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Q9Y3N9 (OR2W1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2W1
Alternative name(s):
Hs6M1-15
Olfactory receptor OR6-13
Gene names
Name:OR2W1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Olfactory receptor 2W1
PRO_0000150511

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 32028Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant811M → V in allele 6M1-15*03. Ref.1
Corresponds to variant rs34892006 [ dbSNP | Ensembl ].
VAR_010953
Natural variant2961D → N in allele 6M1-15*02. Ref.1
Corresponds to variant rs35771565 [ dbSNP | Ensembl ].
VAR_010954

Sequences

Sequence LengthMass (Da)Tools
Q9Y3N9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7A8ECD33F443E1D0

FASTA32036,101
        10         20         30         40         50         60 
MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL LDSQLHTPMY 

        70         80         90        100        110        120 
FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ LYVYMWLGSV ECLLLAVMSY 

       130        140        150        160        170        180 
DRFTAICKPL HYFVVMNPHL CLKMIIMIWS ISLANSVVLC TLTLNLPTCG NNILDHFLCE 

       190        200        210        220        230        240 
LPALVKIACV DTTTVEMSVF ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT 

       250        260        270        280        290        300 
CGSHLTVVSM FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 

       310        320 
LKKLMRFHHK STKIKRNCKS 

« Hide

References

« Hide 'large scale' references
[1]"Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
(In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-81 AND ASN-296.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ302594 Genomic DNA. Translation: CAC20514.1.
AJ302595 Genomic DNA. Translation: CAC20515.1.
AJ302596 Genomic DNA. Translation: CAC20516.1.
AJ302597 Genomic DNA. Translation: CAC20517.1.
AJ302598 Genomic DNA. Translation: CAC20518.1.
AJ302599 Genomic DNA. Translation: CAC20519.1.
AJ302600 Genomic DNA. Translation: CAC20520.1.
AJ302601 Genomic DNA. Translation: CAC20521.1.
AJ302602 Genomic DNA. Translation: CAC20522.1.
AJ302603 Genomic DNA. Translation: CAC20523.1.
AL035402 Genomic DNA. Translation: CAB42853.1.
AL662791 Genomic DNA. Translation: CAI18243.1.
AL662865 Genomic DNA. Translation: CAI41643.1.
AL929561 Genomic DNA. Translation: CAI41768.2.
BX248413 Genomic DNA. Translation: CAM26052.1.
CR759957 Genomic DNA. Translation: CAQ07349.1.
BX927167 Genomic DNA. Translation: CAQ07643.1.
CR936923 Genomic DNA. Translation: CAQ07834.1.
CR759835 Genomic DNA. Translation: CAQ08425.1.
CH471081 Genomic DNA. Translation: EAX03181.1.
BC103870 mRNA. Translation: AAI03871.1.
BC103871 mRNA. Translation: AAI03872.1.
BC103872 mRNA. Translation: AAI03873.1.
AF399628 Genomic DNA. Translation: AAK95113.1.
BK004522 Genomic DNA. Translation: DAA04920.1.
CCDSCCDS4656.1.
RefSeqNP_112165.1. NM_030903.3.
UniGeneHs.553526.

3D structure databases

ProteinModelPortalQ9Y3N9.
SMRQ9Y3N9. Positions 21-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117792. 1 interaction.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Y3N9.

Polymorphism databases

DMDM14423828.

Proteomic databases

PaxDbQ9Y3N9.
PRIDEQ9Y3N9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377175; ENSP00000366380; ENSG00000204704.
ENST00000383654; ENSP00000373150; ENSG00000206525.
ENST00000411447; ENSP00000388144; ENSG00000227639.
ENST00000420540; ENSP00000392635; ENSG00000228977.
ENST00000421027; ENSP00000412537; ENSG00000226463.
ENST00000421766; ENSP00000389825; ENSG00000234101.
ENST00000439723; ENSP00000401866; ENSG00000228652.
ENST00000446776; ENSP00000405025; ENSG00000229328.
GeneID26692.
KEGGhsa:26692.
UCSCuc003nlw.2. human.

Organism-specific databases

CTD26692.
GeneCardsGC06M029011.
GC06Mi29012.
GC06Mj29008.
GC06Mk29012.
GC06Ml29011.
GC06Mm29012.
GC06Mn29011.
GC06Mo29012.
HGNCHGNC:8281. OR2W1.
neXtProtNX_Q9Y3N9.
PharmGKBPA32214.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150761.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ9Y3N9.
KOK04257.
OMALNLPTCG.
OrthoDBEOG78SQJ9.
PhylomeDBQ9Y3N9.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9Y3N9.
CleanExHS_OR2W1.
GenevestigatorQ9Y3N9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2W1.
GenomeRNAi26692.
NextBio49059.
PROQ9Y3N9.

Entry information

Entry nameOR2W1_HUMAN
AccessionPrimary (citable) accession number: Q9Y3N9
Secondary accession number(s): B0S7Y5 expand/collapse secondary AC list , Q5JNZ1, Q6IEU0, Q96R17, Q9GZL0, Q9GZL1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries