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Protein

SH3 domain-binding protein 1

Gene

SH3BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100092-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 1
Short name:
3BP-1
Gene namesi
Name:SH3BP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:10824. SH3BP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23616.
OpenTargetsiENSG00000100092.
PharmGKBiPA35732.

Polymorphism and mutation databases

BioMutaiSH3BP1.
DMDMi51338841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567231 – 701SH3 domain-binding protein 1Add BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei601PhosphothreonineBy similarity1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei641PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3L3.
PaxDbiQ9Y3L3.
PeptideAtlasiQ9Y3L3.
PRIDEiQ9Y3L3.

PTM databases

iPTMnetiQ9Y3L3.
PhosphoSitePlusiQ9Y3L3.

Expressioni

Gene expression databases

BgeeiENSG00000100092.
CleanExiHS_SH3BP1.
ExpressionAtlasiQ9Y3L3. baseline and differential.
GenevisibleiQ9Y3L3. HS.

Organism-specific databases

HPAiHPA000757.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-346869,EBI-710997
TRIP10Q156423EBI-346869,EBI-739936

Protein-protein interaction databases

BioGridi117149. 18 interactors.
IntActiQ9Y3L3. 7 interactors.
MINTiMINT-2823406.
STRINGi9606.ENSP00000350018.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J9DX-ray1.50B/D/F616-625[»]
4J9FX-ray1.09B/D/F616-625[»]
ProteinModelPortaliQ9Y3L3.
SMRiQ9Y3L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 262BARPROSITE-ProRule annotationAdd BLAST246
Domaini276 – 469Rho-GAPPROSITE-ProRule annotationAdd BLAST194

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi617 – 625SH3-bindingBy similarity9

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4270. Eukaryota.
ENOG410XRR2. LUCA.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000179193.
HOVERGENiHBG000015.
InParanoidiQ9Y3L3.
KOiK20652.
OMAiHRPHAKE.
OrthoDBiEOG091G02YP.
PhylomeDBiQ9Y3L3.
TreeFamiTF316514.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3L3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKRQLHRMR QLAQTGSLGR TPETAEFLGE DLLQVEQRLE PAKRAAHNIH
60 70 80 90 100
KRLQACLQGQ SGADMDKRVK KLPLMALSTT MAESFKELDP DSSMGKALEM
110 120 130 140 150
SCAIQNQLAR ILAEFEMTLE RDVLQPLSRL SEEELPAILK HKKSLQKLVS
160 170 180 190 200
DWNTLKSRLS QATKNSGSSQ GLGGSPGSHS HTTMANKVET LKEEEEELKR
210 220 230 240 250
KVEQCRDEYL ADLYHFVTKE DSYANYFIRL LEIQADYHRR SLSSLDTALA
260 270 280 290 300
ELRENHGQAD HSPSMTATHF PRVYGVSLAT HLQELGREIA LPIEACVMML
310 320 330 340 350
LSEGMKEEGL FRLAAGASVL KRLKQTMASD PHSLEEFCSD PHAVAGALKS
360 370 380 390 400
YLRELPEPLM TFDLYDDWMR AASLKEPGAR LQALQEVCSR LPPENLSNLR
410 420 430 440 450
YLMKFLARLA EEQEVNKMTP SNIAIVLGPN LLWPPEKEGD QAQLDAASVS
460 470 480 490 500
SIQVVGVVEA LIQSADTLFP GDINFNVSGL FSAVTLQDTV SDRLASEELP
510 520 530 540 550
STAVPTPATT PAPAPAPAPA PAPALASAAT KERTESEVPP RPASPKVTRS
560 570 580 590 600
PPETAAPVED MARRTKRPAP ARPTMPPPQV SGSRSSPPAP PLPPGSGSPG
610 620 630 640 650
TPQALPRRLV GSSLRAPTVP PPLPPTPPQP ARRQSRRSPA SPSPASPGPA
660 670 680 690 700
SPSPVSLSNP AQVDLGAATA EGGAPEAISG VPTPPAIPPQ PRPRSLASET

N
Length:701
Mass (Da):75,713
Last modified:August 16, 2004 - v3
Checksum:i877D144E81F0F974
GO
Isoform 2 (identifier: Q9Y3L3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-452: DQAQLDAASVSSI → TEPARELGSQTLC
     453-701: Missing.

Show »
Length:452
Mass (Da):50,820
Checksum:iA2C33CFBB2532FD0
GO

Sequence cautioni

The sequence AAH08282 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85842 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85842 differs from that shown. Reason: Erroneous termination at position 56. Translated as Cys.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033450511P → L.Corresponds to variant rs929038dbSNPEnsembl.1
Natural variantiVAR_033451656S → F.Corresponds to variant rs2269548dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011373440 – 452DQAQL…SVSSI → TEPARELGSQTLC in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_011374453 – 701Missing in isoform 2. 1 PublicationAdd BLAST249

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456576 mRNA. Translation: CAG30462.1.
AK124370 mRNA. Translation: BAC85842.1. Different initiation.
Z83844 Genomic DNA. Translation: CAI20370.2.
BC008282 mRNA. Translation: AAH08282.1. Different initiation.
AL157480 mRNA. Translation: CAB75671.2.
CCDSiCCDS13952.2. [Q9Y3L3-1]
PIRiT46916.
RefSeqiNP_061830.3. NM_018957.3. [Q9Y3L3-1]
UniGeneiHs.601143.

Genome annotation databases

EnsembliENST00000357436; ENSP00000350018; ENSG00000100092. [Q9Y3L3-1]
ENST00000417536; ENSP00000411979; ENSG00000100092. [Q9Y3L3-2]
GeneIDi23616.
KEGGihsa:23616.
UCSCiuc003atg.2. human. [Q9Y3L3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456576 mRNA. Translation: CAG30462.1.
AK124370 mRNA. Translation: BAC85842.1. Different initiation.
Z83844 Genomic DNA. Translation: CAI20370.2.
BC008282 mRNA. Translation: AAH08282.1. Different initiation.
AL157480 mRNA. Translation: CAB75671.2.
CCDSiCCDS13952.2. [Q9Y3L3-1]
PIRiT46916.
RefSeqiNP_061830.3. NM_018957.3. [Q9Y3L3-1]
UniGeneiHs.601143.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J9DX-ray1.50B/D/F616-625[»]
4J9FX-ray1.09B/D/F616-625[»]
ProteinModelPortaliQ9Y3L3.
SMRiQ9Y3L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117149. 18 interactors.
IntActiQ9Y3L3. 7 interactors.
MINTiMINT-2823406.
STRINGi9606.ENSP00000350018.

PTM databases

iPTMnetiQ9Y3L3.
PhosphoSitePlusiQ9Y3L3.

Polymorphism and mutation databases

BioMutaiSH3BP1.
DMDMi51338841.

Proteomic databases

EPDiQ9Y3L3.
PaxDbiQ9Y3L3.
PeptideAtlasiQ9Y3L3.
PRIDEiQ9Y3L3.

Protocols and materials databases

DNASUi23616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357436; ENSP00000350018; ENSG00000100092. [Q9Y3L3-1]
ENST00000417536; ENSP00000411979; ENSG00000100092. [Q9Y3L3-2]
GeneIDi23616.
KEGGihsa:23616.
UCSCiuc003atg.2. human. [Q9Y3L3-1]

Organism-specific databases

CTDi23616.
DisGeNETi23616.
GeneCardsiSH3BP1.
H-InvDBHIX0016448.
HIX0016449.
HGNCiHGNC:10824. SH3BP1.
HPAiHPA000757.
neXtProtiNX_Q9Y3L3.
OpenTargetsiENSG00000100092.
PharmGKBiPA35732.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4270. Eukaryota.
ENOG410XRR2. LUCA.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000179193.
HOVERGENiHBG000015.
InParanoidiQ9Y3L3.
KOiK20652.
OMAiHRPHAKE.
OrthoDBiEOG091G02YP.
PhylomeDBiQ9Y3L3.
TreeFamiTF316514.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100092-MONOMER.

Miscellaneous databases

ChiTaRSiSH3BP1. human.
GeneWikiiSH3BP1.
GenomeRNAii23616.
PROiQ9Y3L3.

Gene expression databases

BgeeiENSG00000100092.
CleanExiHS_SH3BP1.
ExpressionAtlasiQ9Y3L3. baseline and differential.
GenevisibleiQ9Y3L3. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei3BP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3L3
Secondary accession number(s): Q5R3N0
, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.