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Protein

Hepatoma-derived growth factor-related protein 3

Gene

HDGFL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances DNA synthesis and may play a role in cell proliferation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name:
HRP-3
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
Gene namesi
Name:HDGFL3Imported
Synonyms:HDGF2, HDGFRP3
ORF Names:CGI-142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24937. HDGFL3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi50810.
OpenTargetsiENSG00000166503.

Polymorphism and mutation databases

BioMutaiHDGFRP3.
DMDMi68052386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917031 – 203Hepatoma-derived growth factor-related protein 3Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei122PhosphoserineBy similarity1
Modified residuei162PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3E1.
MaxQBiQ9Y3E1.
PaxDbiQ9Y3E1.
PeptideAtlasiQ9Y3E1.
PRIDEiQ9Y3E1.
TopDownProteomicsiQ9Y3E1.

PTM databases

iPTMnetiQ9Y3E1.
PhosphoSitePlusiQ9Y3E1.

Expressioni

Tissue specificityi

Detected in testis, heart, spinal cord and brain.1 Publication

Gene expression databases

BgeeiENSG00000166503.
ExpressionAtlasiQ9Y3E1. baseline and differential.
GenevisibleiQ9Y3E1. HS.

Organism-specific databases

HPAiHPA040719.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119129. 16 interactors.
IntActiQ9Y3E1. 4 interactors.
STRINGi9606.ENSP00000299633.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3E1.
SMRiQ9Y3E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68PWWPPROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 148Nuclear localization signalSequence analysisAdd BLAST13

Sequence similaritiesi

Belongs to the HDGF family.Curated

Phylogenomic databases

eggNOGiENOG410IMJ2. Eukaryota.
ENOG41127WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ9Y3E1.
OMAiFTGYQAM.
OrthoDBiEOG091G045X.
PhylomeDBiQ9Y3E1.

Family and domain databases

InterProiView protein in InterPro
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG
60 70 80 90 100
THETAFLGPK DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ
110 120 130 140 150
AIQQQSSSET EGEGGNTADA SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY
160 170 180 190 200
TSKKSSKQSR KSPGDEDDKD CKEEENKSSS EGGDAGNDTR NTTSDLQKTS

EGT
Length:203
Mass (Da):22,620
Last modified:November 1, 1999 - v1
Checksum:i0B660D665F01659C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029156 mRNA. Translation: BAA90477.1.
AF110642 mRNA. Translation: AAM27001.1.
AF151900 mRNA. Translation: AAD34137.1.
AK001280 mRNA. Translation: BAA91597.1.
BC015483 mRNA. Translation: AAH15483.1.
CCDSiCCDS32314.1.
PIRiJC7163.
RefSeqiNP_057157.1. NM_016073.3.
UniGeneiHs.513954.

Genome annotation databases

GeneIDi50810.
KEGGihsa:50810.
UCSCiuc002bjs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029156 mRNA. Translation: BAA90477.1.
AF110642 mRNA. Translation: AAM27001.1.
AF151900 mRNA. Translation: AAD34137.1.
AK001280 mRNA. Translation: BAA91597.1.
BC015483 mRNA. Translation: AAH15483.1.
CCDSiCCDS32314.1.
PIRiJC7163.
RefSeqiNP_057157.1. NM_016073.3.
UniGeneiHs.513954.

3D structure databases

ProteinModelPortaliQ9Y3E1.
SMRiQ9Y3E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119129. 16 interactors.
IntActiQ9Y3E1. 4 interactors.
STRINGi9606.ENSP00000299633.

PTM databases

iPTMnetiQ9Y3E1.
PhosphoSitePlusiQ9Y3E1.

Polymorphism and mutation databases

BioMutaiHDGFRP3.
DMDMi68052386.

Proteomic databases

EPDiQ9Y3E1.
MaxQBiQ9Y3E1.
PaxDbiQ9Y3E1.
PeptideAtlasiQ9Y3E1.
PRIDEiQ9Y3E1.
TopDownProteomicsiQ9Y3E1.

Protocols and materials databases

DNASUi50810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50810.
KEGGihsa:50810.
UCSCiuc002bjs.3. human.

Organism-specific databases

CTDi50810.
DisGeNETi50810.
GeneCardsiHDGFRP3.
HGNCiHGNC:24937. HDGFL3.
HPAiHPA040719.
neXtProtiNX_Q9Y3E1.
OpenTargetsiENSG00000166503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMJ2. Eukaryota.
ENOG41127WD. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiQ9Y3E1.
OMAiFTGYQAM.
OrthoDBiEOG091G045X.
PhylomeDBiQ9Y3E1.

Miscellaneous databases

ChiTaRSiHDGFRP3. human.
GeneWikiiHDGFRP3.
GenomeRNAii50810.
PROiPR:Q9Y3E1.

Gene expression databases

BgeeiENSG00000166503.
ExpressionAtlasiQ9Y3E1. baseline and differential.
GenevisibleiQ9Y3E1. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000313. PWWP_dom.
PfamiView protein in Pfam
PF00855. PWWP. 1 hit.
SMARTiView protein in SMART
SM00293. PWWP. 1 hit.
PROSITEiView protein in PROSITE
PS50812. PWWP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHDGR3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.