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Protein

Ubiquitin-fold modifier-conjugating enzyme 1

Gene

UFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116Glycyl thioester intermediate1

GO - Molecular functioni

  • UFM1 transferase activity Source: UniProtKB

GO - Biological processi

  • protein K69-linked ufmylation Source: UniProtKB
  • protein ufmylation Source: UniProtKB
  • response to endoplasmic reticulum stress Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-fold modifier-conjugating enzyme 1
Short name:
Ufm1-conjugating enzyme 1
Gene namesi
Name:UFC1
ORF Names:CGI-126, HSPC155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143222.11
HGNCiHGNC:26941 UFC1
MIMi610554 gene
neXtProtiNX_Q9Y3C8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30Q → A: Does not affect neither UBA5-binding nor thioester formation with UFM1. 1 Publication1
Mutagenesisi33K → A: Impairs binding to UBA5 and thioester formation with UFM1. 1 Publication1
Mutagenesisi116C → S: Instead of the formation of an intermediate complex with a thiol ester bond between UFC1 (E2-like enzyme) and UFM1 (substrate), a stable complex with an O-ester bond is formed. 1 Publication1

Organism-specific databases

DisGeNETi51506
OpenTargetsiENSG00000143222
PharmGKBiPA142670644

Polymorphism and mutation databases

BioMutaiUFC1
DMDMi116242840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826131 – 167Ubiquitin-fold modifier-conjugating enzyme 1Add BLAST167

Proteomic databases

EPDiQ9Y3C8
MaxQBiQ9Y3C8
PaxDbiQ9Y3C8
PeptideAtlasiQ9Y3C8
PRIDEiQ9Y3C8

PTM databases

iPTMnetiQ9Y3C8
PhosphoSitePlusiQ9Y3C8
SwissPalmiQ9Y3C8

Expressioni

Gene expression databases

BgeeiENSG00000143222
CleanExiHS_UFC1
GenevisibleiQ9Y3C8 HS

Organism-specific databases

HPAiHPA027481
HPA028722

Interactioni

Subunit structurei

Interacts with UBA5 (PubMed:17825256). Interacts with UFL1 (PubMed:20018847). Interacts with KIRREL3 (PubMed:25902260).3 Publications

Protein-protein interaction databases

BioGridi11957745 interactors.
IntActiQ9Y3C8 7 interactors.
STRINGi9606.ENSP00000356982

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 10Combined sources9
Helixi26 – 48Combined sources23
Beta strandi54 – 58Combined sources5
Beta strandi64 – 73Combined sources10
Beta strandi76 – 85Combined sources10
Turni88 – 92Combined sources5
Helixi100 – 102Combined sources3
Turni103 – 105Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi113 – 115Combined sources3
Helixi121 – 128Combined sources8
Helixi134 – 140Combined sources7
Helixi142 – 156Combined sources15
Beta strandi162 – 164Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K07NMR-A1-167[»]
2Z6OX-ray1.60A1-167[»]
2Z6PX-ray1.80A1-167[»]
3EVXX-ray2.54A/B/C/D1-167[»]
ProteinModelPortaliQ9Y3C8
SMRiQ9Y3C8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3C8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3357 Eukaryota
ENOG410ZBCX LUCA
GeneTreeiENSGT00390000008196
HOVERGENiHBG054254
InParanoidiQ9Y3C8
KOiK12165
OMAiEHFKPLW
OrthoDBiEOG091G0MP6
PhylomeDBiQ9Y3C8
TreeFamiTF313587

Family and domain databases

Gene3Di3.10.110.101 hit
InterProiView protein in InterPro
IPR016135 UBQ-conjugating_enzyme/RWD
IPR014806 Ufc1
PANTHERiPTHR12921 PTHR12921, 1 hit
PfamiView protein in Pfam
PF08694 UFC1, 1 hit
PIRSFiPIRSF008716 DUF1782, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y3C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD
60 70 80 90 100
NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP
110 120 130 140 150
ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI
160
PDLIQKGVIQ HKEKCNQ
Length:167
Mass (Da):19,458
Last modified:October 17, 2006 - v3
Checksum:i1675D9187DC43E14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → N in BAF85465 (PubMed:14702039).Curated1
Sequence conflicti160Q → H in BAD15374 (PubMed:15071506).Curated1
Sequence conflicti160Q → H in AAF29119 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02831290Y → C1 PublicationCorresponds to variant dbSNP:rs17849932Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154405 mRNA Translation: BAD15374.1
AF151884 mRNA Translation: AAD34121.1
AF161504 mRNA Translation: AAF29119.1
AK292776 mRNA Translation: BAF85465.1
AL590714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52646.1
CH471121 Genomic DNA Translation: EAW52647.1
BC005187 mRNA Translation: AAH05187.1
CCDSiCCDS1220.1
RefSeqiNP_057490.2, NM_016406.3
XP_016856939.1, XM_017001450.1
XP_016856940.1, XM_017001451.1
UniGeneiHs.301412

Genome annotation databases

EnsembliENST00000368003; ENSP00000356982; ENSG00000143222
GeneIDi51506
KEGGihsa:51506
UCSCiuc001fyd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C8
Secondary accession number(s): A8K9R1
, D3DVF9, Q549X0, Q5VTX1, Q9BS96, Q9P009
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome