Reviewed, UniProtKB/Swiss-Prot Q9Y3D7 (TIM16_HUMAN)

Names and origin

Protein names

Recommended name:
    Mitochondrial import inner membrane translocase subunit Tim16
Alternative name(s):
    Mitochondria-associated granulocyte macrophage CSF-signaling molecule

Gene names

Name:	TIMM16
Synonyms:	MAGMAS, TIM16
ORF Names:	CGI-136

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May be required to regulate the ATP-dependent activity By similarity.
Subunit structure	Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/MAGMAS and TIMM14/DNAJC19 By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane proteinBy similarity.
Tissue specificity	Ubiquitously expressed.
Induction	By GM-CSF.
Domain	The J-like region, although related to the J domain does not have co-chaperone activity By similarity.
Sequence similarities	Belongs to the TIM16/PAM16 family.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Gene Ontology (GO)
Biological process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Mitochondrial import inner membrane translocase subunit Tim16		PRO_0000214078
Regions
	Region	58 – 110	53	J-like
Natural variations
	Natural variant	114	1	Q → K: dbSNP rs11989.		VAR_013764
Experimental info
	Sequence conflict	120	1	G → W in AAD34131. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D7-1 [UniParc]. Last modified September 19, 2002. Version 2. Checksum: 5E7877B30CC89C61	FASTA	125	13,825
	10 20 30 40 50 60 MAKYLAQIIV MGVQVVGRAF ARALRQEFAA SRAAADARGR AGHRSAAASN LSGLSLQEAQ 70 80 90 100 110 120 QILNVSKLSP EEVQKNYEHL FKVNDKSVGG SFYLQSKVVR AKERLDEELK IQAQEDREKG QMPHT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction." Jubinsky P.T., Messer A., Bender J., Morris R.E., Ciraolo G.M., Witte D.P., Hawley R.G., Short M.K. Exp. Hematol. 29:1392-1402(2001) [PubMed: 11750097] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, VARIANT LYS-114. Tissue: Peripheral blood.
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"Magmas expression in neoplastic human prostate." Jubinsky P.T., Short M.K., Mutema G., Morris R.E., Ciraolo G.M., Li M. J. Mol. Histol. 36:69-75(2005) [PubMed: 15704001] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF349455 mRNA. Translation: AAL57767.1. AF151894 mRNA. Translation: AAD34131.1. AK026514 mRNA. Translation: BAB15494.1. CR457362 mRNA. Translation: CAG33643.1. BC005024 mRNA. Translation: AAH05024.1.
RefSeq	NP_057153.8.
UniGene	Hs.644614
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3D7.
Proteomic databases
PeptideAtlas	Q9Y3D7.
Genome annotation databases
Ensembl	ENSG00000217930. Homo sapiens. [Contig view]
GeneID	51025.
KEGG	hsa:51025.
Organism-specific databases
H-InvDB	HIX0012777.
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y3D7.
HOVERGEN	Q9Y3D7.
Gene expression databases
ArrayExpress	Q9Y3D7.
Family and domain databases
InterPro	IPR005341. Protein_transpt. [Graphical view]
PANTHER	PTHR12388. Protein_transpt. 1 hit.
Pfam	PF03656. Pam16. 1 hit. [Graphical view]
ProDom	PD311402. UPF0108. 1 hit. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	53562.

Entry information

Entry name

TIM16_HUMAN

Accession

Primary (citable) accession number: Q9Y3D7
Secondary accession number(s): Q6I9Z3, Q9H5X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 19, 2002
Last modified:	November 4, 2008
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)