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Protein

Zinc finger protein 330

Gene

ZNF330

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 5817C4-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri67 – 10438C4-type 2Sequence AnalysisAdd
BLAST
Zinc fingeri129 – 14921C4-type 3Sequence AnalysisAdd
BLAST
Zinc fingeri175 – 18915C4-type 4Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene namesi
Name:ZNF330
Synonyms:NOA36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:15462. ZNF330.

Subcellular locationi

Nucleus 1 Publication. Nucleusnucleolus 1 Publication. Chromosomecentromere 1 Publication
Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. midbody Source: UniProtKB
  3. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134925405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Zinc finger protein 330PRO_0000066590Add
BLAST

Proteomic databases

MaxQBiQ9Y3S2.
PaxDbiQ9Y3S2.
PeptideAtlasiQ9Y3S2.
PRIDEiQ9Y3S2.

PTM databases

PhosphoSiteiQ9Y3S2.

Expressioni

Tissue specificityi

Widely expressed. Higher expression seen in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9Y3S2.
CleanExiHS_ZNF330.
ExpressionAtlasiQ9Y3S2. baseline and differential.
GenevestigatoriQ9Y3S2.

Organism-specific databases

HPAiHPA015705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF408Q9H9D41EBI-373456,EBI-347633

Protein-protein interaction databases

BioGridi118131. 2 interactions.
IntActiQ9Y3S2. 2 interactions.
STRINGi9606.ENSP00000262990.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 119Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi269 – 28618Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the NOA36 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri42 – 5817C4-type 1Sequence AnalysisAdd
BLAST
Zinc fingeri67 – 10438C4-type 2Sequence AnalysisAdd
BLAST
Zinc fingeri129 – 14921C4-type 3Sequence AnalysisAdd
BLAST
Zinc fingeri175 – 18915C4-type 4Sequence AnalysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG80468.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ9Y3S2.
OMAiVWEHGGR.
OrthoDBiEOG7QVM30.
PhylomeDBiQ9Y3S2.
TreeFamiTF323303.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3S2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK
60 70 80 90 100
NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI
110 120 130 140 150
CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH
160 170 180 190 200
NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDDHTRS
210 220 230 240 250
KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEGDGASGY
260 270 280 290 300
DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
310 320
NLNLGRTYAS GYAHYEEQEN
Length:320
Mass (Da):36,201
Last modified:November 1, 1999 - v1
Checksum:iCC7F03EE70BF8FD1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → A.
Corresponds to variant rs35353789 [ dbSNP | Ensembl ].
VAR_051500
Natural varianti298 – 2981L → M.
Corresponds to variant rs34631212 [ dbSNP | Ensembl ].
VAR_051501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSiCCDS3754.1.
RefSeqiNP_001278931.1. NM_001292002.1.
NP_055302.1. NM_014487.5.
UniGeneiHs.120766.

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
GeneIDi27309.
KEGGihsa:27309.
UCSCiuc003iiq.4. human.

Polymorphism databases

DMDMi51702204.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA. Translation: CAB43112.1.
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
AK315463 mRNA. Translation: BAG37850.1.
CH471056 Genomic DNA. Translation: EAX05089.1.
BC004421 mRNA. Translation: AAH04421.1.
CCDSiCCDS3754.1.
RefSeqiNP_001278931.1. NM_001292002.1.
NP_055302.1. NM_014487.5.
UniGeneiHs.120766.

3D structure databases

ProteinModelPortaliQ9Y3S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118131. 2 interactions.
IntActiQ9Y3S2. 2 interactions.
STRINGi9606.ENSP00000262990.

PTM databases

PhosphoSiteiQ9Y3S2.

Polymorphism databases

DMDMi51702204.

Proteomic databases

MaxQBiQ9Y3S2.
PaxDbiQ9Y3S2.
PeptideAtlasiQ9Y3S2.
PRIDEiQ9Y3S2.

Protocols and materials databases

DNASUi27309.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
GeneIDi27309.
KEGGihsa:27309.
UCSCiuc003iiq.4. human.

Organism-specific databases

CTDi27309.
GeneCardsiGC04P142142.
HGNCiHGNC:15462. ZNF330.
HPAiHPA015705.
MIMi609550. gene.
neXtProtiNX_Q9Y3S2.
PharmGKBiPA134925405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG80468.
GeneTreeiENSGT00390000017043.
HOGENOMiHOG000030400.
HOVERGENiHBG057282.
InParanoidiQ9Y3S2.
OMAiVWEHGGR.
OrthoDBiEOG7QVM30.
PhylomeDBiQ9Y3S2.
TreeFamiTF323303.

Miscellaneous databases

ChiTaRSiZNF330. human.
GeneWikiiZNF330.
GenomeRNAii27309.
NextBioi50311.
PROiQ9Y3S2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y3S2.
CleanExiHS_ZNF330.
ExpressionAtlasiQ9Y3S2. baseline and differential.
GenevestigatoriQ9Y3S2.

Family and domain databases

InterProiIPR010531. NOA36.
[Graphical view]
PANTHERiPTHR13214. PTHR13214. 1 hit.
PfamiPF06524. NOA36. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans."
    Bolivar J., Diaz I., Iglesias C., Valdivia M.M.
    J. Biol. Chem. 274:36456-36464(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Genomic structure and chromosomal localization of the human zinc finger autoantigen NOA36."
    Bolivar J.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN330_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.