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Q9Y3D0

- MIP18_HUMAN

UniProt

Q9Y3D0 - MIP18_HUMAN

Protein

Mitotic spindle-associated MMXD complex subunit MIP18

Gene

FAM96B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB
    2. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Chromosome partition

    Enzyme and pathway databases

    ReactomeiREACT_160176. Cytosolic iron-sulfur cluster assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitotic spindle-associated MMXD complex subunit MIP18
    Alternative name(s):
    MSS19-interacting protein of 18 kDa
    Protein FAM96B
    Gene namesi
    Name:FAM96B
    Synonyms:MIP18
    ORF Names:CGI-128, HSPC118
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:24261. FAM96B.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication

    GO - Cellular componenti

    1. CIA complex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. MMXD complex Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. spindle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 163162Mitotic spindle-associated MMXD complex subunit MIP18PRO_0000212691Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y3D0.
    PaxDbiQ9Y3D0.
    PRIDEiQ9Y3D0.

    PTM databases

    PhosphoSiteiQ9Y3D0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3D0.
    BgeeiQ9Y3D0.
    CleanExiHS_FAM96B.
    GenevestigatoriQ9Y3D0.

    Organism-specific databases

    HPAiHPA041501.
    HPA041736.

    Interactioni

    Subunit structurei

    Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct.3 Publications

    Protein-protein interaction databases

    BioGridi119656. 8 interactions.
    IntActiQ9Y3D0. 4 interactions.
    MINTiMINT-5006739.
    STRINGi9606.ENSP00000387471.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3D0.
    SMRiQ9Y3D0. Positions 43-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MIP18 family.Curated

    Phylogenomic databases

    eggNOGiCOG5133.
    HOVERGENiHBG029509.
    InParanoidiQ9Y3D0.
    OMAiQSTSICL.
    OrthoDBiEOG7034J5.
    PhylomeDBiQ9Y3D0.
    TreeFamiTF105940.

    Family and domain databases

    InterProiIPR002744. DUF59.
    [Graphical view]
    PfamiPF01883. DUF59. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y3D0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI    50
    RSINDPEHPL TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG 100
    LSIKVKLLRS LPQRFKMDVH ITPGTHASEH AVNKQLADKE RVAAALENTH 150
    LLEVVNQCLS ARS 163
    Length:163
    Mass (Da):17,663
    Last modified:November 1, 1999 - v1
    Checksum:i323004BAB92B1486
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151886 mRNA. Translation: AAD34123.1.
    AF161467 mRNA. Translation: AAF29082.1.
    BC001733 mRNA. Translation: AAH01733.1.
    BC005023 mRNA. Translation: AAH05023.1.
    CCDSiCCDS45506.1.
    RefSeqiNP_057146.1. NM_016062.3.
    UniGeneiHs.9825.

    Genome annotation databases

    EnsembliENST00000422424; ENSP00000387471; ENSG00000166595.
    GeneIDi51647.
    KEGGihsa:51647.
    UCSCiuc021tjy.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151886 mRNA. Translation: AAD34123.1 .
    AF161467 mRNA. Translation: AAF29082.1 .
    BC001733 mRNA. Translation: AAH01733.1 .
    BC005023 mRNA. Translation: AAH05023.1 .
    CCDSi CCDS45506.1.
    RefSeqi NP_057146.1. NM_016062.3.
    UniGenei Hs.9825.

    3D structure databases

    ProteinModelPortali Q9Y3D0.
    SMRi Q9Y3D0. Positions 43-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119656. 8 interactions.
    IntActi Q9Y3D0. 4 interactions.
    MINTi MINT-5006739.
    STRINGi 9606.ENSP00000387471.

    PTM databases

    PhosphoSitei Q9Y3D0.

    Proteomic databases

    MaxQBi Q9Y3D0.
    PaxDbi Q9Y3D0.
    PRIDEi Q9Y3D0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000422424 ; ENSP00000387471 ; ENSG00000166595 .
    GeneIDi 51647.
    KEGGi hsa:51647.
    UCSCi uc021tjy.2. human.

    Organism-specific databases

    CTDi 51647.
    GeneCardsi GC16M066965.
    HGNCi HGNC:24261. FAM96B.
    HPAi HPA041501.
    HPA041736.
    MIMi 614778. gene.
    neXtProti NX_Q9Y3D0.
    PharmGKBi PA142671830.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5133.
    HOVERGENi HBG029509.
    InParanoidi Q9Y3D0.
    OMAi QSTSICL.
    OrthoDBi EOG7034J5.
    PhylomeDBi Q9Y3D0.
    TreeFami TF105940.

    Enzyme and pathway databases

    Reactomei REACT_160176. Cytosolic iron-sulfur cluster assembly.

    Miscellaneous databases

    ChiTaRSi FAM96B. human.
    GenomeRNAii 51647.
    NextBioi 55596.
    PROi Q9Y3D0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3D0.
    Bgeei Q9Y3D0.
    CleanExi HS_FAM96B.
    Genevestigatori Q9Y3D0.

    Family and domain databases

    InterProi IPR002744. DUF59.
    [Graphical view ]
    Pfami PF01883. DUF59. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Uterus.
    4. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-22; 117-134 AND 142-162, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic kidney.
    5. "MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."
      Ito S., Tan L.J., Andoh D., Narita T., Seki M., Hirano Y., Narita K., Kuraoka I., Hiraoka Y., Tanaka K.
      Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN MMXD COMPLEX, INTERACTION WITH ERCC2 AND MMS19, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."
      Stehling O., Vashisht A.A., Mascarenhas J., Jonsson Z.O., Sharma T., Netz D.J., Pierik A.J., Wohlschlegel J.A., Lill R.
      Science 337:195-199(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CIA COMPLEX.
    9. "MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."
      Gari K., Leon Ortiz A.M., Borel V., Flynn H., Skehel J.M., Boulton S.J.
      Science 337:243-245(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CIA COMPLEX.

    Entry informationi

    Entry nameiMIP18_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3