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Q9Y3S2 (ZN330_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene names
Name:ZNF330
Synonyms:NOA36
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus. Nucleusnucleolus. Chromosomecentromere. Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis. Ref.1

Tissue specificity

Widely expressed. Higher expression seen in heart and skeletal muscle. Ref.1

Sequence similarities

Belongs to the NOA36 family.

Ontologies

Keywords
   Cellular componentCentromere
Chromosome
Nucleus
   Coding sequence diversityPolymorphism
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentchromosome, centromeric region

Inferred from direct assay Ref.1. Source: UniProtKB

midbody

Inferred from direct assay Ref.1. Source: UniProtKB

nucleolus

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionmetal ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ZNF408Q9H9D41EBI-373456,EBI-347633

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Zinc finger protein 330
PRO_0000066590

Regions

Zinc finger42 – 5817C4-type 1 Potential
Zinc finger67 – 10438C4-type 2 Potential
Zinc finger129 – 14921C4-type 3 Potential
Zinc finger175 – 18915C4-type 4 Potential
Motif3 – 119Nuclear localization signal Potential
Compositional bias269 – 28618Asp/Glu-rich (acidic)

Natural variations

Natural variant281T → A.
Corresponds to variant rs35353789 [ dbSNP | Ensembl ].
VAR_051500
Natural variant2981L → M.
Corresponds to variant rs34631212 [ dbSNP | Ensembl ].
VAR_051501

Sequences

Sequence LengthMass (Da)Tools
Q9Y3S2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: CC7F03EE70BF8FD1

FASTA32036,201
        10         20         30         40         50         60 
MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS 

        70         80         90        100        110        120 
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC 

       130        140        150        160        170        180 
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR 

       190        200        210        220        230        240 
LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG 

       250        260        270        280        290        300 
GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 

       310        320 
NLNLGRTYAS GYAHYEEQEN 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans."
Bolivar J., Diaz I., Iglesias C., Valdivia M.M.
J. Biol. Chem. 274:36456-36464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Genomic structure and chromosomal localization of the human zinc finger autoantigen NOA36."
Bolivar J.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873 expand/collapse EMBL AC list , AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSCCDS3754.1.
RefSeqNP_055302.1. NM_014487.5.
UniGeneHs.120766.

3D structure databases

ProteinModelPortalQ9Y3S2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118131. 2 interactions.
IntActQ9Y3S2. 2 interactions.
STRING9606.ENSP00000262990.

PTM databases

PhosphoSiteQ9Y3S2.

Polymorphism databases

DMDM51702204.

Proteomic databases

MaxQBQ9Y3S2.
PaxDbQ9Y3S2.
PeptideAtlasQ9Y3S2.
PRIDEQ9Y3S2.

Protocols and materials databases

DNASU27309.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262990; ENSP00000262990; ENSG00000109445.
GeneID27309.
KEGGhsa:27309.
UCSCuc003iiq.4. human.

Organism-specific databases

CTD27309.
GeneCardsGC04P142142.
HGNCHGNC:15462. ZNF330.
HPAHPA015705.
MIM609550. gene.
neXtProtNX_Q9Y3S2.
PharmGKBPA134925405.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG80468.
HOGENOMHOG000030400.
HOVERGENHBG057282.
InParanoidQ9Y3S2.
OMAVWEHGGR.
OrthoDBEOG7QVM30.
PhylomeDBQ9Y3S2.
TreeFamTF323303.

Gene expression databases

ArrayExpressQ9Y3S2.
BgeeQ9Y3S2.
CleanExHS_ZNF330.
GenevestigatorQ9Y3S2.

Family and domain databases

InterProIPR010531. NOA36.
[Graphical view]
PANTHERPTHR13214. PTHR13214. 1 hit.
PfamPF06524. NOA36. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF330.
GenomeRNAi27309.
NextBio50311.
PROQ9Y3S2.
SOURCESearch...

Entry information

Entry nameZN330_HUMAN
AccessionPrimary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM