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Protein

Plakophilin-3

Gene

PKP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in junctional plaques.

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesion molecule binding Source: UniProtKB
  • enzyme binding Source: CAFA

GO - Biological processi

  • cornification Source: Reactome
  • desmosome assembly Source: UniProtKB
  • keratinization Source: Reactome
  • negative regulation of mRNA catabolic process Source: CAFA
  • positive regulation of gene expression Source: CAFA
  • protein localization to plasma membrane Source: UniProtKB

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SignaLinkiQ9Y446

Names & Taxonomyi

Protein namesi
Recommended name:
Plakophilin-3
Gene namesi
Name:PKP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000184363.9
HGNCiHGNC:9025 PKP3
MIMi605561 gene
neXtProtiNX_Q9Y446

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11187
OpenTargetsiENSG00000184363
PharmGKBiPA33358

Polymorphism and mutation databases

BioMutaiPKP3
DMDMi20139301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642871 – 797Plakophilin-3Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Omega-N-methylarginineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei250PhosphothreonineCombined sources1
Modified residuei261Omega-N-methylarginineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y446
PaxDbiQ9Y446
PeptideAtlasiQ9Y446
PRIDEiQ9Y446

PTM databases

iPTMnetiQ9Y446
PhosphoSitePlusiQ9Y446
SwissPalmiQ9Y446

Expressioni

Tissue specificityi

Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.1 Publication

Gene expression databases

BgeeiENSG00000184363
CleanExiHS_PKP3
ExpressionAtlasiQ9Y446 baseline and differential
GenevisibleiQ9Y446 HS

Organism-specific databases

HPAiCAB012993
HPA062937

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IQUBQ8NA544EBI-2880227,EBI-10220600

GO - Molecular functioni

  • alpha-catenin binding Source: BHF-UCL
  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cell adhesion molecule binding Source: UniProtKB
  • enzyme binding Source: CAFA

Protein-protein interaction databases

BioGridi116357, 58 interactors
IntActiQ9Y446, 13 interactors
MINTiQ9Y446
STRINGi9606.ENSP00000331678

Structurei

3D structure databases

ProteinModelPortaliQ9Y446
SMRiQ9Y446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 348ARM 1Add BLAST44
Repeati351 – 390ARM 2Add BLAST40
Repeati393 – 432ARM 3Add BLAST40
Repeati449 – 487ARM 4Add BLAST39
Repeati491 – 536ARM 5Add BLAST46
Repeati596 – 637ARM 6Add BLAST42
Repeati645 – 684ARM 7Add BLAST40
Repeati689 – 730ARM 8Add BLAST42

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00760000119167
HOGENOMiHOG000115567
HOVERGENiHBG106682
InParanoidiQ9Y446
OMAiNARNKDE
OrthoDBiEOG091G01WL
PhylomeDBiQ9Y446
TreeFamiTF321877

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028434 Plakophilin-3
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF1 PTHR10372:SF1, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform PKP3a (identifier: Q9Y446-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV
60 70 80 90 100
RARLLQLGQQ PRHNGAAEPE PEAETARGTS RGQYHTLQAG FSSRSQGLSG
110 120 130 140 150
DKTSGFRPIA KPAYSPASWS SRSAVDLSCS RRLSSAHNGG SAFGAAGYGG
160 170 180 190 200
AQPTPPMPTR PVSFHERGGV GSRADYDTLS LRSLRLGPGG LDDRYSLVSE
210 220 230 240 250
QLEPAATSTY RAFAYERQAS SSSSRAGGLD WPEATEVSPS RTIRAPAVRT
260 270 280 290 300
LQRFQSSHRS RGVGGAVPGA VLEPVARAPS VRSLSLSLAD SGHLPDVHGF
310 320 330 340 350
NSYGSHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHKCYSD
360 370 380 390 400
AAAKKQARSL QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNADNKLALV
410 420 430 440 450
EENGIFELLR TLREQDDELR KNVTGILWNL SSSDHLKDRL ARDTLEQLTD
460 470 480 490 500
LVLSPLSGAG GPPLIQQNAS EAEIFYNATG FLRNLSSASQ ATRQKMRECH
510 520 530 540 550
GLVDALVTSI NHALDAGKCE DKSVENAVCV LRNLSYRLYD EMPPSALQRL
560 570 580 590 600
EGRGRRDLAG APPGEVVGCF TPQSRRLREL PLAADALTFA EVSKDPKGLE
610 620 630 640 650
WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA
660 670 680 690 700
LEQERILNPL LDRVRTADHH QLRSLTGLIR NLSRNARNKD EMSTKVVSHL
710 720 730 740 750
IEKLPGSVGE KSPPAEVLVN IIAVLNNLVV ASPIAARDLL YFDGLRKLIF
760 770 780 790
IKKKRDSPDS EKSSRAASSL LANLWQYNKL HRDFRAKGYR KEDFLGP
Length:797
Mass (Da):87,082
Last modified:November 1, 1999 - v1
Checksum:iD43C7E77FA805E7E
GO
Isoform PKP3b (identifier: Q9Y446-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MQDGNFLLSALQ → MESWTPRPSAVASGMSWEAGGIRTTSR

Show »
Length:812
Mass (Da):88,655
Checksum:i174072FD73D1512A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti719V → A in BAD97231 (Ref. 4) Curated1
Sequence conflicti730V → G in BAD97231 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0536461 – 12MQDGN…LSALQ → MESWTPRPSAVASGMSWEAG GIRTTSR in isoform PKP3b. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z98265 mRNA Translation: CAB44310.1
AF053719 mRNA Translation: AAF23050.1
FN421477 mRNA Translation: CAZ65731.1
AK223511 mRNA Translation: BAD97231.1
BC000081 mRNA Translation: AAH00081.1
DA439471 mRNA No translation available.
CCDSiCCDS7695.1 [Q9Y446-1]
RefSeqiNP_001289958.1, NM_001303029.1 [Q9Y446-2]
NP_009114.1, NM_007183.3 [Q9Y446-1]
UniGeneiHs.534395

Genome annotation databases

EnsembliENST00000331563; ENSP00000331678; ENSG00000184363 [Q9Y446-1]
GeneIDi11187
KEGGihsa:11187
UCSCiuc001lpc.3 human [Q9Y446-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

Similar proteinsi

Entry informationi

Entry nameiPKP3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y446
Secondary accession number(s): F8J390, Q53EX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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