Reviewed,
UniProtKB/Swiss-Prot Q9Y3I0 (CV028_HUMAN)
Last modified
November 24, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UPF0027 protein C22orf28 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 505 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the UPF0027 (rtcB) family. |
| Sequence caution | The sequence AAF29081.1 differs from that shown. Reason: Frameshift at positions 295 and 298. The sequence AAF67477.1 differs from that shown. Reason: Frameshift at positions 173 and 180. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cell-matrix adhesion Non-traceable author statement. Source: UniProtKB substrate adhesion-dependent cell spreadingNon-traceable author statement. Source: UniProtKB |
| Molecular function | vinculin binding Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 505 | 505 | UPF0027 protein C22orf28 | PRO_0000255241 | |||||
Amino acid modifications | |||||||||
| Modified residue | 439 | 1 | Phosphoserine Ref.13 | ||||||
| Modified residue | 496 | 1 | N6-acetyllysine Ref.15 | ||||||
Natural variations | |||||||||
| Natural variant | 153 | 1 | V → A: dbSNP rs11545747. | VAR_052485 | |||||
| Natural variant | 343 | 1 | L → F: dbSNP rs17849275. Ref.9 | VAR_028853 | |||||
Experimental info | |||||||||
| Sequence conflict | 296 | 1 | A → P in AAF29081. Ref.2 | ||||||
| Sequence conflict | 303 | 1 | G → V in AAF29081. Ref.2 | ||||||
| Sequence conflict | 303 | 1 | G → V in AAF67477. Ref.3 | ||||||
| Sequence conflict | 427 | 1 | C → R in CAG33456. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed: 12529303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. Chen Z.Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood. |
| [3] | "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. Chen J.-L.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [7] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [9] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-343. Tissue: Choriocarcinoma and Lung carcinoma. |
| [10] | Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 4-14; 45-51; 56-81; 141-158; 199-206; 264-279; 298-308; 442-460 AND 466-476, MASS SPECTROMETRY. Tissue: Hepatoma. |
| [11] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 309-505. Tissue: Testis. |
| [12] | "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress." Guo D., Han J., Adam B.-L., Colburn N.H., Wang M.-H., Dong Z., Eizirik D.L., She J.-X., Wang C.-Y. Biochem. Biophys. Res. Commun. 337:1308-1318(2005) [PubMed: 16236267] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. |
| [13] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, MASS SPECTROMETRY. |
| [14] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [15] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-496, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AL050255 mRNA. Translation: CAB43357.1. AF161466 mRNA. Translation: AAF29081.1. Frameshift. AF155658 mRNA. Translation: AAF67477.1. Frameshift. CR457175 mRNA. Translation: CAG33456.1. CR456450 mRNA. Translation: CAG30336.1. AK312503 mRNA. Translation: BAG35405.1. AL021937 Genomic DNA. Translation: CAB38260.1. CH471095 Genomic DNA. Translation: EAW60021.1. BC000151 mRNA. Translation: AAH00151.1. BC002970 mRNA. Translation: AAH02970.1. BC010308 mRNA. Translation: AAH10308.1. BC016707 mRNA. Translation: AAH16707.1. AL137272 mRNA. Translation: CAB70670.1. | |
| IPI | IPI00550689. |
| PIR | T46344. |
| RefSeq | NP_055121.1. |
| UniGene | Hs.474643 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y3I0. |
PTM databases | |
| PhosphoSite | Q9Y3I0. |
Proteomic databases | |
| PeptideAtlas | Q9Y3I0. |
| PRIDE | Q9Y3I0. |
Genome annotation databases | |
| Ensembl | ENST00000216038; ENSP00000216038; ENSG00000100220; Homo sapiens. [Genome view] |
| GeneID | 51493. |
| KEGG | hsa:51493. |
| UCSC | uc003amm.2. human. |
Organism-specific databases | |
| CTD | 51493. |
| GeneCards | GC22M031113. |
| HGNC | HGNC:26935. C22orf28. |
| HPA | HPA001103. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y3I0. |
| OMA | KQIANVA |
| OrthoDB | EOG9B2WH4 |
Gene expression databases | |
| ArrayExpress | Q9Y3I0. |
| Bgee | Q9Y3I0. |
| CleanEx | HS_C22orf28. |
| Genevestigator | Q9Y3I0. |
| GermOnline | ENSG00000100220. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001233. UPF0027. [Graphical view] |
| PANTHER | PTHR11118. UPF0027. 1 hit. |
| Pfam | PF01139. UPF0027. 1 hit. [Graphical view] |
| PROSITE | PS01288. UPF0027. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 55157. |
Entry information
| Entry name | CV028_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y3I0 Secondary accession number(s): B2R6A8 Q9P0J3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |
| Uncharacterized protein families (UPF) List of uncharacterized protein family (UPF) entries |

Clusters with


