Q9Y3M8 (STA13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 13

Alternative name(s):
46H23.2
Deleted in liver cancer 2 protein
Short name=DLC-2
Rho GTPase-activating protein
START domain-containing protein 13
Short name=StARD13

Gene names

Name:	STARD13
Synonyms:	DLC2, GT650

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Ref.2 Ref.3
Subunit structure	Homodimer. Interacts with TAX1BP1. Ref.2 Ref.9
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet Ref.3 Ref.8.
Tissue specificity	Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines. Ref.1 Ref.2
Sequence similarities	Contains 1 Rho-GAP domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 START domain.

Ontologies

Keywords
Cellular component	Cytoplasm Lipid droplet Membrane Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome lipid particle Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TAX1BP1	Q86VP1	2	EBI-465487,EBI-529518

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y3M8-1)

Also known as: DLC2alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y3M8-2)

Also known as: DLC2beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR

Isoform 3 (identifier: Q9Y3M8-3)

Also known as: DLC2gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Isoform 4 (identifier: Q9Y3M8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MSTGTQPKTKVLSDKRPKERV

Isoform 5 (identifier: Q9Y3M8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR
     695-695: V → E
     696-1113: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1113

1113

StAR-related lipid transfer protein 13

PRO_0000220679

Regions

Domain

55 – 122

68

SAM

Domain

663 – 868

206

Rho-GAP

Domain

899 – 1107

209

START

Amino acid modifications

Modified residue

133

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 118

118

Missing in isoform 3.

VSP_017353

Alternative sequence

1 – 56

56

MFSQV…TKIQQ → MLEPSSVLHANVNQAPLWCL VLRWCRECKDTVCGGKQKSR VNHTFQRR in isoform 2 and isoform 5.

VSP_017354

Alternative sequence

1 – 56

56

MFSQV…TKIQQ → MSTGTQPKTKVLSDKRPKER V in isoform 4.

VSP_017355

Alternative sequence

695

1

V → E in isoform 5.

VSP_017356

Alternative sequence

696 – 1113

418

Missing in isoform 5.

VSP_017357

Natural variant

175

1

T → M.
Corresponds to variant rs9568878 [ dbSNP | Ensembl ].

VAR_037494

Natural variant

250

1

K → R.
Corresponds to variant rs3742321 [ dbSNP | Ensembl ].

VAR_022098

Natural variant

383

1

R → P.
Corresponds to variant rs34425674 [ dbSNP | Ensembl ].

VAR_037495

Natural variant

798

1

N → S.
Corresponds to variant rs35144435 [ dbSNP | Ensembl ].

VAR_037496

Experimental info

Mutagenesis

699

1

R → A: Loss of RhoGAP activity. Ref.1

Mutagenesis

736

1

K → E: Loss of RhoGAP activity. Ref.3

Mutagenesis

740

1

R → E: Loss of RhoGAP activity. Ref.3

Sequence conflict

143

1

K → R in AAQ72791. Ref.2

Sequence conflict

397

1

I → V in AAQ72791. Ref.2

Sequence conflict

1097

1

I → T in AAQ72791. Ref.2

Secondary structure

1

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1113

Helix Strand Turn

Details...

Helix

56 – 69

14

Helix

73 – 77

5

Turn

78 – 82

5

Helix

88 – 92

5

Helix

100 – 102

3

Helix

103 – 117

15

Helix

913 – 924

12

Beta strand

929 – 931

3

Beta strand

934 – 936

3

Beta strand

938 – 942

5

Beta strand

952 – 961

10

Helix

963 – 972

10

Helix

974 – 976

3

Beta strand

985 – 991

7

Beta strand

994 – 1001

8

Beta strand

1004 – 1006

3

Beta strand

1010 – 1020

11

Helix

1023 – 1025

3

Beta strand

1027 – 1033

7

Beta strand

1043 – 1046

4

Beta strand

1049 – 1058

10

Beta strand

1064 – 1072

9

Beta strand

1075 – 1077

3

Turn

1079 – 1084

6

Helix

1085 – 1099

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (DLC2alpha) [UniParc]. Last modified March 7, 2006. Version 2. Checksum: 314F809C23E6E1E4	FASTA	1,113	124,967
	10 20 30 40 50 60 MFSQVPRTPA SGCYYLNSMT PEGQEMYLRF DQTTRRSPYR MSRILARHQL VTKIQQEIEA 70 80 90 100 110 120 KEACDWLRAA GFPQYAQLYE DSQFPINIVA VKNDHDFLEK DLVEPLCRRL NTLNKCASMK 130 140 150 160 170 180 LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS RRWSRVDDLY TLLPRGDRNG SPGGTGMRNT 190 200 210 220 230 240 TSSESVLTDL SEPEVCSIHS ESSGGSDSRS QPGQCCTDNP VMLDAPLVSS SLPQPPRDVL 250 260 270 280 290 300 NHPFHPKNEK PTRARAKSFL KRMETLRGKG AHGRHKGSGR TGGLVISGPM LQQEPESFKA 310 320 330 340 350 360 MQCIQIPNGD LQNSPPPACR KGLPCSGKSS GESSPSEHSS SGVSTPCLKE RKCHEANKRG 370 380 390 400 410 420 GMYLEDLDVL AGTALPDAGD QSRMHEFHSQ ENLVVHIPKD HKPGTFPKAL SIESLSPTDS 430 440 450 460 470 480 SNGVNWRTGS ISLGREQVPG AREPRLMASC HRASRVSIYD NVPGSHLYAS TGDLLDLEKD 490 500 510 520 530 540 DLFPHLDDIL QHVNGLQEVV DDWSKDVLPE LQTHDTLVGE PGLSTFPSPN QITLDFEGNS 550 560 570 580 590 600 VSEGRTTPSD VERDVTSLNE SEPPGVRDRR DSGVGASLTR PNRRLRWNSF QLSHQPRPAP 610 620 630 640 650 660 ASPHISSQTA SQLSLLQRFS LLRLTAIMEK HSMSNKHGWT WSVPKFMKRM KVPDYKDKAV 670 680 690 700 710 720 FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK SGVKSRIHAL RQMNENFPEN 730 740 750 760 770 780 VNYEDQSAYD VADMVKQFFR DLPEPLFTNK LSETFLHIYQ YVSKEQRLQA VQAAILLLAD 790 800 810 820 830 840 ENREVLQTLL CFLNDVVNLV EENQMTPMNL AVCLAPSLFH LNLLKKESSP RVIQKKYATG 850 860 870 880 890 900 KPDQKDLNEN LAAAQGLAHM IMECDRLFEV PHELVAQSRN SYVEAEIHVP TLEELGTQLE 910 920 930 940 950 960 ESGATFHTYL NHLIQGLQKE AKEKFKGWVT CSSTDNTDLA FKKVGDGNPL KLWKASVEVE 970 980 990 1000 1010 1020 APPSVVLNRV LRERHLWDED FVQWKVVETL DRQTEIYQYV LNSMAPHPSR DFVVLRTWKT 1030 1040 1050 1060 1070 1080 DLPKGMCTLV SLSVEHEEAQ LLGGVRAVVM DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE 1090 1100 1110 WYSKGFGHLC AAEVARIRNS FQPLIAEGPE TKI
	Isoform 2 (DLC2beta) [UniParc]. Checksum: C447ADE6F7AAF9D8	FASTA	1,105	123,893
	10 20 30 40 50 60 MLEPSSVLHA NVNQAPLWCL VLRWCRECKD TVCGGKQKSR VNHTFQRREI EAKEACDWLR 70 80 90 100 110 120 AAGFPQYAQL YEDSQFPINI VAVKNDHDFL EKDLVEPLCR RLNTLNKCAS MKLDVNFQRK 130 140 150 160 170 180 KGDDSDEEDL CISNKWTFQR TSRRWSRVDD LYTLLPRGDR NGSPGGTGMR NTTSSESVLT 190 200 210 220 230 240 DLSEPEVCSI HSESSGGSDS RSQPGQCCTD NPVMLDAPLV SSSLPQPPRD VLNHPFHPKN 250 260 270 280 290 300 EKPTRARAKS FLKRMETLRG KGAHGRHKGS GRTGGLVISG PMLQQEPESF KAMQCIQIPN 310 320 330 340 350 360 GDLQNSPPPA CRKGLPCSGK SSGESSPSEH SSSGVSTPCL KERKCHEANK RGGMYLEDLD 370 380 390 400 410 420 VLAGTALPDA GDQSRMHEFH SQENLVVHIP KDHKPGTFPK ALSIESLSPT DSSNGVNWRT 430 440 450 460 470 480 GSISLGREQV PGAREPRLMA SCHRASRVSI YDNVPGSHLY ASTGDLLDLE KDDLFPHLDD 490 500 510 520 530 540 ILQHVNGLQE VVDDWSKDVL PELQTHDTLV GEPGLSTFPS PNQITLDFEG NSVSEGRTTP 550 560 570 580 590 600 SDVERDVTSL NESEPPGVRD RRDSGVGASL TRPNRRLRWN SFQLSHQPRP APASPHISSQ 610 620 630 640 650 660 TASQLSLLQR FSLLRLTAIM EKHSMSNKHG WTWSVPKFMK RMKVPDYKDK AVFGVPLIVH 670 680 690 700 710 720 VQRTGQPLPQ SIQQALRYLR SNCLDQVGLF RKSGVKSRIH ALRQMNENFP ENVNYEDQSA 730 740 750 760 770 780 YDVADMVKQF FRDLPEPLFT NKLSETFLHI YQYVSKEQRL QAVQAAILLL ADENREVLQT 790 800 810 820 830 840 LLCFLNDVVN LVEENQMTPM NLAVCLAPSL FHLNLLKKES SPRVIQKKYA TGKPDQKDLN 850 860 870 880 890 900 ENLAAAQGLA HMIMECDRLF EVPHELVAQS RNSYVEAEIH VPTLEELGTQ LEESGATFHT 910 920 930 940 950 960 YLNHLIQGLQ KEAKEKFKGW VTCSSTDNTD LAFKKVGDGN PLKLWKASVE VEAPPSVVLN 970 980 990 1000 1010 1020 RVLRERHLWD EDFVQWKVVE TLDRQTEIYQ YVLNSMAPHP SRDFVVLRTW KTDLPKGMCT 1030 1040 1050 1060 1070 1080 LVSLSVEHEE AQLLGGVRAV VMDSQYLIEP CGSGKSRLTH ICRIDLKGHS PEWYSKGFGH 1090 1100 LCAAEVARIR NSFQPLIAEG PETKI
	Isoform 3 (DLC2gamma) [UniParc]. Checksum: 3F608FA94A4EF8BF	FASTA	995	111,192
	10 20 30 40 50 60 MKLDVNFQRK KGDDSDEEDL CISNKWTFQR TSRRWSRVDD LYTLLPRGDR NGSPGGTGMR 70 80 90 100 110 120 NTTSSESVLT DLSEPEVCSI HSESSGGSDS RSQPGQCCTD NPVMLDAPLV SSSLPQPPRD 130 140 150 160 170 180 VLNHPFHPKN EKPTRARAKS FLKRMETLRG KGAHGRHKGS GRTGGLVISG PMLQQEPESF 190 200 210 220 230 240 KAMQCIQIPN GDLQNSPPPA CRKGLPCSGK SSGESSPSEH SSSGVSTPCL KERKCHEANK 250 260 270 280 290 300 RGGMYLEDLD VLAGTALPDA GDQSRMHEFH SQENLVVHIP KDHKPGTFPK ALSIESLSPT 310 320 330 340 350 360 DSSNGVNWRT GSISLGREQV PGAREPRLMA SCHRASRVSI YDNVPGSHLY ASTGDLLDLE 370 380 390 400 410 420 KDDLFPHLDD ILQHVNGLQE VVDDWSKDVL PELQTHDTLV GEPGLSTFPS PNQITLDFEG 430 440 450 460 470 480 NSVSEGRTTP SDVERDVTSL NESEPPGVRD RRDSGVGASL TRPNRRLRWN SFQLSHQPRP 490 500 510 520 530 540 APASPHISSQ TASQLSLLQR FSLLRLTAIM EKHSMSNKHG WTWSVPKFMK RMKVPDYKDK 550 560 570 580 590 600 AVFGVPLIVH VQRTGQPLPQ SIQQALRYLR SNCLDQVGLF RKSGVKSRIH ALRQMNENFP 610 620 630 640 650 660 ENVNYEDQSA YDVADMVKQF FRDLPEPLFT NKLSETFLHI YQYVSKEQRL QAVQAAILLL 670 680 690 700 710 720 ADENREVLQT LLCFLNDVVN LVEENQMTPM NLAVCLAPSL FHLNLLKKES SPRVIQKKYA 730 740 750 760 770 780 TGKPDQKDLN ENLAAAQGLA HMIMECDRLF EVPHELVAQS RNSYVEAEIH VPTLEELGTQ 790 800 810 820 830 840 LEESGATFHT YLNHLIQGLQ KEAKEKFKGW VTCSSTDNTD LAFKKVGDGN PLKLWKASVE 850 860 870 880 890 900 VEAPPSVVLN RVLRERHLWD EDFVQWKVVE TLDRQTEIYQ YVLNSMAPHP SRDFVVLRTW 910 920 930 940 950 960 KTDLPKGMCT LVSLSVEHEE AQLLGGVRAV VMDSQYLIEP CGSGKSRLTH ICRIDLKGHS 970 980 990 PEWYSKGFGH LCAAEVARIR NSFQPLIAEG PETKI
	Isoform 4 [UniParc]. Checksum: 1B108966B3EDC44D	FASTA	1,078	120,684
	10 20 30 40 50 60 MSTGTQPKTK VLSDKRPKER VEIEAKEACD WLRAAGFPQY AQLYEDSQFP INIVAVKNDH 70 80 90 100 110 120 DFLEKDLVEP LCRRLNTLNK CASMKLDVNF QRKKGDDSDE EDLCISNKWT FQRTSRRWSR 130 140 150 160 170 180 VDDLYTLLPR GDRNGSPGGT GMRNTTSSES VLTDLSEPEV CSIHSESSGG SDSRSQPGQC 190 200 210 220 230 240 CTDNPVMLDA PLVSSSLPQP PRDVLNHPFH PKNEKPTRAR AKSFLKRMET LRGKGAHGRH 250 260 270 280 290 300 KGSGRTGGLV ISGPMLQQEP ESFKAMQCIQ IPNGDLQNSP PPACRKGLPC SGKSSGESSP 310 320 330 340 350 360 SEHSSSGVST PCLKERKCHE ANKRGGMYLE DLDVLAGTAL PDAGDQSRMH EFHSQENLVV 370 380 390 400 410 420 HIPKDHKPGT FPKALSIESL SPTDSSNGVN WRTGSISLGR EQVPGAREPR LMASCHRASR 430 440 450 460 470 480 VSIYDNVPGS HLYASTGDLL DLEKDDLFPH LDDILQHVNG LQEVVDDWSK DVLPELQTHD 490 500 510 520 530 540 TLVGEPGLST FPSPNQITLD FEGNSVSEGR TTPSDVERDV TSLNESEPPG VRDRRDSGVG 550 560 570 580 590 600 ASLTRPNRRL RWNSFQLSHQ PRPAPASPHI SSQTASQLSL LQRFSLLRLT AIMEKHSMSN 610 620 630 640 650 660 KHGWTWSVPK FMKRMKVPDY KDKAVFGVPL IVHVQRTGQP LPQSIQQALR YLRSNCLDQV 670 680 690 700 710 720 GLFRKSGVKS RIHALRQMNE NFPENVNYED QSAYDVADMV KQFFRDLPEP LFTNKLSETF 730 740 750 760 770 780 LHIYQYVSKE QRLQAVQAAI LLLADENREV LQTLLCFLND VVNLVEENQM TPMNLAVCLA 790 800 810 820 830 840 PSLFHLNLLK KESSPRVIQK KYATGKPDQK DLNENLAAAQ GLAHMIMECD RLFEVPHELV 850 860 870 880 890 900 AQSRNSYVEA EIHVPTLEEL GTQLEESGAT FHTYLNHLIQ GLQKEAKEKF KGWVTCSSTD 910 920 930 940 950 960 NTDLAFKKVG DGNPLKLWKA SVEVEAPPSV VLNRVLRERH LWDEDFVQWK VVETLDRQTE 970 980 990 1000 1010 1020 IYQYVLNSMA PHPSRDFVVL RTWKTDLPKG MCTLVSLSVE HEEAQLLGGV RAVVMDSQYL 1030 1040 1050 1060 1070 IEPCGSGKSR LTHICRIDLK GHSPEWYSKG FGHLCAAEVA RIRNSFQPLI AEGPETKI
	Isoform 5 [UniParc]. Checksum: 4E1B65EA0FDCB836	FASTA	687	76,367
	10 20 30 40 50 60 MLEPSSVLHA NVNQAPLWCL VLRWCRECKD TVCGGKQKSR VNHTFQRREI EAKEACDWLR 70 80 90 100 110 120 AAGFPQYAQL YEDSQFPINI VAVKNDHDFL EKDLVEPLCR RLNTLNKCAS MKLDVNFQRK 130 140 150 160 170 180 KGDDSDEEDL CISNKWTFQR TSRRWSRVDD LYTLLPRGDR NGSPGGTGMR NTTSSESVLT 190 200 210 220 230 240 DLSEPEVCSI HSESSGGSDS RSQPGQCCTD NPVMLDAPLV SSSLPQPPRD VLNHPFHPKN 250 260 270 280 290 300 EKPTRARAKS FLKRMETLRG KGAHGRHKGS GRTGGLVISG PMLQQEPESF KAMQCIQIPN 310 320 330 340 350 360 GDLQNSPPPA CRKGLPCSGK SSGESSPSEH SSSGVSTPCL KERKCHEANK RGGMYLEDLD 370 380 390 400 410 420 VLAGTALPDA GDQSRMHEFH SQENLVVHIP KDHKPGTFPK ALSIESLSPT DSSNGVNWRT 430 440 450 460 470 480 GSISLGREQV PGAREPRLMA SCHRASRVSI YDNVPGSHLY ASTGDLLDLE KDDLFPHLDD 490 500 510 520 530 540 ILQHVNGLQE VVDDWSKDVL PELQTHDTLV GEPGLSTFPS PNQITLDFEG NSVSEGRTTP 550 560 570 580 590 600 SDVERDVTSL NESEPPGVRD RRDSGVGASL TRPNRRLRWN SFQLSHQPRP APASPHISSQ 610 620 630 640 650 660 TASQLSLLQR FSLLRLTAIM EKHSMSNKHG WTWSVPKFMK RMKVPDYKDK AVFGVPLIVH 670 680 VQRTGQPLPQ SIQQALRYLR SNCLDQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma." Ching Y.-P., Wong C.-M., Chan S.-F., Leung T.H.-Y., Ng D.-C., Jin D.-Y., Ng I.O. J. Biol. Chem. 278:10824-10830(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, MUTAGENESIS OF ARG-699.
[2]	"Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins." Nagaraja G.M., Kandpal R.P. Biochem. Biophys. Res. Commun. 313:654-665(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TAX1BP1.
[3]	"Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity." Leung T.H.-Y., Ching Y.-P., Yam J.W.P., Wong C.-M., Yau T.-O., Jin D.-Y., Ng I.O. Proc. Natl. Acad. Sci. U.S.A. 102:15207-15212(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-736 AND ARG-740.
[4]	Rhodes S. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Uterus.
[6]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Skin.
[8]	"Mitochondrial targeting of growth suppressor protein DLC2 through the START domain." Ng D.C.-H., Chan S.-F., Kok K.H., Yam J.W.P., Ching Y.-P., Ng I.O., Jin D.-Y. FEBS Lett. 580:191-198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2." Li H., Fung K.-L., Jin D.-Y., Chung S.S.M., Ching Y.-P., Ng I.O., Sze K.-H., Ko B.C.B., Sun H. Proteins 67:1154-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 56-120, SUBUNIT, INTERACTION WITH MEMBRANE PHOSPHOLIPIDS.
[10]	"The crystal structure of human STARD13 (DLC2) lipid transfer and protein localization domain." Structural genomics consortium (SGC) Submitted (MAY-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 900-1113.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY082589 mRNA. Translation: AAL91648.1.
AY366448 mRNA. Translation: AAQ72791.1.
AY082590 mRNA. Translation: AAL91649.1.
AY082591 mRNA. Translation: AAL91650.1.
AL049801 mRNA. Translation: CAB42562.1.
BX647695 mRNA. Translation: CAI46026.1.
Z84483 Genomic DNA. Translation: CAC94774.1.
AL627232, AL139187 Genomic DNA. Translation: CAM17900.1.
AL139187, AL627232 Genomic DNA. Translation: CAM23625.1.
AL139187 Genomic DNA. Translation: CAM23626.1.
BC046563 mRNA. Translation: AAH46563.1.

IPI

IPI00329291.
IPI00395688.
IPI00419226.
IPI00739795.
IPI00741772.

PIR

H59432.

RefSeq

NP_001230395.1. NM_001243466.1.
NP_001230403.1. NM_001243474.1.
NP_001230405.1. NM_001243476.1.
NP_443083.1. NM_052851.2.
NP_821074.1. NM_178006.3.
NP_821075.1. NM_178007.2.

UniGene

Hs.507704.
Hs.721224.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H80	NMR	-	A	56-120	[»]
2JW2	NMR	-	A	56-120	[»]
2PSO	X-ray	2.80	A/B/C	903-1113	[»]

ProteinModelPortal

Q9Y3M8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y3M8. 9 interactions.

MINT

MINT-1194865.

PTM databases

PhosphoSite

Q9Y3M8.

Polymorphism databases

DMDM

90185285.

Proteomic databases

PaxDb

Q9Y3M8.

PRIDE

Q9Y3M8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000255486; ENSP00000255486; ENSG00000133121.
ENST00000336934; ENSP00000338785; ENSG00000133121.
ENST00000399365; ENSP00000382300; ENSG00000133121.

GeneID

90627.

KEGG

hsa:90627.

UCSC

uc001uuu.3. human.
uc001uuv.3. human.
uc021rhz.1. human.

Organism-specific databases

CTD

90627.

GeneCards

GC13M033677.

H-InvDB

HIX0171887.

HGNC

HGNC:19164. STARD13.

HPA

HPA039535.

MIM

609866. gene.

neXtProt

NX_Q9Y3M8.

PharmGKB

PA38806.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG236923.

HOVERGEN

HBG055955.

InParanoid

Q9Y3M8.

OMA

DEDFVQW.

PhylomeDB

Q9Y3M8.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q9Y3M8.

Bgee

Q9Y3M8.

Genevestigator

Q9Y3M8.

GermOnline

ENSG00000133121. Homo sapiens.

Family and domain databases

Gene3D

1.10.555.10. 1 hit.
3.30.530.20. 1 hit.

InterPro

IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR011510. SAM_2.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]

Pfam

PF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
PF01852. START. 1 hit.
[Graphical view]

SMART

SM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.

PROSITE

PS50238. RHOGAP. 1 hit.
PS50105. SAM_DOMAIN. False negative.
PS50848. START. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

STARD13. human.

EvolutionaryTrace

Q9Y3M8.

GenomeRNAi

90627.

NextBio

76872.

SOURCE

Search...

Entry information

Entry name

STA13_HUMAN

Accession

Primary (citable) accession number: Q9Y3M8
Secondary accession number(s): A2A309 , A2A310, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.