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Protein

Ubiquitin-fold modifier-conjugating enzyme 1

Gene

UFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei116Glycyl thioester intermediate1

GO - Molecular functioni

  • UFM1 transferase activity Source: UniProtKB

GO - Biological processi

  • protein K69-linked ufmylation Source: UniProtKB
  • protein ufmylation Source: UniProtKB
  • response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-fold modifier-conjugating enzyme 1
Short name:
Ufm1-conjugating enzyme 1
Gene namesi
Name:UFC1
ORF Names:CGI-126, HSPC155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26941. UFC1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30Q → A: Does not affect neither UBA5-binding nor thioester formation with UFM1. 1 Publication1
Mutagenesisi33K → A: Impairs binding to UBA5 and thioester formation with UFM1. 1 Publication1
Mutagenesisi116C → S: Instead of the formation of an intermediate complex with a thiol ester bond between UFC1 (E2-like enzyme) and UFM1 (substrate), a stable complex with an O-ester bond is formed. 1 Publication1

Organism-specific databases

DisGeNETi51506.
OpenTargetsiENSG00000143222.
PharmGKBiPA142670644.

Polymorphism and mutation databases

BioMutaiUFC1.
DMDMi116242840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826131 – 167Ubiquitin-fold modifier-conjugating enzyme 1Add BLAST167

Proteomic databases

EPDiQ9Y3C8.
MaxQBiQ9Y3C8.
PaxDbiQ9Y3C8.
PeptideAtlasiQ9Y3C8.
PRIDEiQ9Y3C8.

PTM databases

iPTMnetiQ9Y3C8.
PhosphoSitePlusiQ9Y3C8.
SwissPalmiQ9Y3C8.

Expressioni

Gene expression databases

BgeeiENSG00000143222.
CleanExiHS_UFC1.
GenevisibleiQ9Y3C8. HS.

Organism-specific databases

HPAiHPA027481.
HPA028722.

Interactioni

Subunit structurei

Interacts with UBA5 (PubMed:17825256). Interacts with UFL1 (PubMed:20018847). Interacts with KIRREL3 (PubMed:25902260).3 Publications

Protein-protein interaction databases

BioGridi119577. 45 interactors.
IntActiQ9Y3C8. 4 interactors.
STRINGi9606.ENSP00000356982.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 10Combined sources9
Helixi26 – 48Combined sources23
Beta strandi54 – 58Combined sources5
Beta strandi64 – 73Combined sources10
Beta strandi76 – 85Combined sources10
Turni88 – 92Combined sources5
Helixi100 – 102Combined sources3
Turni103 – 105Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi113 – 115Combined sources3
Helixi121 – 128Combined sources8
Helixi134 – 140Combined sources7
Helixi142 – 156Combined sources15
Beta strandi162 – 164Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K07NMR-A1-167[»]
2Z6OX-ray1.60A1-167[»]
2Z6PX-ray1.80A1-167[»]
3EVXX-ray2.54A/B/C/D1-167[»]
ProteinModelPortaliQ9Y3C8.
SMRiQ9Y3C8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3C8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3357. Eukaryota.
ENOG410ZBCX. LUCA.
GeneTreeiENSGT00390000008196.
HOVERGENiHBG054254.
InParanoidiQ9Y3C8.
KOiK12165.
OMAiEHFKPLW.
OrthoDBiEOG091G0MP6.
PhylomeDBiQ9Y3C8.
TreeFamiTF313587.

Family and domain databases

InterProiIPR016135. UBQ-conjugating_enzyme/RWD.
IPR014806. Ufc1.
[Graphical view]
PANTHERiPTHR12921. PTHR12921. 1 hit.
PfamiPF08694. UFC1. 1 hit.
[Graphical view]
PIRSFiPIRSF008716. DUF1782. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y3C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD
60 70 80 90 100
NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP
110 120 130 140 150
ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI
160
PDLIQKGVIQ HKEKCNQ
Length:167
Mass (Da):19,458
Last modified:October 17, 2006 - v3
Checksum:i1675D9187DC43E14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → N in BAF85465 (PubMed:14702039).Curated1
Sequence conflicti160Q → H in BAD15374 (PubMed:15071506).Curated1
Sequence conflicti160Q → H in AAF29119 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02831290Y → C.1 PublicationCorresponds to variant rs17849932dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154405 mRNA. Translation: BAD15374.1.
AF151884 mRNA. Translation: AAD34121.1.
AF161504 mRNA. Translation: AAF29119.1.
AK292776 mRNA. Translation: BAF85465.1.
AL590714 Genomic DNA. Translation: CAH72141.1.
CH471121 Genomic DNA. Translation: EAW52646.1.
CH471121 Genomic DNA. Translation: EAW52647.1.
BC005187 mRNA. Translation: AAH05187.1.
CCDSiCCDS1220.1.
RefSeqiNP_057490.2. NM_016406.3.
XP_016856939.1. XM_017001450.1.
XP_016856940.1. XM_017001451.1.
UniGeneiHs.301412.

Genome annotation databases

EnsembliENST00000368003; ENSP00000356982; ENSG00000143222.
GeneIDi51506.
KEGGihsa:51506.
UCSCiuc001fyd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154405 mRNA. Translation: BAD15374.1.
AF151884 mRNA. Translation: AAD34121.1.
AF161504 mRNA. Translation: AAF29119.1.
AK292776 mRNA. Translation: BAF85465.1.
AL590714 Genomic DNA. Translation: CAH72141.1.
CH471121 Genomic DNA. Translation: EAW52646.1.
CH471121 Genomic DNA. Translation: EAW52647.1.
BC005187 mRNA. Translation: AAH05187.1.
CCDSiCCDS1220.1.
RefSeqiNP_057490.2. NM_016406.3.
XP_016856939.1. XM_017001450.1.
XP_016856940.1. XM_017001451.1.
UniGeneiHs.301412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K07NMR-A1-167[»]
2Z6OX-ray1.60A1-167[»]
2Z6PX-ray1.80A1-167[»]
3EVXX-ray2.54A/B/C/D1-167[»]
ProteinModelPortaliQ9Y3C8.
SMRiQ9Y3C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119577. 45 interactors.
IntActiQ9Y3C8. 4 interactors.
STRINGi9606.ENSP00000356982.

PTM databases

iPTMnetiQ9Y3C8.
PhosphoSitePlusiQ9Y3C8.
SwissPalmiQ9Y3C8.

Polymorphism and mutation databases

BioMutaiUFC1.
DMDMi116242840.

Proteomic databases

EPDiQ9Y3C8.
MaxQBiQ9Y3C8.
PaxDbiQ9Y3C8.
PeptideAtlasiQ9Y3C8.
PRIDEiQ9Y3C8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368003; ENSP00000356982; ENSG00000143222.
GeneIDi51506.
KEGGihsa:51506.
UCSCiuc001fyd.5. human.

Organism-specific databases

CTDi51506.
DisGeNETi51506.
GeneCardsiUFC1.
HGNCiHGNC:26941. UFC1.
HPAiHPA027481.
HPA028722.
MIMi610554. gene.
neXtProtiNX_Q9Y3C8.
OpenTargetsiENSG00000143222.
PharmGKBiPA142670644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3357. Eukaryota.
ENOG410ZBCX. LUCA.
GeneTreeiENSGT00390000008196.
HOVERGENiHBG054254.
InParanoidiQ9Y3C8.
KOiK12165.
OMAiEHFKPLW.
OrthoDBiEOG091G0MP6.
PhylomeDBiQ9Y3C8.
TreeFamiTF313587.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143222-MONOMER.

Miscellaneous databases

ChiTaRSiUFC1. human.
EvolutionaryTraceiQ9Y3C8.
GenomeRNAii51506.
PROiQ9Y3C8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143222.
CleanExiHS_UFC1.
GenevisibleiQ9Y3C8. HS.

Family and domain databases

InterProiIPR016135. UBQ-conjugating_enzyme/RWD.
IPR014806. Ufc1.
[Graphical view]
PANTHERiPTHR12921. PTHR12921. 1 hit.
PfamiPF08694. UFC1. 1 hit.
[Graphical view]
PIRSFiPIRSF008716. DUF1782. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C8
Secondary accession number(s): A8K9R1
, D3DVF9, Q549X0, Q5VTX1, Q9BS96, Q9P009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.