Q9Y3E1 (HDGR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hepatoma-derived growth factor-related protein 3
Short name=HRP-3

Alternative name(s):
Hepatoma-derived growth factor 2
Short name=HDGF-2

Gene names

Name:	HDGFRP3
Synonyms:	HDGF2
ORF Names:	CGI-142

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances DNA synthesis and may play a role in cell proliferation. Ref.1
Subcellular location	Nucleus Ref.1.
Tissue specificity	Detected in testis, heart, spinal cord and brain. Ref.1
Sequence similarities	Belongs to the HDGF family. Contains 1 PWWP domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Growth factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Hepatoma-derived growth factor-related protein 3		PRO_0000191703
Regions
	Domain	11 – 68	58	PWWP
	Motif	136 – 148	13	Nuclear localization signal Potential
Amino acid modifications
	Modified residue	178	1	Phosphoserine By similarity
	Modified residue	179	1	Phosphoserine By similarity
	Modified residue	180	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3E1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0B660D665F01659C	FASTA	203	22,620
	10 20 30 40 50 60 MARPRPREYK AGDLVFAKMK GYPHWPARID ELPEGAVKPP ANKYPIFFFG THETAFLGPK 70 80 90 100 110 120 DLFPYKEYKD KFGKSNKRKG FNEGLWEIEN NPGVKFTGYQ AIQQQSSSET EGEGGNTADA 130 140 150 160 170 180 SSEEEGDRVE EDGKGKRKNE KAGSKRKKSY TSKKSSKQSR KSPGDEDDKD CKEEENKSSS 190 200 EGGDAGNDTR NTTSDLQKTS EGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus." Ikegame K., Yamamoto M., Kishima Y., Enomoto H., Yoshida K., Suemura M., Kishimoto T., Nakamura H. Biochem. Biophys. Res. Commun. 266:81-87(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Lymphocyte.
[2]	"Cloning of a novel human cDNA which is a homolog to mouse hepatoma-derived growth factor (mHDGF) and termed hHDGF2." Yu L., Fu Q., Tu Q. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB029156 mRNA. Translation: BAA90477.1. AF110642 mRNA. Translation: AAM27001.1. AF151900 mRNA. Translation: AAD34137.1. AK001280 mRNA. Translation: BAA91597.1. BC015483 mRNA. Translation: AAH15483.1.
IPI	IPI00007063.
PIR	JC7163.
RefSeq	NP_057157.1. NM_016073.3.
UniGene	Hs.513954.
3D structure databases
ProteinModelPortal	Q9Y3E1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3E1. 2 interactions.
PTM databases
PhosphoSite	Q9Y3E1.
Polymorphism databases
DMDM	68052386.
Proteomic databases
PaxDb	Q9Y3E1.
PeptideAtlas	Q9Y3E1.
PRIDE	Q9Y3E1.
Protocols and materials databases
DNASU	50810.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	50810.
KEGG	hsa:50810.
UCSC	uc002bjs.1. human.
Organism-specific databases
CTD	50810.
GeneCards	GC15M083784.
HPA	HPA040719.
neXtProt	NX_Q9Y3E1.
Phylogenomic databases
eggNOG	NOG273102.
HOGENOM	HOG000112874.
HOVERGEN	HBG010574.
InParanoid	Q9Y3E1.
OMA	NEKGGSK.
OrthoDB	EOG40VVQS.
PhylomeDB	Q9Y3E1.
Gene expression databases
ArrayExpress	Q9Y3E1.
Bgee	Q9Y3E1.
Genevestigator	Q9Y3E1.
GermOnline	ENSG00000166503. Homo sapiens.
Family and domain databases
InterPro	IPR000313. PWWP. [Graphical view]
Pfam	PF00855. PWWP. 1 hit. [Graphical view]
SMART	SM00293. PWWP. 1 hit. [Graphical view]
PROSITE	PS50812. PWWP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	50810.
NextBio	53254.

Entry information

Entry name

HDGR3_HUMAN

Accession

Primary (citable) accession number: Q9Y3E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.