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Protein

28S ribosomal protein S23, mitochondrial

Gene

MRPS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181610-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S23, mitochondrial
Short name:
MRP-S23
Short name:
S23mt
Gene namesi
Name:MRPS23
ORF Names:CGI-138, HSPC329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14509. MRPS23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Defects in MRPS23 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies.

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi51649.
OpenTargetsiENSG00000181610.
PharmGKBiPA31011.

Polymorphism and mutation databases

BioMutaiMRPS23.
DMDMi31077184.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000877052 – 19028S ribosomal protein S23, mitochondrialAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3D9.
MaxQBiQ9Y3D9.
PaxDbiQ9Y3D9.
PeptideAtlasiQ9Y3D9.
PRIDEiQ9Y3D9.
TopDownProteomicsiQ9Y3D9.

PTM databases

iPTMnetiQ9Y3D9.
PhosphoSitePlusiQ9Y3D9.
SwissPalmiQ9Y3D9.

Expressioni

Gene expression databases

BgeeiENSG00000181610.
CleanExiHS_MRPS23.
ExpressionAtlasiQ9Y3D9. baseline and differential.
GenevisibleiQ9Y3D9. HS.

Organism-specific databases

HPAiHPA023453.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
USHBP1Q8N6Y03EBI-1054270,EBI-739895

Protein-protein interaction databases

BioGridi119657. 53 interactors.
IntActiQ9Y3D9. 13 interactors.
STRINGi9606.ENSP00000320184.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AS1-190[»]
ProteinModelPortaliQ9Y3D9.
SMRiQ9Y3D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J3Q4. Eukaryota.
ENOG4111IJ9. LUCA.
GeneTreeiENSGT00390000009030.
HOGENOMiHOG000059557.
HOVERGENiHBG044512.
InParanoidiQ9Y3D9.
KOiK17402.
OMAiTEDKPIW.
OrthoDBiEOG091G18YA.
PhylomeDBiQ9Y3D9.
TreeFamiTF106116.

Family and domain databases

InterProiIPR019520. Ribosomal_S23/Rsm25.
IPR023611. Ribosomal_S23/S25_mit.
[Graphical view]
PANTHERiPTHR15925. PTHR15925. 1 hit.
PfamiPF10484. MRP-S23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSRLETVG SIFSRTRDLV RAGVLKEKPL WFDVYDAFPP LREPVFQRPR
60 70 80 90 100
VRYGKAKAPI QDIWYHEDRI RAKFYSVYGS GQRAFDLFNP NFKSTCQRFV
110 120 130 140 150
EKYTELQKLG ETDEEKLFVE TGKALLAEGV ILRRVGEART QHGGSHVSRK
160 170 180 190
SEHLSVRPQT ALEENETQKE VPQDQHLEAP ADQSKGLLPP
Length:190
Mass (Da):21,771
Last modified:May 23, 2003 - v2
Checksum:i0A50DEDA9BFB74AF
GO

Sequence cautioni

The sequence AAD34133 differs from that shown. Reason: Frameshift at position 138.Curated
The sequence AAF29007 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11S → C in AAD34133 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07626940P → R Probable disease-associated mutation found in a patient with combined respiratory chain complex deficiencies and hepatic disease. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151896 mRNA. Translation: AAD34133.1. Frameshift.
AF161447 mRNA. Translation: AAF29007.1. Frameshift.
AK312729 mRNA. Translation: BAG35600.1.
CH471109 Genomic DNA. Translation: EAW94503.1.
BC000242 mRNA. Translation: AAH00242.1.
AB061206 Genomic DNA. Translation: BAB54956.1.
CCDSiCCDS11598.1.
RefSeqiNP_057154.2. NM_016070.3.
UniGeneiHs.5836.

Genome annotation databases

EnsembliENST00000313608; ENSP00000320184; ENSG00000181610.
GeneIDi51649.
KEGGihsa:51649.
UCSCiuc002ivc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151896 mRNA. Translation: AAD34133.1. Frameshift.
AF161447 mRNA. Translation: AAF29007.1. Frameshift.
AK312729 mRNA. Translation: BAG35600.1.
CH471109 Genomic DNA. Translation: EAW94503.1.
BC000242 mRNA. Translation: AAH00242.1.
AB061206 Genomic DNA. Translation: BAB54956.1.
CCDSiCCDS11598.1.
RefSeqiNP_057154.2. NM_016070.3.
UniGeneiHs.5836.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AS1-190[»]
ProteinModelPortaliQ9Y3D9.
SMRiQ9Y3D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119657. 53 interactors.
IntActiQ9Y3D9. 13 interactors.
STRINGi9606.ENSP00000320184.

PTM databases

iPTMnetiQ9Y3D9.
PhosphoSitePlusiQ9Y3D9.
SwissPalmiQ9Y3D9.

Polymorphism and mutation databases

BioMutaiMRPS23.
DMDMi31077184.

Proteomic databases

EPDiQ9Y3D9.
MaxQBiQ9Y3D9.
PaxDbiQ9Y3D9.
PeptideAtlasiQ9Y3D9.
PRIDEiQ9Y3D9.
TopDownProteomicsiQ9Y3D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313608; ENSP00000320184; ENSG00000181610.
GeneIDi51649.
KEGGihsa:51649.
UCSCiuc002ivc.4. human.

Organism-specific databases

CTDi51649.
DisGeNETi51649.
GeneCardsiMRPS23.
HGNCiHGNC:14509. MRPS23.
HPAiHPA023453.
MIMi611985. gene.
neXtProtiNX_Q9Y3D9.
OpenTargetsiENSG00000181610.
PharmGKBiPA31011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3Q4. Eukaryota.
ENOG4111IJ9. LUCA.
GeneTreeiENSGT00390000009030.
HOGENOMiHOG000059557.
HOVERGENiHBG044512.
InParanoidiQ9Y3D9.
KOiK17402.
OMAiTEDKPIW.
OrthoDBiEOG091G18YA.
PhylomeDBiQ9Y3D9.
TreeFamiTF106116.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181610-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii51649.
PROiQ9Y3D9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181610.
CleanExiHS_MRPS23.
ExpressionAtlasiQ9Y3D9. baseline and differential.
GenevisibleiQ9Y3D9. HS.

Family and domain databases

InterProiIPR019520. Ribosomal_S23/Rsm25.
IPR023611. Ribosomal_S23/S25_mit.
[Graphical view]
PANTHERiPTHR15925. PTHR15925. 1 hit.
PfamiPF10484. MRP-S23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT23_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D9
Secondary accession number(s): B2R6V3
, Q96Q24, Q9BWH8, Q9P053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 23, 2003
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.