Sal-like protein 2 - Homo sapiens (Human)

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Q9Y467 (SALL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sal-like protein 2

Alternative name(s):
Zinc finger protein 795
Zinc finger protein SALL2
Zinc finger protein Spalt-2
Short name=Sal-2
Short name=hSal2

Gene names

Name:	SALL2
Synonyms:	KIAA0360, SAL2, ZNF795

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1007 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable transcription factor.
Subcellular location	Nucleus Probable.
Tissue specificity	Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in kidney and pancreas.
Developmental stage	In fetal brain exclusively in pontine nuclei.
Sequence similarities	Belongs to the sal C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers.
Sequence caution	The sequence BAA21638.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Non-traceable author statement. Source: UniProtKB sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1007

1007

Sal-like protein 2

PRO_0000047022

Regions

Zinc finger

373 – 395

C2H2-type 1

Zinc finger

401 – 423

C2H2-type 2

Zinc finger

631 – 653

C2H2-type 3

Zinc finger

659 – 681

C2H2-type 4

Zinc finger

691 – 713

C2H2-type 5

Zinc finger

911 – 933

C2H2-type 6

Zinc finger

940 – 964

C2H2-type 7

Compositional bias

135 – 139

Poly-Gly

Compositional bias

158 – 170

Poly-Pro

Compositional bias

256 – 265

Poly-Ser

Compositional bias

764 – 775

Poly-Glu

Compositional bias

816 – 821

Poly-Ala

Compositional bias

838 – 843

Poly-Pro

Amino acid modifications

Modified residue

609

Phosphoserine Ref.7

Modified residue

616

Phosphothreonine Ref.7

Modified residue

623

Phosphoserine Ref.7

Modified residue

797

Phosphoserine Ref.10

Modified residue

802

Phosphoserine Ref.9 Ref.10

Modified residue

806

Phosphoserine Ref.9 Ref.10

Cross-link

911

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.8

Natural variations

Natural variant

S → C.
Corresponds to variant rs2242527 [ dbSNP | Ensembl ].

VAR_014129

Natural variant

122

P → S. Ref.1 Ref.2 Ref.5
Corresponds to variant rs1263811 [ dbSNP | Ensembl ].

VAR_014130

Natural variant

746

G → R. Ref.1 Ref.2 Ref.6
Corresponds to variant rs1263810 [ dbSNP | Ensembl ].

VAR_014131

Experimental info

Sequence conflict

547

R → L in X98834. Ref.1

Sequence conflict

547

R → L in AAI36529. Ref.5

Sequence conflict

547

R → L in AAI36530. Ref.5

Sequence conflict

554

V → M in X98834. Ref.1

Sequence conflict

575 – 581

FPYVLEP → LPLCARA in X98834. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y467 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 9F9335CE7939EFA7
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FASTA

1,007

105,309

        10         20         30         40         50         60 
MSRRKQRKPQ QLISDCEGPS ASENGDASEE DHPQVCAKCC AQFTDPTEFL AHQNACSTDP 

        70         80         90        100        110        120 
PVMVIIGGQE NPNNSSASSE PRPEGHNNPQ VMDTEHSNPP DSGSSVPTDP TWGPERRGEE 

       130        140        150        160        170        180 
SPGHFLVAAT GTAAGGGGGL ILASPKLGAT PLPPESTPAP PPPPPPPPPP GVGSGHLNIP 

       190        200        210        220        230        240 
LILEELRVLQ QRQIHQMQMT EQICRQVLLL GSLGQTVGAP ASPSELPGTG TASSTKPLLP 

       250        260        270        280        290        300 
LFSPIKPVQT SKTLASSSSS SSSSSGAETP KQAFFHLYHP LGSQHPFSAG GVGRSHKPTP 

       310        320        330        340        350        360 
APSPALPGST DQLIASPHLA FPSTTGLLAA QCLGAARGLE ATASPGLLKP KNGSGELSYG 

       370        380        390        400        410        420 
EVMGPLEKPG GRHKCRFCAK VFGSDSALQI HLRSHTGERP YKCNVCGNRF TTRGNLKVHF 

       430        440        450        460        470        480 
HRHREKYPHV QMNPHPVPEH LDYVITSSGL PYGMSVPPEK AEEEAATPGG GVERKPLVAS 

       490        500        510        520        530        540 
TTALSATESL TLLSTSAGTA TAPGLPAFNK FVLMKAVEPK NKADENTPPG SEGSAISGVA 

       550        560        570        580        590        600 
ESSTATRMQL SKLVTSLPSW ALLTNHFKST GSFPFPYVLE PLGASPSETS KLQQLVEKID 

       610        620        630        640        650        660 
RQGAVAVTSA ASGAPTTSAP APSSSASSGP NQCVICLRVL SCPRALRLHY GQHGGERPFK 

       670        680        690        700        710        720 
CKVCGRAFST RGNLRAHFVG HKASPAARAQ NSCPICQKKF TNAVTLQQHV RMHLGGQIPN 

       730        740        750        760        770        780 
GGTALPEGGG AAQENGSEQS TVSGAGSFPQ QQSQQPSPEE ELSEEEEEED EEEEEDVTDE 

       790        800        810        820        830        840 
DSLAGRGSES GGEKAISVRG DSEEASGAEE EVGTVAAAAT AGKEMDSNEK TTQQSSLPPP 

       850        860        870        880        890        900 
PPPDSLDQPQ PMEQGSSGVL GGKEEGGKPE RSSSPASALT PEGEATSVTL VEELSLQEAM 

       910        920        930        940        950        960 
RKEPGESSSR KACEVCGQAF PSQAALEEHQ KTHPKEGPLF TCVFCRQGFL ERATLKKHML 

       970        980        990       1000 
LAHHQVQPFA PHGPQNIAAL SLVPGCSPSI TSTGLSPFPR KDDPTIP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt." Kohlhase J., Schuh R., Dowe G., Kuehnlein R.P., Jaeckle H., Schroeder B., Schulz-Schaeffer W., Kretzschmar H.A., Koehler A., Mueller U., Raab-Vetter M., Burkhardt E., Engel W., Stick R. Genomics 38:291-298(1996) [PubMed: 8975705] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-122 AND ARG-746. Tissue: Fetus.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-122 AND ARG-746. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-122.
[6]	"Homo sapiens mRNA for zinc finger protein, SALL2 exon 2." Morgan J.W., Ford D., Ma Y., Maizel A.L. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 541-1005, VARIANT ARG-746.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609; THR-616 AND SER-623, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells." Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X. Proteomics 8:2885-2896(2008) [PubMed: 18655026] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-911, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-802 AND SER-806, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-797; SER-802 AND SER-806, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X98834 mRNA. No translation available. AB002358 mRNA. Translation: BAA21638.2. Different initiation. AE000521 Genomic DNA. No translation available. AE000658 Genomic DNA. No translation available. BC136528 mRNA. Translation: AAI36529.1. BC136529 mRNA. Translation: AAI36530.1. AF465630 mRNA. Translation: AAL74188.1.
IPI	IPI00144003.
RefSeq	NP_005398.1. NM_005407.1.
UniGene	Hs.416358. Hs.724548.
3D structure databases
ProteinModelPortal	Q9Y467.
SMR	Q9Y467. Positions 371-453, 592-750, 878-966.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4658260.
STRING	Q9Y467.
PTM databases
PhosphoSite	Q9Y467.
Polymorphism databases
DMDM	296453020.
Proteomic databases
PeptideAtlas	Q9Y467.
PRIDE	Q9Y467.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327430; ENSP00000333537; ENSG00000165821.
GeneID	6297.
KEGG	hsa:6297.
Organism-specific databases
CTD	6297.
GeneCards	GC14M021989.
H-InvDB	HIX0202039.
HGNC	HGNC:10526. SALL2.
MIM	602219. gene.
neXtProt	NX_Q9Y467.
PharmGKB	PA34934.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG19045.
GeneTree	ENSGT00550000074555.
HOGENOM	HBG716076.
HOVERGEN	HBG058921.
InParanoid	Q9Y467.
PhylomeDB	Q9Y467.
Gene expression databases
ArrayExpress	Q9Y467.
Bgee	Q9Y467.
CleanEx	HS_SALL2.
Genevestigator	Q9Y467.
GermOnline	ENSG00000165821. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 6 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 7 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 7 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	24449.
SOURCE	Search...

Entry information

Entry name

SALL2_HUMAN

Accession

Primary (citable) accession number: Q9Y467
Secondary accession number(s): B2RMX6, B9EGK8, Q9Y4G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 100 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents