl.1
Natural variantiVAR_052789505C → R. Corresponds to variant dbSNP:rs3764548Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50419 mRNA Translation: BAA23362.1
AK292687 mRNA Translation: BAF85376.1
AC018755 Genomic DNA Translation: AAF87843.1
CH471135 Genomic DNA Translation: EAW72030.1
BC052997 mRNA Translation: AAH52997.1
CCDSiCCDS12837.1
RefSeqiNP_009078.1, NM_007147.3
UniGeneiHs.119014

Genome annotation databases

EnsembliENST00000262259; ENSP00000262259; ENSG00000105497
GeneIDi7728
KEGGihsa:7728
UCSCiuc002pxb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN175_HUMAN
AccessioniPrimary (citable) accession number: Q9Y473
Secondary accession number(s): A8K9H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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