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Protein

Protein dopey-2

Gene

DOPEY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein traffic between late Golgi and early endosomes.By similarity

GO - Biological processi

  • cognition Source: UniProtKB
  • endoplasmic reticulum organization Source: HGNC
  • Golgi to endosome transport Source: HGNC
  • multicellular organism development Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dopey-2
Gene namesi
Name:DOPEY2
Synonyms:C21orf5, KIAA0933
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1291. DOPEY2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25845.

Polymorphism and mutation databases

BioMutaiDOPEY2.
DMDMi311033496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22982298Protein dopey-2PRO_0000190974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei556 – 5561PhosphoserineBy similarity
Modified residuei597 – 5971PhosphoserineBy similarity
Modified residuei1169 – 11691PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3R5.
MaxQBiQ9Y3R5.
PaxDbiQ9Y3R5.
PeptideAtlasiQ9Y3R5.
PRIDEiQ9Y3R5.

PTM databases

iPTMnetiQ9Y3R5.
PhosphoSiteiQ9Y3R5.

Expressioni

Tissue specificityi

Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.2 Publications

Developmental stagei

Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon.2 Publications

Gene expression databases

BgeeiENSG00000142197.
CleanExiHS_DOPEY2.
ExpressionAtlasiQ9Y3R5. baseline and differential.
GenevisibleiQ9Y3R5. HS.

Organism-specific databases

HPAiCAB034922.

Interactioni

Protein-protein interaction databases

BioGridi115302. 4 interactions.
IntActiQ9Y3R5. 1 interaction.
STRINGi9606.ENSP00000382104.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dopey family.Curated

Phylogenomic databases

eggNOGiKOG3613. Eukaryota.
COG5221. LUCA.
GeneTreeiENSGT00390000016421.
HOGENOMiHOG000043862.
HOVERGENiHBG051222.
InParanoidiQ9Y3R5.
OMAiIVAAQMF.
OrthoDBiEOG091G009S.
PhylomeDBiQ9Y3R5.
TreeFamiTF316855.

Family and domain databases

InterProiIPR007249. Dopey_N.
[Graphical view]
PfamiPF04118. Dopey_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3R5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPEEQELLN DYRYRSYSSV IEKALRNFES SSEWADLISS LGKLNKALQS
60 70 80 90 100
NLRYSLLPRR LLISKRLAQC LHPALPSGVH LKALETYEII FKIVGTKWLA
110 120 130 140 150
KDLFLYSCGL FPLLAHAAVS VRPVLLTLYE KYFLPLQKLL LPSLQAFIVG
160 170 180 190 200
LLPGLEEGSE ISDRTDALLL RLSLVVGKEV FYTALWGSVL ASPSIRLPAS
210 220 230 240 250
VFVVGHINRD APGREQKYML GTNHQLTVKS LRASLLDSNV LVQRNNLEIV
260 270 280 290 300
LFFFPFYTCL DSNERAIPLL RSDIVRILSA ATQTLLRRDM SLNRRLYAWL
310 320 330 340 350
LGSDIKGNTV VPESEISNSY EDQSSYFFEK YSKDLLVEGL AEILHQKFID
360 370 380 390 400
ADVEERHHAY LKPFRVLISL LDKPEIGPQV VGNLFLEVIR AFYSYCRDAL
410 420 430 440 450
GSDLKLSYTQ SGNSLISAIK ENRNASEIVK TVNLLITSLS TDFLWDYMTR
460 470 480 490 500
CFEECFRPVK QRYSVRNSVS PPPTVSELCA LLVFLLDVIP LELYSEVQTQ
510 520 530 540 550
YLPQVLGCLV QPLAEDMEAL SLPELTHALK TCFKVLSKVQ MPPSYLDTES
560 570 580 590 600
TSGTSSPVKG ENGKIILETK AVIPGDEDAS FPPLKSEDSG IGLSASSPEL
610 620 630 640 650
SEHLRVPRVS LERDDVWKKG GSMQRTFLCI QELIANFASK NIFGVQLTAS
660 670 680 690 700
GEESKSEEPA GKRDRDGTQS LAANDSSRKN SWEPKPITVP QFKQMLSDLF
710 720 730 740 750
TARGSPFKTK SSESPSSSPS SPARKNGGEW DVEKVVIDLG GSREERREAF
760 770 780 790 800
AAACHLLLDC ATFPVYLSEE ETEQLCATLF QLPGAGDSSF PSWLKSLMTI
810 820 830 840 850
CCCVTDCYLQ NVAISTLLEV INHSQSLALV IEDKMKRYKS SGHNPFFGKL
860 870 880 890 900
QMVTVPPIAP GILKVIAEKT DFYQRVARVL WNQLNKETRE HHVTCVELFY
910 920 930 940 950
RLHCLAPTAN ICEDIICHAL LDPDKGTRLE ALFRFSVIWH LTREIQGSRV
960 970 980 990 1000
TSHNRSFDRS LFVVLDSLAC TDGAIGAAAQ GWLVRALSLG DVARILEPVL
1010 1020 1030 1040 1050
LLLLQPKTQR TSIHCLKQEN SADDLHRWFN RKKTSFREAC AVPEPQESGS
1060 1070 1080 1090 1100
EEHLPLSQFT TVDREAIWAE VEKEPEKYPL RGELSEEELP YYVELPDRTA
1110 1120 1130 1140 1150
HGAPDSSEHT ESADTSSCHT DSENTSSFSS PSHDLQELSN EENCCAPIPM
1160 1170 1180 1190 1200
GGRAYPKRSA LLAAFQSESF KAGAKLSLVR VDSDKTQASE SFSSDEEADL
1210 1220 1230 1240 1250
ELQALTTSRL LKQQRERQEA VEALFKHILL YLQPYDSRRV LYAFSVLEAV
1260 1270 1280 1290 1300
LKTNPKEFIE AVSRTSMDTS STAHLNLISN LLARHQEALI GQSFYGKLQT
1310 1320 1330 1340 1350
QVPNVCPHSL LLELLTYLCL SFLRSYYPCY LKVSHRDILG NRDVQVKSVE
1360 1370 1380 1390 1400
VLIRIMMQLV SVAKSSEGKN VEFIHSLLQR CKVQEFVLLS LSASMYTSQK
1410 1420 1430 1440 1450
RYGLATAHHG RALPEDSLFE ESLINLGQDQ IWSEHPLQIE LLKLLQVLIV
1460 1470 1480 1490 1500
LEHHLGRAHE EAENQPDLSR EWQRALNFQQ AISALQYVQP HPLTSQGLLV
1510 1520 1530 1540 1550
SAVVRGLQPA YGYGMHPAWV SLVTHSLPYF GKSLGWTVTP FVVQICKNLD
1560 1570 1580 1590 1600
DLVKQYESES VKLSVSTTSK RENISPDYPL TLLEGLTTIS HFCLLEQANQ
1610 1620 1630 1640 1650
NKKTMAAGDP ANLRNARNAI LEELPRTVNT MALLWNVLRK EETQKRPVDL
1660 1670 1680 1690 1700
LGATKGSSSV YFKTTKTIRQ KILDFLNPLT AHLGVQLTAA VAAVWSRKKA
1710 1720 1730 1740 1750
QRHSKMKIIP TASASQLTLV DLVCALSTLQ TDTLLHLVKE VVKRPPQVKG
1760 1770 1780 1790 1800
GDEKSPLVDI PVLQFCYAFL QRLPVPALQE NFSSLLGVLK ESVQLNLAPP
1810 1820 1830 1840 1850
GYFLLLSMLN DFVTRTPNLE NKKDQKDLQE ITQKILEAVG NIAGSSLEQT
1860 1870 1880 1890 1900
SWLSRNLEVK AQPQASLEES DAEEDLYDAA AASAMVSSSA PSVYSVQALS
1910 1920 1930 1940 1950
LLAEVLASLL DMVYRSDEKE KAVPLISRLL YYVFPYLRNH SAYNAPSFRA
1960 1970 1980 1990 2000
GAQLLSSLSG YAYTKRAWRK EVLELFLDPA FFQMDTSCVH WKSIIDHLLT
2010 2020 2030 2040 2050
HEKTMFKDLM NMQSSSLKLF SSFEQKAMLL KRQAFAVFSG ELDQYHLYLP
2060 2070 2080 2090 2100
LIQERLTDNL RVGQTSIVAA QMFLFFRVLL LRISPQHLTS LWPIMVSELI
2110 2120 2130 2140 2150
QTFTQLEEDL KDEDESLRST NKVNRTKVSV PDANGPSVGE IPQSELILYL
2160 2170 2180 2190 2200
SACKFLDTAL SFPPDKMPLF QIYRWAFIPE VDTEGPAFLS DVEENHQECK
2210 2220 2230 2240 2250
PHTVRILELL KLKFGEISSS DEITMKSEFP LLRQHSVSSI RQLMPFFMTL
2260 2270 2280 2290
NGAFKTQRQL PADSPGTPFL DFPVTDSPRI LKQLEECIEY DFLEHPEC
Length:2,298
Mass (Da):258,230
Last modified:November 2, 2010 - v5
Checksum:iED317E61F297B8C3
GO
Isoform 2 (identifier: Q9Y3R5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1871-1877: Missing.

Note: No experimental confirmation available.
Show »
Length:2,291
Mass (Da):257,394
Checksum:i4AE8459927485707
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti498 – 4981Q → H in CAB41415 (PubMed:10950924).Curated
Sequence conflicti1318 – 13181L → P in CAB41415 (PubMed:10950924).Curated
Sequence conflicti1886 – 18861V → A in CAB41415 (PubMed:10950924).Curated
Sequence conflicti1974 – 19741E → G in CAB41415 (PubMed:10950924).Curated
Sequence conflicti2154 – 21541K → R in CAB41415 (PubMed:10950924).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1021 – 10211S → W.
Corresponds to variant rs7278340 [ dbSNP | Ensembl ].
VAR_034688
Natural varianti1118 – 11181C → G.1 Publication
Corresponds to variant rs4817788 [ dbSNP | Ensembl ].
VAR_027939
Natural varianti1149 – 11491P → H.1 Publication
Corresponds to variant rs3746866 [ dbSNP | Ensembl ].
VAR_027940
Natural varianti1217 – 12171R → S.
Corresponds to variant rs3746867 [ dbSNP | Ensembl ].
VAR_027941
Natural varianti2139 – 21391G → E.1 Publication
Corresponds to variant rs3827183 [ dbSNP | Ensembl ].
VAR_027942

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1871 – 18777Missing in isoform 2. 1 PublicationVSP_027387

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237839 mRNA. Translation: CAB41415.1.
AP000692
, AP000689, AP000690, AP000691 Genomic DNA. Translation: BAA89431.1.
AP001725 Genomic DNA. Translation: BAA95548.1.
AB023150 mRNA. Translation: BAA76777.2.
CH471079 Genomic DNA. Translation: EAX09743.1.
CH471079 Genomic DNA. Translation: EAX09744.1.
BC012791 mRNA. Translation: AAH12791.1.
CCDSiCCDS13643.1. [Q9Y3R5-1]
RefSeqiNP_001307643.1. NM_001320714.1. [Q9Y3R5-1]
NP_005119.2. NM_005128.3. [Q9Y3R5-1]
UniGeneiHs.204575.

Genome annotation databases

EnsembliENST00000399151; ENSP00000382104; ENSG00000142197. [Q9Y3R5-1]
GeneIDi9980.
KEGGihsa:9980.
UCSCiuc002yvg.4. human. [Q9Y3R5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237839 mRNA. Translation: CAB41415.1.
AP000692
, AP000689, AP000690, AP000691 Genomic DNA. Translation: BAA89431.1.
AP001725 Genomic DNA. Translation: BAA95548.1.
AB023150 mRNA. Translation: BAA76777.2.
CH471079 Genomic DNA. Translation: EAX09743.1.
CH471079 Genomic DNA. Translation: EAX09744.1.
BC012791 mRNA. Translation: AAH12791.1.
CCDSiCCDS13643.1. [Q9Y3R5-1]
RefSeqiNP_001307643.1. NM_001320714.1. [Q9Y3R5-1]
NP_005119.2. NM_005128.3. [Q9Y3R5-1]
UniGeneiHs.204575.

3D structure databases

ProteinModelPortaliQ9Y3R5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115302. 4 interactions.
IntActiQ9Y3R5. 1 interaction.
STRINGi9606.ENSP00000382104.

PTM databases

iPTMnetiQ9Y3R5.
PhosphoSiteiQ9Y3R5.

Polymorphism and mutation databases

BioMutaiDOPEY2.
DMDMi311033496.

Proteomic databases

EPDiQ9Y3R5.
MaxQBiQ9Y3R5.
PaxDbiQ9Y3R5.
PeptideAtlasiQ9Y3R5.
PRIDEiQ9Y3R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399151; ENSP00000382104; ENSG00000142197. [Q9Y3R5-1]
GeneIDi9980.
KEGGihsa:9980.
UCSCiuc002yvg.4. human. [Q9Y3R5-1]

Organism-specific databases

CTDi9980.
GeneCardsiDOPEY2.
HGNCiHGNC:1291. DOPEY2.
HPAiCAB034922.
MIMi604803. gene.
neXtProtiNX_Q9Y3R5.
PharmGKBiPA25845.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3613. Eukaryota.
COG5221. LUCA.
GeneTreeiENSGT00390000016421.
HOGENOMiHOG000043862.
HOVERGENiHBG051222.
InParanoidiQ9Y3R5.
OMAiIVAAQMF.
OrthoDBiEOG091G009S.
PhylomeDBiQ9Y3R5.
TreeFamiTF316855.

Miscellaneous databases

ChiTaRSiDOPEY2. human.
GeneWikiiDOPEY2.
GenomeRNAii9980.
PROiQ9Y3R5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142197.
CleanExiHS_DOPEY2.
ExpressionAtlasiQ9Y3R5. baseline and differential.
GenevisibleiQ9Y3R5. HS.

Family and domain databases

InterProiIPR007249. Dopey_N.
[Graphical view]
PfamiPF04118. Dopey_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3R5
Secondary accession number(s): D3DSG5, Q6PJQ7, Q9UEZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 126 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.