Reviewed, UniProtKB/Swiss-Prot Q9Y426 (CU025_HUMAN)

Names and origin

Protein names

Recommended name:
    C2 domain-containing protein 2

Gene names

Name:	C2CD2
Synonyms:	C21orf25, C21orf258

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C2 domain.
Sequence caution	The sequence BAA95528.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 696	655	C2 domain-containing protein 2		PRO_0000045386
Regions
	Domain	265 – 346	82	C2
Amino acid modifications
	Modified residue	435	1	Phosphoserine Ref.4
	Modified residue	441	1	Phosphoserine Ref.4
	Modified residue	445	1	Phosphothreonine Ref.4
Natural variations
	Natural variant	211	1	V → A: dbSNP rs2839421.		VAR_050928
	Natural variant	618	1	T → A: dbSNP rs9981024.		VAR_050929
Experimental info
	Sequence conflict	460	1	A → T in CAH10536. Ref.3
	Sequence conflict	521 – 525	5	Missing in CAB43307. Ref.3
	Sequence conflict	639	1	H → R in CAH10536. Ref.3
	Sequence conflict	679	1	S → P in CAH10536. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9Y426-1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 73F757C8608061F9	FASTA	696	75,533
	10 20 30 40 50 60 MAMARLGSWL GEAQWLALVS LFVAALATVG LYLAQWALAR ARPQPQRRAV EPGEGPRPGS 70 80 90 100 110 120 DALLSWILTL GSWRSQWQAA WVTALNEEAE RKGGPPFLSF EEDPRQQALE LVVQEVSSVL 130 140 150 160 170 180 RSAEEKVVVC HVVGQAIQFL VSETPALGAG CRLYDMRLSP FHLQLEFHMK EKREDLQISW 190 200 210 220 230 240 SFISVPEMAV NIQPKALGED QVAETSAMSD VLKDILKHLA GSASPSVVLI TKPTTVKEAQ 250 260 270 280 290 300 NLQCAASTAQ ESCPPKPPRA HELKLLVRNI HVLLLSEPGA SGHINAVCVV QLNDPVQRFS 310 320 330 340 350 360 STLTKNTPDL MWEEEFTFEL NAKSKELHLQ ISEAGRSSEG LLATATVPLD LFKKQPSGPQ 370 380 390 400 410 420 SFTLTSGSAC GSSVLGSVTA EFSYMEPGEL KSWPIPPPVP AAKIEKDRTV MPCGTVVTTV 430 440 450 460 470 480 TAVKTKPRVD VGRASPLSSD SPVKTPIKVK VIEKDISVQA IACRSAPVSK TLSSSDTELL 490 500 510 520 530 540 VLNGSDPVAE VAIRQLSESS KLKLKSPRKK STIIISGISK TSLSQDHDAA LMQGYTASVD 550 560 570 580 590 600 STHQEDAPSH PERAAASAPP EEAESAQASL APKPQEDELD SWDLEKEPQA AAWSSQVLLD 610 620 630 640 650 660 PDGDELSESS MSVLEPGTAK KHKGGILRKG AKLFFRRRHQ QKDPGMSQSH NDLVFLEQPE 670 680 690 GSRRKGITLT RILNKKLLSR HRNKNTMNGA PVEPCT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens mRNA for C21orf25 long form, complete cds." Shimizu N., Kudoh J., Shibuya K. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain and Pancreas.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-696. Tissue: Cervix and Uterus.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-441 AND THR-445, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB047784 mRNA. Translation: BAD74068.1. AB047785 mRNA. Translation: BAD74069.1. AP001745 Genomic DNA. Translation: BAA95528.1. Sequence problems. AL050173 mRNA. Translation: CAB43307.1. CR627455 mRNA. Translation: CAH10536.1.
IPI	IPI00471978.
PIR	T08793.
RefSeq	NP_056315.1.
UniGene	Hs.473894 Hs.675058
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y426.
PTM databases
PhosphoSite	Q9Y426.
Proteomic databases
PRIDE	Q9Y426.
Genome annotation databases
Ensembl	ENST00000380486; ENSP00000369853; ENSG00000157617; Homo sapiens. [Genome view]
GeneID	25966.
KEGG	hsa:25966.
UCSC	uc002yzw.1. human.
Organism-specific databases
CTD	25966.
GeneCards	GC21M042179.
HGNC	HGNC:1266. C2CD2.
PharmGKB	PA25822.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y426.
HOVERGEN	Q9Y426.
OMA	KTSLSQD
OrthoDB	EOG98KTWX
Gene expression databases
ArrayExpress	Q9Y426.
Bgee	Q9Y426.
CleanEx	HS_C2CD2.
Genevestigator	Q9Y426.
GermOnline	ENSG00000157617. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_reg_CaLB. [Graphical view]
Pfam	PF00168. C2. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. [Graphical view]
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47596.

Entry information

Entry name

CU025_HUMAN

Accession

Primary (citable) accession number: Q9Y426
Secondary accession number(s): Q5R2V7, Q6AHX8, Q9NSE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 10, 2006
Last modified:	November 24, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.