Reviewed, UniProtKB/Swiss-Prot Q9Y3D8 (KAD6_HUMAN)

Names and origin

Protein names

Recommended name:
    Adenylate kinase isoenzyme 6
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 6

Gene names

Name:	AK6
ORF Names:	AD-004, CGI-137

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Broad activity as an NMP kinase. AMP and dAMP are the preferred substrates of all tested NMPs, but CMP and dCMP are also good substrates. IMP can be phosphorylated, but to a much lesser extent. Adenylate and cytidylate can serve as phosphate acceptors. Ref.5
Catalytic activity	ATP + AMP = 2 ADP.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the adenylate kinase family. AK6 subfamily.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 172

172

Adenylate kinase isoenzyme 6

PRO_0000153896

Regions

Nucleotide binding

10 – 17

8

ATP Potential

Secondary structure

1

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172

Helix Strand Turn

Details...

Beta strand

6 – 9

4

Helix

16 – 27

12

Beta strand

30 – 33

4

Helix

34 – 40

7

Beta strand

49 – 52

4

Helix

58 – 71

14

Beta strand

74 – 77

4

Helix

86 – 88

3

Beta strand

90 – 96

7

Helix

99 – 108

10

Helix

113 – 124

12

Helix

127 – 135

9

Helix

138 – 140

3

Beta strand

141 – 145

5

Helix

149 – 169

21

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D8-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 33F62318FB434301	FASTA	172	20,061
	10 20 30 40 50 60 MLLPNILLTG TPGVGKTTLG KELASKSGLK YINVGDLARE EQLYDGYDEE YDCPILDEDR 70 80 90 100 110 120 VVDELDNQMR EGGVIVDYHG CDFFPERWFH IVFVLRTDTN VLYERLETRG YNEKKLTDNI 130 140 150 160 170 QCEIFQVLYE EATASYKEEI VHQLPSNKPE ELENNVDQIL KWIEQWIKDH NS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"The crystal structure of human adenylate kinase 6: an adenylate kinase localized to the cell nucleus." Ren H., Wang L., Bennett M., Liang Y., Zheng X., Lu F., Li L., Nan J., Luo M., Eriksson S., Zhang C., Su X.-D. Proc. Natl. Acad. Sci. U.S.A. 102:303-308(2005) [PubMed: 15630091] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS), FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF151895 mRNA. Translation: AAD34132.1.
AF110777 mRNA. Translation: AAF14860.1.
BC007349 mRNA. Translation: AAH07349.1.
BC007426 mRNA. Translation: AAH07426.1.

IPI

IPI00032879.

RefSeq

NP_001015891.1.
NP_057367.1.

UniGene

Hs.653163

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1RKB	X-ray	2.00	A	1-172	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q9Y3D8.

Proteomic databases

PeptideAtlas

Q9Y3D8.

PRIDE

Q9Y3D8.

Genome annotation databases

Ensembl

ENST00000380822; ENSP00000370201; ENSG00000185057; Homo sapiens. [Genome view]

GeneID

6880.

KEGG

hsa:6880.

UCSC

uc003jwa.1. human.

Organism-specific databases

CTD

6880.

H-InvDB

HIX0004921.
HIX0057665.

Phylogenomic databases

HOGENOM

Q9Y3D8.

HOVERGEN

Q9Y3D8.

OMA

EDNINQI

Enzyme and pathway databases

BRENDA

2.7.4.3. 247.

Gene expression databases

ArrayExpress

Q9Y3D8.

Bgee

Q9Y3D8.

Genevestigator

Q9Y3D8.

GermOnline

ENSG00000185057. Homo sapiens.

Family and domain databases

InterPro

IPR003959. ATPase_AAA_core.
[Graphical view]

Pfam

PF00004. AAA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

26873.

Entry information

Entry name

KAD6_HUMAN

Accession

Primary (citable) accession number: Q9Y3D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.