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Q9Y3E1

- HDGR3_HUMAN

UniProt

Q9Y3E1 - HDGR3_HUMAN

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Protein

Hepatoma-derived growth factor-related protein 3

Gene

HDGFRP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Enhances DNA synthesis and may play a role in cell proliferation.1 Publication

GO - Biological processi

  1. cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name:
HRP-3
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
Gene namesi
Name:HDGFRP3
Synonyms:HDGF2
ORF Names:CGI-142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Hepatoma-derived growth factor-related protein 3PRO_0000191703Add
BLAST

Proteomic databases

MaxQBiQ9Y3E1.
PaxDbiQ9Y3E1.
PeptideAtlasiQ9Y3E1.
PRIDEiQ9Y3E1.

PTM databases

PhosphoSiteiQ9Y3E1.

Expressioni

Tissue specificityi

Detected in testis, heart, spinal cord and brain.1 Publication

Gene expression databases

BgeeiQ9Y3E1.
ExpressionAtlasiQ9Y3E1. baseline and differential.
GenevestigatoriQ9Y3E1.

Organism-specific databases

HPAiHPA040719.

Interactioni

Protein-protein interaction databases

BioGridi119129. 8 interactions.
IntActiQ9Y3E1. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3E1.
SMRiQ9Y3E1. Positions 8-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6858PWWPPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi136 – 14813Nuclear localization signalSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG273102.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ9Y3E1.
OMAiTHETXAI.
PhylomeDBiQ9Y3E1.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3E1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
AIQQQSSSET EGEGGNTADA SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY
160 170 180 190 200
TSKKSSKQSR KSPGDEDDKD CKEEENKSSS EGGDAGNDTR NTTSDLQKTS

EGT
Length:203
Mass (Da):22,620
Last modified:November 1, 1999 - v1
Checksum:i0B660D665F01659C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029156 mRNA. Translation: BAA90477.1.
AF110642 mRNA. Translation: AAM27001.1.
AF151900 mRNA. Translation: AAD34137.1.
AK001280 mRNA. Translation: BAA91597.1.
BC015483 mRNA. Translation: AAH15483.1.
CCDSiCCDS32314.1.
PIRiJC7163.
RefSeqiNP_057157.1. NM_016073.3.
UniGeneiHs.513954.

Genome annotation databases

GeneIDi50810.
KEGGihsa:50810.
UCSCiuc002bjs.2. human.

Polymorphism databases

DMDMi68052386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029156 mRNA. Translation: BAA90477.1 .
AF110642 mRNA. Translation: AAM27001.1 .
AF151900 mRNA. Translation: AAD34137.1 .
AK001280 mRNA. Translation: BAA91597.1 .
BC015483 mRNA. Translation: AAH15483.1 .
CCDSi CCDS32314.1.
PIRi JC7163.
RefSeqi NP_057157.1. NM_016073.3.
UniGenei Hs.513954.

3D structure databases

ProteinModelPortali Q9Y3E1.
SMRi Q9Y3E1. Positions 8-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119129. 8 interactions.
IntActi Q9Y3E1. 3 interactions.

PTM databases

PhosphoSitei Q9Y3E1.

Polymorphism databases

DMDMi 68052386.

Proteomic databases

MaxQBi Q9Y3E1.
PaxDbi Q9Y3E1.
PeptideAtlasi Q9Y3E1.
PRIDEi Q9Y3E1.

Protocols and materials databases

DNASUi 50810.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 50810.
KEGGi hsa:50810.
UCSCi uc002bjs.2. human.

Organism-specific databases

CTDi 50810.
GeneCardsi GC15M083784.
HPAi HPA040719.
neXtProti NX_Q9Y3E1.

Phylogenomic databases

eggNOGi NOG273102.
GeneTreei ENSGT00530000063013.
HOGENOMi HOG000112874.
HOVERGENi HBG010574.
InParanoidi Q9Y3E1.
OMAi THETXAI.
PhylomeDBi Q9Y3E1.

Miscellaneous databases

ChiTaRSi HDGFRP3. human.
GeneWikii HDGFRP3.
GenomeRNAii 50810.
NextBioi 53254.
PROi Q9Y3E1.

Gene expression databases

Bgeei Q9Y3E1.
ExpressionAtlasi Q9Y3E1. baseline and differential.
Genevestigatori Q9Y3E1.

Family and domain databases

InterProi IPR000313. PWWP_dom.
[Graphical view ]
Pfami PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
PROSITEi PS50812. PWWP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus."
    Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K., Suemura M., Kishimoto T., Nakamura H.
    Biochem. Biophys. Res. Commun. 266:81-87(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Lymphocyte.
  2. "Cloning of a novel human cDNA which is a homolog to mouse hepatoma-derived growth factor (mHDGF) and termed hHDGF2."
    Yu L., Fu Q., Tu Q.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiHDGR3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3