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Q9Y3S2

- ZN330_HUMAN

UniProt

Q9Y3S2 - ZN330_HUMAN

Protein

Zinc finger protein 330

Gene

ZNF330

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri42 – 5817C4-type 1Sequence AnalysisAdd
    BLAST
    Zinc fingeri67 – 10438C4-type 2Sequence AnalysisAdd
    BLAST
    Zinc fingeri129 – 14921C4-type 3Sequence AnalysisAdd
    BLAST
    Zinc fingeri175 – 18915C4-type 4Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 330
    Alternative name(s):
    Nucleolar autoantigen 36
    Nucleolar cysteine-rich protein
    Gene namesi
    Name:ZNF330
    Synonyms:NOA36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:15462. ZNF330.

    Subcellular locationi

    Nucleus 1 Publication. Nucleusnucleolus 1 Publication. Chromosomecentromere 1 Publication
    Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB
    2. midbody Source: UniProtKB
    3. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134925405.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Zinc finger protein 330PRO_0000066590Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y3S2.
    PaxDbiQ9Y3S2.
    PeptideAtlasiQ9Y3S2.
    PRIDEiQ9Y3S2.

    PTM databases

    PhosphoSiteiQ9Y3S2.

    Expressioni

    Tissue specificityi

    Widely expressed. Higher expression seen in heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y3S2.
    BgeeiQ9Y3S2.
    CleanExiHS_ZNF330.
    GenevestigatoriQ9Y3S2.

    Organism-specific databases

    HPAiHPA015705.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ZNF408Q9H9D41EBI-373456,EBI-347633

    Protein-protein interaction databases

    BioGridi118131. 2 interactions.
    IntActiQ9Y3S2. 2 interactions.
    STRINGi9606.ENSP00000262990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3S2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi3 – 119Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 28618Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the NOA36 family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri42 – 5817C4-type 1Sequence AnalysisAdd
    BLAST
    Zinc fingeri67 – 10438C4-type 2Sequence AnalysisAdd
    BLAST
    Zinc fingeri129 – 14921C4-type 3Sequence AnalysisAdd
    BLAST
    Zinc fingeri175 – 18915C4-type 4Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG80468.
    HOGENOMiHOG000030400.
    HOVERGENiHBG057282.
    InParanoidiQ9Y3S2.
    OMAiVWEHGGR.
    OrthoDBiEOG7QVM30.
    PhylomeDBiQ9Y3S2.
    TreeFamiTF323303.

    Family and domain databases

    InterProiIPR010531. NOA36.
    [Graphical view]
    PANTHERiPTHR13214. PTHR13214. 1 hit.
    PfamiPF06524. NOA36. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK    50
    NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI 100
    CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH 150
    NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDDHTRS 200
    KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEGDGASGY 250
    DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 300
    NLNLGRTYAS GYAHYEEQEN 320
    Length:320
    Mass (Da):36,201
    Last modified:November 1, 1999 - v1
    Checksum:iCC7F03EE70BF8FD1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281T → A.
    Corresponds to variant rs35353789 [ dbSNP | Ensembl ].
    VAR_051500
    Natural varianti298 – 2981L → M.
    Corresponds to variant rs34631212 [ dbSNP | Ensembl ].
    VAR_051501

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006591 mRNA. Translation: CAB43112.1.
    AJ404873
    , AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1.
    AK315463 mRNA. Translation: BAG37850.1.
    CH471056 Genomic DNA. Translation: EAX05089.1.
    BC004421 mRNA. Translation: AAH04421.1.
    CCDSiCCDS3754.1.
    RefSeqiNP_055302.1. NM_014487.5.
    UniGeneiHs.120766.

    Genome annotation databases

    EnsembliENST00000262990; ENSP00000262990; ENSG00000109445.
    GeneIDi27309.
    KEGGihsa:27309.
    UCSCiuc003iiq.4. human.

    Polymorphism databases

    DMDMi51702204.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006591 mRNA. Translation: CAB43112.1 .
    AJ404873
    , AJ404874 , AJ404875 , AJ404876 , AJ404877 , AJ404878 , AJ404879 , AJ404880 Genomic DNA. Translation: CAC18679.1 .
    AK315463 mRNA. Translation: BAG37850.1 .
    CH471056 Genomic DNA. Translation: EAX05089.1 .
    BC004421 mRNA. Translation: AAH04421.1 .
    CCDSi CCDS3754.1.
    RefSeqi NP_055302.1. NM_014487.5.
    UniGenei Hs.120766.

    3D structure databases

    ProteinModelPortali Q9Y3S2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118131. 2 interactions.
    IntActi Q9Y3S2. 2 interactions.
    STRINGi 9606.ENSP00000262990.

    PTM databases

    PhosphoSitei Q9Y3S2.

    Polymorphism databases

    DMDMi 51702204.

    Proteomic databases

    MaxQBi Q9Y3S2.
    PaxDbi Q9Y3S2.
    PeptideAtlasi Q9Y3S2.
    PRIDEi Q9Y3S2.

    Protocols and materials databases

    DNASUi 27309.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262990 ; ENSP00000262990 ; ENSG00000109445 .
    GeneIDi 27309.
    KEGGi hsa:27309.
    UCSCi uc003iiq.4. human.

    Organism-specific databases

    CTDi 27309.
    GeneCardsi GC04P142142.
    HGNCi HGNC:15462. ZNF330.
    HPAi HPA015705.
    MIMi 609550. gene.
    neXtProti NX_Q9Y3S2.
    PharmGKBi PA134925405.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80468.
    HOGENOMi HOG000030400.
    HOVERGENi HBG057282.
    InParanoidi Q9Y3S2.
    OMAi VWEHGGR.
    OrthoDBi EOG7QVM30.
    PhylomeDBi Q9Y3S2.
    TreeFami TF323303.

    Miscellaneous databases

    GeneWikii ZNF330.
    GenomeRNAii 27309.
    NextBioi 50311.
    PROi Q9Y3S2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3S2.
    Bgeei Q9Y3S2.
    CleanExi HS_ZNF330.
    Genevestigatori Q9Y3S2.

    Family and domain databases

    InterProi IPR010531. NOA36.
    [Graphical view ]
    PANTHERi PTHR13214. PTHR13214. 1 hit.
    Pfami PF06524. NOA36. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans."
      Bolivar J., Diaz I., Iglesias C., Valdivia M.M.
      J. Biol. Chem. 274:36456-36464(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Genomic structure and chromosomal localization of the human zinc finger autoantigen NOA36."
      Bolivar J.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN330_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3S2
    Secondary accession number(s): B2RDA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3