Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y3D3

- RT16_HUMAN

UniProt

Q9Y3D3 - RT16_HUMAN

Protein

28S ribosomal protein S16, mitochondrial

Gene

MRPS16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S16, mitochondrial
    Short name:
    MRP-S16
    Short name:
    S16mt
    Gene namesi
    Name:MRPS16
    Synonyms:RPMS16
    ORF Names:CGI-132
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14048. MRPS16.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Combined oxidative phosphorylation deficiency 2 (COXPD2) [MIM:610498]: A mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi610498. phenotype.
    Orphaneti254920. Combined oxidative phosphorylation defect type 2.
    PharmGKBiPA31000.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 13710328S ribosomal protein S16, mitochondrialPRO_0000030618Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301Phosphothreonine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y3D3.
    PaxDbiQ9Y3D3.
    PRIDEiQ9Y3D3.

    PTM databases

    PhosphoSiteiQ9Y3D3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3D3.
    BgeeiQ9Y3D3.
    CleanExiHS_MRPS16.
    GenevestigatoriQ9Y3D3.

    Organism-specific databases

    HPAiHPA050081.
    HPA054538.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi119227. 22 interactions.
    IntActiQ9Y3D3. 3 interactions.
    MINTiMINT-6488773.
    STRINGi9606.ENSP00000362036.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3D3.
    SMRiQ9Y3D3. Positions 17-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S16P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0228.
    HOGENOMiHOG000246720.
    HOVERGENiHBG017758.
    InParanoidiQ9Y3D3.
    KOiK02959.
    OrthoDBiEOG7P02KX.
    PhylomeDBiQ9Y3D3.
    TreeFamiTF105637.

    Family and domain databases

    Gene3Di3.30.1320.10. 1 hit.
    HAMAPiMF_00385. Ribosomal_S16.
    InterProiIPR000307. Ribosomal_S16.
    IPR023803. Ribosomal_S16_dom.
    [Graphical view]
    PANTHERiPTHR12919. PTHR12919. 1 hit.
    PfamiPF00886. Ribosomal_S16. 1 hit.
    [Graphical view]
    SUPFAMiSSF54565. SSF54565. 1 hit.
    TIGRFAMsiTIGR00002. S16. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y3D3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ    50
    LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH 100
    PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET 137
    Length:137
    Mass (Da):15,345
    Last modified:November 1, 1999 - v1
    Checksum:iC12B14B1B357F8D6
    GO
    Isoform 2 (identifier: Q9Y3D3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         93-137: LAGFFPLHPM...EATDTEATET → KTDARFPEQGEERPEQHHFPEDLAPARGRGL

    Note: No experimental confirmation available.

    Show »
    Length:123
    Mass (Da):13,829
    Checksum:i7F07429818B68914
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121Y → H.
    Corresponds to variant rs7905009 [ dbSNP | Ensembl ].
    VAR_031525

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei93 – 13745LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationVSP_056498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151890 mRNA. Translation: AAD34127.1.
    AB049948 mRNA. Translation: BAB41001.1.
    AK303204 mRNA. Translation: BAG64294.1.
    AC016394 Genomic DNA. No translation available.
    BC021106 mRNA. Translation: AAH21106.1.
    AB051351 Genomic DNA. Translation: BAB54941.1.
    CCDSiCCDS7323.1.
    RefSeqiNP_057149.1. NM_016065.3.
    UniGeneiHs.180312.

    Genome annotation databases

    EnsembliENST00000372945; ENSP00000362036; ENSG00000182180.
    ENST00000416782; ENSP00000408812; ENSG00000182180.
    GeneIDi51021.
    KEGGihsa:51021.
    UCSCiuc001jts.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151890 mRNA. Translation: AAD34127.1 .
    AB049948 mRNA. Translation: BAB41001.1 .
    AK303204 mRNA. Translation: BAG64294.1 .
    AC016394 Genomic DNA. No translation available.
    BC021106 mRNA. Translation: AAH21106.1 .
    AB051351 Genomic DNA. Translation: BAB54941.1 .
    CCDSi CCDS7323.1.
    RefSeqi NP_057149.1. NM_016065.3.
    UniGenei Hs.180312.

    3D structure databases

    ProteinModelPortali Q9Y3D3.
    SMRi Q9Y3D3. Positions 17-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119227. 22 interactions.
    IntActi Q9Y3D3. 3 interactions.
    MINTi MINT-6488773.
    STRINGi 9606.ENSP00000362036.

    PTM databases

    PhosphoSitei Q9Y3D3.

    Proteomic databases

    MaxQBi Q9Y3D3.
    PaxDbi Q9Y3D3.
    PRIDEi Q9Y3D3.

    Protocols and materials databases

    DNASUi 51021.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372945 ; ENSP00000362036 ; ENSG00000182180 .
    ENST00000416782 ; ENSP00000408812 ; ENSG00000182180 .
    GeneIDi 51021.
    KEGGi hsa:51021.
    UCSCi uc001jts.1. human.

    Organism-specific databases

    CTDi 51021.
    GeneCardsi GC10M075008.
    HGNCi HGNC:14048. MRPS16.
    HPAi HPA050081.
    HPA054538.
    MIMi 609204. gene.
    610498. phenotype.
    neXtProti NX_Q9Y3D3.
    Orphaneti 254920. Combined oxidative phosphorylation defect type 2.
    PharmGKBi PA31000.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0228.
    HOGENOMi HOG000246720.
    HOVERGENi HBG017758.
    InParanoidi Q9Y3D3.
    KOi K02959.
    OrthoDBi EOG7P02KX.
    PhylomeDBi Q9Y3D3.
    TreeFami TF105637.

    Miscellaneous databases

    GeneWikii MRPS16.
    GenomeRNAii 51021.
    NextBioi 53544.
    PROi Q9Y3D3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3D3.
    Bgeei Q9Y3D3.
    CleanExi HS_MRPS16.
    Genevestigatori Q9Y3D3.

    Family and domain databases

    Gene3Di 3.30.1320.10. 1 hit.
    HAMAPi MF_00385. Ribosomal_S16.
    InterProi IPR000307. Ribosomal_S16.
    IPR023803. Ribosomal_S16_dom.
    [Graphical view ]
    PANTHERi PTHR12919. PTHR12919. 1 hit.
    Pfami PF00886. Ribosomal_S16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54565. SSF54565. 1 hit.
    TIGRFAMsi TIGR00002. S16. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-35.
    7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. "Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation."
      Miller C., Saada A., Shaul N., Shabtai N., Ben-Shalom E., Shaag A., Hershkovitz E., Elpeleg O.
      Ann. Neurol. 56:734-738(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN COXPD2.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT16_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3D3
    Secondary accession number(s): B4E032, Q96Q60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3