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Protein

Ras-related protein Rap-2c

Gene

RAP2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi116 – 119GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTP binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123728-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-2c
Gene namesi
Name:RAP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:21165. RAP2C.

Subcellular locationi

GO - Cellular componenti

  • bicellular tight junction Source: UniProtKB
  • cell-cell contact zone Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123728.
PharmGKBiPA134899238.

Polymorphism and mutation databases

DMDMi47117343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000302211 – 180Ras-related protein Rap-2cAdd BLAST180
PropeptideiPRO_0000030222181 – 183Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi176S-palmitoyl cysteineBy similarity1
Lipidationi177S-palmitoyl cysteineBy similarity1
Modified residuei180Cysteine methyl esterBy similarity1
Lipidationi180S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ9Y3L5.
MaxQBiQ9Y3L5.
PaxDbiQ9Y3L5.
PeptideAtlasiQ9Y3L5.
PRIDEiQ9Y3L5.

PTM databases

iPTMnetiQ9Y3L5.
PhosphoSitePlusiQ9Y3L5.
SwissPalmiQ9Y3L5.

Expressioni

Tissue specificityi

Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.2 Publications

Gene expression databases

BgeeiENSG00000123728.
CleanExiHS_RAP2C.
ExpressionAtlasiQ9Y3L5. baseline and differential.
GenevisibleiQ9Y3L5. HS.

Interactioni

Protein-protein interaction databases

BioGridi121785. 20 interactors.
IntActiQ9Y3L5. 4 interactors.
STRINGi9606.ENSP00000340274.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3L5.
SMRiQ9Y3L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9Y3L5.
KOiK07839.
OMAiMERIPIQ.
OrthoDBiEOG091G0OOG.
PhylomeDBiQ9Y3L5.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP
60 70 80 90 100
SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI
110 120 130 140 150
VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK
160 170 180
SMVDELFAEI VRQMNYSSLP EKQDQCCTTC VVQ
Length:183
Mass (Da):20,745
Last modified:November 1, 1999 - v1
Checksum:i6763385F76638324
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135A → V in AAH03403 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY298955 mRNA. Translation: AAP55684.1.
AL049685 mRNA. Translation: CAB41256.1.
AK124801 mRNA. Translation: BAG54098.1.
Z78022 Genomic DNA. Translation: CAI42719.1.
CH471107 Genomic DNA. Translation: EAX11782.1.
BC003403 mRNA. Translation: AAH03403.1.
CCDSiCCDS14632.1.
RefSeqiNP_001258115.1. NM_001271186.1.
NP_001258116.1. NM_001271187.1.
NP_067006.3. NM_021183.4.
XP_011529678.1. XM_011531376.1.
UniGeneiHs.119889.
Hs.743556.

Genome annotation databases

EnsembliENST00000342983; ENSP00000340274; ENSG00000123728.
ENST00000370874; ENSP00000359911; ENSG00000123728.
GeneIDi57826.
KEGGihsa:57826.
UCSCiuc004ewp.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY298955 mRNA. Translation: AAP55684.1.
AL049685 mRNA. Translation: CAB41256.1.
AK124801 mRNA. Translation: BAG54098.1.
Z78022 Genomic DNA. Translation: CAI42719.1.
CH471107 Genomic DNA. Translation: EAX11782.1.
BC003403 mRNA. Translation: AAH03403.1.
CCDSiCCDS14632.1.
RefSeqiNP_001258115.1. NM_001271186.1.
NP_001258116.1. NM_001271187.1.
NP_067006.3. NM_021183.4.
XP_011529678.1. XM_011531376.1.
UniGeneiHs.119889.
Hs.743556.

3D structure databases

ProteinModelPortaliQ9Y3L5.
SMRiQ9Y3L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121785. 20 interactors.
IntActiQ9Y3L5. 4 interactors.
STRINGi9606.ENSP00000340274.

PTM databases

iPTMnetiQ9Y3L5.
PhosphoSitePlusiQ9Y3L5.
SwissPalmiQ9Y3L5.

Polymorphism and mutation databases

DMDMi47117343.

Proteomic databases

EPDiQ9Y3L5.
MaxQBiQ9Y3L5.
PaxDbiQ9Y3L5.
PeptideAtlasiQ9Y3L5.
PRIDEiQ9Y3L5.

Protocols and materials databases

DNASUi57826.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342983; ENSP00000340274; ENSG00000123728.
ENST00000370874; ENSP00000359911; ENSG00000123728.
GeneIDi57826.
KEGGihsa:57826.
UCSCiuc004ewp.5. human.

Organism-specific databases

CTDi57826.
GeneCardsiRAP2C.
HGNCiHGNC:21165. RAP2C.
neXtProtiNX_Q9Y3L5.
OpenTargetsiENSG00000123728.
PharmGKBiPA134899238.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ9Y3L5.
KOiK07839.
OMAiMERIPIQ.
OrthoDBiEOG091G0OOG.
PhylomeDBiQ9Y3L5.
TreeFamiTF313014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123728-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiRAP2C. human.
GenomeRNAii57826.
PROiQ9Y3L5.

Gene expression databases

BgeeiENSG00000123728.
CleanExiHS_RAP2C.
ExpressionAtlasiQ9Y3L5. baseline and differential.
GenevisibleiQ9Y3L5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAP2C_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3L5
Secondary accession number(s): B3KWD6, Q5H9H9, Q9BTS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.