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Protein

Vesicle transport protein GOT1B

Gene

GOLT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein GOT1B
Alternative name(s):
Germ cell tumor 2
Golgi transport 1 homolog B
Putative NF-kappa-B-activating protein 470
hGOT1a
Gene namesi
Name:GOLT1B
Synonyms:GCT2, GOT1A
ORF Names:CGI-141, HDCMA39P, UNQ432/PRO793
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:20175. GOLT1B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 32LumenalSequence analysis2
Transmembranei33 – 53Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini90LumenalSequence analysis1
Transmembranei91 – 109Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini110 – 138CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51026.
OpenTargetsiENSG00000111711.
PharmGKBiPA134898810.

Polymorphism and mutation databases

BioMutaiGOLT1B.
DMDMi20534680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185821 – 138Vesicle transport protein GOT1BAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3E0.
MaxQBiQ9Y3E0.
PaxDbiQ9Y3E0.
PeptideAtlasiQ9Y3E0.
PRIDEiQ9Y3E0.
TopDownProteomicsiQ9Y3E0.

PTM databases

iPTMnetiQ9Y3E0.
PhosphoSitePlusiQ9Y3E0.

Expressioni

Tissue specificityi

Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.1 Publication

Gene expression databases

BgeeiENSG00000111711.
CleanExiHS_GOLT1B.
ExpressionAtlasiQ9Y3E0. baseline and differential.
GenevisibleiQ9Y3E0. HS.

Organism-specific databases

HPAiHPA066383.

Interactioni

Protein-protein interaction databases

BioGridi119232. 176 interactors.
IntActiQ9Y3E0. 177 interactors.
MINTiMINT-3085932.
STRINGi9606.ENSP00000229314.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 108Phe-richAdd BLAST92

Sequence similaritiesi

Belongs to the GOT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1743. Eukaryota.
COG5120. LUCA.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
HOVERGENiHBG009362.
InParanoidiQ9Y3E0.
OMAiAGESNNM.
OrthoDBiEOG091G10MS.
PhylomeDBiQ9Y3E0.
TreeFamiTF300267.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamiPF04178. Got1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI
60 70 80 90 100
GLERTFRFFF QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG
110 120 130
FFPVVVGFIR RVPVLGSLLN LPGIRSFVDK VGESNNMV
Length:138
Mass (Da):15,426
Last modified:November 1, 1999 - v1
Checksum:i2EB85823C34EFAFA
GO

Sequence cautioni

The sequence AAF65181 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → T in AAF65181 (Ref. 5) Curated1
Sequence conflicti54R → K in CAG33670 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151899 mRNA. Translation: AAD34136.1.
AL136571 mRNA. Translation: CAB66506.1.
AB097020 mRNA. Translation: BAC77373.1.
AY358975 mRNA. Translation: AAQ89334.1.
AF068292 mRNA. Translation: AAF65181.1. Different initiation.
CR457389 mRNA. Translation: CAG33670.1.
AK311920 mRNA. Translation: BAG34861.1.
CH471094 Genomic DNA. Translation: EAW96443.1.
BC012455 mRNA. Translation: AAH12455.1.
CCDSiCCDS8689.1.
PIRiT46908.
RefSeqiNP_057156.1. NM_016072.4.
UniGeneiHs.62275.

Genome annotation databases

EnsembliENST00000229314; ENSP00000229314; ENSG00000111711.
GeneIDi51026.
KEGGihsa:51026.
UCSCiuc001rez.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151899 mRNA. Translation: AAD34136.1.
AL136571 mRNA. Translation: CAB66506.1.
AB097020 mRNA. Translation: BAC77373.1.
AY358975 mRNA. Translation: AAQ89334.1.
AF068292 mRNA. Translation: AAF65181.1. Different initiation.
CR457389 mRNA. Translation: CAG33670.1.
AK311920 mRNA. Translation: BAG34861.1.
CH471094 Genomic DNA. Translation: EAW96443.1.
BC012455 mRNA. Translation: AAH12455.1.
CCDSiCCDS8689.1.
PIRiT46908.
RefSeqiNP_057156.1. NM_016072.4.
UniGeneiHs.62275.

3D structure databases

ProteinModelPortaliQ9Y3E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119232. 176 interactors.
IntActiQ9Y3E0. 177 interactors.
MINTiMINT-3085932.
STRINGi9606.ENSP00000229314.

PTM databases

iPTMnetiQ9Y3E0.
PhosphoSitePlusiQ9Y3E0.

Polymorphism and mutation databases

BioMutaiGOLT1B.
DMDMi20534680.

Proteomic databases

EPDiQ9Y3E0.
MaxQBiQ9Y3E0.
PaxDbiQ9Y3E0.
PeptideAtlasiQ9Y3E0.
PRIDEiQ9Y3E0.
TopDownProteomicsiQ9Y3E0.

Protocols and materials databases

DNASUi51026.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229314; ENSP00000229314; ENSG00000111711.
GeneIDi51026.
KEGGihsa:51026.
UCSCiuc001rez.3. human.

Organism-specific databases

CTDi51026.
DisGeNETi51026.
GeneCardsiGOLT1B.
HGNCiHGNC:20175. GOLT1B.
HPAiHPA066383.
MIMi615078. gene.
neXtProtiNX_Q9Y3E0.
OpenTargetsiENSG00000111711.
PharmGKBiPA134898810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1743. Eukaryota.
COG5120. LUCA.
GeneTreeiENSGT00390000014507.
HOGENOMiHOG000035939.
HOVERGENiHBG009362.
InParanoidiQ9Y3E0.
OMAiAGESNNM.
OrthoDBiEOG091G10MS.
PhylomeDBiQ9Y3E0.
TreeFamiTF300267.

Miscellaneous databases

GeneWikiiGOLT1B.
GenomeRNAii51026.
PROiQ9Y3E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111711.
CleanExiHS_GOLT1B.
ExpressionAtlasiQ9Y3E0. baseline and differential.
GenevisibleiQ9Y3E0. HS.

Family and domain databases

InterProiIPR007305. Vesicle_transpt_Got1/SFT2.
[Graphical view]
PfamiPF04178. Got1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOT1B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E0
Secondary accession number(s): B2R4R4
, Q54A40, Q6I9W6, Q9P1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.