ID   CBY1_HUMAN              Reviewed;         126 AA.
AC   Q9Y3M2; B2R4S2; Q66GT6; Q9UIK9;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 195.
DE   RecName: Full=Protein chibby homolog 1;
DE   AltName: Full=ARPP-binding protein;
DE   AltName: Full=Cytosolic leucine-rich protein;
DE   AltName: Full=PIGEA-14;
DE   AltName: Full=PKD2 interactor, Golgi and endoplasmic reticulum-associated 1;
GN   Name=CBY1; Synonyms=ARB1, C22orf2, CBY, PGEA1; ORFNames=HRIHFB2025;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H.;
RT   "A novel cytosolic leucine-rich protein.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Moriyama M., Nakada C., Tsukamoto Y., Baba T., Kondo G., Ishiguro N.,
RA   Horiuchi M., Sekine C., Maeda A.;
RT   "Human ARPP-binding protein, arb1.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA   Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA   Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA   Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and analysis of
RT   500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12529303; DOI=10.1101/gr.695703;
RA   Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA   Bye J.M., Beare D.M., Dunham I.;
RT   "Reevaluating human gene annotation: a second-generation analysis of
RT   chromosome 22.";
RL   Genome Res. 13:27-36(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-126.
RC   TISSUE=Fetal brain;
RA   Ueki N.;
RT   "HRI NTT human fetal brain cDNA project.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP   CTNNB1.
RX   PubMed=12712206; DOI=10.1038/nature01570;
RA   Takemaru K., Yamaguchi S., Lee Y.S., Zhang Y., Carthew R.W., Moon R.T.;
RT   "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless
RT   pathway.";
RL   Nature 422:905-909(2003).
RN   [12]
RP   IDENTIFICATION, FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH PKD2
RP   AND GM130.
RX   PubMed=15194699; DOI=10.1074/jbc.m314206200;
RA   Hidaka S., Koenecke V., Osten L., Witzgall R.;
RT   "PIGEA-14, a novel coiled-coil protein affecting the intracellular
RT   distribution of polycystin-2.";
RL   J. Biol. Chem. 279:35009-35016(2004).
RN   [13]
RP   INTERACTION WITH TCIM AND CTNNB1, AND SUBCELLULAR LOCATION.
RX   PubMed=16424001; DOI=10.1158/0008-5472.can-05-3124;
RA   Jung Y., Bang S., Choi K., Kim E., Kim Y., Kim J., Park J., Koo H.,
RA   Moon R.T., Song K., Lee I.;
RT   "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving
RT   antagonistic activity of Chibby.";
RL   Cancer Res. 66:723-728(2006).
RN   [14]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [15]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [16]
RP   INTERACTION WITH FAM92A AND CIBAR2, AND SUBCELLULAR LOCATION.
RX   PubMed=27528616; DOI=10.1128/mcb.00160-16;
RA   Li F.Q., Chen X., Fisher C., Siller S.S., Zelikman K., Kuriyama R.,
RA   Takemaru K.I.;
RT   "BAR domain-containing FAM92 proteins interact with chibby1 to facilitate
RT   ciliogenesis.";
RL   Mol. Cell. Biol. 36:2668-2680(2016).
RN   [17]
RP   INTERACTION WITH FAM92A, AND SUBCELLULAR LOCATION.
RX   PubMed=30395363; DOI=10.1002/jbmr.3594;
RA   Schrauwen I., Giese A.P., Aziz A., Lafont D.T., Chakchouk I.,
RA   Santos-Cortez R.L.P., Lee K., Acharya A., Khan F.S., Ullah A.,
RA   Nickerson D.A., Bamshad M.J., Ali G., Riazuddin S., Ansar M., Ahmad W.,
RA   Ahmed Z.M., Leal S.M.;
RT   "FAM92A underlies nonsyndromic postaxial polydactyly in humans and an
RT   abnormal limb and digit skeletal phenotype in mice.";
RL   J. Bone Miner. Res. 34:375-386(2019).
CC   -!- FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-
CC       catenin and inhibiting beta-catenin-mediated transcriptional activation
CC       through competition with TCF/LEF transcription factors. Has also been
CC       shown to play a role in regulating the intracellular trafficking of
CC       polycystin-2/PKD2 and possibly of other intracellular proteins.
CC       Promotes adipocyte and cardiomyocyte differentiation.
CC       {ECO:0000269|PubMed:12712206, ECO:0000269|PubMed:15194699}.
CC   -!- SUBUNIT: Homodimer. Interacts with polycystin-2/PKD2 and GM130.
CC       Interacts with the C-terminal region of CTNNB1 (PubMed:12712206,
CC       PubMed:16424001). Interacts (C-terminus) with TCIM (C-terminus), TCIM
CC       competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).
CC       Interacts with FAM92A; this interaction facilitates targeting of FAM92A
CC       to cilium basal body (PubMed:27528616, PubMed:30395363). Interacts with
CC       CIBAR2 (PubMed:27528616). {ECO:0000269|PubMed:12712206,
CC       ECO:0000269|PubMed:15194699, ECO:0000269|PubMed:16424001,
CC       ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}.
CC   -!- INTERACTION:
CC       Q9Y3M2; Q96M91: CFAP53; NbExp=4; IntAct=EBI-947308, EBI-742422;
CC       Q9Y3M2; A1XBS5: CIBAR1; NbExp=3; IntAct=EBI-947308, EBI-2349888;
CC       Q9Y3M2; A1XBS5-3: CIBAR1; NbExp=3; IntAct=EBI-947308, EBI-12348777;
CC       Q9Y3M2; Q8IYY4: DZIP1L; NbExp=3; IntAct=EBI-947308, EBI-10264440;
CC       Q9Y3M2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-947308, EBI-744099;
CC       Q9Y3M2; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-947308, EBI-7225287;
CC       Q9Y3M2; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-947308, EBI-739467;
CC       Q9Y3M2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-947308, EBI-739832;
CC       Q9Y3M2; Q15311: RALBP1; NbExp=4; IntAct=EBI-947308, EBI-749285;
CC       Q9Y3M2; A6NK89: RASSF10; NbExp=3; IntAct=EBI-947308, EBI-6912267;
CC       Q9Y3M2; Q5GJ75: TNFAIP8L3; NbExp=3; IntAct=EBI-947308, EBI-14222571;
CC       Q9Y3M2; Q99816: TSG101; NbExp=3; IntAct=EBI-947308, EBI-346882;
CC       Q9Y3M2; Q6PF05-3: TTC23L; NbExp=3; IntAct=EBI-947308, EBI-10182647;
CC       Q9Y3M2; P62258: YWHAE; NbExp=3; IntAct=EBI-947308, EBI-356498;
CC       Q9Y3M2; P63104: YWHAZ; NbExp=3; IntAct=EBI-947308, EBI-347088;
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:16424001}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000269|PubMed:27528616, ECO:0000269|PubMed:30395363}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000269|PubMed:27528616}. Golgi apparatus. Golgi apparatus, trans-
CC       Golgi network {ECO:0000269|PubMed:16424001}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. Expressed at higher levels in
CC       heart, skeletal muscle, kidney and placenta. Also found in brain, lung,
CC       liver and testis. Significantly down-regulated in thyroid and
CC       metastatic uterine tumors. {ECO:0000269|PubMed:12712206}.
CC   -!- MISCELLANEOUS: 'Chibby' is Japanese for 'small'; the gene was so named
CC       for the RNAi phenotype seen in flies.
CC   -!- SIMILARITY: Belongs to the chibby family. {ECO:0000305}.
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DR   EMBL; AF331041; AAL56062.1; -; mRNA.
DR   EMBL; AB111855; BAC78839.1; -; mRNA.
DR   EMBL; AL136686; CAB66621.1; -; mRNA.
DR   EMBL; AL050345; CAB43547.1; -; mRNA.
DR   EMBL; CR456410; CAG30296.1; -; mRNA.
DR   EMBL; AK311928; BAG34869.1; -; mRNA.
DR   EMBL; AL021707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471095; EAW60254.1; -; Genomic_DNA.
DR   EMBL; BC016139; AAH16139.1; -; mRNA.
DR   EMBL; AB015347; BAA88119.1; -; mRNA.
DR   EMBL; BK005534; DAA05582.1; -; Genomic_DNA.
DR   CCDS; CCDS13974.1; -.
DR   RefSeq; NP_001002880.2; NM_001002880.1.
DR   RefSeq; NP_056188.1; NM_015373.3.
DR   PDB; 4WRQ; X-ray; 2.41 A; C/D=12-29.
DR   PDBsum; 4WRQ; -.
DR   AlphaFoldDB; Q9Y3M2; -.
DR   SMR; Q9Y3M2; -.
DR   BioGRID; 117311; 178.
DR   DIP; DIP-29651N; -.
DR   ELM; Q9Y3M2; -.
DR   IntAct; Q9Y3M2; 45.
DR   MINT; Q9Y3M2; -.
DR   STRING; 9606.ENSP00000478962; -.
DR   iPTMnet; Q9Y3M2; -.
DR   PhosphoSitePlus; Q9Y3M2; -.
DR   BioMuta; CBY1; -.
DR   DMDM; 20454882; -.
DR   EPD; Q9Y3M2; -.
DR   jPOST; Q9Y3M2; -.
DR   MassIVE; Q9Y3M2; -.
DR   MaxQB; Q9Y3M2; -.
DR   PaxDb; 9606-ENSP00000478962; -.
DR   PeptideAtlas; Q9Y3M2; -.
DR   ProteomicsDB; 86044; -.
DR   Pumba; Q9Y3M2; -.
DR   Antibodypedia; 26394; 194 antibodies from 27 providers.
DR   DNASU; 25776; -.
DR   Ensembl; ENST00000216029.8; ENSP00000216029.3; ENSG00000100211.12.
DR   Ensembl; ENST00000396811.6; ENSP00000380026.2; ENSG00000100211.12.
DR   Ensembl; ENST00000411557.6; ENSP00000413934.2; ENSG00000100211.12.
DR   Ensembl; ENST00000416285.6; ENSP00000412260.2; ENSG00000100211.12.
DR   GeneID; 25776; -.
DR   KEGG; hsa:25776; -.
DR   MANE-Select; ENST00000216029.8; ENSP00000216029.3; NM_015373.4; NP_056188.1.
DR   UCSC; uc003awc.5; human.
DR   AGR; HGNC:1307; -.
DR   CTD; 25776; -.
DR   DisGeNET; 25776; -.
DR   GeneCards; CBY1; -.
DR   HGNC; HGNC:1307; CBY1.
DR   HPA; ENSG00000100211; Low tissue specificity.
DR   MalaCards; CBY1; -.
DR   MIM; 607757; gene.
DR   neXtProt; NX_Q9Y3M2; -.
DR   OpenTargets; ENSG00000100211; -.
DR   Orphanet; 475; Joubert syndrome.
DR   PharmGKB; PA25886; -.
DR   VEuPathDB; HostDB:ENSG00000100211; -.
DR   eggNOG; ENOG502S6C8; Eukaryota.
DR   GeneTree; ENSGT00940000153137; -.
DR   InParanoid; Q9Y3M2; -.
DR   OrthoDB; 2903420at2759; -.
DR   PhylomeDB; Q9Y3M2; -.
DR   TreeFam; TF324419; -.
DR   PathwayCommons; Q9Y3M2; -.
DR   Reactome; R-HSA-3769402; Deactivation of the beta-catenin transactivating complex.
DR   SignaLink; Q9Y3M2; -.
DR   SIGNOR; Q9Y3M2; -.
DR   BioGRID-ORCS; 25776; 16 hits in 1152 CRISPR screens.
DR   ChiTaRS; CBY1; human.
DR   GeneWiki; CBY1; -.
DR   GenomeRNAi; 25776; -.
DR   Pharos; Q9Y3M2; Tbio.
DR   PRO; PR:Q9Y3M2; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q9Y3M2; Protein.
DR   Bgee; ENSG00000100211; Expressed in oocyte and 192 other cell types or tissues.
DR   ExpressionAtlas; Q9Y3M2; baseline and differential.
DR   GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR   GO; GO:0008013; F:beta-catenin binding; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IPI:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:CAFA.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0055007; P:cardiac muscle cell differentiation; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0033504; P:floor plate development; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:UniProtKB.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:UniProtKB.
DR   GO; GO:0051289; P:protein homotetramerization; IDA:CAFA.
DR   GO; GO:0008104; P:protein localization; IMP:UniProtKB.
DR   CDD; cd07429; Cby_like; 1.
DR   DisProt; DP00709; -.
DR   InterPro; IPR028118; Chibby_fam.
DR   Pfam; PF14645; Chibby; 1.
DR   Genevisible; Q9Y3M2; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium biogenesis/degradation; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Differentiation; Golgi apparatus; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..126
FT                   /note="Protein chibby homolog 1"
FT                   /id="PRO_0000058354"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..112
FT                   /note="Minimal region for the interaction with PKD2"
FT                   /evidence="ECO:0000269|PubMed:15194699"
FT   COILED          67..125
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        11..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         9
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K4I6"
FT   MOD_RES         20
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   CONFLICT        73
FT                   /note="E -> K (in Ref. 1; AAL56062)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   126 AA;  14470 MW;  0D243AD2CC436E55 CRC64;
     MPFFGNTFSP KKTPPRKSAS LSNLHSLDRS TREVELGLEY GSPTMNLAGQ SLKFENGQWI
     AETGVSGGVD RREVQRLRRR NQQLEEENNL LRLKVDILLD MLSESTAESH LMEKELDELR
     ISRKRK
//