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Q9Y467

- SALL2_HUMAN

UniProt

Q9Y467 - SALL2_HUMAN

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Protein
Sal-like protein 2
Gene
SALL2, KIAA0360, SAL2, ZNF795
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri373 – 39523C2H2-type 1
Add
BLAST
Zinc fingeri401 – 42323C2H2-type 2
Add
BLAST
Zinc fingeri631 – 65323C2H2-type 3
Add
BLAST
Zinc fingeri659 – 68123C2H2-type 4
Add
BLAST
Zinc fingeri691 – 71323C2H2-type 5
Add
BLAST
Zinc fingeri911 – 93323C2H2-type 6
Add
BLAST
Zinc fingeri940 – 96425C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. neural tube development Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 2
Alternative name(s):
Zinc finger protein 795
Zinc finger protein SALL2
Zinc finger protein Spalt-2
Short name:
Sal-2
Short name:
hSal2
Gene namesi
Name:SALL2
Synonyms:KIAA0360, SAL2, ZNF795
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:10526. SALL2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. NuRD complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10071007Sal-like protein 2
PRO_0000047022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431Phosphoserine1 Publication
Modified residuei797 – 7971Phosphoserine1 Publication
Modified residuei802 – 8021Phosphoserine2 Publications
Modified residuei806 – 8061Phosphoserine2 Publications
Cross-linki911 – 911Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Y467.
PaxDbiQ9Y467.
PeptideAtlasiQ9Y467.
PRIDEiQ9Y467.

PTM databases

PhosphoSiteiQ9Y467.

Expressioni

Tissue specificityi

Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in kidney and pancreas.

Developmental stagei

In fetal brain exclusively in pontine nuclei.

Gene expression databases

ArrayExpressiQ9Y467.
BgeeiQ9Y467.
CleanExiHS_SALL2.
GenevestigatoriQ9Y467.

Organism-specific databases

HPAiHPA004162.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NGFRP081383EBI-8541433,EBI-1387782

Protein-protein interaction databases

BioGridi112204. 10 interactions.
IntActiQ9Y467. 1 interaction.
MINTiMINT-4658260.
STRINGi9606.ENSP00000333537.

Structurei

3D structure databases

ProteinModelPortaliQ9Y467.
SMRiQ9Y467. Positions 367-455, 603-716, 908-980.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi135 – 1395Poly-Gly
Compositional biasi158 – 17013Poly-Pro
Add
BLAST
Compositional biasi256 – 26510Poly-Ser
Compositional biasi764 – 77512Poly-Glu
Add
BLAST
Compositional biasi816 – 8216Poly-Ala
Compositional biasi838 – 8436Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG294998.
HOGENOMiHOG000231986.
HOVERGENiHBG058921.
InParanoidiQ9Y467.
OMAiMPAESCE.
OrthoDBiEOG7353W3.
PhylomeDBiQ9Y467.
TreeFamiTF317003.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y467-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRKQRKPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFTDPTEFL     50
AHQNACSTDP PVMVIIGGQE NPNNSSASSE PRPEGHNNPQ VMDTEHSNPP 100
DSGSSVPTDP TWGPERRGEE SPGHFLVAAT GTAAGGGGGL ILASPKLGAT 150
PLPPESTPAP PPPPPPPPPP GVGSGHLNIP LILEELRVLQ QRQIHQMQMT 200
EQICRQVLLL GSLGQTVGAP ASPSELPGTG TASSTKPLLP LFSPIKPVQT 250
SKTLASSSSS SSSSSGAETP KQAFFHLYHP LGSQHPFSAG GVGRSHKPTP 300
APSPALPGST DQLIASPHLA FPSTTGLLAA QCLGAARGLE ATASPGLLKP 350
KNGSGELSYG EVMGPLEKPG GRHKCRFCAK VFGSDSALQI HLRSHTGERP 400
YKCNVCGNRF TTRGNLKVHF HRHREKYPHV QMNPHPVPEH LDYVITSSGL 450
PYGMSVPPEK AEEEAATPGG GVERKPLVAS TTALSATESL TLLSTSAGTA 500
TAPGLPAFNK FVLMKAVEPK NKADENTPPG SEGSAISGVA ESSTATRMQL 550
SKLVTSLPSW ALLTNHFKST GSFPFPYVLE PLGASPSETS KLQQLVEKID 600
RQGAVAVTSA ASGAPTTSAP APSSSASSGP NQCVICLRVL SCPRALRLHY 650
GQHGGERPFK CKVCGRAFST RGNLRAHFVG HKASPAARAQ NSCPICQKKF 700
TNAVTLQQHV RMHLGGQIPN GGTALPEGGG AAQENGSEQS TVSGAGSFPQ 750
QQSQQPSPEE ELSEEEEEED EEEEEDVTDE DSLAGRGSES GGEKAISVRG 800
DSEEASGAEE EVGTVAAAAT AGKEMDSNEK TTQQSSLPPP PPPDSLDQPQ 850
PMEQGSSGVL GGKEEGGKPE RSSSPASALT PEGEATSVTL VEELSLQEAM 900
RKEPGESSSR KACEVCGQAF PSQAALEEHQ KTHPKEGPLF TCVFCRQGFL 950
ERATLKKHML LAHHQVQPFA PHGPQNIAAL SLVPGCSPSI TSTGLSPFPR 1000
KDDPTIP 1007
Length:1,007
Mass (Da):105,309
Last modified:May 18, 2010 - v4
Checksum:i9F9335CE7939EFA7
GO

Sequence cautioni

The sequence BAA21638.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751S → C.
Corresponds to variant rs2242527 [ dbSNP | Ensembl ].
VAR_014129
Natural varianti122 – 1221P → S.3 Publications
Corresponds to variant rs1263811 [ dbSNP | Ensembl ].
VAR_014130
Natural varianti746 – 7461G → R.3 Publications
Corresponds to variant rs1263810 [ dbSNP | Ensembl ].
VAR_014131

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti547 – 5471R → L in X98834. 1 Publication
Sequence conflicti547 – 5471R → L in AAI36529. 1 Publication
Sequence conflicti547 – 5471R → L in AAI36530. 1 Publication
Sequence conflicti554 – 5541V → M in X98834. 1 Publication
Sequence conflicti575 – 5817FPYVLEP → LPLCARA in X98834. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98834 mRNA. No translation available.
AB002358 mRNA. Translation: BAA21638.2. Different initiation.
AE000521 Genomic DNA. No translation available.
AE000658 Genomic DNA. No translation available.
BC136528 mRNA. Translation: AAI36529.1.
BC136529 mRNA. Translation: AAI36530.1.
AF465630 mRNA. Translation: AAL74188.1.
CCDSiCCDS32045.1.
RefSeqiNP_005398.2. NM_005407.2.
UniGeneiHs.416358.
Hs.745364.

Genome annotation databases

EnsembliENST00000327430; ENSP00000333537; ENSG00000165821.
GeneIDi6297.
KEGGihsa:6297.
UCSCiuc001wbe.3. human.

Polymorphism databases

DMDMi296453020.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98834 mRNA. No translation available.
AB002358 mRNA. Translation: BAA21638.2 . Different initiation.
AE000521 Genomic DNA. No translation available.
AE000658 Genomic DNA. No translation available.
BC136528 mRNA. Translation: AAI36529.1 .
BC136529 mRNA. Translation: AAI36530.1 .
AF465630 mRNA. Translation: AAL74188.1 .
CCDSi CCDS32045.1.
RefSeqi NP_005398.2. NM_005407.2.
UniGenei Hs.416358.
Hs.745364.

3D structure databases

ProteinModelPortali Q9Y467.
SMRi Q9Y467. Positions 367-455, 603-716, 908-980.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112204. 10 interactions.
IntActi Q9Y467. 1 interaction.
MINTi MINT-4658260.
STRINGi 9606.ENSP00000333537.

PTM databases

PhosphoSitei Q9Y467.

Polymorphism databases

DMDMi 296453020.

Proteomic databases

MaxQBi Q9Y467.
PaxDbi Q9Y467.
PeptideAtlasi Q9Y467.
PRIDEi Q9Y467.

Protocols and materials databases

DNASUi 6297.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327430 ; ENSP00000333537 ; ENSG00000165821 .
GeneIDi 6297.
KEGGi hsa:6297.
UCSCi uc001wbe.3. human.

Organism-specific databases

CTDi 6297.
GeneCardsi GC14M021989.
HGNCi HGNC:10526. SALL2.
HPAi HPA004162.
MIMi 602219. gene.
neXtProti NX_Q9Y467.
PharmGKBi PA34934.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG294998.
HOGENOMi HOG000231986.
HOVERGENi HBG058921.
InParanoidi Q9Y467.
OMAi MPAESCE.
OrthoDBi EOG7353W3.
PhylomeDBi Q9Y467.
TreeFami TF317003.

Miscellaneous databases

ChiTaRSi SALL2. human.
GeneWikii SALL2.
GenomeRNAii 6297.
NextBioi 24449.
PROi Q9Y467.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y467.
Bgeei Q9Y467.
CleanExi HS_SALL2.
Genevestigatori Q9Y467.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt."
    Kohlhase J., Schuh R., Dowe G., Kuehnlein R.P., Jaeckle H., Schroeder B., Schulz-Schaeffer W., Kretzschmar H.A., Koehler A., Mueller U., Raab-Vetter M., Burkhardt E., Engel W., Stick R.
    Genomics 38:291-298(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-122 AND ARG-746.
    Tissue: Fetus.
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-122 AND ARG-746.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-122.
  6. "Homo sapiens mRNA for zinc finger protein, SALL2 exon 2."
    Morgan J.W., Ford D., Ma Y., Maizel A.L.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 541-1005, VARIANT ARG-746.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-911.
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797; SER-802 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-802 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSALL2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y467
Secondary accession number(s): B2RMX6, B9EGK8, Q9Y4G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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