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Protein

60S ribosomal protein L36

Gene

RPL36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130255-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36
Gene namesi
Name:RPL36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13631. RPL36.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130255.
PharmGKBiPA34730.

Polymorphism and mutation databases

BioMutaiRPL36.
DMDMi7388073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001950072 – 10560S ribosomal protein L36Add BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3U8.
MaxQBiQ9Y3U8.
PaxDbiQ9Y3U8.
PeptideAtlasiQ9Y3U8.
PRIDEiQ9Y3U8.
TopDownProteomicsiQ9Y3U8.

PTM databases

iPTMnetiQ9Y3U8.
PhosphoSitePlusiQ9Y3U8.
SwissPalmiQ9Y3U8.

Expressioni

Gene expression databases

BgeeiENSG00000130255.
CleanExiHS_RPL36.
ExpressionAtlasiQ9Y3U8. baseline and differential.
GenevisibleiQ9Y3U8. HS.

Organism-specific databases

HPAiHPA047153.

Interactioni

Protein-protein interaction databases

BioGridi117388. 128 interactors.
IntActiQ9Y3U8. 28 interactors.
MINTiMINT-1402622.
STRINGi9606.ENSP00000252543.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Li1-105[»]
4V6Xelectron microscopy5.00Ci1-105[»]
5AJ0electron microscopy3.50Ai1-105[»]
ProteinModelPortaliQ9Y3U8.
SMRiQ9Y3U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L36e family.Curated

Phylogenomic databases

eggNOGiKOG3452. Eukaryota.
COG5051. LUCA.
GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
HOVERGENiHBG002152.
InParanoidiQ9Y3U8.
KOiK02920.
OMAiGTHRRAK.
OrthoDBiEOG091G0YP6.
PhylomeDBiQ9Y3U8.
TreeFamiTF314463.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF
60 70 80 90 100
APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA

AAKKD
Length:105
Mass (Da):12,254
Last modified:January 23, 2007 - v3
Checksum:iFEE8850A62080EB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → H in AAD27776 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05180467K → E.Corresponds to variant rs11556110dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061833 Genomic DNA. Translation: BAB79471.1.
AL050273 mRNA. Translation: CAB43374.1.
AF077043 mRNA. Translation: AAD27776.1.
CR533465 mRNA. Translation: CAG38496.1.
AK311990 mRNA. Translation: BAG34928.1.
CH471139 Genomic DNA. Translation: EAW69155.1.
CH471139 Genomic DNA. Translation: EAW69158.1.
BC003052 mRNA. Translation: AAH03052.1.
BC004971 mRNA. Translation: AAH04971.1.
BC091508 mRNA. Translation: AAH91508.1.
CCDSiCCDS12147.1.
PIRiT08720.
RefSeqiNP_056229.2. NM_015414.3.
NP_378669.1. NM_033643.2.
UniGeneiHs.408018.

Genome annotation databases

EnsembliENST00000347512; ENSP00000252543; ENSG00000130255.
ENST00000394580; ENSP00000378081; ENSG00000130255.
ENST00000577222; ENSP00000464342; ENSG00000130255.
ENST00000579649; ENSP00000462609; ENSG00000130255.
GeneIDi25873.
KEGGihsa:25873.
UCSCiuc002mcv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061833 Genomic DNA. Translation: BAB79471.1.
AL050273 mRNA. Translation: CAB43374.1.
AF077043 mRNA. Translation: AAD27776.1.
CR533465 mRNA. Translation: CAG38496.1.
AK311990 mRNA. Translation: BAG34928.1.
CH471139 Genomic DNA. Translation: EAW69155.1.
CH471139 Genomic DNA. Translation: EAW69158.1.
BC003052 mRNA. Translation: AAH03052.1.
BC004971 mRNA. Translation: AAH04971.1.
BC091508 mRNA. Translation: AAH91508.1.
CCDSiCCDS12147.1.
PIRiT08720.
RefSeqiNP_056229.2. NM_015414.3.
NP_378669.1. NM_033643.2.
UniGeneiHs.408018.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Li1-105[»]
4V6Xelectron microscopy5.00Ci1-105[»]
5AJ0electron microscopy3.50Ai1-105[»]
ProteinModelPortaliQ9Y3U8.
SMRiQ9Y3U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117388. 128 interactors.
IntActiQ9Y3U8. 28 interactors.
MINTiMINT-1402622.
STRINGi9606.ENSP00000252543.

PTM databases

iPTMnetiQ9Y3U8.
PhosphoSitePlusiQ9Y3U8.
SwissPalmiQ9Y3U8.

Polymorphism and mutation databases

BioMutaiRPL36.
DMDMi7388073.

Proteomic databases

EPDiQ9Y3U8.
MaxQBiQ9Y3U8.
PaxDbiQ9Y3U8.
PeptideAtlasiQ9Y3U8.
PRIDEiQ9Y3U8.
TopDownProteomicsiQ9Y3U8.

Protocols and materials databases

DNASUi25873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347512; ENSP00000252543; ENSG00000130255.
ENST00000394580; ENSP00000378081; ENSG00000130255.
ENST00000577222; ENSP00000464342; ENSG00000130255.
ENST00000579649; ENSP00000462609; ENSG00000130255.
GeneIDi25873.
KEGGihsa:25873.
UCSCiuc002mcv.4. human.

Organism-specific databases

CTDi25873.
GeneCardsiRPL36.
HGNCiHGNC:13631. RPL36.
HPAiHPA047153.
neXtProtiNX_Q9Y3U8.
OpenTargetsiENSG00000130255.
PharmGKBiPA34730.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3452. Eukaryota.
COG5051. LUCA.
GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
HOVERGENiHBG002152.
InParanoidiQ9Y3U8.
KOiK02920.
OMAiGTHRRAK.
OrthoDBiEOG091G0YP6.
PhylomeDBiQ9Y3U8.
TreeFamiTF314463.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130255-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL36. human.
GeneWikiiRPL36.
GenomeRNAii25873.
PROiQ9Y3U8.

Gene expression databases

BgeeiENSG00000130255.
CleanExiHS_RPL36.
ExpressionAtlasiQ9Y3U8. baseline and differential.
GenevisibleiQ9Y3U8. HS.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL36_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3U8
Secondary accession number(s): B2R4Y1
, D6W634, Q6FIG1, Q9UQF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.