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Protein

Pygopus homolog 1

Gene

PYGO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 398PHD-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: FlyBase

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORiQ9Y3Y4

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 1
Gene namesi
Name:PYGO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000171016.11
HGNCiHGNC:30256 PYGO1
MIMi606902 gene
neXtProtiNX_Q9Y3Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi349E → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi350V → E: Almost complete loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi351N → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi354Q → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi356A → E: Almost complete loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi357I → R: Loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi360E → A: Loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi366W → E: Loss of interaction with H3K4me2. 1 Publication1

Organism-specific databases

DisGeNETi26108
OpenTargetsiENSG00000171016
PharmGKBiPA134875127

Polymorphism and mutation databases

DMDMi23396828

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971211 – 419Pygopus homolog 1Add BLAST419

Proteomic databases

PaxDbiQ9Y3Y4
PeptideAtlasiQ9Y3Y4
PRIDEiQ9Y3Y4

PTM databases

iPTMnetiQ9Y3Y4
PhosphoSitePlusiQ9Y3Y4

Expressioni

Gene expression databases

BgeeiENSG00000171016
CleanExiHS_PYGO1
GenevisibleiQ9Y3Y4 HS

Organism-specific databases

HPAiHPA042248

Interactioni

Subunit structurei

Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL9O005127EBI-3397474,EBI-533127

GO - Molecular functioni

  • methylated histone binding Source: FlyBase

Protein-protein interaction databases

BioGridi117557, 5 interactors
IntActiQ9Y3Y4, 7 interactors
MINTiQ9Y3Y4
STRINGi9606.ENSP00000302327

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi340 – 342Combined sources3
Turni344 – 346Combined sources3
Beta strandi356 – 359Combined sources4
Turni360 – 363Combined sources4
Beta strandi366 – 368Combined sources3
Helixi369 – 372Combined sources4
Helixi376 – 384Combined sources9
Beta strandi388 – 390Combined sources3
Helixi393 – 396Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VP7X-ray1.65A333-402[»]
2VPBX-ray1.59A333-397[»]
2VPDX-ray2.77A/C333-398[»]
2VPEX-ray1.70A/C340-398[»]
2VPGX-ray1.60A/C340-398[»]
ProteinModelPortaliQ9Y3Y4
SMRiQ9Y3Y4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3Y4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 388Interaction with H3K4me2Add BLAST48
Regioni373 – 391Interaction with BCL91 PublicationAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 41Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 135Pro-richAdd BLAST89
Compositional biasi153 – 305Asn-richAdd BLAST153

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 398PHD-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IDYF Eukaryota
ENOG4111FFC LUCA
GeneTreeiENSGT00530000063948
HOGENOMiHOG000001580
HOVERGENiHBG053774
InParanoidiQ9Y3Y4
OMAiPVYPCGI
OrthoDBiEOG091G0KKH
PhylomeDBiQ9Y3Y4
TreeFamiTF333020

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3Y4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAENSPAPA YKVSSHGGDS GLDGLGGPGV QLGSPDKKKR KANTQGPSFP
60 70 80 90 100
PLSEYAPPPN PNSDHLVAAN PFDDNYNTIS YKPLPSSNPY LGPGYPGFGG
110 120 130 140 150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP
160 170 180 190 200
HDNSSFGNPS YNNALSQNVN MPNQHFRQNP AENFSQIPPQ NASQVSNPDL
210 220 230 240 250
ASNFVPGNNS NFTSPLESNH SFIPPPNTFG QAKAPPPKQD FTQGATKNTN
260 270 280 290 300
QNSSAHPPHL NMDDTVNQSN IELKNVNRNN AVNQENSRSS STEATNNNPA
310 320 330 340 350
NGTQNKPRQP RGAADACTTE KSNKSSLHPN RHGHSSSDPV YPCGICTNEV
360 370 380 390 400
NDDQDAILCE ASCQKWFHRI CTGMTETAYG LLTAEASAVW GCDTCMADKD
410
VQLMRTRETF GPSAVGSDA
Length:419
Mass (Da):45,116
Last modified:September 19, 2002 - v2
Checksum:iD5D4E4AA416FD8E4
GO
Isoform 2 (identifier: Q9Y3Y4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MPAENSPAPAYKVSSH → MSAEQEKDPISLKRVR

Show »
Length:419
Mass (Da):45,318
Checksum:iE30602D469C7E1CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051292299P → H. Corresponds to variant dbSNP:rs11858624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566481 – 16MPAEN…KVSSH → MSAEQEKDPISLKRVR in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457207 mRNA Translation: AAL91370.1
EF625686 mRNA Translation: ABU93489.1
AC012378 Genomic DNA No translation available.
AC022083 Genomic DNA No translation available.
AL049925 mRNA Translation: CAB43209.1
CCDSiCCDS10155.1 [Q9Y3Y4-1]
CCDS81885.1 [Q9Y3Y4-2]
PIRiT08663
RefSeqiNP_001317255.1, NM_001330326.1 [Q9Y3Y4-2]
NP_056432.1, NM_015617.2 [Q9Y3Y4-1]
XP_011519748.1, XM_011521446.2 [Q9Y3Y4-2]
UniGeneiHs.256587
Hs.87194

Genome annotation databases

EnsembliENST00000302000; ENSP00000302327; ENSG00000171016 [Q9Y3Y4-1]
ENST00000563719; ENSP00000457777; ENSG00000171016 [Q9Y3Y4-2]
GeneIDi26108
KEGGihsa:26108
UCSCiuc002adf.3 human [Q9Y3Y4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPYGO1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3Y4
Secondary accession number(s): A7Y2D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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