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Q9Y3N9

- OR2W1_HUMAN

UniProt

Q9Y3N9 - OR2W1_HUMAN

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Protein
Olfactory receptor 2W1
Gene
OR2W1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2W1
Alternative name(s):
Hs6M1-15
Olfactory receptor OR6-13
Gene namesi
Name:OR2W1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8281. OR2W1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 10021Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini159 – 19537Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27213Extracellular Reviewed prediction
Add
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 32028Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 2W1
PRO_0000150511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y3N9.
PRIDEiQ9Y3N9.

PTM databases

PhosphoSiteiQ9Y3N9.

Expressioni

Gene expression databases

BgeeiQ9Y3N9.
CleanExiHS_OR2W1.
GenevestigatoriQ9Y3N9.

Interactioni

Protein-protein interaction databases

BioGridi117792. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3N9.
SMRiQ9Y3N9. Positions 21-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150761.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ9Y3N9.
KOiK04257.
OMAiLNLPTCG.
OrthoDBiEOG78SQJ9.
PhylomeDBiQ9Y3N9.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3N9-1 [UniParc]FASTAAdd to Basket

« Hide

MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL    50
LDSQLHTPMY FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ 100
LYVYMWLGSV ECLLLAVMSY DRFTAICKPL HYFVVMNPHL CLKMIIMIWS 150
ISLANSVVLC TLTLNLPTCG NNILDHFLCE LPALVKIACV DTTTVEMSVF 200
ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT CGSHLTVVSM 250
FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 300
LKKLMRFHHK STKIKRNCKS 320
Length:320
Mass (Da):36,101
Last modified:November 1, 1999 - v1
Checksum:i7A8ECD33F443E1D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811M → V in allele 6M1-15*03. 1 Publication
Corresponds to variant rs34892006 [ dbSNP | Ensembl ].
VAR_010953
Natural varianti296 – 2961D → N in allele 6M1-15*02. 1 Publication
Corresponds to variant rs35771565 [ dbSNP | Ensembl ].
VAR_010954

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302594 Genomic DNA. Translation: CAC20514.1.
AJ302595 Genomic DNA. Translation: CAC20515.1.
AJ302596 Genomic DNA. Translation: CAC20516.1.
AJ302597 Genomic DNA. Translation: CAC20517.1.
AJ302598 Genomic DNA. Translation: CAC20518.1.
AJ302599 Genomic DNA. Translation: CAC20519.1.
AJ302600 Genomic DNA. Translation: CAC20520.1.
AJ302601 Genomic DNA. Translation: CAC20521.1.
AJ302602 Genomic DNA. Translation: CAC20522.1.
AJ302603 Genomic DNA. Translation: CAC20523.1.
AL035402 Genomic DNA. Translation: CAB42853.1.
AL662791 Genomic DNA. Translation: CAI18243.1.
AL662865 Genomic DNA. Translation: CAI41643.1.
AL929561 Genomic DNA. Translation: CAI41768.2.
BX248413 Genomic DNA. Translation: CAM26052.1.
CR759957 Genomic DNA. Translation: CAQ07349.1.
BX927167 Genomic DNA. Translation: CAQ07643.1.
CR936923 Genomic DNA. Translation: CAQ07834.1.
CR759835 Genomic DNA. Translation: CAQ08425.1.
CH471081 Genomic DNA. Translation: EAX03181.1.
BC103870 mRNA. Translation: AAI03871.1.
BC103871 mRNA. Translation: AAI03872.1.
BC103872 mRNA. Translation: AAI03873.1.
AF399628 Genomic DNA. Translation: AAK95113.1.
BK004522 Genomic DNA. Translation: DAA04920.1.
CCDSiCCDS4656.1.
RefSeqiNP_112165.1. NM_030903.3.
UniGeneiHs.553526.

Genome annotation databases

EnsembliENST00000377175; ENSP00000366380; ENSG00000204704.
ENST00000383654; ENSP00000373150; ENSG00000206525.
ENST00000411447; ENSP00000388144; ENSG00000227639.
ENST00000420540; ENSP00000392635; ENSG00000228977.
ENST00000421027; ENSP00000412537; ENSG00000226463.
ENST00000421766; ENSP00000389825; ENSG00000234101.
ENST00000439723; ENSP00000401866; ENSG00000228652.
ENST00000446776; ENSP00000405025; ENSG00000229328.
GeneIDi26692.
KEGGihsa:26692.
UCSCiuc003nlw.2. human.

Polymorphism databases

DMDMi14423828.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ302594 Genomic DNA. Translation: CAC20514.1 .
AJ302595 Genomic DNA. Translation: CAC20515.1 .
AJ302596 Genomic DNA. Translation: CAC20516.1 .
AJ302597 Genomic DNA. Translation: CAC20517.1 .
AJ302598 Genomic DNA. Translation: CAC20518.1 .
AJ302599 Genomic DNA. Translation: CAC20519.1 .
AJ302600 Genomic DNA. Translation: CAC20520.1 .
AJ302601 Genomic DNA. Translation: CAC20521.1 .
AJ302602 Genomic DNA. Translation: CAC20522.1 .
AJ302603 Genomic DNA. Translation: CAC20523.1 .
AL035402 Genomic DNA. Translation: CAB42853.1 .
AL662791 Genomic DNA. Translation: CAI18243.1 .
AL662865 Genomic DNA. Translation: CAI41643.1 .
AL929561 Genomic DNA. Translation: CAI41768.2 .
BX248413 Genomic DNA. Translation: CAM26052.1 .
CR759957 Genomic DNA. Translation: CAQ07349.1 .
BX927167 Genomic DNA. Translation: CAQ07643.1 .
CR936923 Genomic DNA. Translation: CAQ07834.1 .
CR759835 Genomic DNA. Translation: CAQ08425.1 .
CH471081 Genomic DNA. Translation: EAX03181.1 .
BC103870 mRNA. Translation: AAI03871.1 .
BC103871 mRNA. Translation: AAI03872.1 .
BC103872 mRNA. Translation: AAI03873.1 .
AF399628 Genomic DNA. Translation: AAK95113.1 .
BK004522 Genomic DNA. Translation: DAA04920.1 .
CCDSi CCDS4656.1.
RefSeqi NP_112165.1. NM_030903.3.
UniGenei Hs.553526.

3D structure databases

ProteinModelPortali Q9Y3N9.
SMRi Q9Y3N9. Positions 21-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117792. 1 interaction.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9Y3N9.

Polymorphism databases

DMDMi 14423828.

Proteomic databases

PaxDbi Q9Y3N9.
PRIDEi Q9Y3N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377175 ; ENSP00000366380 ; ENSG00000204704 .
ENST00000383654 ; ENSP00000373150 ; ENSG00000206525 .
ENST00000411447 ; ENSP00000388144 ; ENSG00000227639 .
ENST00000420540 ; ENSP00000392635 ; ENSG00000228977 .
ENST00000421027 ; ENSP00000412537 ; ENSG00000226463 .
ENST00000421766 ; ENSP00000389825 ; ENSG00000234101 .
ENST00000439723 ; ENSP00000401866 ; ENSG00000228652 .
ENST00000446776 ; ENSP00000405025 ; ENSG00000229328 .
GeneIDi 26692.
KEGGi hsa:26692.
UCSCi uc003nlw.2. human.

Organism-specific databases

CTDi 26692.
GeneCardsi GC06M029011.
GC06Mi29012.
GC06Mj29008.
GC06Mk29012.
GC06Ml29011.
GC06Mm29012.
GC06Mn29011.
GC06Mo29012.
HGNCi HGNC:8281. OR2W1.
neXtProti NX_Q9Y3N9.
PharmGKBi PA32214.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150761.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q9Y3N9.
KOi K04257.
OMAi LNLPTCG.
OrthoDBi EOG78SQJ9.
PhylomeDBi Q9Y3N9.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2W1.
GenomeRNAii 26692.
NextBioi 49059.
PROi Q9Y3N9.

Gene expression databases

Bgeei Q9Y3N9.
CleanExi HS_OR2W1.
Genevestigatori Q9Y3N9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes."
    Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B., Volz A., Younger R., Beck S.
    (In) Kasahara M. (eds.); Major histocompatibility complex-evolution, structure, and function, pp.110-130, Springer-Verlag, Tokyo (2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-81 AND ASN-296.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2W1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3N9
Secondary accession number(s): B0S7Y5
, Q5JNZ1, Q6IEU0, Q96R17, Q9GZL0, Q9GZL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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