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Protein

Mediator of RNA polymerase II transcription subunit 31

Gene

MED31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108590-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 31
Alternative name(s):
Mediator complex subunit 31
Mediator complex subunit SOH1
Short name:
hSOH1
Gene namesi
Name:MED31
Synonyms:SOH1
ORF Names:CGI-125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24260. MED31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51003.
OpenTargetsiENSG00000108590.
PharmGKBiPA134884310.

Polymorphism and mutation databases

BioMutaiMED31.
DMDMi38258656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002125272 – 131Mediator of RNA polymerase II transcription subunit 31Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3C7.
MaxQBiQ9Y3C7.
PaxDbiQ9Y3C7.
PeptideAtlasiQ9Y3C7.
PRIDEiQ9Y3C7.

PTM databases

iPTMnetiQ9Y3C7.
PhosphoSitePlusiQ9Y3C7.

Expressioni

Gene expression databases

BgeeiENSG00000108590.
CleanExiHS_MED31.
ExpressionAtlasiQ9Y3C7. baseline and differential.
GenevisibleiQ9Y3C7. HS.

Organism-specific databases

HPAiHPA035947.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45GO952572EBI-394707,EBI-448202
HTTP428583EBI-394707,EBI-466029

Protein-protein interaction databases

BioGridi119211. 79 interactors.
IntActiQ9Y3C7. 66 interactors.
MINTiMINT-1418286.
STRINGi9606.ENSP00000225728.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3C7.
SMRiQ9Y3C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Gln4

Sequence similaritiesi

Belongs to the Mediator complex subunit 31 family.Curated

Phylogenomic databases

eggNOGiKOG4086. Eukaryota.
COG5088. LUCA.
GeneTreeiENSGT00390000015531.
HOGENOMiHOG000242147.
HOVERGENiHBG052449.
InParanoidiQ9Y3C7.
KOiK15153.
OMAiQCTKFID.
OrthoDBiEOG091G0VGJ.
PhylomeDBiQ9Y3C7.
TreeFamiTF105799.

Family and domain databases

InterProiIPR008831. Mediator_Med31.
[Graphical view]
PANTHERiPTHR13186. PTHR13186. 1 hit.
PfamiPF05669. Med31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN
60 70 80 90 100
YLKYLLYWKD PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ
110 120 130
QILHWQHYSR KRMRLQQALA EQQQQNNTSG K
Length:131
Mass (Da):15,805
Last modified:November 1, 1999 - v1
Checksum:i5DC672ADB994D015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151883 mRNA. Translation: AAD34120.1.
AK311875 mRNA. Translation: BAG34816.1.
CH471108 Genomic DNA. Translation: EAW90301.1.
BC012539 mRNA. Translation: AAH12539.1.
CCDSiCCDS11078.1.
RefSeqiNP_057144.1. NM_016060.2.
UniGeneiHs.567493.

Genome annotation databases

EnsembliENST00000225728; ENSP00000225728; ENSG00000108590.
GeneIDi51003.
KEGGihsa:51003.
UCSCiuc002gdg.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151883 mRNA. Translation: AAD34120.1.
AK311875 mRNA. Translation: BAG34816.1.
CH471108 Genomic DNA. Translation: EAW90301.1.
BC012539 mRNA. Translation: AAH12539.1.
CCDSiCCDS11078.1.
RefSeqiNP_057144.1. NM_016060.2.
UniGeneiHs.567493.

3D structure databases

ProteinModelPortaliQ9Y3C7.
SMRiQ9Y3C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119211. 79 interactors.
IntActiQ9Y3C7. 66 interactors.
MINTiMINT-1418286.
STRINGi9606.ENSP00000225728.

PTM databases

iPTMnetiQ9Y3C7.
PhosphoSitePlusiQ9Y3C7.

Polymorphism and mutation databases

BioMutaiMED31.
DMDMi38258656.

Proteomic databases

EPDiQ9Y3C7.
MaxQBiQ9Y3C7.
PaxDbiQ9Y3C7.
PeptideAtlasiQ9Y3C7.
PRIDEiQ9Y3C7.

Protocols and materials databases

DNASUi51003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225728; ENSP00000225728; ENSG00000108590.
GeneIDi51003.
KEGGihsa:51003.
UCSCiuc002gdg.5. human.

Organism-specific databases

CTDi51003.
DisGeNETi51003.
GeneCardsiMED31.
HGNCiHGNC:24260. MED31.
HPAiHPA035947.
neXtProtiNX_Q9Y3C7.
OpenTargetsiENSG00000108590.
PharmGKBiPA134884310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4086. Eukaryota.
COG5088. LUCA.
GeneTreeiENSGT00390000015531.
HOGENOMiHOG000242147.
HOVERGENiHBG052449.
InParanoidiQ9Y3C7.
KOiK15153.
OMAiQCTKFID.
OrthoDBiEOG091G0VGJ.
PhylomeDBiQ9Y3C7.
TreeFamiTF105799.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108590-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

GeneWikiiMED31.
GenomeRNAii51003.
PROiQ9Y3C7.

Gene expression databases

BgeeiENSG00000108590.
CleanExiHS_MED31.
ExpressionAtlasiQ9Y3C7. baseline and differential.
GenevisibleiQ9Y3C7. HS.

Family and domain databases

InterProiIPR008831. Mediator_Med31.
[Graphical view]
PANTHERiPTHR13186. PTHR13186. 1 hit.
PfamiPF05669. Med31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMED31_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C7
Secondary accession number(s): B2R4L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.