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Protein

Mitotic spindle-associated MMXD complex subunit MIP18

Gene

FAM96B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.1 Publication

GO - Biological processi

  • chromosome segregation Source: UniProtKB
  • iron-sulfur cluster assembly Source: GO_Central

Keywordsi

Biological processChromosome partition

Enzyme and pathway databases

ReactomeiR-HSA-2564830. Cytosolic iron-sulfur cluster assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic spindle-associated MMXD complex subunit MIP18
Alternative name(s):
MSS19-interacting protein of 18 kDa
Protein FAM96B
Gene namesi
Name:FAM96B
Synonyms:MIP18
ORF Names:CGI-128, HSPC118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166595.11.
HGNCiHGNC:24261. FAM96B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51647.
OpenTargetsiENSG00000166595.
PharmGKBiPA142671830.

Polymorphism and mutation databases

BioMutaiFAM96B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002126912 – 163Mitotic spindle-associated MMXD complex subunit MIP18Add BLAST162

Proteomic databases

EPDiQ9Y3D0.
MaxQBiQ9Y3D0.
PaxDbiQ9Y3D0.
PeptideAtlasiQ9Y3D0.
PRIDEiQ9Y3D0.

PTM databases

iPTMnetiQ9Y3D0.
PhosphoSitePlusiQ9Y3D0.

Expressioni

Gene expression databases

BgeeiENSG00000166595.
CleanExiHS_FAM96B.
ExpressionAtlasiQ9Y3D0. baseline and differential.
GenevisibleiQ9Y3D0. HS.

Organism-specific databases

HPAiHPA041501.
HPA041736.

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119656. 67 interactors.
IntActiQ9Y3D0. 25 interactors.
MINTiMINT-5006739.
STRINGi9606.ENSP00000387471.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3D0.
SMRiQ9Y3D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP18 family.Curated

Phylogenomic databases

eggNOGiKOG3381. Eukaryota.
COG5133. LUCA.
GeneTreeiENSGT00390000017697.
HOVERGENiHBG029509.
InParanoidiQ9Y3D0.
OMAiEQAVNKQ.
OrthoDBiEOG091G0OZO.
PhylomeDBiQ9Y3D0.
TreeFamiTF105940.

Family and domain databases

Gene3Di3.30.300.130. 1 hit.
InterProiView protein in InterPro
IPR034904. FSCA_dom.
IPR002744. MIP18-like.
PfamiView protein in Pfam
PF01883. FeS_assembly_P. 1 hit.
SUPFAMiSSF117916. SSF117916. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI
60 70 80 90 100
RSINDPEHPL TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG
110 120 130 140 150
LSIKVKLLRS LPQRFKMDVH ITPGTHASEH AVNKQLADKE RVAAALENTH
160
LLEVVNQCLS ARS
Length:163
Mass (Da):17,663
Last modified:November 1, 1999 - v1
Checksum:i323004BAB92B1486
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151886 mRNA. Translation: AAD34123.1.
AF161467 mRNA. Translation: AAF29082.1.
BC001733 mRNA. Translation: AAH01733.1.
BC005023 mRNA. Translation: AAH05023.1.
CCDSiCCDS45506.1.
RefSeqiNP_057146.1. NM_016062.3.
UniGeneiHs.9825.

Genome annotation databases

EnsembliENST00000422424; ENSP00000387471; ENSG00000166595.
GeneIDi51647.
KEGGihsa:51647.
UCSCiuc059vme.1. human.

Similar proteinsi

Entry informationi

Entry nameiMIP18_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries