Q9Y3E2 (BOLA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 83.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: BolA-like protein 1 Alternative name(s): hBolA | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 137 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subcellular location | Secreted. Note: Could be secreted via a non-classical export pathway. Ref.7 |
| Tissue specificity | Widely expressed. Ref.7 |
| Sequence similarities | Belongs to the bolA/yrbA family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 137 | 137 | BolA-like protein 1 | PRO_0000201233 | |||||
Amino acid modifications | |||||||||
| Modified residue | 81 | 1 | Phosphoserine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 98 | 1 | G → A. Corresponds to variant rs1044808 [ dbSNP | Ensembl ]. | VAR_033630 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon. |
| [6] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [7] | "hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence." Zhou Y.B., Cao J.B., Wan B.B., Wang X.R., Ding G.H., Zhu H., Yang H.M., Wang K.S., Zhang X., Han Z.G. Mol. Cell. Biochem. 317:61-68(2008) [PubMed: 18548201] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [8] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF151901 mRNA. Translation: AAD34138.1. AK313014 mRNA. Translation: BAG35849.1. AL591493 Genomic DNA. Translation: CAI12571.1. CH471121 Genomic DNA. Translation: EAW53599.1. CH471121 Genomic DNA. Translation: EAW53600.1. CH471121 Genomic DNA. Translation: EAW53601.1. CH471121 Genomic DNA. Translation: EAW53602.1. BC063405 mRNA. Translation: AAH63405.1. |
| IPI | IPI00032900. |
| RefSeq | NP_057158.1. NM_016074.3. |
| UniGene | Hs.13880. |
3D structure databases | |
| ProteinModelPortal | Q9Y3E2. |
| SMR | Q9Y3E2. Positions 9-128. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y3E2. |
PTM databases | |
| PhosphoSite | Q9Y3E2. |
Polymorphism databases | |
| DMDM | 8134821. |
Proteomic databases | |
| PeptideAtlas | Q9Y3E2. |
| PRIDE | Q9Y3E2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000369150; ENSP00000358146; ENSG00000178096. ENST00000369152; ENSP00000358148; ENSG00000178096. ENST00000369153; ENSP00000358149; ENSG00000178096. |
| GeneID | 51027. |
| KEGG | hsa:51027. |
| NMPDR | fig|9606.3.peg.1933. |
| UCSC | uc001etf.1. human. |
Organism-specific databases | |
| CTD | 51027. |
| GeneCards | GC01P149859. |
| H-InvDB | HIX0028564. |
| HGNC | HGNC:24263. BOLA1. |
| HPA | HPA007005. |
| MIM | 613181. gene. |
| neXtProt | NX_Q9Y3E2. |
| PharmGKB | PA142672552. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG19949. |
| GeneTree | ENSGT00510000048165. |
| HOGENOM | HBG739421. |
| HOVERGEN | HBG080902. |
| InParanoid | Q9Y3E2. |
| OMA | LHALSMH. |
| OrthoDB | EOG4G1MHQ. |
| PhylomeDB | Q9Y3E2. |
Gene expression databases | |
| ArrayExpress | Q9Y3E2. |
| Bgee | Q9Y3E2. |
| CleanEx | HS_BOLA1. |
| Genevestigator | Q9Y3E2. |
| GermOnline | ENSG00000178096. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002634. BolA. [Graphical view] |
| Gene3D | G3DSA:3.30.300.90. BolA. 1 hit. |
| PANTHER | PTHR12735. BolA. 1 hit. |
| Pfam | PF01722. BolA. 1 hit. [Graphical view] |
| SUPFAM | SSF82657. BolA. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 53569. |
| SOURCE | Search... |
Entry information
| Entry name | BOLA1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y3E2 Secondary accession number(s): B2R7K2, D3DUZ4, Q5QNY0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with