Q9Y3D9 (RT23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S23, mitochondrial
Short name=MRP-S23
Short name=S23mt

Gene names

Name:	MRPS23
ORF Names:	CGI-138, HSPC329

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity.
Subcellular location	Mitochondrion.
Sequence caution	The sequence AAD34133.1 differs from that shown. Reason: Frameshift at position 138. The sequence AAF29007.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	intermediate filament cytoskeleton Inferred from direct assay. Source: HPA mitochondrion Inferred from direct assay. Source: HPA nuclear membrane Inferred from direct assay. Source: HPA ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	28S ribosomal protein S23, mitochondrial		PRO_0000087705
Amino acid modifications
	Modified residue	102	1	N6-acetyllysine Ref.8
Experimental info
	Sequence conflict	11	1	S → C in AAD34133. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D9 [UniParc]. Last modified May 23, 2003. Version 2. Checksum: 0A50DEDA9BFB74AF	FASTA	190	21,771
	10 20 30 40 50 60 MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR VRYGKAKAPI 70 80 90 100 110 120 QDIWYHEDRI RAKFYSVYGS GQRAFDLFNP NFKSTCQRFV EKYTELQKLG ETDEEKLFVE 130 140 150 160 170 180 TGKALLAEGV ILRRVGEART QHGGSHVSRK SEHLSVRPQT ALEENETQKE VPQDQHLEAP 190 ADQSKGLLPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[6]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-98.
[7]	"A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins." Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L. J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-102, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151896 mRNA. Translation: AAD34133.1. Frameshift. AF161447 mRNA. Translation: AAF29007.1. Frameshift. AK312729 mRNA. Translation: BAG35600.1. CH471109 Genomic DNA. Translation: EAW94503.1. BC000242 mRNA. Translation: AAH00242.1. AB061206 Genomic DNA. Translation: BAB54956.1.
IPI	IPI00032881.
RefSeq	NP_057154.2. NM_016070.3.
UniGene	Hs.5836.
3D structure databases
ProteinModelPortal	Q9Y3D9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3D9. 3 interactions.
STRING	9606.ENSP00000320184.
PTM databases
PhosphoSite	Q9Y3D9.
Polymorphism databases
DMDM	31077184.
Proteomic databases
PaxDb	Q9Y3D9.
PeptideAtlas	Q9Y3D9.
PRIDE	Q9Y3D9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313608; ENSP00000320184; ENSG00000181610.
GeneID	51649.
KEGG	hsa:51649.
UCSC	uc002ivc.3. human.
Organism-specific databases
CTD	51649.
GeneCards	GC17M055916.
HGNC	HGNC:14509. MRPS23.
HPA	HPA023453.
MIM	611985. gene.
neXtProt	NX_Q9Y3D9.
PharmGKB	PA31011.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81280.
HOGENOM	HOG000059557.
HOVERGEN	HBG044512.
InParanoid	Q9Y3D9.
OMA	FSRTRNL.
OrthoDB	EOG4FTW1N.
PhylomeDB	Q9Y3D9.
Gene expression databases
Bgee	Q9Y3D9.
CleanEx	HS_MRPS23.
Genevestigator	Q9Y3D9.
GermOnline	ENSG00000181610. Homo sapiens.
Family and domain databases
InterPro	IPR023611. Ribosomal_S23/S25_mit. IPR019520. Ribosomal_S23_mit. [Graphical view]
PANTHER	PTHR15925. PTHR15925. 1 hit.
Pfam	PF10484. MRP-S23. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51649.
NextBio	55600.
SOURCE	Search...

Entry information

Entry name

RT23_HUMAN

Accession

Primary (citable) accession number: Q9Y3D9
Secondary accession number(s): B2R6V3 , Q96Q24, Q9BWH8, Q9P053

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 23, 2003
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.