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Protein

Olfactory receptor 2W1

Gene

OR2W1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124732-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2W1
Alternative name(s):
Hs6M1-15
Olfactory receptor OR6-13
Gene namesi
Name:OR2W1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8281. OR2W1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 320CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26692.
OpenTargetsiENSG00000204704.
ENSG00000206525.
ENSG00000226463.
ENSG00000227639.
ENSG00000228652.
ENSG00000228977.
ENSG00000229328.
ENSG00000234101.
PharmGKBiPA32214.

Polymorphism and mutation databases

BioMutaiOR2W1.
DMDMi14423828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505111 – 320Olfactory receptor 2W1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y3N9.
PeptideAtlasiQ9Y3N9.
PRIDEiQ9Y3N9.

PTM databases

iPTMnetiQ9Y3N9.
PhosphoSitePlusiQ9Y3N9.

Expressioni

Gene expression databases

BgeeiENSG00000204704.
CleanExiHS_OR2W1.
ExpressionAtlasiQ9Y3N9. baseline and differential.
GenevisibleiQ9Y3N9. HS.

Interactioni

Protein-protein interaction databases

BioGridi117792. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVP3. Eukaryota.
ENOG4111D99. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Y3N9.
KOiK04257.
OMAiLNLPTCG.
OrthoDBiEOG091G0CI3.
PhylomeDBiQ9Y3N9.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL
60 70 80 90 100
LDSQLHTPMY FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ
110 120 130 140 150
LYVYMWLGSV ECLLLAVMSY DRFTAICKPL HYFVVMNPHL CLKMIIMIWS
160 170 180 190 200
ISLANSVVLC TLTLNLPTCG NNILDHFLCE LPALVKIACV DTTTVEMSVF
210 220 230 240 250
ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT CGSHLTVVSM
260 270 280 290 300
FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA
310 320
LKKLMRFHHK STKIKRNCKS
Length:320
Mass (Da):36,101
Last modified:November 1, 1999 - v1
Checksum:i7A8ECD33F443E1D0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01095381M → V in allele 6M1-15*03. 1 PublicationCorresponds to variant rs34892006dbSNPEnsembl.1
Natural variantiVAR_010954296D → N in allele 6M1-15*02. 1 PublicationCorresponds to variant rs35771565dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302594 Genomic DNA. Translation: CAC20514.1.
AJ302595 Genomic DNA. Translation: CAC20515.1.
AJ302596 Genomic DNA. Translation: CAC20516.1.
AJ302597 Genomic DNA. Translation: CAC20517.1.
AJ302598 Genomic DNA. Translation: CAC20518.1.
AJ302599 Genomic DNA. Translation: CAC20519.1.
AJ302600 Genomic DNA. Translation: CAC20520.1.
AJ302601 Genomic DNA. Translation: CAC20521.1.
AJ302602 Genomic DNA. Translation: CAC20522.1.
AJ302603 Genomic DNA. Translation: CAC20523.1.
AL035402 Genomic DNA. Translation: CAB42853.1.
AL662791 Genomic DNA. Translation: CAI18243.1.
AL662865 Genomic DNA. Translation: CAI41643.1.
AL929561 Genomic DNA. Translation: CAI41768.2.
BX248413 Genomic DNA. Translation: CAM26052.1.
CR759957 Genomic DNA. Translation: CAQ07349.1.
BX927167 Genomic DNA. Translation: CAQ07643.1.
CR936923 Genomic DNA. Translation: CAQ07834.1.
CR759835 Genomic DNA. Translation: CAQ08425.1.
CH471081 Genomic DNA. Translation: EAX03181.1.
BC103870 mRNA. Translation: AAI03871.1.
BC103871 mRNA. Translation: AAI03872.1.
BC103872 mRNA. Translation: AAI03873.1.
AF399628 Genomic DNA. Translation: AAK95113.1.
BK004522 Genomic DNA. Translation: DAA04920.1.
CCDSiCCDS4656.1.
RefSeqiNP_112165.1. NM_030903.3.
UniGeneiHs.553526.

Genome annotation databases

EnsembliENST00000377175; ENSP00000366380; ENSG00000204704.
ENST00000383654; ENSP00000373150; ENSG00000206525.
ENST00000411447; ENSP00000388144; ENSG00000227639.
ENST00000420540; ENSP00000392635; ENSG00000228977.
ENST00000421027; ENSP00000412537; ENSG00000226463.
ENST00000421766; ENSP00000389825; ENSG00000234101.
ENST00000439723; ENSP00000401866; ENSG00000228652.
ENST00000446776; ENSP00000405025; ENSG00000229328.
GeneIDi26692.
KEGGihsa:26692.
UCSCiuc003nlw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302594 Genomic DNA. Translation: CAC20514.1.
AJ302595 Genomic DNA. Translation: CAC20515.1.
AJ302596 Genomic DNA. Translation: CAC20516.1.
AJ302597 Genomic DNA. Translation: CAC20517.1.
AJ302598 Genomic DNA. Translation: CAC20518.1.
AJ302599 Genomic DNA. Translation: CAC20519.1.
AJ302600 Genomic DNA. Translation: CAC20520.1.
AJ302601 Genomic DNA. Translation: CAC20521.1.
AJ302602 Genomic DNA. Translation: CAC20522.1.
AJ302603 Genomic DNA. Translation: CAC20523.1.
AL035402 Genomic DNA. Translation: CAB42853.1.
AL662791 Genomic DNA. Translation: CAI18243.1.
AL662865 Genomic DNA. Translation: CAI41643.1.
AL929561 Genomic DNA. Translation: CAI41768.2.
BX248413 Genomic DNA. Translation: CAM26052.1.
CR759957 Genomic DNA. Translation: CAQ07349.1.
BX927167 Genomic DNA. Translation: CAQ07643.1.
CR936923 Genomic DNA. Translation: CAQ07834.1.
CR759835 Genomic DNA. Translation: CAQ08425.1.
CH471081 Genomic DNA. Translation: EAX03181.1.
BC103870 mRNA. Translation: AAI03871.1.
BC103871 mRNA. Translation: AAI03872.1.
BC103872 mRNA. Translation: AAI03873.1.
AF399628 Genomic DNA. Translation: AAK95113.1.
BK004522 Genomic DNA. Translation: DAA04920.1.
CCDSiCCDS4656.1.
RefSeqiNP_112165.1. NM_030903.3.
UniGeneiHs.553526.

3D structure databases

ProteinModelPortaliQ9Y3N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117792. 1 interactor.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y3N9.
PhosphoSitePlusiQ9Y3N9.

Polymorphism and mutation databases

BioMutaiOR2W1.
DMDMi14423828.

Proteomic databases

PaxDbiQ9Y3N9.
PeptideAtlasiQ9Y3N9.
PRIDEiQ9Y3N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377175; ENSP00000366380; ENSG00000204704.
ENST00000383654; ENSP00000373150; ENSG00000206525.
ENST00000411447; ENSP00000388144; ENSG00000227639.
ENST00000420540; ENSP00000392635; ENSG00000228977.
ENST00000421027; ENSP00000412537; ENSG00000226463.
ENST00000421766; ENSP00000389825; ENSG00000234101.
ENST00000439723; ENSP00000401866; ENSG00000228652.
ENST00000446776; ENSP00000405025; ENSG00000229328.
GeneIDi26692.
KEGGihsa:26692.
UCSCiuc003nlw.3. human.

Organism-specific databases

CTDi26692.
DisGeNETi26692.
GeneCardsiOR2W1.
HGNCiHGNC:8281. OR2W1.
neXtProtiNX_Q9Y3N9.
OpenTargetsiENSG00000204704.
ENSG00000206525.
ENSG00000226463.
ENSG00000227639.
ENSG00000228652.
ENSG00000228977.
ENSG00000229328.
ENSG00000234101.
PharmGKBiPA32214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVP3. Eukaryota.
ENOG4111D99. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Y3N9.
KOiK04257.
OMAiLNLPTCG.
OrthoDBiEOG091G0CI3.
PhylomeDBiQ9Y3N9.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124732-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2W1.
GenomeRNAii26692.
PROiQ9Y3N9.

Gene expression databases

BgeeiENSG00000204704.
CleanExiHS_OR2W1.
ExpressionAtlasiQ9Y3N9. baseline and differential.
GenevisibleiQ9Y3N9. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2W1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3N9
Secondary accession number(s): B0S7Y5
, Q5JNZ1, Q6IEU0, Q96R17, Q9GZL0, Q9GZL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.