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Protein

Serine-threonine kinase receptor-associated protein

Gene

STRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.2 Publications

GO - Molecular functioni

GO - Biological processi

  • maintenance of gastrointestinal epithelium Source: UniProtKB
  • negative regulation of epithelial cell migration Source: UniProtKB
  • negative regulation of epithelial cell proliferation Source: UniProtKB
  • negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  • negative regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: Ensembl
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-2173788 Downregulation of TGF-beta receptor signaling
SignaLinkiQ9Y3F4
SIGNORiQ9Y3F4

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-threonine kinase receptor-associated protein
Alternative name(s):
MAP activator with WD repeats
UNR-interacting protein
WD-40 repeat protein PT-WD
Gene namesi
Name:STRAP
Synonyms:MAWD, UNRIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000023734.10
HGNCiHGNC:30796 STRAP
MIMi605986 gene
neXtProtiNX_Q9Y3F4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11171
OpenTargetsiENSG00000023734
PharmGKBiPA134867032

Polymorphism and mutation databases

BioMutaiSTRAP
DMDMi12643951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512301 – 350Serine-threonine kinase receptor-associated proteinAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3F4
PaxDbiQ9Y3F4
PeptideAtlasiQ9Y3F4
PRIDEiQ9Y3F4
TopDownProteomicsiQ9Y3F4-1 [Q9Y3F4-1]

2D gel databases

OGPiQ9Y3F4

PTM databases

iPTMnetiQ9Y3F4
PhosphoSitePlusiQ9Y3F4
SwissPalmiQ9Y3F4

Expressioni

Gene expression databases

BgeeiENSG00000023734
CleanExiHS_STRAP
ExpressionAtlasiQ9Y3F4 baseline and differential
GenevisibleiQ9Y3F4 HS

Organism-specific databases

HPAiHPA027320
HPA055557
HPA073876

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6 and GEMIN7. Associates with the SMN complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NME1P155319EBI-727414,EBI-741141

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116342, 94 interactors
CORUMiQ9Y3F4
IntActiQ9Y3F4, 33 interactors
MINTiQ9Y3F4
STRINGi9606.ENSP00000392270

Structurei

3D structure databases

ProteinModelPortaliQ9Y3F4
SMRiQ9Y3F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 56WD 1Add BLAST45
Repeati57 – 96WD 2Add BLAST40
Repeati98 – 137WD 3Add BLAST40
Repeati141 – 179WD 4Add BLAST39
Repeati180 – 212WD 5Add BLAST33
Repeati221 – 262WD 6Add BLAST42
Repeati263 – 302WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat STRAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0278 Eukaryota
ENOG410XPJ4 LUCA
GeneTreeiENSGT00630000089849
HOGENOMiHOG000174258
HOVERGENiHBG055228
InParanoidiQ9Y3F4
KOiK13137
OMAiMISACKD
OrthoDBiEOG091G0BY5
PhylomeDBiQ9Y3F4
TreeFamiTF323287

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD
60 70 80 90 100
WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK
110 120 130 140 150
HIVKTVDFTQ DSNYLLTGGQ DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL
160 170 180 190 200
WCSEDKQILS ADDKTVRLWD HATMTEVKSL NFNMSVSSME YIPEGEILVI
210 220 230 240 250
TYGRSIAFHS AVSLDPIKSF EAPATINSAS LHPEKEFLVA GGEDFKLYKY
260 270 280 290 300
DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY
310 320 330 340 350
GLWKCVLPEE DSGELAKPKI GFPETTEEEL EEIASENSDC IFPSAPDVKA
Length:350
Mass (Da):38,438
Last modified:November 1, 1999 - v1
Checksum:iCFCB34D3946290E2
GO
Isoform 2 (identifier: Q9Y3F4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-37: K → KGAGQHLPRLSGQH

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):39,778
Checksum:i13EA50904C5F24BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24G → D in BAA75544 (PubMed:10646843).Curated1
Sequence conflicti332E → A in AAV38848 (Ref. 6) Curated1
Sequence conflicti339D → E in CAB66626 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05687337K → KGAGQHLPRLSGQH in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010025 mRNA Translation: CAB38041.1
AB024327 mRNA Translation: BAA75544.1
AF161496 mRNA Translation: AAF29111.1
AY049776 mRNA Translation: AAL15433.1
AL136691 mRNA Translation: CAB66626.1
BT020044 mRNA Translation: AAV38847.1
BT020045 mRNA Translation: AAV38848.1
AK297942 mRNA Translation: BAG60258.1
AK312295 mRNA Translation: BAG35222.1
AC022073 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96356.1
BC000162 mRNA Translation: AAH00162.1
BC062306 mRNA Translation: AAH62306.1
CCDSiCCDS8676.1 [Q9Y3F4-1]
RefSeqiNP_009109.3, NM_007178.3 [Q9Y3F4-1]
UniGeneiHs.743971

Genome annotation databases

EnsembliENST00000025399; ENSP00000025399; ENSG00000023734 [Q9Y3F4-2]
ENST00000419869; ENSP00000392270; ENSG00000023734 [Q9Y3F4-1]
GeneIDi11171
KEGGihsa:11171
UCSCiuc001rdc.5 human [Q9Y3F4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTRAP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3F4
Secondary accession number(s): B2R5S5
, B4DNJ6, Q5TZT4, Q9NTK0, Q9UQC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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