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Q9Y450

- HBS1L_HUMAN

UniProt

Q9Y450 - HBS1L_HUMAN

Protein

HBS1-like protein

Gene

HBS1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi267 – 2748GTPBy similarity
    Nucleotide bindingi344 – 3485GTPBy similarity
    Nucleotide bindingi406 – 4094GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: ProtInc
    3. translation elongation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: ProtInc
    2. translation Source: ProtInc

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HBS1-like protein
    Alternative name(s):
    ERFS
    Gene namesi
    Name:HBS1L
    Synonyms:HBS1, KIAA1038
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4834. HBS1L.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29209.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684HBS1-like proteinPRO_0000091491Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171Phosphoserine1 Publication
    Modified residuei127 – 1271Phosphoserine1 Publication
    Modified residuei622 – 6221N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y450.
    PaxDbiQ9Y450.
    PeptideAtlasiQ9Y450.
    PRIDEiQ9Y450.

    PTM databases

    PhosphoSiteiQ9Y450.

    Miscellaneous databases

    PMAP-CutDBQ9Y450.

    Expressioni

    Tissue specificityi

    Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y450.
    BgeeiQ9Y450.
    CleanExiHS_HBS1L.
    GenevestigatoriQ9Y450.

    Organism-specific databases

    HPAiHPA029728.
    HPA029729.

    Interactioni

    Protein-protein interaction databases

    BioGridi115986. 12 interactions.
    IntActiQ9Y450. 8 interactions.
    MINTiMINT-6784072.
    STRINGi9606.ENSP00000356811.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y450.
    SMRiQ9Y450. Positions 60-123, 256-683.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 482225tr-type GPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni267 – 2748G1PROSITE-ProRule annotation
    Regioni323 – 3275G2PROSITE-ProRule annotation
    Regioni344 – 3474G3PROSITE-ProRule annotation
    Regioni406 – 4094G4PROSITE-ProRule annotation
    Regioni445 – 4473G5PROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation
    Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5256.
    HOVERGENiHBG000179.
    InParanoidiQ9Y450.
    KOiK14416.
    OMAiHTPQKGH.
    OrthoDBiEOG7JMGCV.
    PhylomeDBiQ9Y450.
    TreeFamiTF105833.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR015033. HBS1-like_N.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    PF08938. HBS1_N. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    ProDomiPD278081. DUF1916. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y450-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDKPSV    50
    EPVEEYDYED LKESSNSVSN HQLSGFDQAR LYSCLDHMRE VLGDAVPDEI 100
    LIEAVLKNKF DVQKALSGVL EQDRVQSLKD KNEATVSTGK IAKGKPVDSQ 150
    TSRSESEIVP KVAKMTVSGK KQTMGFEVPG VSSEENGHSF HTPQKGPPIE 200
    DAIASSDVLE TASKSANPPH TIQASEEQSS TPAPVKKSGK LRQQIDVKAE 250
    LEKRQGGKQL LNLVVIGHVD AGKSTLMGHM LYLLGNINKR TMHKYEQESK 300
    KAGKASFAYA WVLDETGEER ERGVTMDVGM TKFETTTKVI TLMDAPGHKD 350
    FIPNMITGAA QADVAVLVVD ASRGEFEAGF ETGGQTREHG LLVRSLGVTQ 400
    LAVAVNKMDQ VNWQQERFQE ITGKLGHFLK QAGFKESDVG FIPTSGLSGE 450
    NLITRSQSSE LTKWYKGLCL LEQIDSFKPP QRSIDKPFRL CVSDVFKDQG 500
    SGFCITGKIE AGYIQTGDRL LAMPPNETCT VKGITLHDEP VDWAAAGDHV 550
    SLTLVGMDII KINVGCIFCG PKVPIKACTR FRARILIFNI EIPITKGFPV 600
    LLHYQTVSEP AVIKRLISVL NKSTGEVTKK KPKFLTKGQN ALVELQTQRP 650
    IALELYKDFK ELGRFMLRYG GSTIAAGVVT EIKE 684
    Length:684
    Mass (Da):75,473
    Last modified:November 1, 1999 - v1
    Checksum:iD457ACA3941C4B4B
    GO
    Isoform 2 (identifier: Q9Y450-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-684: KPVDSQTSRS...AAGVVTEIKE → VLFSSSEVSA...ANQKKAFTRE

    Note: Contains a phosphoserine at position 246.

    Show »
    Length:632
    Mass (Da):70,128
    Checksum:i2E634F1A2B1DC232
    GO
    Isoform 3 (identifier: Q9Y450-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         37-78: Missing.

    Show »
    Length:642
    Mass (Da):70,625
    Checksum:i2B120FC9C989EE0C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti440 – 4401G → S.
    Corresponds to variant rs4435957 [ dbSNP | Ensembl ].
    VAR_048963

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei37 – 7842Missing in isoform 3. 1 PublicationVSP_041068Add
    BLAST
    Alternative sequencei145 – 684540KPVDS…TEIKE → VLFSSSEVSADNVQSSYPQS ANHLDYSSKPFDFASSVGKY GLSHNSSVPTHCLLHRKKKL DTRKSEKKLESCKLTKELSL ANLIHDMSRDSCESQPSVRL SSTDSLESLLSKNLDADLLR PHASECISKDDSAFKEIPDL KTIIIKGTTPNNSLYIQNNS LSDFQNIPVQDSLGSSNNPL YLTSSLENMTVDNLNASKET EVGNVSLVEQSAKNHTFKND NLQFSQCESPSLTELFQEHK ENNISQCFTLSDLCNQSSAS FTDLSLGSFPLSQLANRCQS SPGISELTGSLSSLAFHKAS PTRDLENLSLSELIAETIDV DNSQIKKESFEVSLSEVRSP GIDSNIDLSVLIKNPDFVPK PVVDPSIAPSSRTKVLSSKL GKNSNFAKDNKKNNKGSLTR KPPFSLSWTKALAARPSAFA STLCLRYPLKSCKRRTLDLY KTFLYSRQVQDVKDKEISPL VAITPFDFKSASPDDIVKAN QKKAFTRE in isoform 2. 1 PublicationVSP_013624Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87791 mRNA. Translation: AAD00645.1.
    AJ459826 mRNA. Translation: CAD30873.1.
    AJ459827 mRNA. Translation: CAD30874.1.
    AK295545 mRNA. Translation: BAH12101.1.
    AL353596, AL445190 Genomic DNA. Translation: CAI17912.1.
    AL353596, AL445190 Genomic DNA. Translation: CAI17913.1.
    AL353596 Genomic DNA. Translation: CAI17914.1.
    AL445190, AL353596 Genomic DNA. Translation: CAI95161.1.
    AL445190, AL353596 Genomic DNA. Translation: CAI95162.1.
    CH471051 Genomic DNA. Translation: EAW47982.1.
    BC001465 mRNA. Translation: AAH01465.1.
    BC040849 mRNA. Translation: AAH40849.1.
    AB028961 mRNA. Translation: BAA82990.1.
    CCDSiCCDS47479.1. [Q9Y450-4]
    CCDS47480.1. [Q9Y450-2]
    CCDS5173.1. [Q9Y450-1]
    RefSeqiNP_001138630.1. NM_001145158.1. [Q9Y450-4]
    NP_001138679.1. NM_001145207.1. [Q9Y450-2]
    NP_006611.1. NM_006620.3. [Q9Y450-1]
    UniGeneiHs.378532.

    Genome annotation databases

    EnsembliENST00000367822; ENSP00000356796; ENSG00000112339. [Q9Y450-2]
    ENST00000367826; ENSP00000356800; ENSG00000112339. [Q9Y450-4]
    ENST00000367837; ENSP00000356811; ENSG00000112339. [Q9Y450-1]
    GeneIDi10767.
    KEGGihsa:10767.
    UCSCiuc003qey.2. human. [Q9Y450-1]
    uc003qfa.2. human. [Q9Y450-2]
    uc011eda.1. human. [Q9Y450-4]

    Polymorphism databases

    DMDMi68566500.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87791 mRNA. Translation: AAD00645.1 .
    AJ459826 mRNA. Translation: CAD30873.1 .
    AJ459827 mRNA. Translation: CAD30874.1 .
    AK295545 mRNA. Translation: BAH12101.1 .
    AL353596 , AL445190 Genomic DNA. Translation: CAI17912.1 .
    AL353596 , AL445190 Genomic DNA. Translation: CAI17913.1 .
    AL353596 Genomic DNA. Translation: CAI17914.1 .
    AL445190 , AL353596 Genomic DNA. Translation: CAI95161.1 .
    AL445190 , AL353596 Genomic DNA. Translation: CAI95162.1 .
    CH471051 Genomic DNA. Translation: EAW47982.1 .
    BC001465 mRNA. Translation: AAH01465.1 .
    BC040849 mRNA. Translation: AAH40849.1 .
    AB028961 mRNA. Translation: BAA82990.1 .
    CCDSi CCDS47479.1. [Q9Y450-4 ]
    CCDS47480.1. [Q9Y450-2 ]
    CCDS5173.1. [Q9Y450-1 ]
    RefSeqi NP_001138630.1. NM_001145158.1. [Q9Y450-4 ]
    NP_001138679.1. NM_001145207.1. [Q9Y450-2 ]
    NP_006611.1. NM_006620.3. [Q9Y450-1 ]
    UniGenei Hs.378532.

    3D structure databases

    ProteinModelPortali Q9Y450.
    SMRi Q9Y450. Positions 60-123, 256-683.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115986. 12 interactions.
    IntActi Q9Y450. 8 interactions.
    MINTi MINT-6784072.
    STRINGi 9606.ENSP00000356811.

    PTM databases

    PhosphoSitei Q9Y450.

    Polymorphism databases

    DMDMi 68566500.

    Proteomic databases

    MaxQBi Q9Y450.
    PaxDbi Q9Y450.
    PeptideAtlasi Q9Y450.
    PRIDEi Q9Y450.

    Protocols and materials databases

    DNASUi 10767.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367822 ; ENSP00000356796 ; ENSG00000112339 . [Q9Y450-2 ]
    ENST00000367826 ; ENSP00000356800 ; ENSG00000112339 . [Q9Y450-4 ]
    ENST00000367837 ; ENSP00000356811 ; ENSG00000112339 . [Q9Y450-1 ]
    GeneIDi 10767.
    KEGGi hsa:10767.
    UCSCi uc003qey.2. human. [Q9Y450-1 ]
    uc003qfa.2. human. [Q9Y450-2 ]
    uc011eda.1. human. [Q9Y450-4 ]

    Organism-specific databases

    CTDi 10767.
    GeneCardsi GC06M135281.
    HGNCi HGNC:4834. HBS1L.
    HPAi HPA029728.
    HPA029729.
    MIMi 612450. gene.
    neXtProti NX_Q9Y450.
    PharmGKBi PA29209.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5256.
    HOVERGENi HBG000179.
    InParanoidi Q9Y450.
    KOi K14416.
    OMAi HTPQKGH.
    OrthoDBi EOG7JMGCV.
    PhylomeDBi Q9Y450.
    TreeFami TF105833.

    Miscellaneous databases

    ChiTaRSi HBS1L. human.
    GenomeRNAii 10767.
    NextBioi 40885.
    PMAP-CutDB Q9Y450.
    PROi Q9Y450.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y450.
    Bgeei Q9Y450.
    CleanExi HS_HBS1L.
    Genevestigatori Q9Y450.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR015033. HBS1-like_N.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    PF08938. HBS1_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    ProDomi PD278081. DUF1916. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity."
      Wallrapp C., Verrier S.-B., Zhouravleva G., Philippe H., Philippe M., Gress T.M., Jean-Jean O.
      FEBS Lett. 440:387-392(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Pancreatic cancer.
    2. "An integrated physical and transcript map of human 6q23 encompassing a quantitative trait loci for foetal haemaglobin expression."
      Close J.P., Game L.G., Clark B., Thein S.L.
      Thesis (2002), University of Oxford, United Kingdom
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Hippocampus.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix and Placenta.
    7. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-684 (ISOFORMS 1/3).
      Tissue: Brain.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHBS1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y450
    Secondary accession number(s): B7Z365
    , Q4VX89, Q4VX90, Q5T7G3, Q8NDW9, Q9UPW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3