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Q9Y3S2

- ZN330_HUMAN

UniProt

Q9Y3S2 - ZN330_HUMAN

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Protein
Zinc finger protein 330
Gene
ZNF330, NOA36
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 5817C4-type 1 Reviewed prediction
Add
BLAST
Zinc fingeri67 – 10438C4-type 2 Reviewed prediction
Add
BLAST
Zinc fingeri129 – 14921C4-type 3 Reviewed prediction
Add
BLAST
Zinc fingeri175 – 18915C4-type 4 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene namesi
Name:ZNF330
Synonyms:NOA36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:15462. ZNF330.

Subcellular locationi

Nucleus. Nucleusnucleolus. Chromosomecentromere
Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.1 Publication

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. midbody Source: UniProtKB
  3. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134925405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Zinc finger protein 330
PRO_0000066590Add
BLAST

Proteomic databases

MaxQBiQ9Y3S2.
PaxDbiQ9Y3S2.
PeptideAtlasiQ9Y3S2.
PRIDEiQ9Y3S2.

PTM databases

PhosphoSiteiQ9Y3S2.

Expressioni

Tissue specificityi

Widely expressed. Higher expression seen in heart and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ9Y3S2.
BgeeiQ9Y3S2.
CleanExiHS_ZNF330.
GenevestigatoriQ9Y3S2.

Organism-specific databases

HPAiHPA015705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF408Q9H9D41EBI-373456,EBI-347633

Protein-protein interaction databases

BioGridi118131. 2 interactions.
IntActiQ9Y3S2. 2 interactions.
STRINGi9606.ENSP00000262990.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3S2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 119Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi269 – 28618Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Belongs to the NOA36 family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG80468.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ9Y3S2.
OMAiVWEHGGR.
OrthoDBiEOG7QVM30.
PhylomeDBiQ9Y3S2.
TreeFamiTF323303.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3S2-1 [UniParc]FASTAAdd to Basket

« Hide

MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK    50
NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI 100
CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH 150
NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDDHTRS 200
KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEGDGASGY 250
DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 300
NLNLGRTYAS GYAHYEEQEN 320
Length:320
Mass (Da):36,201
Last modified:November 1, 1999 - v1
Checksum:iCC7F03EE70BF8FD1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → A.
Corresponds to variant rs35353789 [ dbSNP | Ensembl ].
VAR_051500
Natural varianti298 – 2981L → M.
Corresponds to variant rs34631212 [ dbSNP | Ensembl ].
VAR_051501

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSiCCDS3754.1.
RefSeqiNP_055302.1. NM_014487.5.
UniGeneiHs.120766.

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
GeneIDi27309.
KEGGihsa:27309.
UCSCiuc003iiq.4. human.

Polymorphism databases

DMDMi51702204.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006591 mRNA. Translation: CAB43112.1 .
AJ404873
, AJ404874 , AJ404875 , AJ404876 , AJ404877 , AJ404878 , AJ404879 , AJ404880 Genomic DNA. Translation: CAC18679.1 .
AK315463 mRNA. Translation: BAG37850.1 .
CH471056 Genomic DNA. Translation: EAX05089.1 .
BC004421 mRNA. Translation: AAH04421.1 .
CCDSi CCDS3754.1.
RefSeqi NP_055302.1. NM_014487.5.
UniGenei Hs.120766.

3D structure databases

ProteinModelPortali Q9Y3S2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118131. 2 interactions.
IntActi Q9Y3S2. 2 interactions.
STRINGi 9606.ENSP00000262990.

PTM databases

PhosphoSitei Q9Y3S2.

Polymorphism databases

DMDMi 51702204.

Proteomic databases

MaxQBi Q9Y3S2.
PaxDbi Q9Y3S2.
PeptideAtlasi Q9Y3S2.
PRIDEi Q9Y3S2.

Protocols and materials databases

DNASUi 27309.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262990 ; ENSP00000262990 ; ENSG00000109445 .
GeneIDi 27309.
KEGGi hsa:27309.
UCSCi uc003iiq.4. human.

Organism-specific databases

CTDi 27309.
GeneCardsi GC04P142142.
HGNCi HGNC:15462. ZNF330.
HPAi HPA015705.
MIMi 609550. gene.
neXtProti NX_Q9Y3S2.
PharmGKBi PA134925405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80468.
HOGENOMi HOG000030400.
HOVERGENi HBG057282.
InParanoidi Q9Y3S2.
OMAi VWEHGGR.
OrthoDBi EOG7QVM30.
PhylomeDBi Q9Y3S2.
TreeFami TF323303.

Miscellaneous databases

GeneWikii ZNF330.
GenomeRNAii 27309.
NextBioi 50311.
PROi Q9Y3S2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y3S2.
Bgeei Q9Y3S2.
CleanExi HS_ZNF330.
Genevestigatori Q9Y3S2.

Family and domain databases

InterProi IPR010531. NOA36.
[Graphical view ]
PANTHERi PTHR13214. PTHR13214. 1 hit.
Pfami PF06524. NOA36. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans."
    Bolivar J., Diaz I., Iglesias C., Valdivia M.M.
    J. Biol. Chem. 274:36456-36464(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Genomic structure and chromosomal localization of the human zinc finger autoantigen NOA36."
    Bolivar J.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN330_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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