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Q9Y467 (SALL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sal-like protein 2
Alternative name(s):
Zinc finger protein 795
Zinc finger protein SALL2
Zinc finger protein Spalt-2
Short name=Sal-2
Short name=hSal2
Gene names
Name:SALL2
Synonyms:KIAA0360, SAL2, ZNF795
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1007 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcription factor.

Subcellular location

Nucleus Probable.

Tissue specificity

Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in kidney and pancreas.

Developmental stage

In fetal brain exclusively in pontine nuclei.

Sequence similarities

Belongs to the sal C2H2-type zinc-finger protein family.

Contains 7 C2H2-type zinc fingers.

Sequence caution

The sequence BAA21638.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NGFRP081383EBI-8541433,EBI-1387782

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10071007Sal-like protein 2
PRO_0000047022

Regions

Zinc finger373 – 39523C2H2-type 1
Zinc finger401 – 42323C2H2-type 2
Zinc finger631 – 65323C2H2-type 3
Zinc finger659 – 68123C2H2-type 4
Zinc finger691 – 71323C2H2-type 5
Zinc finger911 – 93323C2H2-type 6
Zinc finger940 – 96425C2H2-type 7
Compositional bias135 – 1395Poly-Gly
Compositional bias158 – 17013Poly-Pro
Compositional bias256 – 26510Poly-Ser
Compositional bias764 – 77512Poly-Glu
Compositional bias816 – 8216Poly-Ala
Compositional bias838 – 8436Poly-Pro

Amino acid modifications

Modified residue2431Phosphoserine Ref.11
Modified residue7971Phosphoserine Ref.10
Modified residue8021Phosphoserine Ref.10 Ref.11
Modified residue8061Phosphoserine Ref.10 Ref.11
Cross-link911Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8

Natural variations

Natural variant751S → C.
Corresponds to variant rs2242527 [ dbSNP | Ensembl ].
VAR_014129
Natural variant1221P → S. Ref.1 Ref.2 Ref.5
Corresponds to variant rs1263811 [ dbSNP | Ensembl ].
VAR_014130
Natural variant7461G → R. Ref.1 Ref.2 Ref.6
Corresponds to variant rs1263810 [ dbSNP | Ensembl ].
VAR_014131

Experimental info

Sequence conflict5471R → L in X98834. Ref.1
Sequence conflict5471R → L in AAI36529. Ref.5
Sequence conflict5471R → L in AAI36530. Ref.5
Sequence conflict5541V → M in X98834. Ref.1
Sequence conflict575 – 5817FPYVLEP → LPLCARA in X98834. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y467 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 9F9335CE7939EFA7

FASTA1,007105,309
        10         20         30         40         50         60 
MSRRKQRKPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFTDPTEFL AHQNACSTDP 

        70         80         90        100        110        120 
PVMVIIGGQE NPNNSSASSE PRPEGHNNPQ VMDTEHSNPP DSGSSVPTDP TWGPERRGEE 

       130        140        150        160        170        180 
SPGHFLVAAT GTAAGGGGGL ILASPKLGAT PLPPESTPAP PPPPPPPPPP GVGSGHLNIP 

       190        200        210        220        230        240 
LILEELRVLQ QRQIHQMQMT EQICRQVLLL GSLGQTVGAP ASPSELPGTG TASSTKPLLP 

       250        260        270        280        290        300 
LFSPIKPVQT SKTLASSSSS SSSSSGAETP KQAFFHLYHP LGSQHPFSAG GVGRSHKPTP 

       310        320        330        340        350        360 
APSPALPGST DQLIASPHLA FPSTTGLLAA QCLGAARGLE ATASPGLLKP KNGSGELSYG 

       370        380        390        400        410        420 
EVMGPLEKPG GRHKCRFCAK VFGSDSALQI HLRSHTGERP YKCNVCGNRF TTRGNLKVHF 

       430        440        450        460        470        480 
HRHREKYPHV QMNPHPVPEH LDYVITSSGL PYGMSVPPEK AEEEAATPGG GVERKPLVAS 

       490        500        510        520        530        540 
TTALSATESL TLLSTSAGTA TAPGLPAFNK FVLMKAVEPK NKADENTPPG SEGSAISGVA 

       550        560        570        580        590        600 
ESSTATRMQL SKLVTSLPSW ALLTNHFKST GSFPFPYVLE PLGASPSETS KLQQLVEKID 

       610        620        630        640        650        660 
RQGAVAVTSA ASGAPTTSAP APSSSASSGP NQCVICLRVL SCPRALRLHY GQHGGERPFK 

       670        680        690        700        710        720 
CKVCGRAFST RGNLRAHFVG HKASPAARAQ NSCPICQKKF TNAVTLQQHV RMHLGGQIPN 

       730        740        750        760        770        780 
GGTALPEGGG AAQENGSEQS TVSGAGSFPQ QQSQQPSPEE ELSEEEEEED EEEEEDVTDE 

       790        800        810        820        830        840 
DSLAGRGSES GGEKAISVRG DSEEASGAEE EVGTVAAAAT AGKEMDSNEK TTQQSSLPPP 

       850        860        870        880        890        900 
PPPDSLDQPQ PMEQGSSGVL GGKEEGGKPE RSSSPASALT PEGEATSVTL VEELSLQEAM 

       910        920        930        940        950        960 
RKEPGESSSR KACEVCGQAF PSQAALEEHQ KTHPKEGPLF TCVFCRQGFL ERATLKKHML 

       970        980        990       1000 
LAHHQVQPFA PHGPQNIAAL SLVPGCSPSI TSTGLSPFPR KDDPTIP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt."
Kohlhase J., Schuh R., Dowe G., Kuehnlein R.P., Jaeckle H., Schroeder B., Schulz-Schaeffer W., Kretzschmar H.A., Koehler A., Mueller U., Raab-Vetter M., Burkhardt E., Engel W., Stick R.
Genomics 38:291-298(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-122 AND ARG-746.
Tissue: Fetus.
[2]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-122 AND ARG-746.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-122.
[6]"Homo sapiens mRNA for zinc finger protein, SALL2 exon 2."
Morgan J.W., Ford D., Ma Y., Maizel A.L.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 541-1005, VARIANT ARG-746.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-911.
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797; SER-802 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243; SER-802 AND SER-806, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X98834 mRNA. No translation available.
AB002358 mRNA. Translation: BAA21638.2. Different initiation.
AE000521 Genomic DNA. No translation available.
AE000658 Genomic DNA. No translation available.
BC136528 mRNA. Translation: AAI36529.1.
BC136529 mRNA. Translation: AAI36530.1.
AF465630 mRNA. Translation: AAL74188.1.
RefSeqNP_005398.2. NM_005407.2.
UniGeneHs.416358.
Hs.745364.

3D structure databases

ProteinModelPortalQ9Y467.
SMRQ9Y467. Positions 367-455, 603-716, 908-980.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112204. 10 interactions.
IntActQ9Y467. 1 interaction.
MINTMINT-4658260.
STRING9606.ENSP00000333537.

PTM databases

PhosphoSiteQ9Y467.

Polymorphism databases

DMDM296453020.

Proteomic databases

MaxQBQ9Y467.
PaxDbQ9Y467.
PeptideAtlasQ9Y467.
PRIDEQ9Y467.

Protocols and materials databases

DNASU6297.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000327430; ENSP00000333537; ENSG00000165821.
GeneID6297.
KEGGhsa:6297.
UCSCuc001wbe.3. human.

Organism-specific databases

CTD6297.
GeneCardsGC14M021989.
HGNCHGNC:10526. SALL2.
HPAHPA004162.
MIM602219. gene.
neXtProtNX_Q9Y467.
PharmGKBPA34934.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG294998.
HOGENOMHOG000231986.
HOVERGENHBG058921.
InParanoidQ9Y467.
OMAMPAESCE.
OrthoDBEOG7353W3.
PhylomeDBQ9Y467.
TreeFamTF317003.

Gene expression databases

ArrayExpressQ9Y467.
BgeeQ9Y467.
CleanExHS_SALL2.
GenevestigatorQ9Y467.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSALL2. human.
GeneWikiSALL2.
GenomeRNAi6297.
NextBio24449.
PROQ9Y467.
SOURCESearch...

Entry information

Entry nameSALL2_HUMAN
AccessionPrimary (citable) accession number: Q9Y467
Secondary accession number(s): B2RMX6, B9EGK8, Q9Y4G1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM