Nucleolar complex protein 2 homolog

Names and origin

Protein names

Recommended name:
    Nucleolar complex protein 2 homolog
      Short name=Protein NOC2 homolog
Alternative name(s):
    NOC2-like

Gene names

Name:

NOC2L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	749 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Subcellular location	Nucleus › nucleolus. Ref.4
Sequence similarities	Belongs to the NOC2 family.

Hide | Top

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct
BRF2	Q9HAW0	1	EBI-751547,EBI-1055224
ILK	Q13418	1	EBI-751547,EBI-747644
MAGED1	Q9Y5V3	1	EBI-751547,EBI-716006

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 749

749

Nucleolar complex protein 2 homolog

PRO_0000121048

Regions

Compositional bias

104 – 107

4

Poly-Glu

Compositional bias

641 – 749

109

Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue

26

1

Phosphoserine Ref.6

Modified residue

28

1

Phosphoserine Ref.6

Modified residue

30

1

Phosphoserine Ref.6

Modified residue

32

1

Phosphoserine Ref.6

Modified residue

35

1

Phosphoserine Ref.6 Ref.7

Modified residue

49

1

Phosphoserine Ref.7 Ref.9 Ref.10

Modified residue

56

1

Phosphoserine Ref.10 Ref.5

Modified residue

67

1

Phosphoserine Ref.8

Modified residue

93

1

Phosphoserine Ref.6

Modified residue

98

1

Phosphoserine Ref.6

Modified residue

100

1

Phosphoserine Ref.6

Modified residue

102

1

Phosphoserine Ref.6

Modified residue

103

1

Phosphoserine Ref.6

Modified residue

672

1

Phosphoserine Ref.7 Ref.9 Ref.10

Modified residue

673

1

Phosphoserine Ref.9 Ref.10

Modified residue

678

1

Phosphothreonine Ref.10

Modified residue

746

1

Phosphoserine Ref.6

Natural variations

Natural variant

271

1

A → V: dbSNP rs3828049.

VAR_028145

Natural variant

300

1

V → I: dbSNP rs3748597. Ref.2

VAR_028146

Natural variant

556

1

S → L: dbSNP rs35471880.

VAR_050289

Experimental info

Sequence conflict

178

1

R → Q in CAB43240. Ref.1

Sequence conflict

345

1

K → E in CAB43240. Ref.1

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y3T9-1 [UniParc].

Last modified September 19, 2002. Version 3.
Checksum: 825CD88441B5ACFF
Show »

FASTA

749

84,905

        10         20         30         40         50         60 
MAAAGSRKRR LAELTVDEFL ASGFDSESES ESENSPQAET REAREAARSP DKPGGSPSAS 

        70         80         90        100        110        120 
RRKGRASEHK DQLSRLKDRD PEFYKFLQEN DQSLLNFSDS DSSEEEEGPF HSLPDVLEEA 

       130        140        150        160        170        180 
SEEEDGAEEG EDGDRVPRGL KGKKNSVPVT VAMVERWKQA AKQRLTPKLF HEVVQAFRAA 

       190        200        210        220        230        240 
VATTRGDQES AEANKFQVTD SAAFNALVTF CIRDLIGCLQ KLLFGKVAKD SSRMLQPSSS 

       250        260        270        280        290        300 
PLWGKLRVDI KAYLGSAIQL VSCLSETTVL AAVLRHISVL VPCFLTFPKQ CRMLLKRMVV 

       310        320        330        340        350        360 
VWSTGEESLR VLAFLVLSRV CRHKKDTFLG PVLKQMYITY VRNCKFTSPG ALPFISFMQW 

       370        380        390        400        410        420 
TLTELLALEP GVAYQHAFLY IRQLAIHLRN AMTTRKKETY QSVYNWQYVH CLFLWCRVLS 

       430        440        450        460        470        480 
TAGPSEALQP LVYPLAQVII GCIKLIPTAR FYPLRMHCIR ALTLLSGSSG AFIPVLPFIL 

       490        500        510        520        530        540 
EMFQQVDFNR KPGRMSSKPI NFSVILKLSN VNLQEKAYRD GLVEQLYDLT LEYLHSQAHC 

       550        560        570        580        590        600 
IGFPELVLPV VLQLKSFLRE CKVANYCRQV QQLLGKVQEN SAYICSRRQR VSFGVSEQQA 

       610        620        630        640        650        660 
VEAWEKLTRE EGTPLTLYYS HWRKLRDREI QLEISGKERL EDLNFPEIKR RKMADRKDED 

       670        680        690        700        710        720 
RKQFKDLFDL NSSEEDDTEG FSERGILRPL STRHGVEDDE EDEEEGEEDS SNSEDGDPDA 

       730        740 
EAGLAPGELQ QLAQGPEDEL EDLQLSEDD

« Hide

Hide | Top

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-300.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed: 12429849] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, MASS SPECTROMETRY.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-28; SER-30; SER-32; SER-35; SER-93; SER-98; SER-100; SER-102; SER-103 AND SER-746, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Phosphoproteome analysis of the human mitotic spindle." Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35; SER-49 AND SER-672, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-672 AND SER-673, MASS SPECTROMETRY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-56; SER-672; SER-673 AND THR-678, MASS SPECTROMETRY.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	AL050019 mRNA. Translation: CAB43240.2. AL645608 Genomic DNA. Translation: CAI15568.1. BC003555 mRNA. Translation: AAH03555.1.
IPI	IPI00411886.
RefSeq	NP_056473.2.
UniGene	Hs.405987
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3T9. 7 interactions.
PTM databases
PhosphoSite	Q9Y3T9.
2-D gel databases
SWISS-2DPAGE	Q9Y3T9.
Proteomic databases
PRIDE	Q9Y3T9.
Genome annotation databases
Ensembl	ENSG00000188976. Homo sapiens. [Contig view]
GeneID	26155.
KEGG	hsa:26155.
Organism-specific databases
GeneCards	GC01M000869. GC01M000870.
H-InvDB	HIX0029966. HIX0030002.
HGNC	HGNC:24517. NOC2L.
MIM	610770. gene.
PharmGKB	PA142671261.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y3T9.
HOVERGEN	Q9Y3T9.
Gene expression databases
ArrayExpress	Q9Y3T9.
Bgee	Q9Y3T9.
CleanEx	HS_NOC2L.
GermOnline	ENSG00000188976. Homo sapiens.
Family and domain databases
InterPro	IPR005343. UPF0120. [Graphical view]
PANTHER	PTHR12687. UPF0120. 1 hit.
Pfam	PF03715. Noc2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48247.
SOURCE	Search...

Hide | Top

Entry information

Entry name

NOC2L_HUMAN

Accession

Primary (citable) accession number: Q9Y3T9
Secondary accession number(s): Q5SVA3, Q9BTN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 19, 2002
Last modified:	June 16, 2009
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2-D gel databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents