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Protein

StAR-related lipid transfer protein 13

Gene

STARD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.2 Publications

GO - Molecular functioni

GO - Biological processi

  • endothelial cell migration Source: MGI
  • endothelial tube lumen extension Source: MGI
  • negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 13
Alternative name(s):
46H23.2
Deleted in liver cancer 2 protein
Short name:
DLC-2
Rho GTPase-activating protein
START domain-containing protein 13
Short name:
StARD13
Gene namesi
Name:STARD13
Synonyms:DLC2, GT650
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133121.20
HGNCiHGNC:19164 STARD13
MIMi609866 gene
neXtProtiNX_Q9Y3M8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi699R → A: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi736K → E: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi740R → E: Loss of RhoGAP activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi90627
OpenTargetsiENSG00000133121
PharmGKBiPA38806

Polymorphism and mutation databases

BioMutaiSTARD13
DMDMi90185285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206791 – 1113StAR-related lipid transfer protein 13Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei411PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y3M8
PaxDbiQ9Y3M8
PeptideAtlasiQ9Y3M8
PRIDEiQ9Y3M8

PTM databases

iPTMnetiQ9Y3M8
PhosphoSitePlusiQ9Y3M8

Expressioni

Tissue specificityi

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000133121
ExpressionAtlasiQ9Y3M8 baseline and differential
GenevisibleiQ9Y3M8 HS

Organism-specific databases

HPAiHPA039535
HPA058867

Interactioni

Subunit structurei

Homodimer. Interacts with TAX1BP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TAX1BP1Q86VP12EBI-465487,EBI-529518

Protein-protein interaction databases

BioGridi12474438 interactors.
IntActiQ9Y3M8 37 interactors.
MINTiQ9Y3M8
STRINGi9606.ENSP00000338785

Structurei

Secondary structure

11113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 69Combined sources14
Helixi73 – 77Combined sources5
Turni78 – 82Combined sources5
Helixi88 – 92Combined sources5
Helixi100 – 102Combined sources3
Helixi103 – 117Combined sources15
Helixi913 – 924Combined sources12
Beta strandi929 – 931Combined sources3
Beta strandi934 – 936Combined sources3
Beta strandi938 – 942Combined sources5
Beta strandi952 – 961Combined sources10
Helixi963 – 972Combined sources10
Helixi974 – 976Combined sources3
Beta strandi985 – 991Combined sources7
Beta strandi994 – 1001Combined sources8
Beta strandi1004 – 1006Combined sources3
Beta strandi1010 – 1020Combined sources11
Helixi1023 – 1025Combined sources3
Beta strandi1027 – 1033Combined sources7
Beta strandi1043 – 1046Combined sources4
Beta strandi1049 – 1058Combined sources10
Beta strandi1064 – 1072Combined sources9
Beta strandi1075 – 1077Combined sources3
Turni1079 – 1084Combined sources6
Helixi1085 – 1099Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H80NMR-A56-120[»]
2JW2NMR-A56-120[»]
2PSOX-ray2.80A/B/C903-1113[»]
ProteinModelPortaliQ9Y3M8
SMRiQ9Y3M8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3M8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 122SAMAdd BLAST68
Domaini663 – 868Rho-GAPPROSITE-ProRule annotationAdd BLAST206
Domaini899 – 1107STARTPROSITE-ProRule annotationAdd BLAST209

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00760000119123
HOVERGENiHBG055955
InParanoidiQ9Y3M8
KOiK20632
OMAiDEDFVQW
OrthoDBiEOG091G00OE
PhylomeDBiQ9Y3M8
TreeFamiTF314044

Family and domain databases

Gene3Di1.10.555.101 hit
3.30.530.201 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3M8-1) [UniParc]FASTAAdd to basket
Also known as: DLC2alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSQVPRTPA SGCYYLNSMT PEGQEMYLRF DQTTRRSPYR MSRILARHQL
60 70 80 90 100
VTKIQQEIEA KEACDWLRAA GFPQYAQLYE DSQFPINIVA VKNDHDFLEK
110 120 130 140 150
DLVEPLCRRL NTLNKCASMK LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS
160 170 180 190 200
RRWSRVDDLY TLLPRGDRNG SPGGTGMRNT TSSESVLTDL SEPEVCSIHS
210 220 230 240 250
ESSGGSDSRS QPGQCCTDNP VMLDAPLVSS SLPQPPRDVL NHPFHPKNEK
260 270 280 290 300
PTRARAKSFL KRMETLRGKG AHGRHKGSGR TGGLVISGPM LQQEPESFKA
310 320 330 340 350
MQCIQIPNGD LQNSPPPACR KGLPCSGKSS GESSPSEHSS SGVSTPCLKE
360 370 380 390 400
RKCHEANKRG GMYLEDLDVL AGTALPDAGD QSRMHEFHSQ ENLVVHIPKD
410 420 430 440 450
HKPGTFPKAL SIESLSPTDS SNGVNWRTGS ISLGREQVPG AREPRLMASC
460 470 480 490 500
HRASRVSIYD NVPGSHLYAS TGDLLDLEKD DLFPHLDDIL QHVNGLQEVV
510 520 530 540 550
DDWSKDVLPE LQTHDTLVGE PGLSTFPSPN QITLDFEGNS VSEGRTTPSD
560 570 580 590 600
VERDVTSLNE SEPPGVRDRR DSGVGASLTR PNRRLRWNSF QLSHQPRPAP
610 620 630 640 650
ASPHISSQTA SQLSLLQRFS LLRLTAIMEK HSMSNKHGWT WSVPKFMKRM
660 670 680 690 700
KVPDYKDKAV FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK
710 720 730 740 750
SGVKSRIHAL RQMNENFPEN VNYEDQSAYD VADMVKQFFR DLPEPLFTNK
760 770 780 790 800
LSETFLHIYQ YVSKEQRLQA VQAAILLLAD ENREVLQTLL CFLNDVVNLV
810 820 830 840 850
EENQMTPMNL AVCLAPSLFH LNLLKKESSP RVIQKKYATG KPDQKDLNEN
860 870 880 890 900
LAAAQGLAHM IMECDRLFEV PHELVAQSRN SYVEAEIHVP TLEELGTQLE
910 920 930 940 950
ESGATFHTYL NHLIQGLQKE AKEKFKGWVT CSSTDNTDLA FKKVGDGNPL
960 970 980 990 1000
KLWKASVEVE APPSVVLNRV LRERHLWDED FVQWKVVETL DRQTEIYQYV
1010 1020 1030 1040 1050
LNSMAPHPSR DFVVLRTWKT DLPKGMCTLV SLSVEHEEAQ LLGGVRAVVM
1060 1070 1080 1090 1100
DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE WYSKGFGHLC AAEVARIRNS
1110
FQPLIAEGPE TKI
Length:1,113
Mass (Da):124,967
Last modified:March 7, 2006 - v2
Checksum:i314F809C23E6E1E4
GO
Isoform 2 (identifier: Q9Y3M8-2) [UniParc]FASTAAdd to basket
Also known as: DLC2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR

Show »
Length:1,105
Mass (Da):123,893
Checksum:iC447ADE6F7AAF9D8
GO
Isoform 3 (identifier: Q9Y3M8-3) [UniParc]FASTAAdd to basket
Also known as: DLC2gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:995
Mass (Da):111,192
Checksum:i3F608FA94A4EF8BF
GO
Isoform 4 (identifier: Q9Y3M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MSTGTQPKTKVLSDKRPKERV

Show »
Length:1,078
Mass (Da):120,684
Checksum:i1B108966B3EDC44D
GO
Isoform 5 (identifier: Q9Y3M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR
     695-695: V → E
     696-1113: Missing.

Show »
Length:687
Mass (Da):76,367
Checksum:i4E1B65EA0FDCB836
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → R in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti397I → V in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti1097I → T in AAQ72791 (PubMed:14697242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037494175T → M. Corresponds to variant dbSNP:rs9568878Ensembl.1
Natural variantiVAR_022098250K → R. Corresponds to variant dbSNP:rs3742321Ensembl.1
Natural variantiVAR_037495383R → P. Corresponds to variant dbSNP:rs34425674Ensembl.1
Natural variantiVAR_037496798N → S. Corresponds to variant dbSNP:rs35144435Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173531 – 118Missing in isoform 3. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0173541 – 56MFSQV…TKIQQ → MLEPSSVLHANVNQAPLWCL VLRWCRECKDTVCGGKQKSR VNHTFQRR in isoform 2 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_0173551 – 56MFSQV…TKIQQ → MSTGTQPKTKVLSDKRPKER V in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_017356695V → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_017357696 – 1113Missing in isoform 5. 1 PublicationAdd BLAST418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082589 mRNA Translation: AAL91648.1
AY366448 mRNA Translation: AAQ72791.1
AY082590 mRNA Translation: AAL91649.1
AY082591 mRNA Translation: AAL91650.1
AL049801 mRNA Translation: CAB42562.1
BX647695 mRNA Translation: CAI46026.1
Z84483 Genomic DNA Translation: CAC94774.1
AL627232, AL139187 Genomic DNA Translation: CAM17900.1
AL139187, AL627232 Genomic DNA Translation: CAM23625.1
AL139187 Genomic DNA Translation: CAM23626.1
BC046563 mRNA Translation: AAH46563.1
CCDSiCCDS9348.1 [Q9Y3M8-1]
CCDS9349.1 [Q9Y3M8-2]
CCDS9350.1 [Q9Y3M8-3]
PIRiH59432
RefSeqiNP_001230395.1, NM_001243466.1 [Q9Y3M8-5]
NP_001230403.1, NM_001243474.1
NP_001230405.1, NM_001243476.2
NP_443083.1, NM_052851.2 [Q9Y3M8-3]
NP_821074.1, NM_178006.3 [Q9Y3M8-1]
NP_821075.1, NM_178007.2 [Q9Y3M8-2]
UniGeneiHs.156551
Hs.507704
Hs.721224

Genome annotation databases

EnsembliENST00000255486; ENSP00000255486; ENSG00000133121 [Q9Y3M8-2]
ENST00000336934; ENSP00000338785; ENSG00000133121 [Q9Y3M8-1]
ENST00000399365; ENSP00000382300; ENSG00000133121 [Q9Y3M8-3]
GeneIDi90627
KEGGihsa:90627
UCSCiuc001uuu.4 human [Q9Y3M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTA13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3M8
Secondary accession number(s): A2A309
, A2A310, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome