ID   FA32A_HUMAN             Reviewed;         112 AA.
AC   Q9Y421; Q9BT02;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   27-MAR-2024, entry version 161.
DE   RecName: Full=Protein FAM32A;
DE   AltName: Full=Ovarian tumor-associated gene 12;
DE            Short=OTAG-12;
GN   Name=FAM32A; Synonyms=OTAG12; ORFNames=CGI-144;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA   Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT   "Identification of novel human genes evolutionarily conserved in
RT   Caenorhabditis elegans by comparative proteomics.";
RL   Genome Res. 10:703-713(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Uterus;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, Lung, and Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING,
RP   AND INDUCTION.
RX   PubMed=21339736; DOI=10.1038/onc.2011.11;
RA   Chen X., Zhang H., Aravindakshan J.P., Gotlieb W.H., Sairam M.R.;
RT   "Anti-proliferative and pro-apoptotic actions of a novel human and mouse
RT   ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing
RT   and drug sensitization.";
RL   Oncogene 30:2874-2887(2011).
CC   -!- FUNCTION: Isoform 1, but not isoform 2 or isoform 3, may induce G2
CC       arrest and apoptosis. May also increase cell sensitivity to apoptotic
CC       stimuli. {ECO:0000269|PubMed:21339736}.
CC   -!- INTERACTION:
CC       Q9Y421; Q9HCG8: CWC22; NbExp=2; IntAct=EBI-726146, EBI-373289;
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=OTAG-12b;
CC         IsoId=Q9Y421-1; Sequence=Displayed;
CC       Name=2; Synonyms=OTAG-12a;
CC         IsoId=Q9Y421-2; Sequence=VSP_043861;
CC       Name=3; Synonyms=OTAG-12c;
CC         IsoId=Q9Y421-3; Sequence=VSP_043860;
CC   -!- TISSUE SPECIFICITY: Expressed in ovary, with isoform 1 being
CC       predominant. {ECO:0000269|PubMed:21339736}.
CC   -!- INDUCTION: By etoposide, puromycin or carboplatin.
CC       {ECO:0000269|PubMed:21339736}.
CC   -!- SIMILARITY: Belongs to the FAM32 family. {ECO:0000305}.
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DR   EMBL; AF151902; AAD34139.1; -; mRNA.
DR   EMBL; AL050157; CAB43298.2; -; mRNA.
DR   EMBL; BC000639; AAH00639.1; -; mRNA.
DR   EMBL; BC004447; AAH04447.1; -; mRNA.
DR   EMBL; BC017286; AAH17286.1; -; mRNA.
DR   EMBL; BU543240; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS12341.1; -. [Q9Y421-1]
DR   PIR; T08783; T08783.
DR   RefSeq; NP_054796.1; NM_014077.3. [Q9Y421-1]
DR   PDB; 6QDV; EM; 3.30 A; G=53-112.
DR   PDB; 7W5A; EM; 3.60 A; z=1-112.
DR   PDB; 7W5B; EM; 4.30 A; z=1-112.
DR   PDB; 8C6J; EM; 2.80 A; G=1-112.
DR   PDBsum; 6QDV; -.
DR   PDBsum; 7W5A; -.
DR   PDBsum; 7W5B; -.
DR   PDBsum; 8C6J; -.
DR   AlphaFoldDB; Q9Y421; -.
DR   EMDB; EMD-16452; -.
DR   EMDB; EMD-32319; -.
DR   EMDB; EMD-32321; -.
DR   EMDB; EMD-4525; -.
DR   SMR; Q9Y421; -.
DR   BioGRID; 117488; 24.
DR   IntAct; Q9Y421; 8.
DR   MINT; Q9Y421; -.
DR   STRING; 9606.ENSP00000263384; -.
DR   iPTMnet; Q9Y421; -.
DR   PhosphoSitePlus; Q9Y421; -.
DR   BioMuta; FAM32A; -.
DR   DMDM; 74753494; -.
DR   EPD; Q9Y421; -.
DR   jPOST; Q9Y421; -.
DR   MassIVE; Q9Y421; -.
DR   MaxQB; Q9Y421; -.
DR   PaxDb; 9606-ENSP00000263384; -.
DR   PeptideAtlas; Q9Y421; -.
DR   ProteomicsDB; 86090; -. [Q9Y421-1]
DR   ProteomicsDB; 86091; -. [Q9Y421-2]
DR   ProteomicsDB; 86092; -. [Q9Y421-3]
DR   Pumba; Q9Y421; -.
DR   TopDownProteomics; Q9Y421-1; -. [Q9Y421-1]
DR   Antibodypedia; 54347; 72 antibodies from 16 providers.
DR   DNASU; 26017; -.
DR   Ensembl; ENST00000263384.12; ENSP00000263384.6; ENSG00000105058.12. [Q9Y421-1]
DR   Ensembl; ENST00000589852.5; ENSP00000465969.1; ENSG00000105058.12. [Q9Y421-3]
DR   GeneID; 26017; -.
DR   KEGG; hsa:26017; -.
DR   MANE-Select; ENST00000263384.12; ENSP00000263384.6; NM_014077.4; NP_054796.1.
DR   UCSC; uc002ndt.4; human. [Q9Y421-1]
DR   AGR; HGNC:24563; -.
DR   CTD; 26017; -.
DR   DisGeNET; 26017; -.
DR   GeneCards; FAM32A; -.
DR   HGNC; HGNC:24563; FAM32A.
DR   HPA; ENSG00000105058; Low tissue specificity.
DR   MIM; 614554; gene.
DR   neXtProt; NX_Q9Y421; -.
DR   OpenTargets; ENSG00000105058; -.
DR   PharmGKB; PA134956082; -.
DR   VEuPathDB; HostDB:ENSG00000105058; -.
DR   eggNOG; KOG3410; Eukaryota.
DR   GeneTree; ENSGT00390000013811; -.
DR   HOGENOM; CLU_098435_3_0_1; -.
DR   InParanoid; Q9Y421; -.
DR   OMA; QLSEHHD; -.
DR   OrthoDB; 5400346at2759; -.
DR   PhylomeDB; Q9Y421; -.
DR   TreeFam; TF314020; -.
DR   PathwayCommons; Q9Y421; -.
DR   Reactome; R-HSA-72163; mRNA Splicing - Major Pathway.
DR   SignaLink; Q9Y421; -.
DR   BioGRID-ORCS; 26017; 599 hits in 1156 CRISPR screens.
DR   ChiTaRS; FAM32A; human.
DR   GeneWiki; FAM32A; -.
DR   GenomeRNAi; 26017; -.
DR   Pharos; Q9Y421; Tdark.
DR   PRO; PR:Q9Y421; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9Y421; Protein.
DR   Bgee; ENSG00000105058; Expressed in cortical plate and 208 other cell types or tissues.
DR   ExpressionAtlas; Q9Y421; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; IDA:LIFEdb.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR013865; FAM32A.
DR   PANTHER; PTHR13282:SF6; PROTEIN FAM32A; 1.
DR   PANTHER; PTHR13282; UNCHARACTERIZED; 1.
DR   Pfam; PF08555; FAM32A; 1.
DR   Genevisible; Q9Y421; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Apoptosis; Cell cycle; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..112
FT                   /note="Protein FAM32A"
FT                   /id="PRO_0000223250"
FT   REGION          23..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..24
FT                   /note="MEAYEQVQKGPLKLKGVAELGVTK -> MSFS (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_043860"
FT   VAR_SEQ         74..112
FT                   /note="MERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK -> GHQTSCIAT
FT                   GFQGHKANAARSYAWIQNWYCVPSS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_043861"
SQ   SEQUENCE   112 AA;  13178 MW;  7FAF15315E9D580C CRC64;
     MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE KRRGLDKRTP
     AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT EHYDIPKVSW TK
//