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Q9Y3C7

- MED31_HUMAN

UniProt

Q9Y3C7 - MED31_HUMAN

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Protein
Mediator of RNA polymerase II transcription subunit 31
Gene
MED31, SOH1, CGI-125
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. gene expression Source: Reactome
  2. limb development Source: Ensembl
  3. negative regulation of fibroblast proliferation Source: Ensembl
  4. protein complex assembly Source: Ensembl
  5. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_12627. Generic Transcription Pathway.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 31
Alternative name(s):
Mediator complex subunit 31
Mediator complex subunit SOH1
Short name:
hSOH1
Gene namesi
Name:MED31
Synonyms:SOH1
ORF Names:CGI-125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24260. MED31.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. mediator complex Source: InterPro
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 131130Mediator of RNA polymerase II transcription subunit 31
PRO_0000212527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y3C7.
PaxDbiQ9Y3C7.
PRIDEiQ9Y3C7.

PTM databases

PhosphoSiteiQ9Y3C7.

Expressioni

Gene expression databases

ArrayExpressiQ9Y3C7.
BgeeiQ9Y3C7.
CleanExiHS_MED31.
GenevestigatoriQ9Y3C7.

Organism-specific databases

HPAiHPA035947.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GADD45GO952572EBI-394707,EBI-448202
HTTP428583EBI-394707,EBI-466029

Protein-protein interaction databases

BioGridi119211. 68 interactions.
IntActiQ9Y3C7. 60 interactions.
MINTiMINT-1418286.
STRINGi9606.ENSP00000225728.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3C7.
SMRiQ9Y3C7. Positions 17-79.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1254Poly-Gln

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5088.
HOGENOMiHOG000242147.
HOVERGENiHBG052449.
InParanoidiQ9Y3C7.
KOiK15153.
OMAiSDDTGNR.
OrthoDBiEOG761BWW.
PhylomeDBiQ9Y3C7.
TreeFamiTF105799.

Family and domain databases

InterProiIPR008831. Mediator_Med31.
[Graphical view]
PANTHERiPTHR13186. PTHR13186. 1 hit.
PfamiPF05669. Med31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3C7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN    50
YLKYLLYWKD PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ 100
QILHWQHYSR KRMRLQQALA EQQQQNNTSG K 131
Length:131
Mass (Da):15,805
Last modified:November 1, 1999 - v1
Checksum:i5DC672ADB994D015
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151883 mRNA. Translation: AAD34120.1.
AK311875 mRNA. Translation: BAG34816.1.
CH471108 Genomic DNA. Translation: EAW90301.1.
BC012539 mRNA. Translation: AAH12539.1.
CCDSiCCDS11078.1.
RefSeqiNP_057144.1. NM_016060.2.
UniGeneiHs.567493.

Genome annotation databases

EnsembliENST00000225728; ENSP00000225728; ENSG00000108590.
GeneIDi51003.
KEGGihsa:51003.
UCSCiuc002gdg.4. human.

Polymorphism databases

DMDMi38258656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151883 mRNA. Translation: AAD34120.1 .
AK311875 mRNA. Translation: BAG34816.1 .
CH471108 Genomic DNA. Translation: EAW90301.1 .
BC012539 mRNA. Translation: AAH12539.1 .
CCDSi CCDS11078.1.
RefSeqi NP_057144.1. NM_016060.2.
UniGenei Hs.567493.

3D structure databases

ProteinModelPortali Q9Y3C7.
SMRi Q9Y3C7. Positions 17-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119211. 68 interactions.
IntActi Q9Y3C7. 60 interactions.
MINTi MINT-1418286.
STRINGi 9606.ENSP00000225728.

PTM databases

PhosphoSitei Q9Y3C7.

Polymorphism databases

DMDMi 38258656.

Proteomic databases

MaxQBi Q9Y3C7.
PaxDbi Q9Y3C7.
PRIDEi Q9Y3C7.

Protocols and materials databases

DNASUi 51003.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225728 ; ENSP00000225728 ; ENSG00000108590 .
GeneIDi 51003.
KEGGi hsa:51003.
UCSCi uc002gdg.4. human.

Organism-specific databases

CTDi 51003.
GeneCardsi GC17M006546.
HGNCi HGNC:24260. MED31.
HPAi HPA035947.
neXtProti NX_Q9Y3C7.
PharmGKBi PA134884310.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5088.
HOGENOMi HOG000242147.
HOVERGENi HBG052449.
InParanoidi Q9Y3C7.
KOi K15153.
OMAi SDDTGNR.
OrthoDBi EOG761BWW.
PhylomeDBi Q9Y3C7.
TreeFami TF105799.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_12627. Generic Transcription Pathway.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

GeneWikii MED31.
GenomeRNAii 51003.
NextBioi 53464.
PROi Q9Y3C7.

Gene expression databases

ArrayExpressi Q9Y3C7.
Bgeei Q9Y3C7.
CleanExi HS_MED31.
Genevestigatori Q9Y3C7.

Family and domain databases

InterProi IPR008831. Mediator_Med31.
[Graphical view ]
PANTHERi PTHR13186. PTHR13186. 1 hit.
Pfami PF05669. Med31. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
    Gu W., Malik S., Ito M., Yuan C.-X., Fondell J.D., Zhang X., Martinez E., Qin J., Roeder R.G.
    Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SMCC COMPLEX.
  6. "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
    Kang Y.K., Guermah M., Yuan C.-X., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, INTERACTION OF THE MEDIATOR COMPLEX WITH ESR1 AND ESR2.
  7. "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."
    Sato S., Tomomori-Sato C., Banks C.A.S., Sorokina I., Parmely T.J., Kong S.E., Jin J., Cai Y., Lane W.S., Brower C.S., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 278:15123-15127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MED19.
  8. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
    Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
    Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
  9. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
    Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
    Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMED31_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C7
Secondary accession number(s): B2R4L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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