Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pygopus homolog 1

Gene

PYGO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 398PHD-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171016-MONOMER.
ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SIGNORiQ9Y3Y4.

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 1
Gene namesi
Name:PYGO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:30256. PYGO1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi349E → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi350V → E: Almost complete loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi351N → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi354Q → A: Reduces interaction with H3K4me2. 1 Publication1
Mutagenesisi356A → E: Almost complete loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi357I → R: Loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi360E → A: Loss of interaction with H3K4me2. 1 Publication1
Mutagenesisi366W → E: Loss of interaction with H3K4me2. 1 Publication1

Organism-specific databases

DisGeNETi26108.
OpenTargetsiENSG00000171016.
PharmGKBiPA134875127.

Polymorphism and mutation databases

DMDMi23396828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971211 – 419Pygopus homolog 1Add BLAST419

Proteomic databases

PaxDbiQ9Y3Y4.
PeptideAtlasiQ9Y3Y4.
PRIDEiQ9Y3Y4.

PTM databases

iPTMnetiQ9Y3Y4.
PhosphoSitePlusiQ9Y3Y4.

Expressioni

Gene expression databases

BgeeiENSG00000171016.
CleanExiHS_PYGO1.
GenevisibleiQ9Y3Y4. HS.

Organism-specific databases

HPAiHPA042248.

Interactioni

Subunit structurei

Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL9O005127EBI-3397474,EBI-533127

Protein-protein interaction databases

BioGridi117557. 6 interactors.
IntActiQ9Y3Y4. 7 interactors.
MINTiMINT-7969845.
STRINGi9606.ENSP00000302327.

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi340 – 342Combined sources3
Turni344 – 346Combined sources3
Beta strandi356 – 359Combined sources4
Turni360 – 363Combined sources4
Beta strandi366 – 368Combined sources3
Helixi369 – 372Combined sources4
Helixi376 – 384Combined sources9
Beta strandi388 – 390Combined sources3
Helixi393 – 396Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VP7X-ray1.65A333-402[»]
2VPBX-ray1.59A333-397[»]
2VPDX-ray2.77A/C333-398[»]
2VPEX-ray1.70A/C340-398[»]
2VPGX-ray1.60A/C340-398[»]
ProteinModelPortaliQ9Y3Y4.
SMRiQ9Y3Y4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3Y4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 388Interaction with H3K4me2Add BLAST48
Regioni373 – 391Interaction with BCL91 PublicationAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 41Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 135Pro-richAdd BLAST89
Compositional biasi153 – 305Asn-richAdd BLAST153

Sequence similaritiesi

Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri340 – 398PHD-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IDYF. Eukaryota.
ENOG4111FFC. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9Y3Y4.
OMAiSAVWGCD.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9Y3Y4.
TreeFamiTF333020.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3Y4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAENSPAPA YKVSSHGGDS GLDGLGGPGV QLGSPDKKKR KANTQGPSFP
60 70 80 90 100
PLSEYAPPPN PNSDHLVAAN PFDDNYNTIS YKPLPSSNPY LGPGYPGFGG
110 120 130 140 150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP
160 170 180 190 200
HDNSSFGNPS YNNALSQNVN MPNQHFRQNP AENFSQIPPQ NASQVSNPDL
210 220 230 240 250
ASNFVPGNNS NFTSPLESNH SFIPPPNTFG QAKAPPPKQD FTQGATKNTN
260 270 280 290 300
QNSSAHPPHL NMDDTVNQSN IELKNVNRNN AVNQENSRSS STEATNNNPA
310 320 330 340 350
NGTQNKPRQP RGAADACTTE KSNKSSLHPN RHGHSSSDPV YPCGICTNEV
360 370 380 390 400
NDDQDAILCE ASCQKWFHRI CTGMTETAYG LLTAEASAVW GCDTCMADKD
410
VQLMRTRETF GPSAVGSDA
Length:419
Mass (Da):45,116
Last modified:September 19, 2002 - v2
Checksum:iD5D4E4AA416FD8E4
GO
Isoform 2 (identifier: Q9Y3Y4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MPAENSPAPAYKVSSH → MSAEQEKDPISLKRVR

Show »
Length:419
Mass (Da):45,318
Checksum:iE30602D469C7E1CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051292299P → H.Corresponds to variant rs11858624dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566481 – 16MPAEN…KVSSH → MSAEQEKDPISLKRVR in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457207 mRNA. Translation: AAL91370.1.
EF625686 mRNA. Translation: ABU93489.1.
AC012378 Genomic DNA. No translation available.
AC022083 Genomic DNA. No translation available.
AL049925 mRNA. Translation: CAB43209.1.
CCDSiCCDS10155.1. [Q9Y3Y4-1]
CCDS81885.1. [Q9Y3Y4-2]
PIRiT08663.
RefSeqiNP_001317255.1. NM_001330326.1.
NP_056432.1. NM_015617.2. [Q9Y3Y4-1]
XP_011519748.1. XM_011521446.2. [Q9Y3Y4-2]
UniGeneiHs.256587.
Hs.87194.

Genome annotation databases

EnsembliENST00000302000; ENSP00000302327; ENSG00000171016. [Q9Y3Y4-1]
ENST00000563719; ENSP00000457777; ENSG00000171016. [Q9Y3Y4-2]
GeneIDi26108.
KEGGihsa:26108.
UCSCiuc002adf.3. human. [Q9Y3Y4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457207 mRNA. Translation: AAL91370.1.
EF625686 mRNA. Translation: ABU93489.1.
AC012378 Genomic DNA. No translation available.
AC022083 Genomic DNA. No translation available.
AL049925 mRNA. Translation: CAB43209.1.
CCDSiCCDS10155.1. [Q9Y3Y4-1]
CCDS81885.1. [Q9Y3Y4-2]
PIRiT08663.
RefSeqiNP_001317255.1. NM_001330326.1.
NP_056432.1. NM_015617.2. [Q9Y3Y4-1]
XP_011519748.1. XM_011521446.2. [Q9Y3Y4-2]
UniGeneiHs.256587.
Hs.87194.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VP7X-ray1.65A333-402[»]
2VPBX-ray1.59A333-397[»]
2VPDX-ray2.77A/C333-398[»]
2VPEX-ray1.70A/C340-398[»]
2VPGX-ray1.60A/C340-398[»]
ProteinModelPortaliQ9Y3Y4.
SMRiQ9Y3Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117557. 6 interactors.
IntActiQ9Y3Y4. 7 interactors.
MINTiMINT-7969845.
STRINGi9606.ENSP00000302327.

PTM databases

iPTMnetiQ9Y3Y4.
PhosphoSitePlusiQ9Y3Y4.

Polymorphism and mutation databases

DMDMi23396828.

Proteomic databases

PaxDbiQ9Y3Y4.
PeptideAtlasiQ9Y3Y4.
PRIDEiQ9Y3Y4.

Protocols and materials databases

DNASUi26108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302000; ENSP00000302327; ENSG00000171016. [Q9Y3Y4-1]
ENST00000563719; ENSP00000457777; ENSG00000171016. [Q9Y3Y4-2]
GeneIDi26108.
KEGGihsa:26108.
UCSCiuc002adf.3. human. [Q9Y3Y4-1]

Organism-specific databases

CTDi26108.
DisGeNETi26108.
GeneCardsiPYGO1.
HGNCiHGNC:30256. PYGO1.
HPAiHPA042248.
MIMi606902. gene.
neXtProtiNX_Q9Y3Y4.
OpenTargetsiENSG00000171016.
PharmGKBiPA134875127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYF. Eukaryota.
ENOG4111FFC. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9Y3Y4.
OMAiSAVWGCD.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9Y3Y4.
TreeFamiTF333020.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171016-MONOMER.
ReactomeiR-HSA-201722. Formation of the beta-catenin:TCF transactivating complex.
R-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SIGNORiQ9Y3Y4.

Miscellaneous databases

EvolutionaryTraceiQ9Y3Y4.
GenomeRNAii26108.
PROiQ9Y3Y4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171016.
CleanExiHS_PYGO1.
GenevisibleiQ9Y3Y4. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYGO1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3Y4
Secondary accession number(s): A7Y2D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.