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Protein

StAR-related lipid transfer protein 13

Gene

STARD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.2 Publications

GO - Molecular functioni

GO - Biological processi

  • endothelial cell migration Source: MGI
  • endothelial tube lumen extension Source: MGI
  • negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133121-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 13
Alternative name(s):
46H23.2
Deleted in liver cancer 2 protein
Short name:
DLC-2
Rho GTPase-activating protein
START domain-containing protein 13
Short name:
StARD13
Gene namesi
Name:STARD13
Synonyms:DLC2, GT650
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:19164. STARD13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi699R → A: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi736K → E: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi740R → E: Loss of RhoGAP activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi90627.
OpenTargetsiENSG00000133121.
PharmGKBiPA38806.

Polymorphism and mutation databases

BioMutaiSTARD13.
DMDMi90185285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206791 – 1113StAR-related lipid transfer protein 13Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei411PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y3M8.
PaxDbiQ9Y3M8.
PeptideAtlasiQ9Y3M8.
PRIDEiQ9Y3M8.

PTM databases

iPTMnetiQ9Y3M8.
PhosphoSitePlusiQ9Y3M8.

Expressioni

Tissue specificityi

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.2 Publications

Gene expression databases

BgeeiENSG00000133121.
ExpressionAtlasiQ9Y3M8. baseline and differential.
GenevisibleiQ9Y3M8. HS.

Organism-specific databases

HPAiHPA039535.
HPA058867.

Interactioni

Subunit structurei

Homodimer. Interacts with TAX1BP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TAX1BP1Q86VP12EBI-465487,EBI-529518

Protein-protein interaction databases

BioGridi124744. 12 interactors.
IntActiQ9Y3M8. 11 interactors.
MINTiMINT-1194865.
STRINGi9606.ENSP00000338785.

Structurei

Secondary structure

11113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 69Combined sources14
Helixi73 – 77Combined sources5
Turni78 – 82Combined sources5
Helixi88 – 92Combined sources5
Helixi100 – 102Combined sources3
Helixi103 – 117Combined sources15
Helixi913 – 924Combined sources12
Beta strandi929 – 931Combined sources3
Beta strandi934 – 936Combined sources3
Beta strandi938 – 942Combined sources5
Beta strandi952 – 961Combined sources10
Helixi963 – 972Combined sources10
Helixi974 – 976Combined sources3
Beta strandi985 – 991Combined sources7
Beta strandi994 – 1001Combined sources8
Beta strandi1004 – 1006Combined sources3
Beta strandi1010 – 1020Combined sources11
Helixi1023 – 1025Combined sources3
Beta strandi1027 – 1033Combined sources7
Beta strandi1043 – 1046Combined sources4
Beta strandi1049 – 1058Combined sources10
Beta strandi1064 – 1072Combined sources9
Beta strandi1075 – 1077Combined sources3
Turni1079 – 1084Combined sources6
Helixi1085 – 1099Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H80NMR-A56-120[»]
2JW2NMR-A56-120[»]
2PSOX-ray2.80A/B/C903-1113[»]
ProteinModelPortaliQ9Y3M8.
SMRiQ9Y3M8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3M8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 122SAMAdd BLAST68
Domaini663 – 868Rho-GAPPROSITE-ProRule annotationAdd BLAST206
Domaini899 – 1107STARTPROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2200. Eukaryota.
ENOG410XQ10. LUCA.
GeneTreeiENSGT00760000119123.
HOVERGENiHBG055955.
InParanoidiQ9Y3M8.
KOiK20632.
OMAiFVQWKVV.
OrthoDBiEOG091G00OE.
PhylomeDBiQ9Y3M8.
TreeFamiTF314044.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3M8-1) [UniParc]FASTAAdd to basket
Also known as: DLC2alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSQVPRTPA SGCYYLNSMT PEGQEMYLRF DQTTRRSPYR MSRILARHQL
60 70 80 90 100
VTKIQQEIEA KEACDWLRAA GFPQYAQLYE DSQFPINIVA VKNDHDFLEK
110 120 130 140 150
DLVEPLCRRL NTLNKCASMK LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS
160 170 180 190 200
RRWSRVDDLY TLLPRGDRNG SPGGTGMRNT TSSESVLTDL SEPEVCSIHS
210 220 230 240 250
ESSGGSDSRS QPGQCCTDNP VMLDAPLVSS SLPQPPRDVL NHPFHPKNEK
260 270 280 290 300
PTRARAKSFL KRMETLRGKG AHGRHKGSGR TGGLVISGPM LQQEPESFKA
310 320 330 340 350
MQCIQIPNGD LQNSPPPACR KGLPCSGKSS GESSPSEHSS SGVSTPCLKE
360 370 380 390 400
RKCHEANKRG GMYLEDLDVL AGTALPDAGD QSRMHEFHSQ ENLVVHIPKD
410 420 430 440 450
HKPGTFPKAL SIESLSPTDS SNGVNWRTGS ISLGREQVPG AREPRLMASC
460 470 480 490 500
HRASRVSIYD NVPGSHLYAS TGDLLDLEKD DLFPHLDDIL QHVNGLQEVV
510 520 530 540 550
DDWSKDVLPE LQTHDTLVGE PGLSTFPSPN QITLDFEGNS VSEGRTTPSD
560 570 580 590 600
VERDVTSLNE SEPPGVRDRR DSGVGASLTR PNRRLRWNSF QLSHQPRPAP
610 620 630 640 650
ASPHISSQTA SQLSLLQRFS LLRLTAIMEK HSMSNKHGWT WSVPKFMKRM
660 670 680 690 700
KVPDYKDKAV FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK
710 720 730 740 750
SGVKSRIHAL RQMNENFPEN VNYEDQSAYD VADMVKQFFR DLPEPLFTNK
760 770 780 790 800
LSETFLHIYQ YVSKEQRLQA VQAAILLLAD ENREVLQTLL CFLNDVVNLV
810 820 830 840 850
EENQMTPMNL AVCLAPSLFH LNLLKKESSP RVIQKKYATG KPDQKDLNEN
860 870 880 890 900
LAAAQGLAHM IMECDRLFEV PHELVAQSRN SYVEAEIHVP TLEELGTQLE
910 920 930 940 950
ESGATFHTYL NHLIQGLQKE AKEKFKGWVT CSSTDNTDLA FKKVGDGNPL
960 970 980 990 1000
KLWKASVEVE APPSVVLNRV LRERHLWDED FVQWKVVETL DRQTEIYQYV
1010 1020 1030 1040 1050
LNSMAPHPSR DFVVLRTWKT DLPKGMCTLV SLSVEHEEAQ LLGGVRAVVM
1060 1070 1080 1090 1100
DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE WYSKGFGHLC AAEVARIRNS
1110
FQPLIAEGPE TKI
Length:1,113
Mass (Da):124,967
Last modified:March 7, 2006 - v2
Checksum:i314F809C23E6E1E4
GO
Isoform 2 (identifier: Q9Y3M8-2) [UniParc]FASTAAdd to basket
Also known as: DLC2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR

Show »
Length:1,105
Mass (Da):123,893
Checksum:iC447ADE6F7AAF9D8
GO
Isoform 3 (identifier: Q9Y3M8-3) [UniParc]FASTAAdd to basket
Also known as: DLC2gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:995
Mass (Da):111,192
Checksum:i3F608FA94A4EF8BF
GO
Isoform 4 (identifier: Q9Y3M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MSTGTQPKTKVLSDKRPKERV

Show »
Length:1,078
Mass (Da):120,684
Checksum:i1B108966B3EDC44D
GO
Isoform 5 (identifier: Q9Y3M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR
     695-695: V → E
     696-1113: Missing.

Show »
Length:687
Mass (Da):76,367
Checksum:i4E1B65EA0FDCB836
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → R in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti397I → V in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti1097I → T in AAQ72791 (PubMed:14697242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037494175T → M.Corresponds to variant rs9568878dbSNPEnsembl.1
Natural variantiVAR_022098250K → R.Corresponds to variant rs3742321dbSNPEnsembl.1
Natural variantiVAR_037495383R → P.Corresponds to variant rs34425674dbSNPEnsembl.1
Natural variantiVAR_037496798N → S.Corresponds to variant rs35144435dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173531 – 118Missing in isoform 3. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0173541 – 56MFSQV…TKIQQ → MLEPSSVLHANVNQAPLWCL VLRWCRECKDTVCGGKQKSR VNHTFQRR in isoform 2 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_0173551 – 56MFSQV…TKIQQ → MSTGTQPKTKVLSDKRPKER V in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_017356695V → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_017357696 – 1113Missing in isoform 5. 1 PublicationAdd BLAST418

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082589 mRNA. Translation: AAL91648.1.
AY366448 mRNA. Translation: AAQ72791.1.
AY082590 mRNA. Translation: AAL91649.1.
AY082591 mRNA. Translation: AAL91650.1.
AL049801 mRNA. Translation: CAB42562.1.
BX647695 mRNA. Translation: CAI46026.1.
Z84483 Genomic DNA. Translation: CAC94774.1.
AL627232, AL139187 Genomic DNA. Translation: CAM17900.1.
AL139187, AL627232 Genomic DNA. Translation: CAM23625.1.
AL139187 Genomic DNA. Translation: CAM23626.1.
BC046563 mRNA. Translation: AAH46563.1.
CCDSiCCDS9348.1. [Q9Y3M8-1]
CCDS9349.1. [Q9Y3M8-2]
CCDS9350.1. [Q9Y3M8-3]
PIRiH59432.
RefSeqiNP_001230395.1. NM_001243466.1. [Q9Y3M8-5]
NP_001230403.1. NM_001243474.1.
NP_001230405.1. NM_001243476.2.
NP_443083.1. NM_052851.2. [Q9Y3M8-3]
NP_821074.1. NM_178006.3. [Q9Y3M8-1]
NP_821075.1. NM_178007.2. [Q9Y3M8-2]
UniGeneiHs.156551.
Hs.507704.
Hs.721224.

Genome annotation databases

EnsembliENST00000255486; ENSP00000255486; ENSG00000133121. [Q9Y3M8-2]
ENST00000336934; ENSP00000338785; ENSG00000133121. [Q9Y3M8-1]
ENST00000399365; ENSP00000382300; ENSG00000133121. [Q9Y3M8-3]
GeneIDi90627.
KEGGihsa:90627.
UCSCiuc001uuu.4. human. [Q9Y3M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082589 mRNA. Translation: AAL91648.1.
AY366448 mRNA. Translation: AAQ72791.1.
AY082590 mRNA. Translation: AAL91649.1.
AY082591 mRNA. Translation: AAL91650.1.
AL049801 mRNA. Translation: CAB42562.1.
BX647695 mRNA. Translation: CAI46026.1.
Z84483 Genomic DNA. Translation: CAC94774.1.
AL627232, AL139187 Genomic DNA. Translation: CAM17900.1.
AL139187, AL627232 Genomic DNA. Translation: CAM23625.1.
AL139187 Genomic DNA. Translation: CAM23626.1.
BC046563 mRNA. Translation: AAH46563.1.
CCDSiCCDS9348.1. [Q9Y3M8-1]
CCDS9349.1. [Q9Y3M8-2]
CCDS9350.1. [Q9Y3M8-3]
PIRiH59432.
RefSeqiNP_001230395.1. NM_001243466.1. [Q9Y3M8-5]
NP_001230403.1. NM_001243474.1.
NP_001230405.1. NM_001243476.2.
NP_443083.1. NM_052851.2. [Q9Y3M8-3]
NP_821074.1. NM_178006.3. [Q9Y3M8-1]
NP_821075.1. NM_178007.2. [Q9Y3M8-2]
UniGeneiHs.156551.
Hs.507704.
Hs.721224.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H80NMR-A56-120[»]
2JW2NMR-A56-120[»]
2PSOX-ray2.80A/B/C903-1113[»]
ProteinModelPortaliQ9Y3M8.
SMRiQ9Y3M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124744. 12 interactors.
IntActiQ9Y3M8. 11 interactors.
MINTiMINT-1194865.
STRINGi9606.ENSP00000338785.

PTM databases

iPTMnetiQ9Y3M8.
PhosphoSitePlusiQ9Y3M8.

Polymorphism and mutation databases

BioMutaiSTARD13.
DMDMi90185285.

Proteomic databases

EPDiQ9Y3M8.
PaxDbiQ9Y3M8.
PeptideAtlasiQ9Y3M8.
PRIDEiQ9Y3M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255486; ENSP00000255486; ENSG00000133121. [Q9Y3M8-2]
ENST00000336934; ENSP00000338785; ENSG00000133121. [Q9Y3M8-1]
ENST00000399365; ENSP00000382300; ENSG00000133121. [Q9Y3M8-3]
GeneIDi90627.
KEGGihsa:90627.
UCSCiuc001uuu.4. human. [Q9Y3M8-1]

Organism-specific databases

CTDi90627.
DisGeNETi90627.
GeneCardsiSTARD13.
H-InvDBHIX0171887.
HGNCiHGNC:19164. STARD13.
HPAiHPA039535.
HPA058867.
MIMi609866. gene.
neXtProtiNX_Q9Y3M8.
OpenTargetsiENSG00000133121.
PharmGKBiPA38806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2200. Eukaryota.
ENOG410XQ10. LUCA.
GeneTreeiENSGT00760000119123.
HOVERGENiHBG055955.
InParanoidiQ9Y3M8.
KOiK20632.
OMAiFVQWKVV.
OrthoDBiEOG091G00OE.
PhylomeDBiQ9Y3M8.
TreeFamiTF314044.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133121-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiSTARD13. human.
EvolutionaryTraceiQ9Y3M8.
GeneWikiiSTARD13.
GenomeRNAii90627.
PROiQ9Y3M8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133121.
ExpressionAtlasiQ9Y3M8. baseline and differential.
GenevisibleiQ9Y3M8. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTA13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3M8
Secondary accession number(s): A2A309
, A2A310, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.