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Q9Y3C8

- UFC1_HUMAN

UniProt

Q9Y3C8 - UFC1_HUMAN

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Protein
Ubiquitin-fold modifier-conjugating enzyme 1
Gene
UFC1, CGI-126, HSPC155
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161Glycyl thioester intermediate

GO - Molecular functioni

  1. UFM1 conjugating enzyme activity Source: UniProtKB
  2. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein ufmylation Source: UniProtKB
  2. response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-fold modifier-conjugating enzyme 1
Short name:
Ufm1-conjugating enzyme 1
Gene namesi
Name:UFC1
ORF Names:CGI-126, HSPC155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26941. UFC1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi30 – 301Q → A: Does not affect neither UBA5-binding nor thioester formation with UFM1. 1 Publication
Mutagenesisi33 – 331K → A: Impairs binding to UBA5 and thioester formation with UFM1. 1 Publication
Mutagenesisi116 – 1161C → S: Instead of the formation of an intermediate complex with a thiol ester bond between UFC1 (E2-like enzyme) and UFM1 (substrate), a stable complex with an O-ester bond is formed. 1 Publication

Organism-specific databases

PharmGKBiPA142670644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Ubiquitin-fold modifier-conjugating enzyme 1
PRO_0000082613Add
BLAST

Proteomic databases

MaxQBiQ9Y3C8.
PaxDbiQ9Y3C8.
PeptideAtlasiQ9Y3C8.
PRIDEiQ9Y3C8.

PTM databases

PhosphoSiteiQ9Y3C8.

Expressioni

Gene expression databases

BgeeiQ9Y3C8.
CleanExiHS_UFC1.
GenevestigatoriQ9Y3C8.

Organism-specific databases

HPAiHPA027481.
HPA028722.

Interactioni

Subunit structurei

Interacts with UBA5. Interacts with UFL1.2 Publications

Protein-protein interaction databases

BioGridi119577. 26 interactions.
IntActiQ9Y3C8. 1 interaction.
STRINGi9606.ENSP00000356982.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 109
Helixi26 – 4823
Beta strandi54 – 585
Beta strandi64 – 7310
Beta strandi76 – 8510
Turni88 – 925
Helixi100 – 1023
Turni103 – 1053
Beta strandi107 – 1093
Beta strandi113 – 1153
Helixi121 – 1288
Helixi134 – 1407
Helixi142 – 15615
Beta strandi162 – 1643

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K07NMR-A1-167[»]
2Z6OX-ray1.60A1-167[»]
2Z6PX-ray1.80A1-167[»]
3EVXX-ray2.54A/B/C/D1-167[»]
ProteinModelPortaliQ9Y3C8.
SMRiQ9Y3C8. Positions 1-166.

Miscellaneous databases

EvolutionaryTraceiQ9Y3C8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG318908.
HOVERGENiHBG054254.
InParanoidiQ9Y3C8.
KOiK12165.
OMAiGTKWFGK.
OrthoDBiEOG7JMGFR.
PhylomeDBiQ9Y3C8.
TreeFamiTF313587.

Family and domain databases

InterProiIPR016135. UBQ-conjugating_enzyme/RWD.
IPR014806. Ufc1.
[Graphical view]
PANTHERiPTHR12921. PTHR12921. 1 hit.
PfamiPF08694. UFC1. 1 hit.
[Graphical view]
PIRSFiPIRSF008716. DUF1782. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y3C8-1 [UniParc]FASTAAdd to Basket

« Hide

MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD    50
NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP 100
ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI 150
PDLIQKGVIQ HKEKCNQ 167
Length:167
Mass (Da):19,458
Last modified:October 17, 2006 - v3
Checksum:i1675D9187DC43E14
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901Y → C.1 Publication
Corresponds to variant rs17849932 [ dbSNP | Ensembl ].
VAR_028312

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591I → N in BAF85465. 1 Publication
Sequence conflicti160 – 1601Q → H in BAD15374. 1 Publication
Sequence conflicti160 – 1601Q → H in AAF29119. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB154405 mRNA. Translation: BAD15374.1.
AF151884 mRNA. Translation: AAD34121.1.
AF161504 mRNA. Translation: AAF29119.1.
AK292776 mRNA. Translation: BAF85465.1.
AL590714 Genomic DNA. Translation: CAH72141.1.
CH471121 Genomic DNA. Translation: EAW52646.1.
CH471121 Genomic DNA. Translation: EAW52647.1.
BC005187 mRNA. Translation: AAH05187.1.
CCDSiCCDS1220.1.
RefSeqiNP_057490.2. NM_016406.3.
UniGeneiHs.301412.

Genome annotation databases

EnsembliENST00000368003; ENSP00000356982; ENSG00000143222.
GeneIDi51506.
KEGGihsa:51506.
UCSCiuc001fyd.4. human.

Polymorphism databases

DMDMi116242840.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB154405 mRNA. Translation: BAD15374.1 .
AF151884 mRNA. Translation: AAD34121.1 .
AF161504 mRNA. Translation: AAF29119.1 .
AK292776 mRNA. Translation: BAF85465.1 .
AL590714 Genomic DNA. Translation: CAH72141.1 .
CH471121 Genomic DNA. Translation: EAW52646.1 .
CH471121 Genomic DNA. Translation: EAW52647.1 .
BC005187 mRNA. Translation: AAH05187.1 .
CCDSi CCDS1220.1.
RefSeqi NP_057490.2. NM_016406.3.
UniGenei Hs.301412.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2K07 NMR - A 1-167 [» ]
2Z6O X-ray 1.60 A 1-167 [» ]
2Z6P X-ray 1.80 A 1-167 [» ]
3EVX X-ray 2.54 A/B/C/D 1-167 [» ]
ProteinModelPortali Q9Y3C8.
SMRi Q9Y3C8. Positions 1-166.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119577. 26 interactions.
IntActi Q9Y3C8. 1 interaction.
STRINGi 9606.ENSP00000356982.

PTM databases

PhosphoSitei Q9Y3C8.

Polymorphism databases

DMDMi 116242840.

Proteomic databases

MaxQBi Q9Y3C8.
PaxDbi Q9Y3C8.
PeptideAtlasi Q9Y3C8.
PRIDEi Q9Y3C8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368003 ; ENSP00000356982 ; ENSG00000143222 .
GeneIDi 51506.
KEGGi hsa:51506.
UCSCi uc001fyd.4. human.

Organism-specific databases

CTDi 51506.
GeneCardsi GC01P161122.
HGNCi HGNC:26941. UFC1.
HPAi HPA027481.
HPA028722.
MIMi 610554. gene.
neXtProti NX_Q9Y3C8.
PharmGKBi PA142670644.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318908.
HOVERGENi HBG054254.
InParanoidi Q9Y3C8.
KOi K12165.
OMAi GTKWFGK.
OrthoDBi EOG7JMGFR.
PhylomeDBi Q9Y3C8.
TreeFami TF313587.

Miscellaneous databases

ChiTaRSi UFC1. human.
EvolutionaryTracei Q9Y3C8.
GenomeRNAii 51506.
NextBioi 55190.
PROi Q9Y3C8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y3C8.
CleanExi HS_UFC1.
Genevestigatori Q9Y3C8.

Family and domain databases

InterProi IPR016135. UBQ-conjugating_enzyme/RWD.
IPR014806. Ufc1.
[Graphical view ]
PANTHERi PTHR12921. PTHR12921. 1 hit.
Pfami PF08694. UFC1. 1 hit.
[Graphical view ]
PIRSFi PIRSF008716. DUF1782. 1 hit.
SUPFAMi SSF54495. SSF54495. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier."
    Komatsu M., Chiba T., Tatsumi K., Iemura S., Tanida I., Okazaki N., Ueno T., Kominami E., Natsume T., Tanaka K.
    EMBO J. 23:1977-1986(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-116.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-90.
    Tissue: Urinary bladder.
  8. Cited for: INTERACTION WITH UFL1.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "GFT NMR based resonance assignment for the 21 kDa human protein UFC1."
    Liu G., Aramini J., Atreya H.S., Eletsky A., Xiao R., Acton T., Ma L., Montelione G.T., Szyperski T.
    J. Biomol. NMR 32:261-261(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY STRUCTURE BY NMR.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS), INTERACTION WITH UBA5, MUTAGENESIS OF GLN-30 AND LYS-33.
  12. "NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway."
    Liu G., Forouhar F., Eletsky A., Atreya H.S., Aramini J.M., Xiao R., Huang Y.J., Abashidze M., Seetharaman J., Liu J., Rost B., Acton T., Montelione G.T., Hunt J.F., Szyperski T.
    J. Struct. Funct. Genomics 10:127-136(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS), STRUCTURE BY NMR.

Entry informationi

Entry nameiUFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C8
Secondary accession number(s): A8K9R1
, D3DVF9, Q549X0, Q5VTX1, Q9BS96, Q9P009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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