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Protein

Methionine-R-sulfoxide reductase B2, mitochondrial

Gene

MSRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.1 Publication

Catalytic activityi

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi146ZincPROSITE-ProRule annotation1
Metal bindingi149ZincPROSITE-ProRule annotation1
Active sitei169NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • peptide-methionine (R)-S-oxide reductase activity Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: HGNC

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • protein repair Source: HGNC
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148450-MONOMER.
BRENDAi1.8.4.12. 2681.
1.8.4.B3. 2681.
ReactomeiR-HSA-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B2, mitochondrial (EC:1.8.4.-)
Short name:
MsrB2
Gene namesi
Name:MSRB2
Synonyms:CBS-1, MSRB
ORF Names:CGI-131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17061. MSRB2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • mitochondrion Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi22921.
OpenTargetsiENSG00000148450.
PharmGKBiPA134979691.

Chemistry databases

ChEMBLiCHEMBL3509603.
DrugBankiDB00134. L-Methionine.

Polymorphism and mutation databases

BioMutaiMSRB2.
DMDMi182676405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000014032421 – 182Methionine-R-sulfoxide reductase B2, mitochondrialAdd BLAST162

Proteomic databases

EPDiQ9Y3D2.
MaxQBiQ9Y3D2.
PaxDbiQ9Y3D2.
PeptideAtlasiQ9Y3D2.
PRIDEiQ9Y3D2.

PTM databases

iPTMnetiQ9Y3D2.
PhosphoSitePlusiQ9Y3D2.
SwissPalmiQ9Y3D2.

Expressioni

Tissue specificityi

Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.2 Publications

Gene expression databases

BgeeiENSG00000148450.
CleanExiHS_MSRB2.
ExpressionAtlasiQ9Y3D2. baseline and differential.
GenevisibleiQ9Y3D2. HS.

Organism-specific databases

HPAiHPA027933.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116583. 7 interactors.
IntActiQ9Y3D2. 2 interactors.
STRINGi9606.ENSP00000365693.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3D2.
SMRiQ9Y3D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 180MsrBPROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000046802.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9Y3D2.
KOiK07305.
OMAiHGTWERD.
OrthoDBiEOG091G043K.
PhylomeDBiQ9Y3D2.
TreeFamiTF329147.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLLWLLRG LTLGTAPRRA VRGQAGGGGP GTGPGLGEAG SLATCELPLA
60 70 80 90 100
KSEWQKKLTP EQFYVTREKG TEPPFSGIYL NNKEAGMYHC VCCDSPLFSS
110 120 130 140 150
EKKYCSGTGW PSFSEAHGTS GSDESHTGIL RRLDTSLGSA RTEVVCKQCE
160 170 180
AHLGHVFPDG PGPNGQRFCI NSVALKFKPR KH
Length:182
Mass (Da):19,536
Last modified:April 8, 2008 - v2
Checksum:iDFD1D0BF249D45BE
GO

Sequence cautioni

The sequence AAD34126 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63F → L in AAH18030 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05044846E → G.Corresponds to variant rs2296466dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122004 mRNA. Translation: AAD38899.1.
AF151889 mRNA. Translation: AAD34126.1. Frameshift.
EF444983 Genomic DNA. Translation: ACA05998.1.
AL139281 Genomic DNA. Translation: CAI12665.1.
CH471072 Genomic DNA. Translation: EAW86135.1.
BC018030 mRNA. Translation: AAH18030.1.
BC117471 mRNA. Translation: AAI17472.1.
BC130380 mRNA. Translation: AAI30381.1.
CCDSiCCDS41495.1.
RefSeqiNP_036360.3. NM_012228.3.
UniGeneiHs.461420.

Genome annotation databases

EnsembliENST00000376510; ENSP00000365693; ENSG00000148450.
GeneIDi22921.
KEGGihsa:22921.
UCSCiuc001iro.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122004 mRNA. Translation: AAD38899.1.
AF151889 mRNA. Translation: AAD34126.1. Frameshift.
EF444983 Genomic DNA. Translation: ACA05998.1.
AL139281 Genomic DNA. Translation: CAI12665.1.
CH471072 Genomic DNA. Translation: EAW86135.1.
BC018030 mRNA. Translation: AAH18030.1.
BC117471 mRNA. Translation: AAI17472.1.
BC130380 mRNA. Translation: AAI30381.1.
CCDSiCCDS41495.1.
RefSeqiNP_036360.3. NM_012228.3.
UniGeneiHs.461420.

3D structure databases

ProteinModelPortaliQ9Y3D2.
SMRiQ9Y3D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116583. 7 interactors.
IntActiQ9Y3D2. 2 interactors.
STRINGi9606.ENSP00000365693.

Chemistry databases

ChEMBLiCHEMBL3509603.
DrugBankiDB00134. L-Methionine.

PTM databases

iPTMnetiQ9Y3D2.
PhosphoSitePlusiQ9Y3D2.
SwissPalmiQ9Y3D2.

Polymorphism and mutation databases

BioMutaiMSRB2.
DMDMi182676405.

Proteomic databases

EPDiQ9Y3D2.
MaxQBiQ9Y3D2.
PaxDbiQ9Y3D2.
PeptideAtlasiQ9Y3D2.
PRIDEiQ9Y3D2.

Protocols and materials databases

DNASUi22921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376510; ENSP00000365693; ENSG00000148450.
GeneIDi22921.
KEGGihsa:22921.
UCSCiuc001iro.4. human.

Organism-specific databases

CTDi22921.
DisGeNETi22921.
GeneCardsiMSRB2.
H-InvDBHIX0035324.
HGNCiHGNC:17061. MSRB2.
HPAiHPA027933.
MIMi613782. gene.
neXtProtiNX_Q9Y3D2.
OpenTargetsiENSG00000148450.
PharmGKBiPA134979691.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000046802.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9Y3D2.
KOiK07305.
OMAiHGTWERD.
OrthoDBiEOG091G043K.
PhylomeDBiQ9Y3D2.
TreeFamiTF329147.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148450-MONOMER.
BRENDAi1.8.4.12. 2681.
1.8.4.B3. 2681.
ReactomeiR-HSA-5676934. Protein repair.

Miscellaneous databases

GeneWikiiMSRB2.
GenomeRNAii22921.
PROiQ9Y3D2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148450.
CleanExiHS_MSRB2.
ExpressionAtlasiQ9Y3D2. baseline and differential.
GenevisibleiQ9Y3D2. HS.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D2
Secondary accession number(s): Q17R44, Q4G1C7, Q9Y5W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.