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Protein

Mediator of RNA polymerase II transcription subunit 31

Gene

MED31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 31
Alternative name(s):
Mediator complex subunit 31
Mediator complex subunit SOH1
Short name:
hSOH1
Gene namesi
Name:MED31
Synonyms:SOH1
ORF Names:CGI-125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108590.10
HGNCiHGNC:24260 MED31
neXtProtiNX_Q9Y3C7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108590
PharmGKBiPA134884310

Polymorphism and mutation databases

BioMutaiMED31
DMDMi38258656

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002125272 – 131Mediator of RNA polymerase II transcription subunit 31Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3C7
MaxQBiQ9Y3C7
PaxDbiQ9Y3C7
PeptideAtlasiQ9Y3C7
PRIDEiQ9Y3C7

PTM databases

iPTMnetiQ9Y3C7
PhosphoSitePlusiQ9Y3C7

Expressioni

Gene expression databases

BgeeiENSG00000108590
CleanExiHS_MED31
ExpressionAtlasiQ9Y3C7 baseline and differential
GenevisibleiQ9Y3C7 HS

Organism-specific databases

HPAiHPA035947

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11921180 interactors.
CORUMiQ9Y3C7
IntActiQ9Y3C7 66 interactors.
MINTiQ9Y3C7
STRINGi9606.ENSP00000225728

Structurei

3D structure databases

ProteinModelPortaliQ9Y3C7
SMRiQ9Y3C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Gln4

Sequence similaritiesi

Belongs to the Mediator complex subunit 31 family.Curated

Phylogenomic databases

eggNOGiKOG4086 Eukaryota
COG5088 LUCA
GeneTreeiENSGT00390000015531
HOGENOMiHOG000242147
HOVERGENiHBG052449
InParanoidiQ9Y3C7
KOiK15153
OMAiQCTKFID
OrthoDBiEOG091G0VGJ
PhylomeDBiQ9Y3C7
TreeFamiTF105799

Family and domain databases

Gene3Di1.10.10.13401 hit
InterProiView protein in InterPro
IPR038089 Med31_sf
IPR008831 Mediator_Med31
PANTHERiPTHR13186 PTHR13186, 1 hit
PfamiView protein in Pfam
PF05669 Med31, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN
60 70 80 90 100
YLKYLLYWKD PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ
110 120 130
QILHWQHYSR KRMRLQQALA EQQQQNNTSG K
Length:131
Mass (Da):15,805
Last modified:November 1, 1999 - v1
Checksum:i5DC672ADB994D015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151883 mRNA Translation: AAD34120.1
AK311875 mRNA Translation: BAG34816.1
CH471108 Genomic DNA Translation: EAW90301.1
BC012539 mRNA Translation: AAH12539.1
CCDSiCCDS11078.1
RefSeqiNP_057144.1, NM_016060.2
UniGeneiHs.567493

Genome annotation databases

EnsembliENST00000225728; ENSP00000225728; ENSG00000108590
GeneIDi51003
KEGGihsa:51003
UCSCiuc002gdg.5 human

Similar proteinsi

Entry informationi

Entry nameiMED31_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C7
Secondary accession number(s): B2R4L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome