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Protein

Nucleolar complex protein 2 homolog

Gene

NOC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.3 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone binding Source: UniProtKB
  • nucleosome binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • repressing transcription factor binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to UV Source: UniProtKB
  • chromatin assembly Source: UniProtKB
  • negative regulation of B cell apoptotic process Source: UniProtKB
  • negative regulation of histone acetylation Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • nucleolus to nucleoplasm transport Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: Reactome
  • ribosomal large subunit biogenesis Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-32561-MONOMER.
ReactomeiR-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 2 homolog
Short name:
Protein NOC2 homolog
Alternative name(s):
NOC2-like protein
Novel INHAT repressor
Gene namesi
Name:NOC2L
Synonyms:NIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24517. NOC2L.

Subcellular locationi

  • Nucleusnucleoplasm
  • Nucleusnucleolus

  • Note: Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

GO - Cellular componenti

  • cytoplasm Source: HPA
  • Noc1p-Noc2p complex Source: GO_Central
  • Noc2p-Noc3p complex Source: GO_Central
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26155.
OpenTargetsiENSG00000188976.
PharmGKBiPA142671261.

Polymorphism and mutation databases

BioMutaiNOC2L.
DMDMi317373580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210481 – 749Nucleolar complex protein 2 homologAdd BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei678PhosphothreonineCombined sources1
Modified residuei746PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3T9.
MaxQBiQ9Y3T9.
PaxDbiQ9Y3T9.
PeptideAtlasiQ9Y3T9.
PRIDEiQ9Y3T9.

2D gel databases

SWISS-2DPAGEQ9Y3T9.

PTM databases

iPTMnetiQ9Y3T9.
PhosphoSitePlusiQ9Y3T9.
SwissPalmiQ9Y3T9.

Expressioni

Inductioni

Up-regulated by IL4 and CD40L in B-cells.1 Publication

Gene expression databases

BgeeiENSG00000188976.
CleanExiHS_NOC2L.
GenevisibleiQ9Y3T9. HS.

Organism-specific databases

HPAiHPA044258.
HPA062195.

Interactioni

Subunit structurei

Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN7O152652EBI-751547,EBI-708350
TP53P046378EBI-751547,EBI-366083

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • repressing transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117586. 84 interactors.
IntActiQ9Y3T9. 23 interactors.
MINTiMINT-1461800.
STRINGi9606.ENSP00000317992.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 107Poly-Glu4
Compositional biasi641 – 749Asp/Glu-rich (acidic)Add BLAST109

Sequence similaritiesi

Belongs to the NOC2 family.Curated

Phylogenomic databases

eggNOGiKOG2256. Eukaryota.
COG5604. LUCA.
GeneTreeiENSGT00390000010057.
HOGENOMiHOG000007977.
HOVERGENiHBG029261.
InParanoidiQ9Y3T9.
KOiK14833.
OMAiVLAFRCA.
OrthoDBiEOG091G04LC.
PhylomeDBiQ9Y3T9.
TreeFamiTF314829.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005343. Noc2.
[Graphical view]
PANTHERiPTHR12687. PTHR12687. 1 hit.
PfamiPF03715. Noc2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9Y3T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGSRKRR LAELTVDEFL ASGFDSESES ESENSPQAET REAREAARSP
60 70 80 90 100
DKPGGSPSAS RRKGRASEHK DQLSRLKDRD PEFYKFLQEN DQSLLNFSDS
110 120 130 140 150
DSSEEEEGPF HSLPDVLEEA SEEEDGAEEG EDGDRVPRGL KGKKNSVPVT
160 170 180 190 200
VAMVERWKQA AKQRLTPKLF HEVVQAFRAA VATTRGDQES AEANKFQVTD
210 220 230 240 250
SAAFNALVTF CIRDLIGCLQ KLLFGKVAKD SSRMLQPSSS PLWGKLRVDI
260 270 280 290 300
KAYLGSAIQL VSCLSETTVL AAVLRHISVL VPCFLTFPKQ CRMLLKRMVI
310 320 330 340 350
VWSTGEESLR VLAFLVLSRV CRHKKDTFLG PVLKQMYITY VRNCKFTSPG
360 370 380 390 400
ALPFISFMQW TLTELLALEP GVAYQHAFLY IRQLAIHLRN AMTTRKKETY
410 420 430 440 450
QSVYNWQYVH CLFLWCRVLS TAGPSEALQP LVYPLAQVII GCIKLIPTAR
460 470 480 490 500
FYPLRMHCIR ALTLLSGSSG AFIPVLPFIL EMFQQVDFNR KPGRMSSKPI
510 520 530 540 550
NFSVILKLSN VNLQEKAYRD GLVEQLYDLT LEYLHSQAHC IGFPELVLPV
560 570 580 590 600
VLQLKSFLRE CKVANYCRQV QQLLGKVQEN SAYICSRRQR VSFGVSEQQA
610 620 630 640 650
VEAWEKLTRE EGTPLTLYYS HWRKLRDREI QLEISGKERL EDLNFPEIKR
660 670 680 690 700
RKMADRKDED RKQFKDLFDL NSSEEDDTEG FSERGILRPL STRHGVEDDE
710 720 730 740
EDEEEGEEDS SNSEDGDPDA EAGLAPGELQ QLAQGPEDEL EDLQLSEDD
Length:749
Mass (Da):84,919
Last modified:January 11, 2011 - v4
Checksum:iB178FE65E711CFDB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178R → Q in CAB43240 (PubMed:11230166).Curated1
Sequence conflicti345K → E in CAB43240 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028145271A → V.Corresponds to variant rs3828049dbSNPEnsembl.1
Natural variantiVAR_028146300I → V.2 PublicationsCorresponds to variant rs3748597dbSNPEnsembl.1
Natural variantiVAR_050289556S → L.Corresponds to variant rs35471880dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050019 mRNA. Translation: CAB43240.2.
AL645608 Genomic DNA. Translation: CAI15568.1.
BC003555 mRNA. Translation: AAH03555.1.
CCDSiCCDS3.1.
RefSeqiNP_056473.2. NM_015658.3.
UniGeneiHs.405987.

Genome annotation databases

EnsembliENST00000327044; ENSP00000317992; ENSG00000188976.
GeneIDi26155.
KEGGihsa:26155.
UCSCiuc001abz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050019 mRNA. Translation: CAB43240.2.
AL645608 Genomic DNA. Translation: CAI15568.1.
BC003555 mRNA. Translation: AAH03555.1.
CCDSiCCDS3.1.
RefSeqiNP_056473.2. NM_015658.3.
UniGeneiHs.405987.

3D structure databases

ProteinModelPortaliQ9Y3T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117586. 84 interactors.
IntActiQ9Y3T9. 23 interactors.
MINTiMINT-1461800.
STRINGi9606.ENSP00000317992.

PTM databases

iPTMnetiQ9Y3T9.
PhosphoSitePlusiQ9Y3T9.
SwissPalmiQ9Y3T9.

Polymorphism and mutation databases

BioMutaiNOC2L.
DMDMi317373580.

2D gel databases

SWISS-2DPAGEQ9Y3T9.

Proteomic databases

EPDiQ9Y3T9.
MaxQBiQ9Y3T9.
PaxDbiQ9Y3T9.
PeptideAtlasiQ9Y3T9.
PRIDEiQ9Y3T9.

Protocols and materials databases

DNASUi26155.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327044; ENSP00000317992; ENSG00000188976.
GeneIDi26155.
KEGGihsa:26155.
UCSCiuc001abz.5. human.

Organism-specific databases

CTDi26155.
DisGeNETi26155.
GeneCardsiNOC2L.
H-InvDBHIX0029966.
HIX0030002.
HGNCiHGNC:24517. NOC2L.
HPAiHPA044258.
HPA062195.
MIMi610770. gene.
neXtProtiNX_Q9Y3T9.
OpenTargetsiENSG00000188976.
PharmGKBiPA142671261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2256. Eukaryota.
COG5604. LUCA.
GeneTreeiENSGT00390000010057.
HOGENOMiHOG000007977.
HOVERGENiHBG029261.
InParanoidiQ9Y3T9.
KOiK14833.
OMAiVLAFRCA.
OrthoDBiEOG091G04LC.
PhylomeDBiQ9Y3T9.
TreeFamiTF314829.

Enzyme and pathway databases

BioCyciZFISH:G66-32561-MONOMER.
ReactomeiR-HSA-6804756. Regulation of TP53 Activity through Phosphorylation.

Miscellaneous databases

ChiTaRSiNOC2L. human.
GeneWikiiNOC2L.
GenomeRNAii26155.
PROiQ9Y3T9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188976.
CleanExiHS_NOC2L.
GenevisibleiQ9Y3T9. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005343. Noc2.
[Graphical view]
PANTHERiPTHR12687. PTHR12687. 1 hit.
PfamiPF03715. Noc2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC2L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3T9
Secondary accession number(s): Q5SVA3, Q9BTN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.