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Q9Y3D3 (RT16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S16, mitochondrial

Short name=MRP-S16
Short name=S16mt
Gene names
Name:MRPS16
Synonyms:RPMS16
ORF Names:CGI-132
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion HAMAP-Rule MF_00385.

Involvement in disease

Combined oxidative phosphorylation deficiency 2 (COXPD2) [MIM:610498]: A mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities

Belongs to the ribosomal protein S16P family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement Ref.5. Source: UniProtKB

   Cellular_componentmitochondrial small ribosomal subunit

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionstructural constituent of ribosome

Non-traceable author statement Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3434Mitochondrion Potential
Chain35 – 13710328S ribosomal protein S16, mitochondrial HAMAP-Rule MF_00385
PRO_0000030618

Amino acid modifications

Modified residue1301Phosphothreonine Ref.7 Ref.8 Ref.11

Natural variations

Natural variant121Y → H.
Corresponds to variant rs7905009 [ dbSNP | Ensembl ].
VAR_031525

Sequences

Sequence LengthMass (Da)Tools
Q9Y3D3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: C12B14B1B357F8D6

FASTA13715,345
        10         20         30         40         50         60 
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS 

        70         80         90        100        110        120 
HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH PMMITNAERL RRKRAREVLL 

       130 
ASQKTDAEAT DTEATET 

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-35.
[5]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation."
Miller C., Saada A., Shaul N., Shabtai N., Ben-Shalom E., Shaag A., Hershkovitz E., Elpeleg O.
Ann. Neurol. 56:734-738(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN COXPD2.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151890 mRNA. Translation: AAD34127.1.
AB049948 mRNA. Translation: BAB41001.1.
BC021106 mRNA. Translation: AAH21106.1.
AB051351 Genomic DNA. Translation: BAB54941.1.
RefSeqNP_057149.1. NM_016065.3.
UniGeneHs.180312.

3D structure databases

ProteinModelPortalQ9Y3D3.
SMRQ9Y3D3. Positions 17-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119227. 22 interactions.
IntActQ9Y3D3. 3 interactions.
MINTMINT-6488773.
STRING9606.ENSP00000362036.

PTM databases

PhosphoSiteQ9Y3D3.

Proteomic databases

PaxDbQ9Y3D3.
PRIDEQ9Y3D3.

Protocols and materials databases

DNASU51021.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372945; ENSP00000362036; ENSG00000182180.
GeneID51021.
KEGGhsa:51021.
UCSCuc001jts.1. human.

Organism-specific databases

CTD51021.
GeneCardsGC10M075008.
HGNCHGNC:14048. MRPS16.
HPAHPA050081.
HPA054538.
MIM609204. gene.
610498. phenotype.
neXtProtNX_Q9Y3D3.
Orphanet254920. Combined oxidative phosphorylation defect type 2.
PharmGKBPA31000.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0228.
HOGENOMHOG000246720.
HOVERGENHBG017758.
InParanoidQ9Y3D3.
KOK02959.
OrthoDBEOG7P02KX.
PhylomeDBQ9Y3D3.
TreeFamTF105637.

Gene expression databases

ArrayExpressQ9Y3D3.
BgeeQ9Y3D3.
CleanExHS_MRPS16.
GenevestigatorQ9Y3D3.

Family and domain databases

Gene3D3.30.1320.10. 1 hit.
HAMAPMF_00385. Ribosomal_S16.
InterProIPR000307. Ribosomal_S16.
IPR023803. Ribosomal_S16_dom.
[Graphical view]
PANTHERPTHR12919. PTHR12919. 1 hit.
PfamPF00886. Ribosomal_S16. 1 hit.
[Graphical view]
SUPFAMSSF54565. SSF54565. 1 hit.
TIGRFAMsTIGR00002. S16. 1 hit.
ProtoNetSearch...

Other

GeneWikiMRPS16.
GenomeRNAi51021.
NextBio53544.
PROQ9Y3D3.
SOURCESearch...

Entry information

Entry nameRT16_HUMAN
AccessionPrimary (citable) accession number: Q9Y3D3
Secondary accession number(s): Q96Q60
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM