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Q9Y3Q7

- ADA18_HUMAN

UniProt

Q9Y3Q7 - ADA18_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 18

Gene

ADAM18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein By similarity.By similarity

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. metallopeptidase activity Source: ProtInc
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Protein family/group databases

    MEROPSiM12.957.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 18
    Short name:
    ADAM 18
    Alternative name(s):
    Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
    Short name:
    tMDC III
    Gene namesi
    Name:ADAM18
    Synonyms:TMDC3
    ORF Names:UNQ858/PRO1867
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:196. ADAM18.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 184168Sequence AnalysisPRO_0000029096Add
    BLAST
    Chaini185 – 739555Disintegrin and metalloproteinase domain-containing protein 18PRO_0000029097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi293 ↔ 376By similarity
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi335 ↔ 360By similarity
    Disulfide bondi337 ↔ 342By similarity
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi450 ↔ 471By similarity
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi611 – 6111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 636By similarity
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 642By similarity
    Disulfide bondi644 ↔ 653By similarity

    Post-translational modificationi

    The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y3Q7.
    PRIDEiQ9Y3Q7.

    PTM databases

    PhosphoSiteiQ9Y3Q7.

    Expressioni

    Tissue specificityi

    Expressed specifically in testis.

    Gene expression databases

    ArrayExpressiQ9Y3Q7.
    BgeeiQ9Y3Q7.
    CleanExiHS_ADAM18.
    GenevestigatoriQ9Y3Q7.

    Organism-specific databases

    HPAiHPA027605.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3Q7.
    SMRiQ9Y3Q7. Positions 184-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini177 – 687511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini709 – 73931CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei688 – 70821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini184 – 381198Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini390 – 47990DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini620 – 65435EGF-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi480 – 622143Cys-richAdd
    BLAST

    Domaini

    A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.By similarity

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329803.
    HOGENOMiHOG000230883.
    HOVERGENiHBG103628.
    InParanoidiQ9Y3Q7.
    KOiK16909.
    OMAiDYMGSEM.
    OrthoDBiEOG7W1537.
    PhylomeDBiQ9Y3Q7.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y3Q7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFLLLALLTE LGRLQAHEGS EGIFLHVTVP RKIKSNDSEV SERKMIYIIT    50
    IDGQPYTLHL GKQSFLPQNF LVYTYNETGS LHSVSPYFMM HCHYQGYAAE 100
    FPNSFVTLSI CSGLRGFLQF ENISYGIEPV ESSARFEHII YQMKNNDPNV 150
    SILAVNYSHI WQKDQPYKVP LNSQIKNLSK LLPQYLEIYI IVEKALYDYM 200
    GSEMMAVTQK IVQVIGLVNT MFTQFKLTVI LSSLELWSNE NQISTSGDAD 250
    DILQRFLAWK RDYLILRPHD IAYLLVYRKH PKYVGATFPG TVCNKSYDAG 300
    IAMYPDAIGL EGFSVIIAQL LGLNVGLTYD DITQCFCLRA TCIMNHEAVS 350
    ASGRKIFSNC SMHDYRYFVS KFETKCLQKL SNLQPLHQNQ PVCGNGILES 400
    NEECDCGNKN ECQFKKCCDY NTCKLKGSVK CGSGPCCTSK CELSIAGTPC 450
    RKSIDPECDF TEYCNGTSSN CVPDTYALNG RLCKLGTAYC YNGQCQTTDN 500
    QCAKIFGKGA QGAPFACFKE VNSLHERSEN CGFKNSQPLP CERKDVLCGK 550
    LACVQPHKNA NKSDAQSTVY SYIQDHVCVS IATGSSMRSD GTDNAYVADG 600
    TMCGPEMYCV NKTCRKVHLM GYNCNATTKC KGKGICNNFG NCQCFPGHRP 650
    PDCKFQFGSP GGSIDDGNFQ KSGDFYTEKG YNTHWNNWFI LSFCIFLPFF 700
    IVFTTVIFKR NEISKSCNRE NAEYNRNSSV VSESDDVGH 739
    Length:739
    Mass (Da):82,856
    Last modified:November 1, 1999 - v1
    Checksum:i2D8BE9A975072CDD
    GO
    Isoform 2 (identifier: Q9Y3Q7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         197-220: Missing.

    Show »
    Length:715
    Mass (Da):80,183
    Checksum:iEF8EB71EBA6AB9DB
    GO
    Isoform 3 (identifier: Q9Y3Q7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         175-182: IKNLSKLL → VTVIILML
         183-739: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:182
    Mass (Da):20,853
    Checksum:i8B524D83BC944C8B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701P → S in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066312
    Natural varianti212 – 2121V → F.
    Corresponds to variant rs10093794 [ dbSNP | Ensembl ].
    VAR_051588
    Natural varianti284 – 2841V → G in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066313
    Natural varianti344 – 3441M → I in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066314
    Natural varianti362 – 3621M → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066315
    Natural varianti536 – 5361S → L in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066316

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei175 – 1828IKNLSKLL → VTVIILML in isoform 3. 1 PublicationVSP_043285
    Alternative sequencei183 – 739557Missing in isoform 3. 1 PublicationVSP_043286Add
    BLAST
    Alternative sequencei197 – 22024Missing in isoform 2. 1 PublicationVSP_012033Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133004 mRNA. Translation: CAB40812.1.
    AY358321 mRNA. Translation: AAQ88687.1.
    AK313961 mRNA. Translation: BAG36677.1.
    AC109633 Genomic DNA. No translation available.
    AC136365 Genomic DNA. No translation available.
    BC034624 mRNA. Translation: AAH34624.1.
    BC070279 mRNA. Translation: AAH70279.1.
    BC121045 mRNA. Translation: AAI21046.1.
    CCDSiCCDS55225.1. [Q9Y3Q7-3]
    CCDS6113.1. [Q9Y3Q7-1]
    RefSeqiNP_001177885.1. NM_001190956.1. [Q9Y3Q7-3]
    NP_055052.1. NM_014237.2. [Q9Y3Q7-1]
    UniGeneiHs.127930.

    Genome annotation databases

    EnsembliENST00000265707; ENSP00000265707; ENSG00000168619. [Q9Y3Q7-1]
    ENST00000379866; ENSP00000369195; ENSG00000168619. [Q9Y3Q7-2]
    ENST00000520772; ENSP00000429908; ENSG00000168619. [Q9Y3Q7-3]
    GeneIDi8749.
    KEGGihsa:8749.
    UCSCiuc003xnh.3. human. [Q9Y3Q7-3]
    uc003xni.3. human. [Q9Y3Q7-1]
    uc010lwx.3. human. [Q9Y3Q7-2]

    Polymorphism databases

    DMDMi20137582.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133004 mRNA. Translation: CAB40812.1 .
    AY358321 mRNA. Translation: AAQ88687.1 .
    AK313961 mRNA. Translation: BAG36677.1 .
    AC109633 Genomic DNA. No translation available.
    AC136365 Genomic DNA. No translation available.
    BC034624 mRNA. Translation: AAH34624.1 .
    BC070279 mRNA. Translation: AAH70279.1 .
    BC121045 mRNA. Translation: AAI21046.1 .
    CCDSi CCDS55225.1. [Q9Y3Q7-3 ]
    CCDS6113.1. [Q9Y3Q7-1 ]
    RefSeqi NP_001177885.1. NM_001190956.1. [Q9Y3Q7-3 ]
    NP_055052.1. NM_014237.2. [Q9Y3Q7-1 ]
    UniGenei Hs.127930.

    3D structure databases

    ProteinModelPortali Q9Y3Q7.
    SMRi Q9Y3Q7. Positions 184-657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265707.

    Protein family/group databases

    MEROPSi M12.957.

    PTM databases

    PhosphoSitei Q9Y3Q7.

    Polymorphism databases

    DMDMi 20137582.

    Proteomic databases

    PaxDbi Q9Y3Q7.
    PRIDEi Q9Y3Q7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265707 ; ENSP00000265707 ; ENSG00000168619 . [Q9Y3Q7-1 ]
    ENST00000379866 ; ENSP00000369195 ; ENSG00000168619 . [Q9Y3Q7-2 ]
    ENST00000520772 ; ENSP00000429908 ; ENSG00000168619 . [Q9Y3Q7-3 ]
    GeneIDi 8749.
    KEGGi hsa:8749.
    UCSCi uc003xnh.3. human. [Q9Y3Q7-3 ]
    uc003xni.3. human. [Q9Y3Q7-1 ]
    uc010lwx.3. human. [Q9Y3Q7-2 ]

    Organism-specific databases

    CTDi 8749.
    GeneCardsi GC08P039459.
    HGNCi HGNC:196. ADAM18.
    HPAi HPA027605.
    neXtProti NX_Q9Y3Q7.
    PharmGKBi PA24513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329803.
    HOGENOMi HOG000230883.
    HOVERGENi HBG103628.
    InParanoidi Q9Y3Q7.
    KOi K16909.
    OMAi DYMGSEM.
    OrthoDBi EOG7W1537.
    PhylomeDBi Q9Y3Q7.
    TreeFami TF314733.

    Miscellaneous databases

    ChiTaRSi ADAM18. human.
    GeneWikii ADAM18.
    GenomeRNAii 8749.
    NextBioi 32825.
    PROi Q9Y3Q7.

    Gene expression databases

    ArrayExpressi Q9Y3Q7.
    Bgeei Q9Y3Q7.
    CleanExi HS_ADAM18.
    Genevestigatori Q9Y3Q7.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the human tMDC III sperm surface protein transcript."
      Hall L., Frayne J., Dimsey E.A.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
      Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-170; GLY-284; ILE-344; LYS-362 AND LEU-536.

    Entry informationi

    Entry nameiADA18_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3Q7
    Secondary accession number(s): B2R9Y0
    , Q0VAI4, Q6IRW9, Q6UXJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3