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Protein

BolA-like protein 1

Gene

BOLA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).By similarity1 Publication1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
BolA-like protein 1Curated
Alternative name(s):
hBolA1 Publication
Gene namesi
Name:BOLA1Imported
ORF Names:CGI-1431 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24263. BOLA1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178096.
PharmGKBiPA142672552.

Polymorphism and mutation databases

BioMutaiBOLA1.
DMDMi8134821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002012331 – 137BolA-like protein 1Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3E2.
MaxQBiQ9Y3E2.
PaxDbiQ9Y3E2.
PeptideAtlasiQ9Y3E2.
PRIDEiQ9Y3E2.

PTM databases

iPTMnetiQ9Y3E2.
PhosphoSitePlusiQ9Y3E2.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000178096.
CleanExiHS_BOLA1.
GenevisibleiQ9Y3E2. HS.

Organism-specific databases

HPAiHPA007005.

Interactioni

Subunit structurei

Interacts with GLRX5 (PubMed:22746225, PubMed:27532773, PubMed:27532772).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119233. 26 interactors.
IntActiQ9Y3E2. 7 interactors.
STRINGi9606.ENSP00000358146.

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 43Combined sources12
Beta strandi47 – 53Combined sources7
Helixi55 – 57Combined sources3
Beta strandi67 – 73Combined sources7
Helixi75 – 77Combined sources3
Helixi82 – 92Combined sources11
Helixi94 – 98Combined sources5
Beta strandi102 – 109Combined sources8
Helixi111 – 116Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LCINMR-A21-137[»]
ProteinModelPortaliQ9Y3E2.
SMRiQ9Y3E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BolA/IbaG family.Curated

Phylogenomic databases

eggNOGiKOG2313. Eukaryota.
COG0271. LUCA.
GeneTreeiENSGT00510000048165.
HOGENOMiHOG000255169.
HOVERGENiHBG080902.
InParanoidiQ9Y3E2.
KOiK05527.
OMAiSKKTRGT.
OrthoDBiEOG091G14DH.
PhylomeDBiQ9Y3E2.
TreeFamiTF354266.

Family and domain databases

InterProiView protein in InterPro
IPR002634. BolA.
PANTHERiPTHR12735. PTHR12735. 1 hit.
PfamiView protein in Pfam
PF01722. BolA. 1 hit.
SUPFAMiSSF82657. SSF82657. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y3E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGRLVLGL VSMAGRVCLC QGSAGSGAIG PVEAAIRTKL EEALSPEVLE
60 70 80 90 100
LRNESGGHAV PPGSETHFRV AVVSSRFEGL SPLQRHRLVH AALAEELGGP
110 120 130
VHALAIQART PAQWRENSQL DTSPPCLGGN KKTLGTP
Length:137
Mass (Da):14,289
Last modified:November 1, 1999 - v1
Checksum:i0E1E05BCDB7620A9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03363098G → A. Corresponds to variant dbSNP:rs1044808Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151901 mRNA. Translation: AAD34138.1.
AK313014 mRNA. Translation: BAG35849.1.
AL591493 Genomic DNA. Translation: CAI12571.1.
CH471121 Genomic DNA. Translation: EAW53599.1.
CH471121 Genomic DNA. Translation: EAW53600.1.
CH471121 Genomic DNA. Translation: EAW53601.1.
CH471121 Genomic DNA. Translation: EAW53602.1.
BC063405 mRNA. Translation: AAH63405.1.
CCDSiCCDS939.1.
RefSeqiNP_001307954.1. NM_001321025.1.
NP_001307955.1. NM_001321026.1.
NP_057158.1. NM_016074.4.
XP_006711411.1. XM_006711348.3.
UniGeneiHs.13880.

Genome annotation databases

EnsembliENST00000369150; ENSP00000358146; ENSG00000178096.
ENST00000369152; ENSP00000358148; ENSG00000178096.
ENST00000369153; ENSP00000358149; ENSG00000178096.
GeneIDi51027.
KEGGihsa:51027.
UCSCiuc001etf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBOLA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E2
Secondary accession number(s): B2R7K2, D3DUZ4, Q5QNY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially reported to be secreted via a non-classical export pathway (PubMed:18548201). It was however later shown that it localizes to mitochondria, in agreement with other members of the family (PubMed:22746225).2 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families