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Q9Y3D0 (MIP18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitotic spindle-associated MMXD complex subunit MIP18
Alternative name(s):
MSS19-interacting protein of 18 kDa
Protein FAM96B
Gene names
Name:FAM96B
Synonyms:MIP18
ORF Names:CGI-128, HSPC118
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Ref.5

Subunit structure

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct. Ref.5 Ref.8 Ref.9

Subcellular location

Nucleus. Cytoplasmcytoskeletonspindle Ref.5.

Sequence similarities

Belongs to the MIP18 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 163162Mitotic spindle-associated MMXD complex subunit MIP18
PRO_0000212691

Sequences

Sequence LengthMass (Da)Tools
Q9Y3D0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 323004BAB92B1486

FASTA16317,663
        10         20         30         40         50         60 
MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI RSINDPEHPL 

        70         80         90        100        110        120 
TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG LSIKVKLLRS LPQRFKMDVH 

       130        140        150        160 
ITPGTHASEH AVNKQLADKE RVAAALENTH LLEVVNQCLS ARS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Uterus.
[4]Bienvenut W.V., Waridel P., Quadroni M.
Submitted (MAR-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-22; 117-134 AND 142-162, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[5]"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."
Ito S., Tan L.J., Andoh D., Narita T., Seki M., Hirano Y., Narita K., Kuraoka I., Hiraoka Y., Tanaka K.
Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN MMXD COMPLEX, INTERACTION WITH ERCC2 AND MMS19, SUBCELLULAR LOCATION.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."
Stehling O., Vashisht A.A., Mascarenhas J., Jonsson Z.O., Sharma T., Netz D.J., Pierik A.J., Wohlschlegel J.A., Lill R.
Science 337:195-199(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CIA COMPLEX.
[9]"MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."
Gari K., Leon Ortiz A.M., Borel V., Flynn H., Skehel J.M., Boulton S.J.
Science 337:243-245(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CIA COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151886 mRNA. Translation: AAD34123.1.
AF161467 mRNA. Translation: AAF29082.1.
BC001733 mRNA. Translation: AAH01733.1.
BC005023 mRNA. Translation: AAH05023.1.
RefSeqNP_057146.1. NM_016062.3.
UniGeneHs.9825.

3D structure databases

ProteinModelPortalQ9Y3D0.
SMRQ9Y3D0. Positions 43-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119656. 8 interactions.
IntActQ9Y3D0. 4 interactions.
MINTMINT-5006739.
STRING9606.ENSP00000387471.

PTM databases

PhosphoSiteQ9Y3D0.

Proteomic databases

PaxDbQ9Y3D0.
PRIDEQ9Y3D0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000422424; ENSP00000387471; ENSG00000166595.
GeneID51647.
KEGGhsa:51647.
UCSCuc021tjy.2. human.

Organism-specific databases

CTD51647.
GeneCardsGC16M066965.
HGNCHGNC:24261. FAM96B.
HPAHPA041501.
HPA041736.
MIM614778. gene.
neXtProtNX_Q9Y3D0.
PharmGKBPA142671830.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5133.
HOVERGENHBG029509.
InParanoidQ9Y3D0.
OMARFKIDVH.
OrthoDBEOG7034J5.
PhylomeDBQ9Y3D0.
TreeFamTF105940.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ9Y3D0.
BgeeQ9Y3D0.
CleanExHS_FAM96B.
GenevestigatorQ9Y3D0.

Family and domain databases

InterProIPR002744. DUF59.
[Graphical view]
PfamPF01883. DUF59. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM96B. human.
GenomeRNAi51647.
NextBio55596.
PROQ9Y3D0.
SOURCESearch...

Entry information

Entry nameMIP18_HUMAN
AccessionPrimary (citable) accession number: Q9Y3D0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM