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Protein

28S ribosomal protein S16, mitochondrial

Gene

MRPS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational initiation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • organelle organization Source: Reactome
  • translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S16, mitochondrial
Short name:
MRP-S16
Short name:
S16mt
Gene namesi
Name:MRPS16
Synonyms:RPMS16
ORF Names:CGI-132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14048. MRPS16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 2 (COXPD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.

See also OMIM:610498

Organism-specific databases

MIMi610498. phenotype.
Orphaneti254920. Combined oxidative phosphorylation defect type 2.
PharmGKBiPA31000.

Polymorphism and mutation databases

BioMutaiMRPS16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 13710328S ribosomal protein S16, mitochondrialPRO_0000030618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301Phosphothreonine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y3D3.
PaxDbiQ9Y3D3.
PRIDEiQ9Y3D3.

PTM databases

PhosphoSiteiQ9Y3D3.

Expressioni

Gene expression databases

BgeeiQ9Y3D3.
CleanExiHS_MRPS16.
ExpressionAtlasiQ9Y3D3. baseline and differential.
GenevisibleiQ9Y3D3. HS.

Organism-specific databases

HPAiHPA050081.
HPA054538.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119227. 24 interactions.
IntActiQ9Y3D3. 3 interactions.
MINTiMINT-6488773.
STRINGi9606.ENSP00000362036.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AM1-137[»]
ProteinModelPortaliQ9Y3D3.
SMRiQ9Y3D3. Positions 16-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S16P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0228.
GeneTreeiENSGT00390000014309.
HOGENOMiHOG000246720.
HOVERGENiHBG017758.
InParanoidiQ9Y3D3.
KOiK02959.
OMAiANRPFYR.
OrthoDBiEOG7P02KX.
PhylomeDBiQ9Y3D3.
TreeFamiTF105637.

Family and domain databases

Gene3Di3.30.1320.10. 1 hit.
HAMAPiMF_00385. Ribosomal_S16.
InterProiIPR000307. Ribosomal_S16.
IPR023803. Ribosomal_S16_dom.
[Graphical view]
PANTHERiPTHR12919. PTHR12919. 1 hit.
PfamiPF00886. Ribosomal_S16. 1 hit.
[Graphical view]
SUPFAMiSSF54565. SSF54565. 1 hit.
TIGRFAMsiTIGR00002. S16. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ
60 70 80 90 100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH
110 120 130
PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET
Length:137
Mass (Da):15,345
Last modified:November 1, 1999 - v1
Checksum:iC12B14B1B357F8D6
GO
Isoform 2 (identifier: Q9Y3D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-137: LAGFFPLHPM...EATDTEATET → KTDARFPEQGEERPEQHHFPEDLAPARGRGL

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,829
Checksum:i7F07429818B68914
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121Y → H.
Corresponds to variant rs7905009 [ dbSNP | Ensembl ].
VAR_031525

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 13745LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationVSP_056498Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA. Translation: AAD34127.1.
AB049948 mRNA. Translation: BAB41001.1.
AK303204 mRNA. Translation: BAG64294.1.
AC016394 Genomic DNA. No translation available.
BC021106 mRNA. Translation: AAH21106.1.
AB051351 Genomic DNA. Translation: BAB54941.1.
CCDSiCCDS7323.1. [Q9Y3D3-1]
RefSeqiNP_057149.1. NM_016065.3. [Q9Y3D3-1]
UniGeneiHs.180312.

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180.
GeneIDi51021.
KEGGihsa:51021.
UCSCiuc001jts.1. human. [Q9Y3D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA. Translation: AAD34127.1.
AB049948 mRNA. Translation: BAB41001.1.
AK303204 mRNA. Translation: BAG64294.1.
AC016394 Genomic DNA. No translation available.
BC021106 mRNA. Translation: AAH21106.1.
AB051351 Genomic DNA. Translation: BAB54941.1.
CCDSiCCDS7323.1. [Q9Y3D3-1]
RefSeqiNP_057149.1. NM_016065.3. [Q9Y3D3-1]
UniGeneiHs.180312.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AM1-137[»]
ProteinModelPortaliQ9Y3D3.
SMRiQ9Y3D3. Positions 16-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119227. 24 interactions.
IntActiQ9Y3D3. 3 interactions.
MINTiMINT-6488773.
STRINGi9606.ENSP00000362036.

PTM databases

PhosphoSiteiQ9Y3D3.

Polymorphism and mutation databases

BioMutaiMRPS16.

Proteomic databases

MaxQBiQ9Y3D3.
PaxDbiQ9Y3D3.
PRIDEiQ9Y3D3.

Protocols and materials databases

DNASUi51021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180.
GeneIDi51021.
KEGGihsa:51021.
UCSCiuc001jts.1. human. [Q9Y3D3-1]

Organism-specific databases

CTDi51021.
GeneCardsiGC10M075008.
HGNCiHGNC:14048. MRPS16.
HPAiHPA050081.
HPA054538.
MIMi609204. gene.
610498. phenotype.
neXtProtiNX_Q9Y3D3.
Orphaneti254920. Combined oxidative phosphorylation defect type 2.
PharmGKBiPA31000.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0228.
GeneTreeiENSGT00390000014309.
HOGENOMiHOG000246720.
HOVERGENiHBG017758.
InParanoidiQ9Y3D3.
KOiK02959.
OMAiANRPFYR.
OrthoDBiEOG7P02KX.
PhylomeDBiQ9Y3D3.
TreeFamiTF105637.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS16. human.
GeneWikiiMRPS16.
GenomeRNAii51021.
NextBioi35476633.
PROiQ9Y3D3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y3D3.
CleanExiHS_MRPS16.
ExpressionAtlasiQ9Y3D3. baseline and differential.
GenevisibleiQ9Y3D3. HS.

Family and domain databases

Gene3Di3.30.1320.10. 1 hit.
HAMAPiMF_00385. Ribosomal_S16.
InterProiIPR000307. Ribosomal_S16.
IPR023803. Ribosomal_S16_dom.
[Graphical view]
PANTHERiPTHR12919. PTHR12919. 1 hit.
PfamiPF00886. Ribosomal_S16. 1 hit.
[Graphical view]
SUPFAMiSSF54565. SSF54565. 1 hit.
TIGRFAMsiTIGR00002. S16. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-35.
  7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation."
    Miller C., Saada A., Shaul N., Shabtai N., Ben-Shalom E., Shaag A., Hershkovitz E., Elpeleg O.
    Ann. Neurol. 56:734-738(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN COXPD2.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D3
Secondary accession number(s): B4E032, Q96Q60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.