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Q9Y3N9

- OR2W1_HUMAN

UniProt

Q9Y3N9 - OR2W1_HUMAN

Protein

Olfactory receptor 2W1

Gene

OR2W1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2W1
    Alternative name(s):
    Hs6M1-15
    Olfactory receptor OR6-13
    Gene namesi
    Name:OR2W1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8281. OR2W1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32214.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Olfactory receptor 2W1PRO_0000150511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y3N9.
    PRIDEiQ9Y3N9.

    PTM databases

    PhosphoSiteiQ9Y3N9.

    Expressioni

    Gene expression databases

    BgeeiQ9Y3N9.
    CleanExiHS_OR2W1.
    GenevestigatoriQ9Y3N9.

    Interactioni

    Protein-protein interaction databases

    BioGridi117792. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3N9.
    SMRiQ9Y3N9. Positions 21-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 32028CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150761.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ9Y3N9.
    KOiK04257.
    OMAiLNLPTCG.
    OrthoDBiEOG78SQJ9.
    PhylomeDBiQ9Y3N9.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3N9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL    50
    LDSQLHTPMY FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ 100
    LYVYMWLGSV ECLLLAVMSY DRFTAICKPL HYFVVMNPHL CLKMIIMIWS 150
    ISLANSVVLC TLTLNLPTCG NNILDHFLCE LPALVKIACV DTTTVEMSVF 200
    ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT CGSHLTVVSM 250
    FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 300
    LKKLMRFHHK STKIKRNCKS 320
    Length:320
    Mass (Da):36,101
    Last modified:November 1, 1999 - v1
    Checksum:i7A8ECD33F443E1D0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811M → V in allele 6M1-15*03. 1 Publication
    Corresponds to variant rs34892006 [ dbSNP | Ensembl ].
    VAR_010953
    Natural varianti296 – 2961D → N in allele 6M1-15*02. 1 Publication
    Corresponds to variant rs35771565 [ dbSNP | Ensembl ].
    VAR_010954

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302594 Genomic DNA. Translation: CAC20514.1.
    AJ302595 Genomic DNA. Translation: CAC20515.1.
    AJ302596 Genomic DNA. Translation: CAC20516.1.
    AJ302597 Genomic DNA. Translation: CAC20517.1.
    AJ302598 Genomic DNA. Translation: CAC20518.1.
    AJ302599 Genomic DNA. Translation: CAC20519.1.
    AJ302600 Genomic DNA. Translation: CAC20520.1.
    AJ302601 Genomic DNA. Translation: CAC20521.1.
    AJ302602 Genomic DNA. Translation: CAC20522.1.
    AJ302603 Genomic DNA. Translation: CAC20523.1.
    AL035402 Genomic DNA. Translation: CAB42853.1.
    AL662791 Genomic DNA. Translation: CAI18243.1.
    AL662865 Genomic DNA. Translation: CAI41643.1.
    AL929561 Genomic DNA. Translation: CAI41768.2.
    BX248413 Genomic DNA. Translation: CAM26052.1.
    CR759957 Genomic DNA. Translation: CAQ07349.1.
    BX927167 Genomic DNA. Translation: CAQ07643.1.
    CR936923 Genomic DNA. Translation: CAQ07834.1.
    CR759835 Genomic DNA. Translation: CAQ08425.1.
    CH471081 Genomic DNA. Translation: EAX03181.1.
    BC103870 mRNA. Translation: AAI03871.1.
    BC103871 mRNA. Translation: AAI03872.1.
    BC103872 mRNA. Translation: AAI03873.1.
    AF399628 Genomic DNA. Translation: AAK95113.1.
    BK004522 Genomic DNA. Translation: DAA04920.1.
    CCDSiCCDS4656.1.
    RefSeqiNP_112165.1. NM_030903.3.
    UniGeneiHs.553526.

    Genome annotation databases

    EnsembliENST00000377175; ENSP00000366380; ENSG00000204704.
    ENST00000383654; ENSP00000373150; ENSG00000206525.
    ENST00000411447; ENSP00000388144; ENSG00000227639.
    ENST00000420540; ENSP00000392635; ENSG00000228977.
    ENST00000421027; ENSP00000412537; ENSG00000226463.
    ENST00000421766; ENSP00000389825; ENSG00000234101.
    ENST00000439723; ENSP00000401866; ENSG00000228652.
    ENST00000446776; ENSP00000405025; ENSG00000229328.
    GeneIDi26692.
    KEGGihsa:26692.
    UCSCiuc003nlw.2. human.

    Polymorphism databases

    DMDMi14423828.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ302594 Genomic DNA. Translation: CAC20514.1 .
    AJ302595 Genomic DNA. Translation: CAC20515.1 .
    AJ302596 Genomic DNA. Translation: CAC20516.1 .
    AJ302597 Genomic DNA. Translation: CAC20517.1 .
    AJ302598 Genomic DNA. Translation: CAC20518.1 .
    AJ302599 Genomic DNA. Translation: CAC20519.1 .
    AJ302600 Genomic DNA. Translation: CAC20520.1 .
    AJ302601 Genomic DNA. Translation: CAC20521.1 .
    AJ302602 Genomic DNA. Translation: CAC20522.1 .
    AJ302603 Genomic DNA. Translation: CAC20523.1 .
    AL035402 Genomic DNA. Translation: CAB42853.1 .
    AL662791 Genomic DNA. Translation: CAI18243.1 .
    AL662865 Genomic DNA. Translation: CAI41643.1 .
    AL929561 Genomic DNA. Translation: CAI41768.2 .
    BX248413 Genomic DNA. Translation: CAM26052.1 .
    CR759957 Genomic DNA. Translation: CAQ07349.1 .
    BX927167 Genomic DNA. Translation: CAQ07643.1 .
    CR936923 Genomic DNA. Translation: CAQ07834.1 .
    CR759835 Genomic DNA. Translation: CAQ08425.1 .
    CH471081 Genomic DNA. Translation: EAX03181.1 .
    BC103870 mRNA. Translation: AAI03871.1 .
    BC103871 mRNA. Translation: AAI03872.1 .
    BC103872 mRNA. Translation: AAI03873.1 .
    AF399628 Genomic DNA. Translation: AAK95113.1 .
    BK004522 Genomic DNA. Translation: DAA04920.1 .
    CCDSi CCDS4656.1.
    RefSeqi NP_112165.1. NM_030903.3.
    UniGenei Hs.553526.

    3D structure databases

    ProteinModelPortali Q9Y3N9.
    SMRi Q9Y3N9. Positions 21-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117792. 1 interaction.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Y3N9.

    Polymorphism databases

    DMDMi 14423828.

    Proteomic databases

    PaxDbi Q9Y3N9.
    PRIDEi Q9Y3N9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377175 ; ENSP00000366380 ; ENSG00000204704 .
    ENST00000383654 ; ENSP00000373150 ; ENSG00000206525 .
    ENST00000411447 ; ENSP00000388144 ; ENSG00000227639 .
    ENST00000420540 ; ENSP00000392635 ; ENSG00000228977 .
    ENST00000421027 ; ENSP00000412537 ; ENSG00000226463 .
    ENST00000421766 ; ENSP00000389825 ; ENSG00000234101 .
    ENST00000439723 ; ENSP00000401866 ; ENSG00000228652 .
    ENST00000446776 ; ENSP00000405025 ; ENSG00000229328 .
    GeneIDi 26692.
    KEGGi hsa:26692.
    UCSCi uc003nlw.2. human.

    Organism-specific databases

    CTDi 26692.
    GeneCardsi GC06M029011.
    GC06Mi29012.
    GC06Mj29008.
    GC06Mk29012.
    GC06Ml29011.
    GC06Mm29012.
    GC06Mn29011.
    GC06Mo29012.
    HGNCi HGNC:8281. OR2W1.
    neXtProti NX_Q9Y3N9.
    PharmGKBi PA32214.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150761.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q9Y3N9.
    KOi K04257.
    OMAi LNLPTCG.
    OrthoDBi EOG78SQJ9.
    PhylomeDBi Q9Y3N9.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2W1.
    GenomeRNAii 26692.
    NextBioi 49059.
    PROi Q9Y3N9.

    Gene expression databases

    Bgeei Q9Y3N9.
    CleanExi HS_OR2W1.
    Genevestigatori Q9Y3N9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
      Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
      (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-81 AND ASN-296.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2W1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3N9
    Secondary accession number(s): B0S7Y5
    , Q5JNZ1, Q6IEU0, Q96R17, Q9GZL0, Q9GZL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3