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Protein

HBS1-like protein

Gene

HBS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi267 – 274GTPBy similarity8
Nucleotide bindingi344 – 348GTPBy similarity5
Nucleotide bindingi406 – 409GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: ProtInc
  • translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

  • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Source: Reactome
  • signal transduction Source: ProtInc
  • translation Source: ProtInc

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-429958. mRNA decay by 3' to 5' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
HBS1-like protein
Alternative name(s):
ERFS
Gene namesi
Name:HBS1L
Synonyms:HBS1, KIAA1038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112339.14.
HGNCiHGNC:4834. HBS1L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10767.
OpenTargetsiENSG00000112339.
PharmGKBiPA29209.

Polymorphism and mutation databases

BioMutaiHBS1L.
DMDMi68566500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000914911 – 684HBS1-like proteinAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei154PhosphoserineCombined sources1
Modified residuei231PhosphothreonineCombined sources1
Modified residuei622N6-acetyllysineBy similarity1
Isoform 2 (identifier: Q9Y450-2)
Modified residuei246PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y450.
PaxDbiQ9Y450.
PeptideAtlasiQ9Y450.
PRIDEiQ9Y450.

PTM databases

iPTMnetiQ9Y450.
PhosphoSitePlusiQ9Y450.

Miscellaneous databases

PMAP-CutDBiQ9Y450.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000112339.
CleanExiHS_HBS1L.
ExpressionAtlasiQ9Y450. baseline and differential.
GenevisibleiQ9Y450. HS.

Organism-specific databases

HPAiHPA029728.
HPA029729.

Interactioni

Protein-protein interaction databases

BioGridi115986. 46 interactors.
IntActiQ9Y450. 19 interactors.
MINTiMINT-6784072.
STRINGi9606.ENSP00000356811.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LZWelectron microscopy3.53jj1-684[»]
5LZXelectron microscopy3.67jj1-684[»]
5LZYelectron microscopy3.99jj1-684[»]
5LZZelectron microscopy3.47jj1-684[»]
ProteinModelPortaliQ9Y450.
SMRiQ9Y450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 482tr-type GAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni267 – 274G18
Regioni323 – 327G25
Regioni344 – 347G34
Regioni406 – 409G44
Regioni445 – 447G53

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOVERGENiHBG000179.
InParanoidiQ9Y450.
KOiK14416.
OMAiHMIVIGH.
OrthoDBiEOG091G0637.
PhylomeDBiQ9Y450.
TreeFamiTF105833.

Family and domain databases

InterProiView protein in InterPro
IPR004161. EFTu-like_2.
IPR015033. HBS1-like_N.
IPR037189. HBS1-like_N_sf.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel_sf.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
PRINTSiPR00315. ELONGATNFCT.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD278081. DUF1916. 1 hit.
SUPFAMiSSF109732. SSF109732. 1 hit.
SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51722. G_TR_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y450-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDKPSV
60 70 80 90 100
EPVEEYDYED LKESSNSVSN HQLSGFDQAR LYSCLDHMRE VLGDAVPDEI
110 120 130 140 150
LIEAVLKNKF DVQKALSGVL EQDRVQSLKD KNEATVSTGK IAKGKPVDSQ
160 170 180 190 200
TSRSESEIVP KVAKMTVSGK KQTMGFEVPG VSSEENGHSF HTPQKGPPIE
210 220 230 240 250
DAIASSDVLE TASKSANPPH TIQASEEQSS TPAPVKKSGK LRQQIDVKAE
260 270 280 290 300
LEKRQGGKQL LNLVVIGHVD AGKSTLMGHM LYLLGNINKR TMHKYEQESK
310 320 330 340 350
KAGKASFAYA WVLDETGEER ERGVTMDVGM TKFETTTKVI TLMDAPGHKD
360 370 380 390 400
FIPNMITGAA QADVAVLVVD ASRGEFEAGF ETGGQTREHG LLVRSLGVTQ
410 420 430 440 450
LAVAVNKMDQ VNWQQERFQE ITGKLGHFLK QAGFKESDVG FIPTSGLSGE
460 470 480 490 500
NLITRSQSSE LTKWYKGLCL LEQIDSFKPP QRSIDKPFRL CVSDVFKDQG
510 520 530 540 550
SGFCITGKIE AGYIQTGDRL LAMPPNETCT VKGITLHDEP VDWAAAGDHV
560 570 580 590 600
SLTLVGMDII KINVGCIFCG PKVPIKACTR FRARILIFNI EIPITKGFPV
610 620 630 640 650
LLHYQTVSEP AVIKRLISVL NKSTGEVTKK KPKFLTKGQN ALVELQTQRP
660 670 680
IALELYKDFK ELGRFMLRYG GSTIAAGVVT EIKE
Length:684
Mass (Da):75,473
Last modified:November 1, 1999 - v1
Checksum:iD457ACA3941C4B4B
GO
Isoform 2 (identifier: Q9Y450-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-684: KPVDSQTSRS...AAGVVTEIKE → VLFSSSEVSA...ANQKKAFTRE

Show »
Length:632
Mass (Da):70,128
Checksum:i2E634F1A2B1DC232
GO
Isoform 3 (identifier: Q9Y450-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-78: Missing.

Show »
Length:642
Mass (Da):70,625
Checksum:i2B120FC9C989EE0C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048963440G → S. Corresponds to variant dbSNP:rs4435957Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04106837 – 78Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_013624145 – 684KPVDS…TEIKE → VLFSSSEVSADNVQSSYPQS ANHLDYSSKPFDFASSVGKY GLSHNSSVPTHCLLHRKKKL DTRKSEKKLESCKLTKELSL ANLIHDMSRDSCESQPSVRL SSTDSLESLLSKNLDADLLR PHASECISKDDSAFKEIPDL KTIIIKGTTPNNSLYIQNNS LSDFQNIPVQDSLGSSNNPL YLTSSLENMTVDNLNASKET EVGNVSLVEQSAKNHTFKND NLQFSQCESPSLTELFQEHK ENNISQCFTLSDLCNQSSAS FTDLSLGSFPLSQLANRCQS SPGISELTGSLSSLAFHKAS PTRDLENLSLSELIAETIDV DNSQIKKESFEVSLSEVRSP GIDSNIDLSVLIKNPDFVPK PVVDPSIAPSSRTKVLSSKL GKNSNFAKDNKKNNKGSLTR KPPFSLSWTKALAARPSAFA STLCLRYPLKSCKRRTLDLY KTFLYSRQVQDVKDKEISPL VAITPFDFKSASPDDIVKAN QKKAFTRE in isoform 2. 1 PublicationAdd BLAST540

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87791 mRNA. Translation: AAD00645.1.
AJ459826 mRNA. Translation: CAD30873.1.
AJ459827 mRNA. Translation: CAD30874.1.
AK295545 mRNA. Translation: BAH12101.1.
AL353596 Genomic DNA. No translation available.
AL445190 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW47982.1.
BC001465 mRNA. Translation: AAH01465.1.
BC040849 mRNA. Translation: AAH40849.1.
AB028961 mRNA. Translation: BAA82990.1.
CCDSiCCDS47479.1. [Q9Y450-4]
CCDS47480.1. [Q9Y450-2]
CCDS5173.1. [Q9Y450-1]
RefSeqiNP_001138630.1. NM_001145158.1. [Q9Y450-4]
NP_001138679.1. NM_001145207.1. [Q9Y450-2]
NP_006611.1. NM_006620.3. [Q9Y450-1]
UniGeneiHs.378532.

Genome annotation databases

EnsembliENST00000367822; ENSP00000356796; ENSG00000112339. [Q9Y450-2]
ENST00000367826; ENSP00000356800; ENSG00000112339. [Q9Y450-4]
ENST00000367837; ENSP00000356811; ENSG00000112339. [Q9Y450-1]
GeneIDi10767.
KEGGihsa:10767.
UCSCiuc003qez.4. human. [Q9Y450-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBS1L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y450
Secondary accession number(s): B7Z365
, Q4VX89, Q4VX90, Q5T7G3, Q8NDW9, Q9UPW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families