Reviewed,
UniProtKB/Swiss-Prot Q9Y426 (CU025_HUMAN)
Last modified
November 24, 2009.
Version 64.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: C2 domain-containing protein 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 696 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Secreted Potential. |
| Sequence similarities | Contains 1 C2 domain. |
| Sequence caution | The sequence BAA95528.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytosol Inferred from direct assay. Source: UniProtKB extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 41 | 41 | Potential | ||||||
| Chain | 42 – 696 | 655 | C2 domain-containing protein 2 | PRO_0000045386 | |||||
Regions | |||||||||
| Domain | 265 – 346 | 82 | C2 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 435 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 441 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 445 | 1 | Phosphothreonine Ref.4 | ||||||
Natural variations | |||||||||
| Natural variant | 211 | 1 | V → A: dbSNP rs2839421. | VAR_050928 | |||||
| Natural variant | 618 | 1 | T → A: dbSNP rs9981024. | VAR_050929 | |||||
Experimental info | |||||||||
| Sequence conflict | 460 | 1 | A → T in CAH10536. Ref.3 | ||||||
| Sequence conflict | 521 – 525 | 5 | Missing in CAB43307. Ref.3 | ||||||
| Sequence conflict | 639 | 1 | H → R in CAH10536. Ref.3 | ||||||
| Sequence conflict | 679 | 1 | S → P in CAH10536. Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AB047784 mRNA. Translation: BAD74068.1. AB047785 mRNA. Translation: BAD74069.1. AP001745 Genomic DNA. Translation: BAA95528.1. Sequence problems. AL050173 mRNA. Translation: CAB43307.1. CR627455 mRNA. Translation: CAH10536.1. | |
| IPI | IPI00471978. |
| PIR | T08793. |
| RefSeq | NP_056315.1. |
| UniGene | Hs.473894 Hs.675058 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y426. |
PTM databases | |
| PhosphoSite | Q9Y426. |
Proteomic databases | |
| PRIDE | Q9Y426. |
Genome annotation databases | |
| Ensembl | ENST00000380486; ENSP00000369853; ENSG00000157617; Homo sapiens. [Genome view] |
| GeneID | 25966. |
| KEGG | hsa:25966. |
| UCSC | uc002yzw.1. human. |
Organism-specific databases | |
| CTD | 25966. |
| GeneCards | GC21M042179. |
| HGNC | HGNC:1266. C2CD2. |
| PharmGKB | PA25822. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9Y426. |
| HOVERGEN | Q9Y426. |
| OMA | KTSLSQD |
| OrthoDB | EOG98KTWX |
Gene expression databases | |
| ArrayExpress | Q9Y426. |
| Bgee | Q9Y426. |
| CleanEx | HS_C2CD2. |
| Genevestigator | Q9Y426. |
| GermOnline | ENSG00000157617. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_reg_CaLB. [Graphical view] |
| Pfam | PF00168. C2. 1 hit. [Graphical view] |
| SMART | SM00239. C2. 1 hit. [Graphical view] |
| PROSITE | PS50004. C2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 47596. |
Entry information
| Entry name | CU025_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y426 Secondary accession number(s): Q5R2V7, Q6AHX8, Q9NSE6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 21 Human chromosome 21: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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