Q9Y3S2 (ZN330_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 330

Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein

Gene names

Name:	ZNF330
Synonyms:	NOA36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus. Nucleus › nucleolus. Chromosome › centromere. Note: Predominantly expressed in the nucleolus. In mitosis associated with centromeres and concentrated at the midbody in cytokinesis. Ref.1
Tissue specificity	Widely expressed. Higher expression seen in heart and skeletal muscle. Ref.1
Sequence similarities	Belongs to the NOA36 family.

Ontologies

Keywords
Cellular component	Centromere Chromosome Nucleus
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromosome, centromeric region Inferred from direct assay Ref.1. Source: UniProtKB midbody Inferred from direct assay Ref.1. Source: UniProtKB nucleolus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	metal ion binding Non-traceable author statement Ref.1. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ZNF408	Q9H9D4	1	EBI-373456,EBI-347633

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Zinc finger protein 330		PRO_0000066590
Regions
	Zinc finger	42 – 58	17	C4-type 1 Potential
	Zinc finger	67 – 104	38	C4-type 2 Potential
	Zinc finger	129 – 149	21	C4-type 3 Potential
	Zinc finger	175 – 189	15	C4-type 4 Potential
	Motif	3 – 11	9	Nuclear localization signal Potential
	Compositional bias	269 – 286	18	Asp/Glu-rich (acidic)
Natural variations
	Natural variant	28	1	T → A. Corresponds to variant rs35353789 [ dbSNP | Ensembl ].		VAR_051500
	Natural variant	298	1	L → M. Corresponds to variant rs34631212 [ dbSNP | Ensembl ].		VAR_051501

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3S2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CC7F03EE70BF8FD1	FASTA	320	36,201
	10 20 30 40 50 60 MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS 70 80 90 100 110 120 VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC 130 140 150 160 170 180 ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR 190 200 210 220 230 240 LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG 250 260 270 280 290 300 GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT 310 320 NLNLGRTYAS GYAHYEEQEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans." Bolivar J., Diaz I., Iglesias C., Valdivia M.M. J. Biol. Chem. 274:36456-36464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Genomic structure and chromosomal localization of the human zinc finger autoantigen NOA36." Bolivar J. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006591 mRNA. Translation: CAB43112.1. AJ404873 , AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA. Translation: CAC18679.1. AK315463 mRNA. Translation: BAG37850.1. CH471056 Genomic DNA. Translation: EAX05089.1. BC004421 mRNA. Translation: AAH04421.1.
IPI	IPI00004942.
RefSeq	NP_055302.1. NM_014487.4.
UniGene	Hs.120766.
3D structure databases
ProteinModelPortal	Q9Y3S2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3S2. 2 interactions.
STRING	9606.ENSP00000262990.
PTM databases
PhosphoSite	Q9Y3S2.
Polymorphism databases
DMDM	51702204.
Proteomic databases
PaxDb	Q9Y3S2.
PeptideAtlas	Q9Y3S2.
PRIDE	Q9Y3S2.
Protocols and materials databases
DNASU	27309.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262990; ENSP00000262990; ENSG00000109445.
GeneID	27309.
KEGG	hsa:27309.
UCSC	uc003iiq.4. human.
Organism-specific databases
CTD	27309.
GeneCards	GC04P142142.
HGNC	HGNC:15462. ZNF330.
HPA	HPA015705.
MIM	609550. gene.
neXtProt	NX_Q9Y3S2.
PharmGKB	PA134925405.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80468.
HOGENOM	HOG000030400.
HOVERGEN	HBG057282.
InParanoid	Q9Y3S2.
OMA	VWEHGGR.
OrthoDB	EOG4S7JQQ.
PhylomeDB	Q9Y3S2.
Gene expression databases
ArrayExpress	Q9Y3S2.
Bgee	Q9Y3S2.
CleanEx	HS_ZNF330.
Genevestigator	Q9Y3S2.
GermOnline	ENSG00000109445. Homo sapiens.
Family and domain databases
InterPro	IPR010531. NOA36. [Graphical view]
PANTHER	PTHR13214. PTHR13214. 1 hit.
Pfam	PF06524. NOA36. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27309.
NextBio	50311.
SOURCE	Search...

Entry information

Entry name

ZN330_HUMAN

Accession

Primary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.