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Protein

Zinc finger protein 330

Gene

ZNF330

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

GO - Molecular functioni

  • metal ion binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene namesi
Name:ZNF330
Synonyms:NOA36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:15462. ZNF330.

Subcellular locationi

  • Nucleus 1 Publication
  • Nucleusnucleolus 1 Publication
  • Chromosomecentromere 1 Publication

  • Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.

GO - Cellular componenti

  • chromosome, centromeric region Source: UniProtKB
  • midbody Source: UniProtKB
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27309.
OpenTargetsiENSG00000109445.
PharmGKBiPA134925405.

Polymorphism and mutation databases

BioMutaiZNF330.
DMDMi51702204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665901 – 320Zinc finger protein 330Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3S2.
MaxQBiQ9Y3S2.
PaxDbiQ9Y3S2.
PeptideAtlasiQ9Y3S2.
PRIDEiQ9Y3S2.

PTM databases

iPTMnetiQ9Y3S2.
PhosphoSitePlusiQ9Y3S2.
SwissPalmiQ9Y3S2.

Expressioni

Tissue specificityi

Widely expressed. Higher expression seen in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000109445.
CleanExiHS_ZNF330.
ExpressionAtlasiQ9Y3S2. baseline and differential.
GenevisibleiQ9Y3S2. HS.

Organism-specific databases

HPAiHPA015705.
HPA056325.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RWDD4Q6NW294EBI-373456,EBI-743971
ZNF408Q9H9D43EBI-373456,EBI-347633

Protein-protein interaction databases

BioGridi118131. 3 interactors.
IntActiQ9Y3S2. 20 interactors.
STRINGi9606.ENSP00000262990.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 11Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 286Asp/Glu-rich (acidic)Add BLAST18

Sequence similaritiesi

Belongs to the NOA36 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEDV. Eukaryota.
ENOG410XNTY. LUCA.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ9Y3S2.
OMAiTHACTCP.
OrthoDBiEOG091G0DRZ.
PhylomeDBiQ9Y3S2.
TreeFamiTF323303.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK
60 70 80 90 100
NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI
110 120 130 140 150
CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH
160 170 180 190 200
NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDDHTRS
210 220 230 240 250
KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEGDGASGY
260 270 280 290 300
DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
310 320
NLNLGRTYAS GYAHYEEQEN
Length:320
Mass (Da):36,201
Last modified:November 1, 1999 - v1
Checksum:iCC7F03EE70BF8FD1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05150028T → A.Corresponds to variant rs35353789dbSNPEnsembl.1
Natural variantiVAR_051501298L → M.Corresponds to variant rs34631212dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSiCCDS3754.1.
RefSeqiNP_001278931.1. NM_001292002.1.
NP_055302.1. NM_014487.5.
XP_016863522.1. XM_017008033.1.
UniGeneiHs.120766.

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
GeneIDi27309.
KEGGihsa:27309.
UCSCiuc003iiq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSiCCDS3754.1.
RefSeqiNP_001278931.1. NM_001292002.1.
NP_055302.1. NM_014487.5.
XP_016863522.1. XM_017008033.1.
UniGeneiHs.120766.

3D structure databases

ProteinModelPortaliQ9Y3S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118131. 3 interactors.
IntActiQ9Y3S2. 20 interactors.
STRINGi9606.ENSP00000262990.

PTM databases

iPTMnetiQ9Y3S2.
PhosphoSitePlusiQ9Y3S2.
SwissPalmiQ9Y3S2.

Polymorphism and mutation databases

BioMutaiZNF330.
DMDMi51702204.

Proteomic databases

EPDiQ9Y3S2.
MaxQBiQ9Y3S2.
PaxDbiQ9Y3S2.
PeptideAtlasiQ9Y3S2.
PRIDEiQ9Y3S2.

Protocols and materials databases

DNASUi27309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
GeneIDi27309.
KEGGihsa:27309.
UCSCiuc003iiq.5. human.

Organism-specific databases

CTDi27309.
DisGeNETi27309.
GeneCardsiZNF330.
HGNCiHGNC:15462. ZNF330.
HPAiHPA015705.
HPA056325.
MIMi609550. gene.
neXtProtiNX_Q9Y3S2.
OpenTargetsiENSG00000109445.
PharmGKBiPA134925405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDV. Eukaryota.
ENOG410XNTY. LUCA.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ9Y3S2.
OMAiTHACTCP.
OrthoDBiEOG091G0DRZ.
PhylomeDBiQ9Y3S2.
TreeFamiTF323303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109445-MONOMER.

Miscellaneous databases

ChiTaRSiZNF330. human.
GeneWikiiZNF330.
GenomeRNAii27309.
PROiQ9Y3S2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109445.
CleanExiHS_ZNF330.
ExpressionAtlasiQ9Y3S2. baseline and differential.
GenevisibleiQ9Y3S2. HS.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN330_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.