Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y3E1

- HDGR3_HUMAN

UniProt

Q9Y3E1 - HDGR3_HUMAN

Protein

Hepatoma-derived growth factor-related protein 3

Gene

HDGFRP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enhances DNA synthesis and may play a role in cell proliferation.1 Publication

    GO - Biological processi

    1. cell proliferation Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatoma-derived growth factor-related protein 3
    Short name:
    HRP-3
    Alternative name(s):
    Hepatoma-derived growth factor 2
    Short name:
    HDGF-2
    Gene namesi
    Name:HDGFRP3
    Synonyms:HDGF2
    ORF Names:CGI-142
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Hepatoma-derived growth factor-related protein 3PRO_0000191703Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y3E1.
    PaxDbiQ9Y3E1.
    PeptideAtlasiQ9Y3E1.
    PRIDEiQ9Y3E1.

    PTM databases

    PhosphoSiteiQ9Y3E1.

    Expressioni

    Tissue specificityi

    Detected in testis, heart, spinal cord and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y3E1.
    BgeeiQ9Y3E1.
    GenevestigatoriQ9Y3E1.

    Organism-specific databases

    HPAiHPA040719.

    Interactioni

    Protein-protein interaction databases

    BioGridi119129. 4 interactions.
    IntActiQ9Y3E1. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3E1.
    SMRiQ9Y3E1. Positions 8-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 6858PWWPPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi136 – 14813Nuclear localization signalSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HDGF family.Curated
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG273102.
    HOGENOMiHOG000112874.
    HOVERGENiHBG010574.
    InParanoidiQ9Y3E1.
    OMAiTHETXAI.
    PhylomeDBiQ9Y3E1.

    Family and domain databases

    InterProiIPR000313. PWWP_dom.
    [Graphical view]
    PfamiPF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    PROSITEiPS50812. PWWP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG    50
    THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ 100
    AIQQQSSSET EGEGGNTADA SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY 150
    TSKKSSKQSR KSPGDEDDKD CKEEENKSSS EGGDAGNDTR NTTSDLQKTS 200
    EGT 203
    Length:203
    Mass (Da):22,620
    Last modified:November 1, 1999 - v1
    Checksum:i0B660D665F01659C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029156 mRNA. Translation: BAA90477.1.
    AF110642 mRNA. Translation: AAM27001.1.
    AF151900 mRNA. Translation: AAD34137.1.
    AK001280 mRNA. Translation: BAA91597.1.
    BC015483 mRNA. Translation: AAH15483.1.
    CCDSiCCDS32314.1.
    PIRiJC7163.
    RefSeqiNP_057157.1. NM_016073.3.
    UniGeneiHs.513954.

    Genome annotation databases

    GeneIDi50810.
    KEGGihsa:50810.
    UCSCiuc002bjs.2. human.

    Polymorphism databases

    DMDMi68052386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029156 mRNA. Translation: BAA90477.1 .
    AF110642 mRNA. Translation: AAM27001.1 .
    AF151900 mRNA. Translation: AAD34137.1 .
    AK001280 mRNA. Translation: BAA91597.1 .
    BC015483 mRNA. Translation: AAH15483.1 .
    CCDSi CCDS32314.1.
    PIRi JC7163.
    RefSeqi NP_057157.1. NM_016073.3.
    UniGenei Hs.513954.

    3D structure databases

    ProteinModelPortali Q9Y3E1.
    SMRi Q9Y3E1. Positions 8-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119129. 4 interactions.
    IntActi Q9Y3E1. 3 interactions.

    PTM databases

    PhosphoSitei Q9Y3E1.

    Polymorphism databases

    DMDMi 68052386.

    Proteomic databases

    MaxQBi Q9Y3E1.
    PaxDbi Q9Y3E1.
    PeptideAtlasi Q9Y3E1.
    PRIDEi Q9Y3E1.

    Protocols and materials databases

    DNASUi 50810.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 50810.
    KEGGi hsa:50810.
    UCSCi uc002bjs.2. human.

    Organism-specific databases

    CTDi 50810.
    GeneCardsi GC15M083784.
    HPAi HPA040719.
    neXtProti NX_Q9Y3E1.

    Phylogenomic databases

    eggNOGi NOG273102.
    HOGENOMi HOG000112874.
    HOVERGENi HBG010574.
    InParanoidi Q9Y3E1.
    OMAi THETXAI.
    PhylomeDBi Q9Y3E1.

    Miscellaneous databases

    GeneWikii HDGFRP3.
    GenomeRNAii 50810.
    NextBioi 53254.
    PROi Q9Y3E1.

    Gene expression databases

    ArrayExpressi Q9Y3E1.
    Bgeei Q9Y3E1.
    Genevestigatori Q9Y3E1.

    Family and domain databases

    InterProi IPR000313. PWWP_dom.
    [Graphical view ]
    Pfami PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    PROSITEi PS50812. PWWP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus."
      Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K., Suemura M., Kishimoto T., Nakamura H.
      Biochem. Biophys. Res. Commun. 266:81-87(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Lymphocyte.
    2. "Cloning of a novel human cDNA which is a homolog to mouse hepatoma-derived growth factor (mHDGF) and termed hHDGF2."
      Yu L., Fu Q., Tu Q.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiHDGR3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3