Q9Y3D5 (RT18C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S18c, mitochondrial
Short name=MRP-S18-c
Short name=Mrps18-c
Short name=S18mt-c

Alternative name(s):
28S ribosomal protein S18-1, mitochondrial
Short name=MRP-S18-1

Gene names

Name:	MRPS18C
ORF Names:	CGI-134

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.3.
Sequence similarities	Belongs to the ribosomal protein S18P family. UniProtKB P80382

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.3. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Inferred from direct assay Ref.3. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 142		28S ribosomal protein S18c, mitochondrial		PRO_0000030629

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 375E0F8558492E63	FASTA	142	15,850
	10 20 30 40 50 60 MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL PISMENPYKE 70 80 90 100 110 120 PLKKCILCGK HVDYKNVQLL SQFVSPFTGC IYGRHITGLC GKKQKEITKA IKRAQIMGFM 130 140 PVTYKDPAYL KDPKVCNIRY RE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151892 mRNA. Translation: AAD34129.1. BC005186 mRNA. Translation: AAH05186.1.
IPI	IPI00007049.
RefSeq	NP_057151.1. NM_016067.2.
UniGene	Hs.334772. Hs.436161.
3D structure databases
ProteinModelPortal	Q9Y3D5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000295491.
PTM databases
PhosphoSite	Q9Y3D5.
Polymorphism databases
DMDM	24212202.
Proteomic databases
PaxDb	Q9Y3D5.
PeptideAtlas	Q9Y3D5.
PRIDE	Q9Y3D5.
Protocols and materials databases
DNASU	51023.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295491; ENSP00000295491; ENSG00000163319.
GeneID	51023.
KEGG	hsa:51023.
UCSC	uc003hor.4. human.
Organism-specific databases
CTD	51023.
GeneCards	GC04P084301.
H-InvDB	HIX0034634.
HGNC	HGNC:16633. MRPS18C.
HPA	HPA050404.
MIM	611983. gene.
neXtProt	NX_Q9Y3D5.
PharmGKB	PA31005.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242052.
HOGENOM	HOG000218466.
HOVERGEN	HBG068938.
InParanoid	Q9Y3D5.
KO	K02963.
OMA	DPKICNI.
OrthoDB	EOG44J2KC.
PhylomeDB	Q9Y3D5.
Gene expression databases
ArrayExpress	Q9Y3D5.
Bgee	Q9Y3D5.
CleanEx	HS_MRPS18C.
Genevestigator	Q9Y3D5.
GermOnline	ENSG00000163319. Homo sapiens.
Family and domain databases
Gene3D	4.10.640.10. 1 hit.
InterPro	IPR001648. Ribosomal_S18. IPR018275. Ribosomal_S18_CS. [Graphical view]
PANTHER	PTHR13479. PTHR13479. 1 hit.
Pfam	PF01084. Ribosomal_S18. 1 hit. [Graphical view]
ProDom	PD002239. Ribosomal_S18. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF46911. Ribosomal_S18. 1 hit.
TIGRFAMs	TIGR00165. S18. 1 hit.
PROSITE	PS00057. RIBOSOMAL_S18. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPS18C. human.
GenomeRNAi	51023.
NextBio	53554.
SOURCE	Search...

Entry information

Entry name

RT18C_HUMAN

Accession

Primary (citable) accession number: Q9Y3D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.