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Q9Y3D9

- RT23_HUMAN

UniProt

Q9Y3D9 - RT23_HUMAN

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Protein

28S ribosomal protein S23, mitochondrial

Gene

MRPS23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S23, mitochondrial
Short name:
MRP-S23
Short name:
S23mt
Gene namesi
Name:MRPS23
ORF Names:CGI-138, HSPC329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14509. MRPS23.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament cytoskeleton Source: HPA
  2. mitochondrion Source: HPA
  3. nuclear membrane Source: HPA
  4. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19019028S ribosomal protein S23, mitochondrialPRO_0000087705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y3D9.
PaxDbiQ9Y3D9.
PeptideAtlasiQ9Y3D9.
PRIDEiQ9Y3D9.

PTM databases

PhosphoSiteiQ9Y3D9.

Expressioni

Gene expression databases

BgeeiQ9Y3D9.
CleanExiHS_MRPS23.
ExpressionAtlasiQ9Y3D9. baseline and differential.
GenevestigatoriQ9Y3D9.

Organism-specific databases

HPAiHPA023453.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi119657. 34 interactions.
IntActiQ9Y3D9. 7 interactions.
STRINGi9606.ENSP00000320184.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG81280.
GeneTreeiENSGT00390000009030.
HOGENOMiHOG000059557.
HOVERGENiHBG044512.
InParanoidiQ9Y3D9.
KOiK17402.
OMAiFSRTRNL.
OrthoDBiEOG7TBC3P.
PhylomeDBiQ9Y3D9.
TreeFamiTF106116.

Family and domain databases

InterProiIPR019520. Ribosomal_S23/Rsm25.
IPR023611. Ribosomal_S23/S25_mit.
[Graphical view]
PANTHERiPTHR15925. PTHR15925. 1 hit.
PfamiPF10484. MRP-S23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3D9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR
60 70 80 90 100
VRYGKAKAPI QDIWYHEDRI RAKFYSVYGS GQRAFDLFNP NFKSTCQRFV
110 120 130 140 150
EKYTELQKLG ETDEEKLFVE TGKALLAEGV ILRRVGEART QHGGSHVSRK
160 170 180 190
SEHLSVRPQT ALEENETQKE VPQDQHLEAP ADQSKGLLPP
Length:190
Mass (Da):21,771
Last modified:May 23, 2003 - v2
Checksum:i0A50DEDA9BFB74AF
GO

Sequence cautioni

The sequence AAD34133.1 differs from that shown. Reason: Frameshift at position 138.
The sequence AAF29007.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111S → C in AAD34133. (PubMed:10810093)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151896 mRNA. Translation: AAD34133.1. Frameshift.
AF161447 mRNA. Translation: AAF29007.1. Frameshift.
AK312729 mRNA. Translation: BAG35600.1.
CH471109 Genomic DNA. Translation: EAW94503.1.
BC000242 mRNA. Translation: AAH00242.1.
AB061206 Genomic DNA. Translation: BAB54956.1.
CCDSiCCDS11598.1.
RefSeqiNP_057154.2. NM_016070.3.
UniGeneiHs.5836.

Genome annotation databases

EnsembliENST00000313608; ENSP00000320184; ENSG00000181610.
GeneIDi51649.
KEGGihsa:51649.
UCSCiuc002ivc.3. human.

Polymorphism databases

DMDMi31077184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151896 mRNA. Translation: AAD34133.1 . Frameshift.
AF161447 mRNA. Translation: AAF29007.1 . Frameshift.
AK312729 mRNA. Translation: BAG35600.1 .
CH471109 Genomic DNA. Translation: EAW94503.1 .
BC000242 mRNA. Translation: AAH00242.1 .
AB061206 Genomic DNA. Translation: BAB54956.1 .
CCDSi CCDS11598.1.
RefSeqi NP_057154.2. NM_016070.3.
UniGenei Hs.5836.

3D structure databases

ProteinModelPortali Q9Y3D9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119657. 34 interactions.
IntActi Q9Y3D9. 7 interactions.
STRINGi 9606.ENSP00000320184.

PTM databases

PhosphoSitei Q9Y3D9.

Polymorphism databases

DMDMi 31077184.

Proteomic databases

MaxQBi Q9Y3D9.
PaxDbi Q9Y3D9.
PeptideAtlasi Q9Y3D9.
PRIDEi Q9Y3D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313608 ; ENSP00000320184 ; ENSG00000181610 .
GeneIDi 51649.
KEGGi hsa:51649.
UCSCi uc002ivc.3. human.

Organism-specific databases

CTDi 51649.
GeneCardsi GC17M055916.
HGNCi HGNC:14509. MRPS23.
HPAi HPA023453.
MIMi 611985. gene.
neXtProti NX_Q9Y3D9.
PharmGKBi PA31011.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81280.
GeneTreei ENSGT00390000009030.
HOGENOMi HOG000059557.
HOVERGENi HBG044512.
InParanoidi Q9Y3D9.
KOi K17402.
OMAi FSRTRNL.
OrthoDBi EOG7TBC3P.
PhylomeDBi Q9Y3D9.
TreeFami TF106116.

Miscellaneous databases

GenomeRNAii 51649.
NextBioi 55600.
PROi Q9Y3D9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y3D9.
CleanExi HS_MRPS23.
ExpressionAtlasi Q9Y3D9. baseline and differential.
Genevestigatori Q9Y3D9.

Family and domain databases

InterProi IPR019520. Ribosomal_S23/Rsm25.
IPR023611. Ribosomal_S23/S25_mit.
[Graphical view ]
PANTHERi PTHR15925. PTHR15925. 1 hit.
Pfami PF10484. MRP-S23. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-98.
  7. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
    J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT23_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D9
Secondary accession number(s): B2R6V3
, Q96Q24, Q9BWH8, Q9P053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 23, 2003
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3