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Q9Y3D5 (RT18C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S18c, mitochondrial

Short name=MRP-S18-c
Short name=Mrps18-c
Short name=S18mt-c
Alternative name(s):
28S ribosomal protein S18-1, mitochondrial
Short name=MRP-S18-1
Gene names
Name:MRPS18C
ORF Names:CGI-134
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion Ref.3.

Sequence similarities

Belongs to the ribosomal protein S18P family. UniProtKB P80382

Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement Ref.3. Source: UniProtKB

   Cellular_componentmitochondrial small ribosomal subunit

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_functionstructural constituent of ribosome

Non-traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 14228S ribosomal protein S18c, mitochondrialPRO_0000030629

Sequences

Sequence LengthMass (Da)Tools
Q9Y3D5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 375E0F8558492E63

FASTA14215,850
        10         20         30         40         50         60 
MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL PISMENPYKE 

        70         80         90        100        110        120 
PLKKCILCGK HVDYKNVQLL SQFVSPFTGC IYGRHITGLC GKKQKEITKA IKRAQIMGFM 

       130        140 
PVTYKDPAYL KDPKVCNIRY RE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151892 mRNA. Translation: AAD34129.1.
BC005186 mRNA. Translation: AAH05186.1.
RefSeqNP_057151.1. NM_016067.2.
UniGeneHs.334772.
Hs.436161.

3D structure databases

ProteinModelPortalQ9Y3D5.
SMRQ9Y3D5. Positions 73-125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119229. 2 interactions.
STRING9606.ENSP00000295491.

PTM databases

PhosphoSiteQ9Y3D5.

Polymorphism databases

DMDM24212202.

Proteomic databases

PaxDbQ9Y3D5.
PeptideAtlasQ9Y3D5.
PRIDEQ9Y3D5.

Protocols and materials databases

DNASU51023.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295491; ENSP00000295491; ENSG00000163319.
GeneID51023.
KEGGhsa:51023.
UCSCuc003hor.4. human.

Organism-specific databases

CTD51023.
GeneCardsGC04P084301.
H-InvDBHIX0034634.
HGNCHGNC:16633. MRPS18C.
HPAHPA050404.
MIM611983. gene.
neXtProtNX_Q9Y3D5.
PharmGKBPA31005.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242052.
HOGENOMHOG000218466.
HOVERGENHBG068938.
InParanoidQ9Y3D5.
KOK02963.
OMADPKICNI.
OrthoDBEOG7JDR1D.
PhylomeDBQ9Y3D5.
TreeFamTF315059.

Gene expression databases

ArrayExpressQ9Y3D5.
BgeeQ9Y3D5.
CleanExHS_MRPS18C.
GenevestigatorQ9Y3D5.

Family and domain databases

Gene3D4.10.640.10. 1 hit.
InterProIPR001648. Ribosomal_S18.
IPR018275. Ribosomal_S18_CS.
[Graphical view]
PANTHERPTHR13479. PTHR13479. 1 hit.
PfamPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF46911. SSF46911. 1 hit.
TIGRFAMsTIGR00165. S18. 1 hit.
PROSITEPS00057. RIBOSOMAL_S18. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPS18C. human.
GenomeRNAi51023.
NextBio53554.
PROQ9Y3D5.
SOURCESearch...

Entry information

Entry nameRT18C_HUMAN
AccessionPrimary (citable) accession number: Q9Y3D5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM