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Q9Y3U8

- RL36_HUMAN

UniProt

Q9Y3U8 - RL36_HUMAN

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Protein

60S ribosomal protein L36

Gene

RPL36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. RNA metabolic process Source: Reactome
  6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  7. translation Source: UniProtKB
  8. translational elongation Source: Reactome
  9. translational initiation Source: Reactome
  10. translational termination Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
  13. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36
Gene namesi
Name:RPL36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13631. RPL36.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic large ribosomal subunit Source: UniProtKB
  4. membrane Source: UniProtKB
  5. nucleolus Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 10510460S ribosomal protein L36PRO_0000195007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y3U8.
PaxDbiQ9Y3U8.
PeptideAtlasiQ9Y3U8.
PRIDEiQ9Y3U8.

PTM databases

PhosphoSiteiQ9Y3U8.

Expressioni

Gene expression databases

BgeeiQ9Y3U8.
CleanExiHS_RPL36.
ExpressionAtlasiQ9Y3U8. baseline and differential.
GenevestigatoriQ9Y3U8.

Organism-specific databases

HPAiHPA047153.

Interactioni

Protein-protein interaction databases

BioGridi117388. 65 interactions.
IntActiQ9Y3U8. 14 interactions.
MINTiMINT-1402622.
STRINGi9606.ENSP00000252543.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00i1-105[»]
ProteinModelPortaliQ9Y3U8.
SMRiQ9Y3U8. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L36e family.Curated

Phylogenomic databases

eggNOGiCOG5051.
GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
HOVERGENiHBG002152.
InParanoidiQ9Y3U8.
KOiK02920.
OMAiGTHRRAK.
OrthoDBiEOG7FV3T1.
PhylomeDBiQ9Y3U8.
TreeFamiTF314463.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3U8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF
60 70 80 90 100
APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA

AAKKD
Length:105
Mass (Da):12,254
Last modified:January 23, 2007 - v3
Checksum:iFEE8850A62080EB3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291R → H in AAD27776. (PubMed:11042152)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671K → E.
Corresponds to variant rs11556110 [ dbSNP | Ensembl ].
VAR_051804

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB061833 Genomic DNA. Translation: BAB79471.1.
AL050273 mRNA. Translation: CAB43374.1.
AF077043 mRNA. Translation: AAD27776.1.
CR533465 mRNA. Translation: CAG38496.1.
AK311990 mRNA. Translation: BAG34928.1.
CH471139 Genomic DNA. Translation: EAW69155.1.
CH471139 Genomic DNA. Translation: EAW69158.1.
BC003052 mRNA. Translation: AAH03052.1.
BC004971 mRNA. Translation: AAH04971.1.
BC091508 mRNA. Translation: AAH91508.1.
CCDSiCCDS12147.1.
PIRiT08720.
RefSeqiNP_056229.2. NM_015414.3.
NP_378669.1. NM_033643.2.
UniGeneiHs.408018.

Genome annotation databases

EnsembliENST00000347512; ENSP00000252543; ENSG00000130255.
ENST00000394580; ENSP00000378081; ENSG00000130255.
ENST00000577222; ENSP00000464342; ENSG00000130255.
ENST00000579649; ENSP00000462609; ENSG00000130255.
GeneIDi25873.
KEGGihsa:25873.
UCSCiuc002mcv.3. human.

Polymorphism databases

DMDMi7388073.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB061833 Genomic DNA. Translation: BAB79471.1 .
AL050273 mRNA. Translation: CAB43374.1 .
AF077043 mRNA. Translation: AAD27776.1 .
CR533465 mRNA. Translation: CAG38496.1 .
AK311990 mRNA. Translation: BAG34928.1 .
CH471139 Genomic DNA. Translation: EAW69155.1 .
CH471139 Genomic DNA. Translation: EAW69158.1 .
BC003052 mRNA. Translation: AAH03052.1 .
BC004971 mRNA. Translation: AAH04971.1 .
BC091508 mRNA. Translation: AAH91508.1 .
CCDSi CCDS12147.1.
PIRi T08720.
RefSeqi NP_056229.2. NM_015414.3.
NP_378669.1. NM_033643.2.
UniGenei Hs.408018.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 i 1-105 [» ]
ProteinModelPortali Q9Y3U8.
SMRi Q9Y3U8. Positions 2-103.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117388. 65 interactions.
IntActi Q9Y3U8. 14 interactions.
MINTi MINT-1402622.
STRINGi 9606.ENSP00000252543.

PTM databases

PhosphoSitei Q9Y3U8.

Polymorphism databases

DMDMi 7388073.

Proteomic databases

MaxQBi Q9Y3U8.
PaxDbi Q9Y3U8.
PeptideAtlasi Q9Y3U8.
PRIDEi Q9Y3U8.

Protocols and materials databases

DNASUi 25873.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347512 ; ENSP00000252543 ; ENSG00000130255 .
ENST00000394580 ; ENSP00000378081 ; ENSG00000130255 .
ENST00000577222 ; ENSP00000464342 ; ENSG00000130255 .
ENST00000579649 ; ENSP00000462609 ; ENSG00000130255 .
GeneIDi 25873.
KEGGi hsa:25873.
UCSCi uc002mcv.3. human.

Organism-specific databases

CTDi 25873.
GeneCardsi GC19P005674.
HGNCi HGNC:13631. RPL36.
HPAi HPA047153.
neXtProti NX_Q9Y3U8.
PharmGKBi PA34730.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5051.
GeneTreei ENSGT00390000011943.
HOGENOMi HOG000155312.
HOVERGENi HBG002152.
InParanoidi Q9Y3U8.
KOi K02920.
OMAi GTHRRAK.
OrthoDBi EOG7FV3T1.
PhylomeDBi Q9Y3U8.
TreeFami TF314463.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RpL36. human.
GeneWikii RPL36.
GenomeRNAii 25873.
NextBioi 47268.
PROi Q9Y3U8.

Gene expression databases

Bgeei Q9Y3U8.
CleanExi HS_RPL36.
ExpressionAtlasi Q9Y3U8. baseline and differential.
Genevestigatori Q9Y3U8.

Family and domain databases

InterProi IPR000509. Ribosomal_L36e.
[Graphical view ]
PANTHERi PTHR10114. PTHR10114. 1 hit.
Pfami PF01158. Ribosomal_L36e. 1 hit.
[Graphical view ]
PROSITEi PS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
    Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
    Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood, Kidney and Skin.
  8. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
    Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
    J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10, IDENTIFICATION BY MASS SPECTROMETRY.
  9. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 46-55 AND 88-98, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL36_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3U8
Secondary accession number(s): B2R4Y1
, D6W634, Q6FIG1, Q9UQF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3