Q9Y3I1 (FBX7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box only protein 7

Gene names

Name:	FBXO7
Synonyms:	FBX7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	522 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Ref.9 Ref.11
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Ref.8 Ref.9 Ref.10 Ref.11
Subcellular location	Cytoplasm. Nucleus Ref.10.
Involvement in disease	Parkinson disease 15 (PARK15) [MIM:260300]: A neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12
Sequence similarities	Contains 1 F-box domain.
Sequence caution	The sequence AAF04471.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Neurodegeneration Parkinsonism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Inferred from electronic annotation. Source: UniProtKB-KW regulation of protein stability Inferred from direct assay Ref.9. Source: UniProtKB ubiquitin-dependent protein catabolic process Traceable author statement Ref.7. Source: ProtInc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell ubiquitin ligase complex Traceable author statement Ref.7. Source: ProtInc
Molecular_function	ubiquitin-protein ligase activity Traceable author statement Ref.7. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SKP1	P63208	2	EBI-1161222,EBI-307486

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y3I1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y3I1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     80-91: DDIPAPNIPSST → MARPPGGSGPLL

Isoform 3 (identifier: Q9Y3I1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 522	522	F-box only protein 7		PRO_0000119885
Regions
	Domain	329 – 375	47	F-box
Natural variations
	Alternative sequence	1 – 114	114	Missing in isoform 3.		VSP_044723
	Alternative sequence	1 – 79	79	Missing in isoform 2.		VSP_041073
	Alternative sequence	80 – 91	12	DDIPA…IPSST → MARPPGGSGPLL in isoform 2.		VSP_041074
	Natural variant	115	1	M → I. Ref.4 Ref.6 Ref.7 Ref.12 Corresponds to variant rs11107 [ dbSNP | Ensembl ].		VAR_021408
	Natural variant	378	1	R → G in PARK15. Ref.12		VAR_047938
	Natural variant	481	1	R → C Found in two patients with Kufor-Rakeb syndrome also carrying R-877 in ATP13A2. Ref.13		VAR_066022
Experimental info
	Sequence conflict	79	1	Q → H in AAF04471. Ref.7
	Sequence conflict	84	1	A → P in AAF04471. Ref.7
	Sequence conflict	154	1	N → S in BAG63187. Ref.4
	Sequence conflict	169	1	M → L in AAF04471. Ref.7
	Sequence conflict	224	1	M → L in AAF04471. Ref.7
	Sequence conflict	241	1	P → H in AAF04471. Ref.7
	Sequence conflict	328	1	D → N in AAF04471. Ref.7
	Sequence conflict	413	1	M → L in AAF04471. Ref.7
	Sequence conflict	475	1	F → L in AAF04471. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: C4E5E70A0747287A	FASTA	522	58,503
	10 20 30 40 50 60 MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL NYKDPLTGDE 70 80 90 100 110 120 ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN NEQPSLATSS NQTSMQDEQP 130 140 150 160 170 180 SDSFQGQAAQ SGVWNDDSML GPSQNFEAES IQDNAHMAEG TGFYPSEPML CSESVEGQVP 190 200 210 220 230 240 HSLETLYQSA DCSDANDALI VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH 250 260 270 280 290 300 PLCEGSSATL TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD 310 320 330 340 350 360 LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR SVLSLSAVCR 370 380 390 400 410 420 DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH IQRKESPKGR FVMLLPSSTH 430 440 450 460 470 480 TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP 490 500 510 520 RFDPVGPLPG PNPILPGRGG PNDRFPFRPS RGRPTDGRLS FM
	Isoform 2 [UniParc]. Checksum: 263A319CE0096FFB	FASTA	443	49,358
	10 20 30 40 50 60 MARPPGGSGP LLDSEHSSLQ NNEQPSLATS SNQTSMQDEQ PSDSFQGQAA QSGVWNDDSM 70 80 90 100 110 120 LGPSQNFEAE SIQDNAHMAE GTGFYPSEPM LCSESVEGQV PHSLETLYQS ADCSDANDAL 130 140 150 160 170 180 IVLIHLLMLE SGYIPQGTEA KALSMPEKWK LSGVYKLQYM HPLCEGSSAT LTCVPLGNLI 190 200 210 220 230 240 VVNATLKINN EIRSVKRLQL LPESFICKEK LGENVANIYK DLQKLSRLFK DQLVYPLLAF 250 260 270 280 290 300 TRQALNLPDV FGLVVLPLEL KLRIFRLLDV RSVLSLSAVC RDLFTASNDP LLWRFLYLRD 310 320 330 340 350 360 FRDNTVRVQD TDWKELYRKR HIQRKESPKG RFVMLLPSST HTIPFYPNPL HPRPFPSSRL 370 380 390 400 410 420 PPGIIGGEYD QRPTLPYVGD PISSLIPGPG ETPSQFPPLR PRFDPVGPLP GPNPILPGRG 430 440 GPNDRFPFRP SRGRPTDGRL SFM
	Isoform 3 [UniParc]. Checksum: FE4FE5ECFEAC37C5	FASTA	408	45,781
	10 20 30 40 50 60 MQDEQPSDSF QGQAAQSGVW NDDSMLGPSQ NFEAESIQDN AHMAEGTGFY PSEPMLCSES 70 80 90 100 110 120 VEGQVPHSLE TLYQSADCSD ANDALIVLIH LLMLESGYIP QGTEAKALSM PEKWKLSGVY 130 140 150 160 170 180 KLQYMHPLCE GSSATLTCVP LGNLIVVNAT LKINNEIRSV KRLQLLPESF ICKEKLGENV 190 200 210 220 230 240 ANIYKDLQKL SRLFKDQLVY PLLAFTRQAL NLPDVFGLVV LPLELKLRIF RLLDVRSVLS 250 260 270 280 290 300 LSAVCRDLFT ASNDPLLWRF LYLRDFRDNT VRVQDTDWKE LYRKRHIQRK ESPKGRFVML 310 320 330 340 350 360 LPSSTHTIPF YPNPLHPRPF PSSRLPPGII GGEYDQRPTL PYVGDPISSL IPGPGETPSQ 370 380 390 400 FPPLRPRFDP VGPLPGPNPI LPGRGGPNDR FPFRPSRGRP TDGRLSFM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and expression analysis of new members of the mammalian F-box protein family." Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C. Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ILE-115. Tissue: Heart and Testis.
[5]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-115. Tissue: Pancreas.
[7]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-522 (ISOFORM 1), VARIANT ILE-115.
[8]	"Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma." Tsou A.-P., Yang C.-W., Huang C.-Y.F., Yu R.C.-T., Lee Y.-C.G., Chang C.-W., Chen B.-R., Chung Y.-F., Fann M.-J., Chi C.-W., Chiu J.-H., Chou C.-K. Oncogene 22:298-307(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DLGAP5, IDENTIFICATION IN SCF COMPLEX.
[9]	"Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region." Hsu J.-M., Lee Y.-C.G., Yu C.-T.R., Huang C.-Y.F. J. Biol. Chem. 279:32592-32602(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DLGAP5; CUL1 AND SKP1, FUNCTION IN UBIQUITINATION OF DLGAP5.
[10]	"Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6." Laman H., Funes J.M., Ye H., Henderson S., Galinanes-Garcia L., Hara E., Knowles P., McDonald N., Boshoff C. EMBO J. 24:3104-3116(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CDK6, SUBCELLULAR LOCATION.
[11]	"The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination." Chang Y.F., Cheng C.M., Chang L.K., Jong Y.J., Yuo C.Y. Biochem. Biophys. Res. Commun. 342:1022-1026(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BIRC2, FUNCTION IN UBIQUITINATION OF BIRC2.
[12]	"Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays." Shojaee S., Sina F., Banihosseini S.S., Kazemi M.H., Kalhor R., Shahidi G.-A., Fakhrai-Rad H., Ronaghi M., Elahi E. Am. J. Hum. Genet. 82:1375-1384(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT PARK15 GLY-378, VARIANT ILE-115.
[13]	"Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability." Santoro L., Breedveld G.J., Manganelli F., Iodice R., Pisciotta C., Nolano M., Punzo F., Quarantelli M., Pappata S., Di Fonzo A., Oostra B.A., Bonifati V. Neurogenetics 12:33-39(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CYS-481.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233225 mRNA. Translation: AAF67155.1. AL050254 mRNA. Translation: CAB43356.1. CR456491 mRNA. Translation: CAG30377.1. AK297841 mRNA. Translation: BAG60175.1. AK301716 mRNA. Translation: BAG63187.1. AL021937, AL035068, Z71183 Genomic DNA. Translation: CAI19587.1. AL021937, AL035068, Z71183 Genomic DNA. Translation: CAI19588.2. AL035068, AL021937, Z71183 Genomic DNA. Translation: CAI19333.1. AL035068, AL021937, Z71183 Genomic DNA. Translation: CAI19334.2. Z71183, AL021937, AL035068 Genomic DNA. Translation: CAI18782.1. Z71183, AL021937, AL035068 Genomic DNA. Translation: CAI18783.2. BC008361 mRNA. Translation: AAH08361.1. AF129537 mRNA. Translation: AAF04471.1. Different initiation.
IPI	IPI00294567. IPI00651672. IPI00853513.
RefSeq	NP_001028196.1. NM_001033024.1. NP_001244919.1. NM_001257990.1. NP_036311.3. NM_012179.3.
UniGene	Hs.5912.
3D structure databases
ProteinModelPortal	Q9Y3I1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3I1. 6 interactions.
MINT	MINT-108554.
STRING	9606.ENSP00000266087.
PTM databases
PhosphoSite	Q9Y3I1.
Polymorphism databases
DMDM	13124249.
Proteomic databases
PaxDb	Q9Y3I1.
PRIDE	Q9Y3I1.
Protocols and materials databases
DNASU	25793.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266087; ENSP00000266087; ENSG00000100225. ENST00000382058; ENSP00000371490; ENSG00000100225. ENST00000397426; ENSP00000380571; ENSG00000100225.
GeneID	25793.
KEGG	hsa:25793.
UCSC	uc003amq.3. human. uc003amt.3. human.
Organism-specific databases
CTD	25793.
GeneCards	GC22P032870.
HGNC	HGNC:13586. FBXO7.
HPA	CAB034296. HPA032114.
MIM	260300. phenotype. 605648. gene.
neXtProt	NX_Q9Y3I1.
Orphanet	171695. Parkinsonian-pyramidal syndrome.
PharmGKB	PA28047.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78399.
HOGENOM	HOG000112551.
HOVERGEN	HBG005648.
KO	K10293.
OMA	WKELYRK.
OrthoDB	EOG4ZGPD5.
PhylomeDB	Q9Y3I1.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9Y3I1.
Bgee	Q9Y3I1.
CleanEx	HS_FBXO7.
Genevestigator	Q9Y3I1.
GermOnline	ENSG00000100225. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. IPR021625. Inhibitor_PI31. [Graphical view]
Pfam	PF00646. F-box. 1 hit. PF11566. PI31_Prot_N. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FBXO7. human.
GenomeRNAi	25793.
NextBio	46969.
SOURCE	Search...

Entry information

Entry name

FBX7_HUMAN

Accession

Primary (citable) accession number: Q9Y3I1
Secondary accession number(s): B4DNB3 , B4DWX5, Q5TGC4, Q5TI86, Q96HM6, Q9UF21, Q9UKT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.