Q9Y3D0 (MIP18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitotic spindle-associated MMXD complex subunit MIP18

Alternative name(s):
MSS19-interacting protein of 18 kDa
Protein FAM96B

Gene names

Name:	FAM96B
Synonyms:	MIP18
ORF Names:	CGI-128, HSPC118

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Ref.5
Subunit structure	Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with ERCC2 and MMS19; the interaction is direct. Ref.5 Ref.7 Ref.8
Subcellular location	Nucleus. Cytoplasm › cytoskeleton › spindle Ref.5.
Sequence similarities	Belongs to the MIP18 family.

Ontologies

Keywords
Biological process	Chromosome partition
Cellular component	Cytoplasm Cytoskeleton Nucleus
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	chromosome segregation Inferred from mutant phenotype Ref.5. Source: UniProtKB
Cellular_component	CIA complex Inferred from direct assay Ref.8Ref.7. Source: UniProtKB MMXD complex Inferred from direct assay Ref.5. Source: UniProtKB nucleus Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 163	162	Mitotic spindle-associated MMXD complex subunit MIP18		PRO_0000212691

Sequences

	Sequence		Length	Mass (Da)
	Q9Y3D0 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 323004BAB92B1486	FASTA	163	17,663
	10 20 30 40 50 60 MVGGGGVGGG LLENANPLIY QRSGERPVTA GEEDEQVPDS IDAREIFDLI RSINDPEHPL 70 80 90 100 110 120 TLEELNVVEQ VRVQVSDPES TVAVAFTPTI PHCSMATLIG LSIKVKLLRS LPQRFKMDVH 130 140 150 160 ITPGTHASEH AVNKQLADKE RVAAALENTH LLEVVNQCLS ARS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Uterus.
[4]	Bienvenut W.V., Waridel P., Quadroni M. Submitted (MAR-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-22; 117-134 AND 142-162, CLEAVAGE OF INITIATOR METHIONINE, LACK OF N-TERMINAL ACETYLATION, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation." Ito S., Tan L.J., Andoh D., Narita T., Seki M., Hirano Y., Narita K., Kuraoka I., Hiraoka Y., Tanaka K. Mol. Cell 39:632-640(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN MMXD COMPLEX, INTERACTION WITH ERCC2 AND MMS19, SUBCELLULAR LOCATION.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity." Stehling O., Vashisht A.A., Mascarenhas J., Jonsson Z.O., Sharma T., Netz D.J., Pierik A.J., Wohlschlegel J.A., Lill R. Science 337:195-199(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE CIA COMPLEX.
[8]	"MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism." Gari K., Leon Ortiz A.M., Borel V., Flynn H., Skehel J.M., Boulton S.J. Science 337:243-245(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE CIA COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151886 mRNA. Translation: AAD34123.1. AF161467 mRNA. Translation: AAF29082.1. BC001733 mRNA. Translation: AAH01733.1. BC005023 mRNA. Translation: AAH05023.1.
IPI	IPI00007024.
RefSeq	NP_057146.1. NM_016062.3.
UniGene	Hs.9825.
3D structure databases
ProteinModelPortal	Q9Y3D0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3D0. 4 interactions.
MINT	MINT-5006739.
STRING	9606.ENSP00000387471.
PTM databases
PhosphoSite	Q9Y3D0.
Polymorphism databases
DMDM	20454862.
Proteomic databases
PaxDb	Q9Y3D0.
PRIDE	Q9Y3D0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422424; ENSP00000387471; ENSG00000166595.
GeneID	51647.
KEGG	hsa:51647.
UCSC	uc021tjy.1. human.
Organism-specific databases
CTD	51647.
GeneCards	GC16M066965.
HGNC	HGNC:24261. FAM96B.
HPA	HPA041501. HPA041736.
MIM	614778. gene.
neXtProt	NX_Q9Y3D0.
PharmGKB	PA142671830.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5133.
HOVERGEN	HBG029509.
InParanoid	Q9Y3D0.
OMA	IGLSIRV.
OrthoDB	EOG4ZW5CB.
Gene expression databases
Bgee	Q9Y3D0.
CleanEx	HS_FAM96B.
Genevestigator	Q9Y3D0.
GermOnline	ENSG00000166595. Homo sapiens.
Family and domain databases
InterPro	IPR002744. DUF59. [Graphical view]
Pfam	PF01883. DUF59. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAM96B. human.
GenomeRNAi	51647.
NextBio	55596.
SOURCE	Search...

Entry information

Entry name

MIP18_HUMAN

Accession

Primary (citable) accession number: Q9Y3D0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.