Q9Y3D3 (RT16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S16, mitochondrial
Short name=MRP-S16
Short name=S16mt

Gene names

Name:	MRPS16
Synonyms:	RPMS16
ORF Names:	CGI-132

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion.
Involvement in disease	Combined oxidative phosphorylation deficiency 2 (COXPD2) [MIM:610498]: A mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities	Belongs to the ribosomal protein S16P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.5. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Inferred from direct assay Ref.5. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion Potential
	Chain	35 – 137	103	28S ribosomal protein S16, mitochondrial		PRO_0000030618
Amino acid modifications
	Modified residue	130	1	Phosphothreonine Ref.7 Ref.8 Ref.11
Natural variations
	Natural variant	12	1	Y → H. Corresponds to variant rs7905009 [ dbSNP | Ensembl ].		VAR_031525

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: C12B14B1B357F8D6	FASTA	137	15,345
	10 20 30 40 50 60 MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS 70 80 90 100 110 120 HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH PMMITNAERL RRKRAREVLL 130 ASQKTDAEAT DTEATET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-35.
[5]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation." Miller C., Saada A., Shaul N., Shabtai N., Ben-Shalom E., Shaag A., Hershkovitz E., Elpeleg O. Ann. Neurol. 56:734-738(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN COXPD2.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151890 mRNA. Translation: AAD34127.1. AB049948 mRNA. Translation: BAB41001.1. BC021106 mRNA. Translation: AAH21106.1. AB051351 Genomic DNA. Translation: BAB54941.1.
IPI	IPI00032872.
RefSeq	NP_057149.1. NM_016065.3.
UniGene	Hs.180312.
3D structure databases
ProteinModelPortal	Q9Y3D3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3D3. 1 interaction.
MINT	MINT-6488773.
STRING	9606.ENSP00000362036.
PTM databases
PhosphoSite	Q9Y3D3.
Polymorphism databases
DMDM	13633952.
Proteomic databases
PaxDb	Q9Y3D3.
PRIDE	Q9Y3D3.
Protocols and materials databases
DNASU	51021.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372945; ENSP00000362036; ENSG00000182180.
GeneID	51021.
KEGG	hsa:51021.
UCSC	uc001jts.1. human.
Organism-specific databases
CTD	51021.
GeneCards	GC10M075008.
HGNC	HGNC:14048. MRPS16.
MIM	609204. gene. 610498. phenotype.
neXtProt	NX_Q9Y3D3.
Orphanet	254920. Combined oxidative phosphorylation defect type 2.
PharmGKB	PA31000.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0228.
HOGENOM	HOG000246720.
HOVERGEN	HBG017758.
InParanoid	Q9Y3D3.
KO	K02959.
OrthoDB	EOG4D7Z73.
Gene expression databases
ArrayExpress	Q9Y3D3.
Bgee	Q9Y3D3.
CleanEx	HS_MRPS16.
Genevestigator	Q9Y3D3.
GermOnline	ENSG00000182180. Homo sapiens.
Family and domain databases
Gene3D	3.30.1320.10. 1 hit.
InterPro	IPR000307. Ribosomal_S16. IPR023803. Ribosomal_S16_dom. [Graphical view]
PANTHER	PTHR12919. PTHR12919. 1 hit.
Pfam	PF00886. Ribosomal_S16. 1 hit. [Graphical view]
SUPFAM	SSF54565. Ribosomal_S16. 1 hit.
TIGRFAMs	TIGR00002. S16. 1 hit.
PROSITE	PS00732. RIBOSOMAL_S16. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51021.
NextBio	53544.
SOURCE	Search...

Entry information

Entry name

RT16_HUMAN

Accession

Primary (citable) accession number: Q9Y3D3
Secondary accession number(s): Q96Q60

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.