Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y3U8

- RL36_HUMAN

UniProt

Q9Y3U8 - RL36_HUMAN

Protein

60S ribosomal protein L36

Gene

RPL36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L36
    Gene namesi
    Name:RPL36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13631. RPL36.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleolus Source: LIFEdb

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 10510460S ribosomal protein L36PRO_0000195007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y3U8.
    PaxDbiQ9Y3U8.
    PeptideAtlasiQ9Y3U8.
    PRIDEiQ9Y3U8.

    PTM databases

    PhosphoSiteiQ9Y3U8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3U8.
    BgeeiQ9Y3U8.
    CleanExiHS_RPL36.
    GenevestigatoriQ9Y3U8.

    Organism-specific databases

    HPAiHPA047153.

    Interactioni

    Protein-protein interaction databases

    BioGridi117388. 65 interactions.
    IntActiQ9Y3U8. 14 interactions.
    MINTiMINT-1402622.
    STRINGi9606.ENSP00000252543.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00i1-105[»]
    ProteinModelPortaliQ9Y3U8.
    SMRiQ9Y3U8. Positions 1-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L36e family.Curated

    Phylogenomic databases

    eggNOGiCOG5051.
    HOGENOMiHOG000155312.
    HOVERGENiHBG002152.
    InParanoidiQ9Y3U8.
    KOiK02920.
    OMAiGTHRRAK.
    OrthoDBiEOG7FV3T1.
    PhylomeDBiQ9Y3U8.
    TreeFamiTF314463.

    Family and domain databases

    InterProiIPR000509. Ribosomal_L36e.
    [Graphical view]
    PANTHERiPTHR10114. PTHR10114. 1 hit.
    PfamiPF01158. Ribosomal_L36e. 1 hit.
    [Graphical view]
    PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y3U8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF    50
    APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA 100
    AAKKD 105
    Length:105
    Mass (Da):12,254
    Last modified:January 23, 2007 - v3
    Checksum:iFEE8850A62080EB3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291R → H in AAD27776. (PubMed:11042152)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671K → E.
    Corresponds to variant rs11556110 [ dbSNP | Ensembl ].
    VAR_051804

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061833 Genomic DNA. Translation: BAB79471.1.
    AL050273 mRNA. Translation: CAB43374.1.
    AF077043 mRNA. Translation: AAD27776.1.
    CR533465 mRNA. Translation: CAG38496.1.
    AK311990 mRNA. Translation: BAG34928.1.
    CH471139 Genomic DNA. Translation: EAW69155.1.
    CH471139 Genomic DNA. Translation: EAW69158.1.
    BC003052 mRNA. Translation: AAH03052.1.
    BC004971 mRNA. Translation: AAH04971.1.
    BC091508 mRNA. Translation: AAH91508.1.
    CCDSiCCDS12147.1.
    PIRiT08720.
    RefSeqiNP_056229.2. NM_015414.3.
    NP_378669.1. NM_033643.2.
    UniGeneiHs.408018.

    Genome annotation databases

    EnsembliENST00000347512; ENSP00000252543; ENSG00000130255.
    ENST00000394580; ENSP00000378081; ENSG00000130255.
    ENST00000577222; ENSP00000464342; ENSG00000130255.
    ENST00000579649; ENSP00000462609; ENSG00000130255.
    GeneIDi25873.
    KEGGihsa:25873.
    UCSCiuc002mcv.3. human.

    Polymorphism databases

    DMDMi7388073.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB061833 Genomic DNA. Translation: BAB79471.1 .
    AL050273 mRNA. Translation: CAB43374.1 .
    AF077043 mRNA. Translation: AAD27776.1 .
    CR533465 mRNA. Translation: CAG38496.1 .
    AK311990 mRNA. Translation: BAG34928.1 .
    CH471139 Genomic DNA. Translation: EAW69155.1 .
    CH471139 Genomic DNA. Translation: EAW69158.1 .
    BC003052 mRNA. Translation: AAH03052.1 .
    BC004971 mRNA. Translation: AAH04971.1 .
    BC091508 mRNA. Translation: AAH91508.1 .
    CCDSi CCDS12147.1.
    PIRi T08720.
    RefSeqi NP_056229.2. NM_015414.3.
    NP_378669.1. NM_033643.2.
    UniGenei Hs.408018.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 i 1-105 [» ]
    ProteinModelPortali Q9Y3U8.
    SMRi Q9Y3U8. Positions 1-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117388. 65 interactions.
    IntActi Q9Y3U8. 14 interactions.
    MINTi MINT-1402622.
    STRINGi 9606.ENSP00000252543.

    PTM databases

    PhosphoSitei Q9Y3U8.

    Polymorphism databases

    DMDMi 7388073.

    Proteomic databases

    MaxQBi Q9Y3U8.
    PaxDbi Q9Y3U8.
    PeptideAtlasi Q9Y3U8.
    PRIDEi Q9Y3U8.

    Protocols and materials databases

    DNASUi 25873.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000347512 ; ENSP00000252543 ; ENSG00000130255 .
    ENST00000394580 ; ENSP00000378081 ; ENSG00000130255 .
    ENST00000577222 ; ENSP00000464342 ; ENSG00000130255 .
    ENST00000579649 ; ENSP00000462609 ; ENSG00000130255 .
    GeneIDi 25873.
    KEGGi hsa:25873.
    UCSCi uc002mcv.3. human.

    Organism-specific databases

    CTDi 25873.
    GeneCardsi GC19P005674.
    HGNCi HGNC:13631. RPL36.
    HPAi HPA047153.
    neXtProti NX_Q9Y3U8.
    PharmGKBi PA34730.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5051.
    HOGENOMi HOG000155312.
    HOVERGENi HBG002152.
    InParanoidi Q9Y3U8.
    KOi K02920.
    OMAi GTHRRAK.
    OrthoDBi EOG7FV3T1.
    PhylomeDBi Q9Y3U8.
    TreeFami TF314463.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RpL36. human.
    GeneWikii RPL36.
    GenomeRNAii 25873.
    NextBioi 47268.
    PROi Q9Y3U8.

    Gene expression databases

    ArrayExpressi Q9Y3U8.
    Bgeei Q9Y3U8.
    CleanExi HS_RPL36.
    Genevestigatori Q9Y3U8.

    Family and domain databases

    InterProi IPR000509. Ribosomal_L36e.
    [Graphical view ]
    PANTHERi PTHR10114. PTHR10114. 1 hit.
    Pfami PF01158. Ribosomal_L36e. 1 hit.
    [Graphical view ]
    PROSITEi PS01190. RIBOSOMAL_L36E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood, Kidney and Skin.
    8. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
      Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
      J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10, IDENTIFICATION BY MASS SPECTROMETRY.
    9. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 46-55 AND 88-98, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL36_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3U8
    Secondary accession number(s): B2R4Y1
    , D6W634, Q6FIG1, Q9UQF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3