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Q9Y3D9

- RT23_HUMAN

UniProt

Q9Y3D9 - RT23_HUMAN

Protein

28S ribosomal protein S23, mitochondrial

Gene

MRPS23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (23 May 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S23, mitochondrial
    Short name:
    MRP-S23
    Short name:
    S23mt
    Gene namesi
    Name:MRPS23
    ORF Names:CGI-138, HSPC329
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14509. MRPS23.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament cytoskeleton Source: HPA
    2. mitochondrion Source: HPA
    3. nuclear membrane Source: HPA
    4. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19019028S ribosomal protein S23, mitochondrialPRO_0000087705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y3D9.
    PaxDbiQ9Y3D9.
    PeptideAtlasiQ9Y3D9.
    PRIDEiQ9Y3D9.

    PTM databases

    PhosphoSiteiQ9Y3D9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3D9.
    BgeeiQ9Y3D9.
    CleanExiHS_MRPS23.
    GenevestigatoriQ9Y3D9.

    Organism-specific databases

    HPAiHPA023453.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

    Protein-protein interaction databases

    BioGridi119657. 18 interactions.
    IntActiQ9Y3D9. 7 interactions.
    STRINGi9606.ENSP00000320184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3D9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG81280.
    HOGENOMiHOG000059557.
    HOVERGENiHBG044512.
    InParanoidiQ9Y3D9.
    KOiK17402.
    OMAiFSRTRNL.
    OrthoDBiEOG7TBC3P.
    PhylomeDBiQ9Y3D9.
    TreeFamiTF106116.

    Family and domain databases

    InterProiIPR019520. Ribosomal_S23/Rsm25.
    IPR023611. Ribosomal_S23/S25_mit.
    [Graphical view]
    PANTHERiPTHR15925. PTHR15925. 1 hit.
    PfamiPF10484. MRP-S23. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR    50
    VRYGKAKAPI QDIWYHEDRI RAKFYSVYGS GQRAFDLFNP NFKSTCQRFV 100
    EKYTELQKLG ETDEEKLFVE TGKALLAEGV ILRRVGEART QHGGSHVSRK 150
    SEHLSVRPQT ALEENETQKE VPQDQHLEAP ADQSKGLLPP 190
    Length:190
    Mass (Da):21,771
    Last modified:May 23, 2003 - v2
    Checksum:i0A50DEDA9BFB74AF
    GO

    Sequence cautioni

    The sequence AAD34133.1 differs from that shown. Reason: Frameshift at position 138.
    The sequence AAF29007.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111S → C in AAD34133. (PubMed:10810093)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151896 mRNA. Translation: AAD34133.1. Frameshift.
    AF161447 mRNA. Translation: AAF29007.1. Frameshift.
    AK312729 mRNA. Translation: BAG35600.1.
    CH471109 Genomic DNA. Translation: EAW94503.1.
    BC000242 mRNA. Translation: AAH00242.1.
    AB061206 Genomic DNA. Translation: BAB54956.1.
    CCDSiCCDS11598.1.
    RefSeqiNP_057154.2. NM_016070.3.
    UniGeneiHs.5836.

    Genome annotation databases

    EnsembliENST00000313608; ENSP00000320184; ENSG00000181610.
    GeneIDi51649.
    KEGGihsa:51649.
    UCSCiuc002ivc.3. human.

    Polymorphism databases

    DMDMi31077184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151896 mRNA. Translation: AAD34133.1 . Frameshift.
    AF161447 mRNA. Translation: AAF29007.1 . Frameshift.
    AK312729 mRNA. Translation: BAG35600.1 .
    CH471109 Genomic DNA. Translation: EAW94503.1 .
    BC000242 mRNA. Translation: AAH00242.1 .
    AB061206 Genomic DNA. Translation: BAB54956.1 .
    CCDSi CCDS11598.1.
    RefSeqi NP_057154.2. NM_016070.3.
    UniGenei Hs.5836.

    3D structure databases

    ProteinModelPortali Q9Y3D9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119657. 18 interactions.
    IntActi Q9Y3D9. 7 interactions.
    STRINGi 9606.ENSP00000320184.

    PTM databases

    PhosphoSitei Q9Y3D9.

    Polymorphism databases

    DMDMi 31077184.

    Proteomic databases

    MaxQBi Q9Y3D9.
    PaxDbi Q9Y3D9.
    PeptideAtlasi Q9Y3D9.
    PRIDEi Q9Y3D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313608 ; ENSP00000320184 ; ENSG00000181610 .
    GeneIDi 51649.
    KEGGi hsa:51649.
    UCSCi uc002ivc.3. human.

    Organism-specific databases

    CTDi 51649.
    GeneCardsi GC17M055916.
    HGNCi HGNC:14509. MRPS23.
    HPAi HPA023453.
    MIMi 611985. gene.
    neXtProti NX_Q9Y3D9.
    PharmGKBi PA31011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81280.
    HOGENOMi HOG000059557.
    HOVERGENi HBG044512.
    InParanoidi Q9Y3D9.
    KOi K17402.
    OMAi FSRTRNL.
    OrthoDBi EOG7TBC3P.
    PhylomeDBi Q9Y3D9.
    TreeFami TF106116.

    Miscellaneous databases

    GenomeRNAii 51649.
    NextBioi 55600.
    PROi Q9Y3D9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3D9.
    Bgeei Q9Y3D9.
    CleanExi HS_MRPS23.
    Genevestigatori Q9Y3D9.

    Family and domain databases

    InterProi IPR019520. Ribosomal_S23/Rsm25.
    IPR023611. Ribosomal_S23/S25_mit.
    [Graphical view ]
    PANTHERi PTHR15925. PTHR15925. 1 hit.
    Pfami PF10484. MRP-S23. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Human partial CDS from CD34+ stem cells."
      Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-98.
    7. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
      J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT23_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3D9
    Secondary accession number(s): B2R6V3
    , Q96Q24, Q9BWH8, Q9P053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 23, 2003
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3