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Q9Y3E1 (HDGR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hepatoma-derived growth factor-related protein 3

Short name=HRP-3
Alternative name(s):
Hepatoma-derived growth factor 2
Short name=HDGF-2
Gene names
Name:HDGFRP3
Synonyms:HDGF2
ORF Names:CGI-142
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances DNA synthesis and may play a role in cell proliferation. Ref.1

Subcellular location

Nucleus Ref.1.

Tissue specificity

Detected in testis, heart, spinal cord and brain. Ref.1

Sequence similarities

Belongs to the HDGF family.

Contains 1 PWWP domain.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionGrowth factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Hepatoma-derived growth factor-related protein 3
PRO_0000191703

Regions

Domain11 – 6858PWWP
Motif136 – 14813Nuclear localization signal Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Y3E1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 0B660D665F01659C

FASTA20322,620
        10         20         30         40         50         60 
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK 

        70         80         90        100        110        120 
DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA 

       130        140        150        160        170        180 
SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS 

       190        200 
EGGDAGNDTR NTTSDLQKTS EGT 

« Hide

References

« Hide 'large scale' references
[1]"A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus."
Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K., Suemura M., Kishimoto T., Nakamura H.
Biochem. Biophys. Res. Commun. 266:81-87(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Lymphocyte.
[2]"Cloning of a novel human cDNA which is a homolog to mouse hepatoma-derived growth factor (mHDGF) and termed hHDGF2."
Yu L., Fu Q., Tu Q.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029156 mRNA. Translation: BAA90477.1.
AF110642 mRNA. Translation: AAM27001.1.
AF151900 mRNA. Translation: AAD34137.1.
AK001280 mRNA. Translation: BAA91597.1.
BC015483 mRNA. Translation: AAH15483.1.
PIRJC7163.
RefSeqNP_057157.1. NM_016073.3.
UniGeneHs.513954.

3D structure databases

ProteinModelPortalQ9Y3E1.
SMRQ9Y3E1. Positions 8-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119129. 4 interactions.
IntActQ9Y3E1. 3 interactions.

PTM databases

PhosphoSiteQ9Y3E1.

Polymorphism databases

DMDM68052386.

Proteomic databases

PaxDbQ9Y3E1.
PeptideAtlasQ9Y3E1.
PRIDEQ9Y3E1.

Protocols and materials databases

DNASU50810.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID50810.
KEGGhsa:50810.
UCSCuc002bjs.2. human.

Organism-specific databases

CTD50810.
GeneCardsGC15M083784.
HPAHPA040719.
neXtProtNX_Q9Y3E1.

Phylogenomic databases

eggNOGNOG273102.
HOGENOMHOG000112874.
HOVERGENHBG010574.
InParanoidQ9Y3E1.
OMANDTRNTA.
PhylomeDBQ9Y3E1.

Gene expression databases

ArrayExpressQ9Y3E1.
BgeeQ9Y3E1.
GenevestigatorQ9Y3E1.

Family and domain databases

InterProIPR000313. PWWP_dom.
[Graphical view]
PfamPF00855. PWWP. 1 hit.
[Graphical view]
SMARTSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHDGFRP3.
GenomeRNAi50810.
NextBio53254.
PROQ9Y3E1.

Entry information

Entry nameHDGR3_HUMAN
AccessionPrimary (citable) accession number: Q9Y3E1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM