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Protein

28S ribosomal protein S16, mitochondrial

Gene

MRPS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166330-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S16, mitochondrial
Short name:
MRP-S16
Short name:
S16mt
Gene namesi
Name:MRPS16
Synonyms:RPMS16
ORF Names:CGI-132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14048. MRPS16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 2 (COXPD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.
See also OMIM:610498

Organism-specific databases

DisGeNETi51021.
MalaCardsiMRPS16.
MIMi610498. phenotype.
OpenTargetsiENSG00000182180.
Orphaneti254920. Combined oxidative phosphorylation defect type 2.
PharmGKBiPA31000.

Polymorphism and mutation databases

BioMutaiMRPS16.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
ChainiPRO_000003061835 – 13728S ribosomal protein S16, mitochondrialAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3D3.
PaxDbiQ9Y3D3.
PeptideAtlasiQ9Y3D3.
PRIDEiQ9Y3D3.

PTM databases

iPTMnetiQ9Y3D3.
PhosphoSitePlusiQ9Y3D3.

Expressioni

Gene expression databases

BgeeiENSG00000182180.
CleanExiHS_MRPS16.
ExpressionAtlasiQ9Y3D3. baseline and differential.
GenevisibleiQ9Y3D3. HS.

Organism-specific databases

HPAiHPA050081.
HPA054538.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119227. 31 interactors.
IntActiQ9Y3D3. 5 interactors.
MINTiMINT-6488773.
STRINGi9606.ENSP00000362036.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AM1-137[»]
ProteinModelPortaliQ9Y3D3.
SMRiQ9Y3D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S16P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3419. Eukaryota.
COG0228. LUCA.
GeneTreeiENSGT00390000014309.
HOGENOMiHOG000246720.
HOVERGENiHBG017758.
InParanoidiQ9Y3D3.
KOiK02959.
OMAiEQLGCYD.
OrthoDBiEOG091G15N9.
PhylomeDBiQ9Y3D3.
TreeFamiTF105637.

Family and domain databases

Gene3Di3.30.1320.10. 1 hit.
HAMAPiMF_00385. Ribosomal_S16. 1 hit.
InterProiIPR000307. Ribosomal_S16.
IPR023803. Ribosomal_S16_dom.
[Graphical view]
PANTHERiPTHR12919. PTHR12919. 1 hit.
PfamiPF00886. Ribosomal_S16. 1 hit.
[Graphical view]
SUPFAMiSSF54565. SSF54565. 1 hit.
TIGRFAMsiTIGR00002. S16. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ
60 70 80 90 100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH
110 120 130
PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET
Length:137
Mass (Da):15,345
Last modified:November 1, 1999 - v1
Checksum:iC12B14B1B357F8D6
GO
Isoform 2 (identifier: Q9Y3D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-137: LAGFFPLHPM...EATDTEATET → KTDARFPEQGEERPEQHHFPEDLAPARGRGL

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,829
Checksum:i7F07429818B68914
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03152512Y → H.Corresponds to variant rs7905009dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05649893 – 137LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA. Translation: AAD34127.1.
AB049948 mRNA. Translation: BAB41001.1.
AK303204 mRNA. Translation: BAG64294.1.
AC016394 Genomic DNA. No translation available.
BC021106 mRNA. Translation: AAH21106.1.
AB051351 Genomic DNA. Translation: BAB54941.1.
CCDSiCCDS7323.1. [Q9Y3D3-1]
RefSeqiNP_057149.1. NM_016065.3. [Q9Y3D3-1]
UniGeneiHs.180312.

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180. [Q9Y3D3-1]
GeneIDi51021.
KEGGihsa:51021.
UCSCiuc001jts.1. human. [Q9Y3D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA. Translation: AAD34127.1.
AB049948 mRNA. Translation: BAB41001.1.
AK303204 mRNA. Translation: BAG64294.1.
AC016394 Genomic DNA. No translation available.
BC021106 mRNA. Translation: AAH21106.1.
AB051351 Genomic DNA. Translation: BAB54941.1.
CCDSiCCDS7323.1. [Q9Y3D3-1]
RefSeqiNP_057149.1. NM_016065.3. [Q9Y3D3-1]
UniGeneiHs.180312.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AM1-137[»]
ProteinModelPortaliQ9Y3D3.
SMRiQ9Y3D3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119227. 31 interactors.
IntActiQ9Y3D3. 5 interactors.
MINTiMINT-6488773.
STRINGi9606.ENSP00000362036.

PTM databases

iPTMnetiQ9Y3D3.
PhosphoSitePlusiQ9Y3D3.

Polymorphism and mutation databases

BioMutaiMRPS16.

Proteomic databases

EPDiQ9Y3D3.
PaxDbiQ9Y3D3.
PeptideAtlasiQ9Y3D3.
PRIDEiQ9Y3D3.

Protocols and materials databases

DNASUi51021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180. [Q9Y3D3-1]
GeneIDi51021.
KEGGihsa:51021.
UCSCiuc001jts.1. human. [Q9Y3D3-1]

Organism-specific databases

CTDi51021.
DisGeNETi51021.
GeneCardsiMRPS16.
HGNCiHGNC:14048. MRPS16.
HPAiHPA050081.
HPA054538.
MalaCardsiMRPS16.
MIMi609204. gene.
610498. phenotype.
neXtProtiNX_Q9Y3D3.
OpenTargetsiENSG00000182180.
Orphaneti254920. Combined oxidative phosphorylation defect type 2.
PharmGKBiPA31000.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3419. Eukaryota.
COG0228. LUCA.
GeneTreeiENSGT00390000014309.
HOGENOMiHOG000246720.
HOVERGENiHBG017758.
InParanoidiQ9Y3D3.
KOiK02959.
OMAiEQLGCYD.
OrthoDBiEOG091G15N9.
PhylomeDBiQ9Y3D3.
TreeFamiTF105637.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166330-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS16. human.
GeneWikiiMRPS16.
GenomeRNAii51021.
PROiQ9Y3D3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182180.
CleanExiHS_MRPS16.
ExpressionAtlasiQ9Y3D3. baseline and differential.
GenevisibleiQ9Y3D3. HS.

Family and domain databases

Gene3Di3.30.1320.10. 1 hit.
HAMAPiMF_00385. Ribosomal_S16. 1 hit.
InterProiIPR000307. Ribosomal_S16.
IPR023803. Ribosomal_S16_dom.
[Graphical view]
PANTHERiPTHR12919. PTHR12919. 1 hit.
PfamiPF00886. Ribosomal_S16. 1 hit.
[Graphical view]
SUPFAMiSSF54565. SSF54565. 1 hit.
TIGRFAMsiTIGR00002. S16. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D3
Secondary accession number(s): B4E032, Q96Q60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.