Q9Y426 (CU025_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C2 domain-containing protein 2

Gene names

Name:	C2CD2
Synonyms:	C21orf25, C21orf258

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 C2 domain.
Sequence caution	The sequence BAA95528.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH10536.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from direct assay PubMed 16780588. Source: UniProtKB extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay PubMed 16780588. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y426-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y426-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Isoform 3 (identifier: Q9Y426-3)

The sequence of this isoform differs from the canonical sequence as follows:
     521-525: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 41	41	Potential
	Chain	42 – 696	655	C2 domain-containing protein 2		PRO_0000045386
Regions
	Domain	265 – 346	82	C2
Amino acid modifications
	Modified residue	435	1	Phosphoserine Ref.4
	Modified residue	441	1	Phosphoserine Ref.4
	Modified residue	445	1	Phosphothreonine Ref.4
Natural variations
	Alternative sequence	1 – 155	155	Missing in isoform 2.		VSP_041071
	Alternative sequence	521 – 525	5	Missing in isoform 3.		VSP_041072
	Natural variant	211	1	V → A. Corresponds to variant rs2839421 [ dbSNP | Ensembl ].		VAR_050928
	Natural variant	618	1	T → A. Corresponds to variant rs9981024 [ dbSNP | Ensembl ].		VAR_050929
Experimental info
	Sequence conflict	460	1	A → T in CAH10536. Ref.2
	Sequence conflict	639	1	H → R in CAH10536. Ref.2
	Sequence conflict	679	1	S → P in CAH10536. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 73F757C8608061F9	FASTA	696	75,533
	10 20 30 40 50 60 MAMARLGSWL GEAQWLALVS LFVAALATVG LYLAQWALAR ARPQPQRRAV EPGEGPRPGS 70 80 90 100 110 120 DALLSWILTL GSWRSQWQAA WVTALNEEAE RKGGPPFLSF EEDPRQQALE LVVQEVSSVL 130 140 150 160 170 180 RSAEEKVVVC HVVGQAIQFL VSETPALGAG CRLYDMRLSP FHLQLEFHMK EKREDLQISW 190 200 210 220 230 240 SFISVPEMAV NIQPKALGED QVAETSAMSD VLKDILKHLA GSASPSVVLI TKPTTVKEAQ 250 260 270 280 290 300 NLQCAASTAQ ESCPPKPPRA HELKLLVRNI HVLLLSEPGA SGHINAVCVV QLNDPVQRFS 310 320 330 340 350 360 STLTKNTPDL MWEEEFTFEL NAKSKELHLQ ISEAGRSSEG LLATATVPLD LFKKQPSGPQ 370 380 390 400 410 420 SFTLTSGSAC GSSVLGSVTA EFSYMEPGEL KSWPIPPPVP AAKIEKDRTV MPCGTVVTTV 430 440 450 460 470 480 TAVKTKPRVD VGRASPLSSD SPVKTPIKVK VIEKDISVQA IACRSAPVSK TLSSSDTELL 490 500 510 520 530 540 VLNGSDPVAE VAIRQLSESS KLKLKSPRKK STIIISGISK TSLSQDHDAA LMQGYTASVD 550 560 570 580 590 600 STHQEDAPSH PERAAASAPP EEAESAQASL APKPQEDELD SWDLEKEPQA AAWSSQVLLD 610 620 630 640 650 660 PDGDELSESS MSVLEPGTAK KHKGGILRKG AKLFFRRRHQ QKDPGMSQSH NDLVFLEQPE 670 680 690 GSRRKGITLT RILNKKLLSR HRNKNTMNGA PVEPCT
	Isoform 2 [UniParc]. Checksum: 64DD4953464F1942	FASTA	541	58,613
	10 20 30 40 50 60 MRLSPFHLQL EFHMKEKRED LQISWSFISV PEMAVNIQPK ALGEDQVAET SAMSDVLKDI 70 80 90 100 110 120 LKHLAGSASP SVVLITKPTT VKEAQNLQCA ASTAQESCPP KPPRAHELKL LVRNIHVLLL 130 140 150 160 170 180 SEPGASGHIN AVCVVQLNDP VQRFSSTLTK NTPDLMWEEE FTFELNAKSK ELHLQISEAG 190 200 210 220 230 240 RSSEGLLATA TVPLDLFKKQ PSGPQSFTLT SGSACGSSVL GSVTAEFSYM EPGELKSWPI 250 260 270 280 290 300 PPPVPAAKIE KDRTVMPCGT VVTTVTAVKT KPRVDVGRAS PLSSDSPVKT PIKVKVIEKD 310 320 330 340 350 360 ISVQAIACRS APVSKTLSSS DTELLVLNGS DPVAEVAIRQ LSESSKLKLK SPRKKSTIII 370 380 390 400 410 420 SGISKTSLSQ DHDAALMQGY TASVDSTHQE DAPSHPERAA ASAPPEEAES AQASLAPKPQ 430 440 450 460 470 480 EDELDSWDLE KEPQAAAWSS QVLLDPDGDE LSESSMSVLE PGTAKKHKGG ILRKGAKLFF 490 500 510 520 530 540 RRRHQQKDPG MSQSHNDLVF LEQPEGSRRK GITLTRILNK KLLSRHRNKN TMNGAPVEPC T
	Isoform 3 [UniParc]. Checksum: 53B21D413BF4EC76	FASTA	691	75,017
	10 20 30 40 50 60 MAMARLGSWL GEAQWLALVS LFVAALATVG LYLAQWALAR ARPQPQRRAV EPGEGPRPGS 70 80 90 100 110 120 DALLSWILTL GSWRSQWQAA WVTALNEEAE RKGGPPFLSF EEDPRQQALE LVVQEVSSVL 130 140 150 160 170 180 RSAEEKVVVC HVVGQAIQFL VSETPALGAG CRLYDMRLSP FHLQLEFHMK EKREDLQISW 190 200 210 220 230 240 SFISVPEMAV NIQPKALGED QVAETSAMSD VLKDILKHLA GSASPSVVLI TKPTTVKEAQ 250 260 270 280 290 300 NLQCAASTAQ ESCPPKPPRA HELKLLVRNI HVLLLSEPGA SGHINAVCVV QLNDPVQRFS 310 320 330 340 350 360 STLTKNTPDL MWEEEFTFEL NAKSKELHLQ ISEAGRSSEG LLATATVPLD LFKKQPSGPQ 370 380 390 400 410 420 SFTLTSGSAC GSSVLGSVTA EFSYMEPGEL KSWPIPPPVP AAKIEKDRTV MPCGTVVTTV 430 440 450 460 470 480 TAVKTKPRVD VGRASPLSSD SPVKTPIKVK VIEKDISVQA IACRSAPVSK TLSSSDTELL 490 500 510 520 530 540 VLNGSDPVAE VAIRQLSESS KLKLKSPRKK STIIISGISK DHDAALMQGY TASVDSTHQE 550 560 570 580 590 600 DAPSHPERAA ASAPPEEAES AQASLAPKPQ EDELDSWDLE KEPQAAAWSS QVLLDPDGDE 610 620 630 640 650 660 LSESSMSVLE PGTAKKHKGG ILRKGAKLFF RRRHQQKDPG MSQSHNDLVF LEQPEGSRRK 670 680 690 GITLTRILNK KLLSRHRNKN TMNGAPVEPC T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens mRNA for C21orf25 long form, complete cds." Shimizu N., Kudoh J., Shibuya K. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain and Pancreas.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 511-696 (ISOFORM 3). Tissue: Cervix, Testis and Uterus.
[3]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435; SER-441 AND THR-445, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB047784 mRNA. Translation: BAD74068.1. AB047785 mRNA. Translation: BAD74069.1. AL050173 mRNA. Translation: CAB43307.1. AL833323 mRNA. No translation available. CR627455 mRNA. Translation: CAH10536.1. Sequence problems. AP001745 Genomic DNA. Translation: BAA95528.1. Sequence problems. AP001619 Genomic DNA. No translation available.
IPI	IPI00471978. IPI00747092. IPI00790223.
PIR	T08793.
RefSeq	NP_056315.1. NM_015500.1. NP_950251.1. NM_199050.2.
UniGene	Hs.473894. Hs.675058.
3D structure databases
ProteinModelPortal	Q9Y426.
SMR	Q9Y426. Positions 264-385.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y426. 1 interaction.
STRING	9606.ENSP00000369853.
PTM databases
PhosphoSite	Q9Y426.
Polymorphism databases
DMDM	85681926.
Proteomic databases
PaxDb	Q9Y426.
PRIDE	Q9Y426.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329623; ENSP00000329302; ENSG00000157617. ENST00000380486; ENSP00000369853; ENSG00000157617.
GeneID	25966.
KEGG	hsa:25966.
UCSC	uc002yzu.3. human.
Organism-specific databases
CTD	25966.
GeneCards	GC21M043306.
HGNC	HGNC:1266. C2CD2.
HPA	HPA030924.
neXtProt	NX_Q9Y426.
PharmGKB	PA162379018.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47970.
HOGENOM	HOG000008704.
HOVERGEN	HBG098030.
InParanoid	Q9Y426.
OMA	HQQKDPG.
OrthoDB	EOG4S4PGC.
Gene expression databases
Bgee	Q9Y426.
CleanEx	HS_C2CD2.
Genevestigator	Q9Y426.
GermOnline	ENSG00000157617. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view]
Pfam	PF00168. C2. 1 hit. [Graphical view]
SMART	SM00239. C2. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	25966.
NextBio	47596.

Entry information

Entry name

CU025_HUMAN

Accession

Primary (citable) accession number: Q9Y426
Secondary accession number(s): Q5R2V7, Q6AHX8, Q9NSE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 10, 2006
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.