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Protein

28S ribosomal protein S18c, mitochondrial

Gene

MRPS18C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c, this protein) binds to the same site as bacterial bS18, mS40 (bS18b) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18c, mitochondrial
Short name:
MRP-S18-c
Short name:
Mrps18-c
Short name:
S18mt-c
Alternative name(s):
28S ribosomal protein S18-1, mitochondrial
Short name:
MRP-S18-1
Mitochondrial small ribosomal subunit protein bS18c1 Publication
Mitochondrial small ribosomal subunit protein bS18m1 Publication
Gene namesi
Name:MRPS18C
ORF Names:CGI-134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163319.10.
HGNCiHGNC:16633. MRPS18C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51023.
OpenTargetsiENSG00000163319.
PharmGKBiPA31005.

Polymorphism and mutation databases

BioMutaiMRPS18C.
DMDMi24212202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030629? – 14228S ribosomal protein S18c, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9Y3D5.
MaxQBiQ9Y3D5.
PaxDbiQ9Y3D5.
PeptideAtlasiQ9Y3D5.
PRIDEiQ9Y3D5.

PTM databases

iPTMnetiQ9Y3D5.
PhosphoSitePlusiQ9Y3D5.

Expressioni

Gene expression databases

BgeeiENSG00000163319.
CleanExiHS_MRPS18C.
ExpressionAtlasiQ9Y3D5. baseline and differential.
GenevisibleiQ9Y3D5. HS.

Organism-specific databases

HPAiHPA050404.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS18m has a zinc binding site.1 Publication

Protein-protein interaction databases

BioGridi119229. 63 interactors.
CORUMiQ9Y3D5.
IntActiQ9Y3D5. 1 interactor.
STRINGi9606.ENSP00000295491.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AP1-142[»]
ProteinModelPortaliQ9Y3D5.
SMRiQ9Y3D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial ribosomal protein bS18 family.By similarity

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3162. Eukaryota.
COG0238. LUCA.
GeneTreeiENSGT00390000003791.
HOGENOMiHOG000218466.
HOVERGENiHBG068938.
InParanoidiQ9Y3D5.
KOiK02963.
OMAiYHKDLDF.
OrthoDBiEOG091G11KE.
PhylomeDBiQ9Y3D5.
TreeFamiTF315059.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiView protein in InterPro
IPR001648. Ribosomal_S18.
IPR018275. Ribosomal_S18_CS.
PfamiView protein in Pfam
PF01084. Ribosomal_S18. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002239. Ribosomal_S18. 1 hit.
SUPFAMiSSF46911. SSF46911. 1 hit.
TIGRFAMsiTIGR00165. S18. 1 hit.
PROSITEiView protein in PROSITE
PS00057. RIBOSOMAL_S18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL
60 70 80 90 100
PISMENPYKE PLKKCILCGK HVDYKNVQLL SQFVSPFTGC IYGRHITGLC
110 120 130 140
GKKQKEITKA IKRAQIMGFM PVTYKDPAYL KDPKVCNIRY RE
Length:142
Mass (Da):15,850
Last modified:November 1, 1999 - v1
Checksum:i375E0F8558492E63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151892 mRNA. Translation: AAD34129.1.
BC005186 mRNA. Translation: AAH05186.1.
CCDSiCCDS3604.1.
RefSeqiNP_001284698.1. NM_001297769.1.
NP_001284699.1. NM_001297770.1.
NP_057151.1. NM_016067.3.
UniGeneiHs.334772.
Hs.436161.

Genome annotation databases

EnsembliENST00000295491; ENSP00000295491; ENSG00000163319.
GeneIDi51023.
KEGGihsa:51023.
UCSCiuc003hor.5. human.

Similar proteinsi

Entry informationi

Entry nameiRT18C_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families