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Protein

BolA-like protein 1

Gene

BOLA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 1
Alternative name(s):
hBolA
Gene namesi
Name:BOLA1
ORF Names:CGI-143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24263. BOLA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672552.

Polymorphism and mutation databases

BioMutaiBOLA1.
DMDMi8134821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137BolA-like protein 1PRO_0000201233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3E2.
MaxQBiQ9Y3E2.
PaxDbiQ9Y3E2.
PeptideAtlasiQ9Y3E2.
PRIDEiQ9Y3E2.

PTM databases

iPTMnetiQ9Y3E2.
PhosphoSiteiQ9Y3E2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ9Y3E2.
CleanExiHS_BOLA1.
GenevisibleiQ9Y3E2. HS.

Organism-specific databases

HPAiHPA007005.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BIRC2Q134903EBI-1049556,EBI-514538
C1orf94Q6P1W53EBI-1049556,EBI-946029
GLRX3O760035EBI-1049556,EBI-374781

Protein-protein interaction databases

BioGridi119233. 15 interactions.
IntActiQ9Y3E2. 3 interactions.
STRINGi9606.ENSP00000358146.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3E2.
SMRiQ9Y3E2. Positions 9-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

eggNOGiKOG2313. Eukaryota.
COG0271. LUCA.
GeneTreeiENSGT00510000048165.
HOGENOMiHOG000255169.
HOVERGENiHBG080902.
InParanoidiQ9Y3E2.
KOiK05527.
OMAiINESHNH.
OrthoDBiEOG7J1825.
PhylomeDBiQ9Y3E2.
TreeFamiTF354266.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
SUPFAMiSSF82657. SSF82657. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y3E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGRLVLGL VSMAGRVCLC QGSAGSGAIG PVEAAIRTKL EEALSPEVLE
60 70 80 90 100
LRNESGGHAV PPGSETHFRV AVVSSRFEGL SPLQRHRLVH AALAEELGGP
110 120 130
VHALAIQART PAQWRENSQL DTSPPCLGGN KKTLGTP
Length:137
Mass (Da):14,289
Last modified:November 1, 1999 - v1
Checksum:i0E1E05BCDB7620A9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981G → A.
Corresponds to variant rs1044808 [ dbSNP | Ensembl ].
VAR_033630

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151901 mRNA. Translation: AAD34138.1.
AK313014 mRNA. Translation: BAG35849.1.
AL591493 Genomic DNA. Translation: CAI12571.1.
CH471121 Genomic DNA. Translation: EAW53599.1.
CH471121 Genomic DNA. Translation: EAW53600.1.
CH471121 Genomic DNA. Translation: EAW53601.1.
CH471121 Genomic DNA. Translation: EAW53602.1.
BC063405 mRNA. Translation: AAH63405.1.
CCDSiCCDS939.1.
RefSeqiNP_057158.1. NM_016074.4.
XP_006711411.1. XM_006711348.2.
UniGeneiHs.13880.

Genome annotation databases

EnsembliENST00000369150; ENSP00000358146; ENSG00000178096.
ENST00000369152; ENSP00000358148; ENSG00000178096.
ENST00000369153; ENSP00000358149; ENSG00000178096.
GeneIDi51027.
KEGGihsa:51027.
UCSCiuc001etf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151901 mRNA. Translation: AAD34138.1.
AK313014 mRNA. Translation: BAG35849.1.
AL591493 Genomic DNA. Translation: CAI12571.1.
CH471121 Genomic DNA. Translation: EAW53599.1.
CH471121 Genomic DNA. Translation: EAW53600.1.
CH471121 Genomic DNA. Translation: EAW53601.1.
CH471121 Genomic DNA. Translation: EAW53602.1.
BC063405 mRNA. Translation: AAH63405.1.
CCDSiCCDS939.1.
RefSeqiNP_057158.1. NM_016074.4.
XP_006711411.1. XM_006711348.2.
UniGeneiHs.13880.

3D structure databases

ProteinModelPortaliQ9Y3E2.
SMRiQ9Y3E2. Positions 9-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119233. 15 interactions.
IntActiQ9Y3E2. 3 interactions.
STRINGi9606.ENSP00000358146.

PTM databases

iPTMnetiQ9Y3E2.
PhosphoSiteiQ9Y3E2.

Polymorphism and mutation databases

BioMutaiBOLA1.
DMDMi8134821.

Proteomic databases

EPDiQ9Y3E2.
MaxQBiQ9Y3E2.
PaxDbiQ9Y3E2.
PeptideAtlasiQ9Y3E2.
PRIDEiQ9Y3E2.

Protocols and materials databases

DNASUi51027.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369150; ENSP00000358146; ENSG00000178096.
ENST00000369152; ENSP00000358148; ENSG00000178096.
ENST00000369153; ENSP00000358149; ENSG00000178096.
GeneIDi51027.
KEGGihsa:51027.
UCSCiuc001etf.4. human.

Organism-specific databases

CTDi51027.
GeneCardsiBOLA1.
HGNCiHGNC:24263. BOLA1.
HPAiHPA007005.
MIMi613181. gene.
neXtProtiNX_Q9Y3E2.
PharmGKBiPA142672552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2313. Eukaryota.
COG0271. LUCA.
GeneTreeiENSGT00510000048165.
HOGENOMiHOG000255169.
HOVERGENiHBG080902.
InParanoidiQ9Y3E2.
KOiK05527.
OMAiINESHNH.
OrthoDBiEOG7J1825.
PhylomeDBiQ9Y3E2.
TreeFamiTF354266.

Miscellaneous databases

GenomeRNAii51027.
NextBioi53569.
PROiQ9Y3E2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y3E2.
CleanExiHS_BOLA1.
GenevisibleiQ9Y3E2. HS.

Family and domain databases

Gene3Di3.30.300.90. 1 hit.
InterProiIPR002634. BolA.
[Graphical view]
PfamiPF01722. BolA. 1 hit.
[Graphical view]
SUPFAMiSSF82657. SSF82657. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  6. "hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence."
    Zhou Y.B., Cao J.B., Wan B.B., Wang X.R., Ding G.H., Zhu H., Yang H.M., Wang K.S., Zhang X., Han Z.G.
    Mol. Cell. Biochem. 317:61-68(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOLA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E2
Secondary accession number(s): B2R7K2, D3DUZ4, Q5QNY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.