Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y3S1 (WNK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase WNK2

EC=2.7.11.1
Alternative name(s):
Antigen NY-CO-43
Protein kinase lysine-deficient 2
Protein kinase with no lysine 2
Serologically defined colon cancer antigen 43
Gene names
Name:WNK2
Synonyms:KIAA1760, PRKWNK2, SDCCAG43
ORF Names:P/OKcl.13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2297 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Ref.8 Ref.10 Ref.14

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB Q9H4A3

Enzyme regulation

Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity By similarity. UniProtKB Q9JIH7

Subunit structure

Forms a complex with the phosphorylated form of STK39 By similarity.

Subcellular location

Cytoplasm. Cell membrane Ref.8 Ref.10.

Tissue specificity

Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon. Ref.1 Ref.8 Ref.14

Post-translational modification

Autophosphorylated. Ref.8 Ref.10 Ref.14

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.

Contains 1 protein kinase domain.

Caution

Cys-224 is present instead of the conserved Lys which is expected to be an active site residue. Lys-207 appears to fulfill the required catalytic function. UniProtKB Q9JIH7

Sequence caution

The sequence AAH37965.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q9Y3S1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.5 (identifier: Q9Y3S1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1345-1381: Missing.
     2247-2261: DGALGTARRNQVWFG → GSCGPRAVSTPTSYT
     2262-2297: Missing.
Note: No experimental confirmation available.
Isoform 3 Ref.4 (identifier: Q9Y3S1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.
     680-731: Missing.
     843-845: LAA → RTR
     846-2297: Missing.
Note: Incomplete sequence.
Isoform 4 Ref.7 (identifier: Q9Y3S1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2248-2254: GALGTAR → PESEKPD
     2255-2297: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22972297Serine/threonine-protein kinase WNK2
PRO_0000086822

Regions

Domain195 – 453259Protein kinase
Nucleotide binding201 – 2099ATP By similarity UniProtKB Q8TDX7

Sites

Active site3231Proton acceptor By similarity UniProtKB Q8TDX7
Binding site2071ATP By similarity UniProtKB Q9JIH7

Amino acid modifications

Modified residue451Phosphoserine Ref.14
Modified residue3521Phosphoserine; by autocatalysis By similarity UniProtKB Q9JIH7
Modified residue3561Phosphoserine; by autocatalysis By similarity UniProtKB Q9JIH7
Modified residue5601Phosphoserine Ref.14
Modified residue11501Phosphoserine Ref.14
Modified residue12621Phosphoserine Ref.14
Modified residue15881Phosphoserine Ref.14
Modified residue16851Phosphoserine Ref.14
Modified residue17361Phosphoserine Ref.14
Modified residue18171Phosphoserine Ref.11 Ref.13 Ref.14
Modified residue18181Phosphoserine Ref.11 Ref.13 Ref.14
Modified residue18621Phosphoserine Ref.14 Ref.15
Modified residue18891Phosphoserine By similarity
Modified residue20671Phosphoserine Ref.14

Natural variations

Alternative sequence1 – 1414Missing in isoform 3. Ref.4
VSP_050639
Alternative sequence680 – 73152Missing in isoform 3. Ref.4
VSP_050640
Alternative sequence843 – 8453LAA → RTR in isoform 3. Ref.4
VSP_050641
Alternative sequence846 – 22971452Missing in isoform 3. Ref.4
VSP_050642
Alternative sequence1345 – 138137Missing in isoform 2. Ref.5
VSP_050643
Alternative sequence2247 – 226115DGALG…QVWFG → GSCGPRAVSTPTSYT in isoform 2. Ref.5
VSP_050644
Alternative sequence2248 – 22547GALGTAR → PESEKPD in isoform 4. UniProtKB Q9JIH7
VSP_050645
Alternative sequence2255 – 229743Missing in isoform 4. Ref.7
VSP_050646
Alternative sequence2262 – 229736Missing in isoform 2. Ref.5
VSP_050647
Natural variant8281V → M.
Corresponds to variant rs10761203 [ dbSNP | Ensembl ].
VAR_057114
Natural variant9741R → L.
Corresponds to variant rs10114908 [ dbSNP | Ensembl ].
VAR_059773

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 2, 2004. Version 4.
Checksum: 33D2EF2BFA6A1BD2

FASTA2,297242,676
        10         20         30         40         50         60 
MDGDGGRRDV PGTLMEPGRG AGPAGMAEPR AKAARPGPQR FLRRSVVESD QEEPPGLEAA 

        70         80         90        100        110        120 
EAPGPQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA LVAQPGAPGA PADAGPEPVG 

       130        140        150        160        170        180 
TQEPGPDPIA AAVETAPAPD GGPREEAAAT VRKEDEGAAE AKPEPGRTRR DEPEEEEDDE 

       190        200        210        220        230        240 
DDLKAVATSL DGRFLKFDIE LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK 

       250        260        270        280        290        300 
EEAEMLKGLQ HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS 

       310        320        330        340        350        360 
WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR ASFAKSVIGT 

       370        380        390        400        410        420 
PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ NAAQIYRKVT CGIKPASFEK 

       430        440        450        460        470        480 
VHDPEIKEII GECICKNKEE RYEIKDLLSH AFFAEDTGVR VELAEEDHGR KSTIALRLWV 

       490        500        510        520        530        540 
EDPKKLKGKP KDNGAIEFTF DLEKETPDEV AQEMIESGFF HESDVKIVAK SIRDRVALIQ 

       550        560        570        580        590        600 
WRRERIWPAL QPKEQQDVGS PDKARGPPVP LQVQVTYHAQ AGQPGPPEPE EPEADQHLLP 

       610        620        630        640        650        660 
PTLPTSATSL ASDSTFDSGQ GSTVYSDSQS SQQSVMLGSL ADAAPSPAQC VCSPPVSEGP 

       670        680        690        700        710        720 
VLPQSLPSLG AYQQPTAAPG LPVGSVPAPA CPPSLQQHFP DPAMSFAPVL PPPSTPMPTG 

       730        740        750        760        770        780 
PGQPAPPGQQ PPPLAQPTPL PQVLAPQPVV PLQPVPPHLP PYLAPASQVG APAQLKPLQM 

       790        800        810        820        830        840 
PQAPLQPLAQ VPPQMPPIPV VPPITPLAGI DGLPPALPDL PTATVPPVPP PQYFSPAVIL 

       850        860        870        880        890        900 
PSLAAPLPPA SPALPLQAVK LPHPPGAPLA MPCRTIVPNA PATIPLLAVA PPGVAALSIH 

       910        920        930        940        950        960 
SAVAQLPGQP VYPAAFPQMA PTDVPPSPHH TVQNMRATPP QPALPPQPTL PPQPVLPPQP 

       970        980        990       1000       1010       1020 
TLPPQPVLPP QPTRPPQPVL PPQPMLPPQP VLPPQPALPV RPEPLQPHLP EQAAPAATPG 

      1030       1040       1050       1060       1070       1080 
SQILLGHPAP YAVDVAAQVP TVPVPPAAVL SPPLPEVLLP AAPELLPQFP SSLATVSASV 

      1090       1100       1110       1120       1130       1140 
QSVPTQTATL LPPANPPLPG GPGIASPCPT VQLTVEPVQE EQASQDKPPG LPQSCESYGG 

      1150       1160       1170       1180       1190       1200 
SDVTSGKELS DSCEGAFGGG RLEGRAARKH HRRSTRARSR QERASRPRLT ILNVCNTGDK 

      1210       1220       1230       1240       1250       1260 
MVECQLETHN HKMVTFKFDL DGDAPDEIAT YMVEHDFILQ AERETFIEQM KDVMDKAEDM 

      1270       1280       1290       1300       1310       1320 
LSEDTDADRG SDPGTSPPHL STCGLGTGEE SRQSQANAPV YQQNVLHTGK RWFIICPVAE 

      1330       1340       1350       1360       1370       1380 
HPAPEAPESS PPLPLSSLPP EASQGPCRGL TLPCLPWRRA ACGAVFLSLF SAESAQSKQP 

      1390       1400       1410       1420       1430       1440 
PDSAPYKDQL SSKEQPSFLA SQQLLSQAGP SNPPGAPPAP LAPSSPPVTA LPQDGAAPAT 

      1450       1460       1470       1480       1490       1500 
STMPEPASGT ASQAGGPGTP QGLTSELETS QPLAETHEAP LAVQPLVVGL APCTPAPEAA 

      1510       1520       1530       1540       1550       1560 
STRDASAPRE PLPPPAPEPS PHSGTPQPAL GQPAPLLPAA VGAVSLATSQ LPSPPLGPTV 

      1570       1580       1590       1600       1610       1620 
PPQPPSALES DGEGPPPRVG FVDSTIKSLD EKLRTLLYQE HVPTSSASAG TPVEVGDRDF 

      1630       1640       1650       1660       1670       1680 
TLEPLRGDQP RSEVCGGDLA LPPVPKEAVS GRVQLPQPLV EKSELAPTRG AVMEQGTSSS 

      1690       1700       1710       1720       1730       1740 
MTAESSPRSM LGYDRDGRQV ASDSHVVPSV PQDVPAFVRP ARVEPTDRDG GEAGESSAEP 

      1750       1760       1770       1780       1790       1800 
PPSDMGTVGG QASHPQTLGA RALGSPRKRP EQQDVSSPAK TVGRFSVVST QDEWTLASPH 

      1810       1820       1830       1840       1850       1860 
SLRYSAPPDV YLDEAPSSPD VKLAVRRAQT ASSIEVGVGE PVSSDSGDEG PRARPPVQKQ 

      1870       1880       1890       1900       1910       1920 
ASLPVSGSVA GDFVKKATAF LQRPSRAGSL GPETPSRVGM KVPTISVTSF HSQSSYISSD 

      1930       1940       1950       1960       1970       1980 
NDSELEDADI KKELQSLREK HLKEISELQS QQKQEIEALY RRLGKPLPPN VGFFHTAPPT 

      1990       2000       2010       2020       2030       2040 
GRRRKTSKSK LKAGKLLNPL VRQLKVVASS TGHLADSSRG PPAKDPAQAS VGLTADSTGL 

      2050       2060       2070       2080       2090       2100 
SGKAVQTQQP CSVRASLSSD ICSGLASDGG GARGQGWTVY HPTSERVTYK SSSKPRARFL 

      2110       2120       2130       2140       2150       2160 
SGPVSVSIWS ALKRLCLGKE HSSRSSTSSL APGPEPGPQP ALHVQAQVNN SNNKKGTFTD 

      2170       2180       2190       2200       2210       2220 
DLHKLVDEWT SKTVGAAQLK PTLNQLKQTQ KLQDMEAQAG WAAPGEARAM TAPRAGVGMP 

      2230       2240       2250       2260       2270       2280 
RLPPAPGPLS TTVIPGAAPT LSVPTPDGAL GTARRNQVWF GLRVPPTACC GHSTQPRGGQ 

      2290 
RVGSKTASFA ASDPVRS 

« Hide

Isoform 2 [UniParc].

Checksum: BB5BC60D70A6E6D7
Show »

FASTA2,224234,948
Isoform 3 [UniParc].

Checksum: CC1BEDD3568635CD
Show »

FASTA77984,868
Isoform 4 [UniParc].

Checksum: 8C4E5F1DB7EAD99A
Show »

FASTA2,254238,279

References

« Hide 'large scale' references
[1]"WNK kinases, a novel protein kinase subfamily in multi-cellular organisms."
Verissimo F., Jordan P.
Oncogene 20:5562-5569(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
Tissue: Colon epithelium.
[2]Jordan P.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Molecular basis of T cell-mediated recognition of pancreatic cancer cells."
Ito M., Shichijo S., Tsuda N., Ochi M., Harashima N., Saito N., Itoh K.
Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-845 (ISOFORM 3).
Tissue: Pancreatic cancer.
[5]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-2297 (ISOFORM 2).
Tissue: Brain.
[6]Ohara O., Nagase T., Kikuno R.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1609-2297 (ISOFORM 4).
Tissue: Lung.
[8]"Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2."
Moniz S., Verissimo F., Matos P., Brazao R., Silva E., Kotelevets L., Kotevelets L., Chastre E., Gespach C., Jordan P.
Oncogene 26:6071-6081(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
[9]Erratum
Moniz S., Verissimo F., Matos P., Brazao R., Silva E., Kotelevets L., Kotevelets L., Chastre E., Gespach C., Jordan P.
Oncogene 27:155-155(2008)
[10]"WNK2 modulates MEK1 activity through the Rho GTPase pathway."
Moniz S., Matos P., Jordan P.
Cell. Signal. 20:1762-1768(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1817 AND SER-1818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1817 AND SER-1818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[14]"WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters."
Rinehart J., Vazquez N., Kahle K.T., Hodson C.A., Ring A.M., Gulcicek E.E., Louvi A., Bobadilla N.A., Gamba G., Lifton R.P.
J. Biol. Chem. 286:30171-30180(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION AT SER-45; SER-560; SER-1150; SER-1262; SER-1588; SER-1685; SER-1736; SER-1817; SER-1818; SER-1862 AND SER-2067.
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1862, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ242724 mRNA. Translation: CAB44308.5.
AL390760, AL354991, AL583839 Genomic DNA. Translation: CAH73069.3.
AL390760, AL354991, AL583839 Genomic DNA. Translation: CAH73070.2.
AL583839, AL354991, AL390760 Genomic DNA. Translation: CAI12344.3.
AL583839, AL354991, AL390760 Genomic DNA. Translation: CAI12345.2.
AL354991, AL390760, AL583839 Genomic DNA. Translation: CAI14449.3.
AL354991, AL390760, AL583839 Genomic DNA. Translation: CAI14450.2.
AB044546 mRNA. Translation: BAB18648.1.
AB051547 mRNA. Translation: BAB21851.2.
BC037965 mRNA. Translation: AAH37965.1. Different initiation.
RefSeqNP_001269323.1. NM_001282394.1. [Q9Y3S1-1]
XP_005252197.1. XM_005252140.1. [Q9Y3S1-2]
UniGeneHs.654856.

3D structure databases

ProteinModelPortalQ9Y3S1.
SMRQ9Y3S1. Positions 184-545.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122423. 7 interactions.
IntActQ9Y3S1. 8 interactions.
MINTMINT-7241250.
STRING9606.ENSP00000297954.

Chemistry

BindingDBQ9Y3S1.
ChEMBLCHEMBL5639.
GuidetoPHARMACOLOGY2281.

PTM databases

PhosphoSiteQ9Y3S1.

Polymorphism databases

DMDM41688799.

Proteomic databases

MaxQBQ9Y3S1.
PaxDbQ9Y3S1.
PRIDEQ9Y3S1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297954; ENSP00000297954; ENSG00000165238. [Q9Y3S1-1]
GeneID65268.
KEGGhsa:65268.
UCSCuc004ati.1. human. [Q9Y3S1-1]
uc011lud.1. human. [Q9Y3S1-2]

Organism-specific databases

CTD65268.
GeneCardsGC09P095947.
HGNCHGNC:14542. WNK2.
HPACAB017813.
HPA015555.
HPA016519.
MIM606249. gene.
neXtProtNX_Q9Y3S1.
PharmGKBPA33783.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000139922.
HOVERGENHBG050345.
InParanoidQ9Y3S1.
KOK08867.
OMAVKLPHPP.
PhylomeDBQ9Y3S1.
TreeFamTF315363.

Enzyme and pathway databases

SignaLinkQ9Y3S1.

Gene expression databases

ArrayExpressQ9Y3S1.
BgeeQ9Y3S1.
CleanExHS_WNK2.
GenevestigatorQ9Y3S1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiWNK2.
GenomeRNAi65268.
NextBio67408.
PROQ9Y3S1.
SOURCESearch...

Entry information

Entry nameWNK2_HUMAN
AccessionPrimary (citable) accession number: Q9Y3S1
Secondary accession number(s): Q5VWF1 expand/collapse secondary AC list , Q5VWF2, Q8IY36, Q9C0A3, Q9H3P4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: May 14, 2014
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM