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Protein

28S ribosomal protein S18c, mitochondrial

Gene

MRPS18C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18c, mitochondrial
Short name:
MRP-S18-c
Short name:
Mrps18-c
Short name:
S18mt-c
Alternative name(s):
28S ribosomal protein S18-1, mitochondrial
Short name:
MRP-S18-1
Gene namesi
Name:MRPS18C
ORF Names:CGI-134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:16633. MRPS18C.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31005.

Polymorphism and mutation databases

BioMutaiMRPS18C.
DMDMi24212202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 14228S ribosomal protein S18c, mitochondrialPRO_0000030629
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9Y3D5.
PaxDbiQ9Y3D5.
PeptideAtlasiQ9Y3D5.
PRIDEiQ9Y3D5.

PTM databases

PhosphoSiteiQ9Y3D5.

Expressioni

Gene expression databases

BgeeiQ9Y3D5.
CleanExiHS_MRPS18C.
ExpressionAtlasiQ9Y3D5. baseline and differential.
GenevisibleiQ9Y3D5. HS.

Organism-specific databases

HPAiHPA050404.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119229. 18 interactions.
STRINGi9606.ENSP00000295491.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AP1-142[»]
ProteinModelPortaliQ9Y3D5.
SMRiQ9Y3D5. Positions 73-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S18P family.By similarity

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG242052.
GeneTreeiENSGT00390000003791.
HOGENOMiHOG000218466.
HOVERGENiHBG068938.
InParanoidiQ9Y3D5.
KOiK02963.
OMAiDPKICNI.
OrthoDBiEOG7JDR1D.
PhylomeDBiQ9Y3D5.
TreeFamiTF315059.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiIPR001648. Ribosomal_S18.
IPR018275. Ribosomal_S18_CS.
[Graphical view]
PANTHERiPTHR13479. PTHR13479. 1 hit.
PfamiPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomiPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46911. SSF46911. 1 hit.
TIGRFAMsiTIGR00165. S18. 1 hit.
PROSITEiPS00057. RIBOSOMAL_S18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL
60 70 80 90 100
PISMENPYKE PLKKCILCGK HVDYKNVQLL SQFVSPFTGC IYGRHITGLC
110 120 130 140
GKKQKEITKA IKRAQIMGFM PVTYKDPAYL KDPKVCNIRY RE
Length:142
Mass (Da):15,850
Last modified:November 1, 1999 - v1
Checksum:i375E0F8558492E63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151892 mRNA. Translation: AAD34129.1.
BC005186 mRNA. Translation: AAH05186.1.
CCDSiCCDS3604.1.
RefSeqiNP_001284698.1. NM_001297769.1.
NP_001284699.1. NM_001297770.1.
NP_057151.1. NM_016067.3.
UniGeneiHs.334772.
Hs.436161.

Genome annotation databases

EnsembliENST00000295491; ENSP00000295491; ENSG00000163319.
GeneIDi51023.
KEGGihsa:51023.
UCSCiuc003hor.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151892 mRNA. Translation: AAD34129.1.
BC005186 mRNA. Translation: AAH05186.1.
CCDSiCCDS3604.1.
RefSeqiNP_001284698.1. NM_001297769.1.
NP_001284699.1. NM_001297770.1.
NP_057151.1. NM_016067.3.
UniGeneiHs.334772.
Hs.436161.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AP1-142[»]
ProteinModelPortaliQ9Y3D5.
SMRiQ9Y3D5. Positions 73-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119229. 18 interactions.
STRINGi9606.ENSP00000295491.

PTM databases

PhosphoSiteiQ9Y3D5.

Polymorphism and mutation databases

BioMutaiMRPS18C.
DMDMi24212202.

Proteomic databases

MaxQBiQ9Y3D5.
PaxDbiQ9Y3D5.
PeptideAtlasiQ9Y3D5.
PRIDEiQ9Y3D5.

Protocols and materials databases

DNASUi51023.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295491; ENSP00000295491; ENSG00000163319.
GeneIDi51023.
KEGGihsa:51023.
UCSCiuc003hor.4. human.

Organism-specific databases

CTDi51023.
GeneCardsiGC04P084301.
H-InvDBHIX0034634.
HGNCiHGNC:16633. MRPS18C.
HPAiHPA050404.
MIMi611983. gene.
neXtProtiNX_Q9Y3D5.
PharmGKBiPA31005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG242052.
GeneTreeiENSGT00390000003791.
HOGENOMiHOG000218466.
HOVERGENiHBG068938.
InParanoidiQ9Y3D5.
KOiK02963.
OMAiDPKICNI.
OrthoDBiEOG7JDR1D.
PhylomeDBiQ9Y3D5.
TreeFamiTF315059.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS18C. human.
GenomeRNAii51023.
NextBioi53554.
PROiQ9Y3D5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y3D5.
CleanExiHS_MRPS18C.
ExpressionAtlasiQ9Y3D5. baseline and differential.
GenevisibleiQ9Y3D5. HS.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiIPR001648. Ribosomal_S18.
IPR018275. Ribosomal_S18_CS.
[Graphical view]
PANTHERiPTHR13479. PTHR13479. 1 hit.
PfamiPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomiPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46911. SSF46911. 1 hit.
TIGRFAMsiTIGR00165. S18. 1 hit.
PROSITEiPS00057. RIBOSOMAL_S18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT18C_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.