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Protein

Nucleolar protein 16

Gene

NOP16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 16
Alternative name(s):
HBV pre-S2 trans-regulated protein 3
Gene namesi
Name:NOP16
ORF Names:CGI-117, HSPC111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000048162.19.
HGNCiHGNC:26934. NOP16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51491.
OpenTargetsiENSG00000048162.
PharmGKBiPA164724025.

Polymorphism and mutation databases

BioMutaiNOP16.
DMDMi115311631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508171 – 178Nucleolar protein 16Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphothreonineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Cross-linki74Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei90N6-acetyllysineCombined sources1
Modified residuei144PhosphothreonineCombined sources1
Isoform 2 (identifier: Q9Y3C1-2)
Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sourcesCurated
Isoform 3 (identifier: Q9Y3C1-3)
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y3C1.
PaxDbiQ9Y3C1.
PeptideAtlasiQ9Y3C1.
PRIDEiQ9Y3C1.
TopDownProteomicsiQ9Y3C1-1. [Q9Y3C1-1]

2D gel databases

SWISS-2DPAGEiQ9Y3C1.

PTM databases

iPTMnetiQ9Y3C1.
PhosphoSitePlusiQ9Y3C1.
SwissPalmiQ9Y3C1.

Expressioni

Gene expression databases

BgeeiENSG00000048162.
CleanExiHS_NOP16.
ExpressionAtlasiQ9Y3C1. baseline and differential.
GenevisibleiQ9Y3C1. HS.

Organism-specific databases

HPAiHPA036506.
HPA058147.

Interactioni

Protein-protein interaction databases

BioGridi119568. 40 interactors.
IntActiQ9Y3C1. 7 interactors.
MINTiMINT-4728468.
STRINGi9606.ENSP00000373810.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NOP16 family.Curated

Phylogenomic databases

eggNOGiKOG4706. Eukaryota.
ENOG4111QB6. LUCA.
GeneTreeiENSGT00390000003426.
HOGENOMiHOG000169215.
HOVERGENiHBG098588.
InParanoidiQ9Y3C1.
OMAiKPDWPEY.
PhylomeDBiQ9Y3C1.
TreeFamiTF323541.

Family and domain databases

InterProiView protein in InterPro
IPR019002. Ribosome_biogenesis_Nop16.
PANTHERiPTHR13243. PTHR13243. 1 hit.
PfamiView protein in Pfam
PF09420. Nop16. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3C1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKAKGKTRR QKFGYSVNRK RLNRNARRKA APRIECSHIR HAWDHAKSVR
60 70 80 90 100
QNLAEMGLAV DPNRAVPLRK RKVKAMEVDI EERPKELVRK PYVLNDLEAE
110 120 130 140 150
ASLPEKKGNT LSRDLIDYVR YMVENHGEDY KAMARDEKNY YQDTPKQIRS
160 170
KINVYKRFYP AEWQDFLDSL QKRKMEVE
Length:178
Mass (Da):21,188
Last modified:September 19, 2006 - v2
Checksum:iD9139BE32DA81FC5
GO
Isoform 2 (identifier: Q9Y3C1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-178: AMARDEKNYY...SLQKRKMEVE → SGKTSSILCR...RVGDVNIVCT

Show »
Length:236
Mass (Da):27,306
Checksum:iFD6FA2B669720AA7
GO
Isoform 3 (identifier: Q9Y3C1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-178: AMARDEKNYY...SLQKRKMEVE → QSGKTSSILC...QNLLFSGWVM

Note: No experimental confirmation available.Combined sources
Show »
Length:232
Mass (Da):26,561
Checksum:i6DB17D8B0E4F0AD7
GO

Sequence cautioni

Q9Y3C1: The sequence AAH19331 differs from that shown. Reason: Frameshift at position 195.Curated
Q9Y3C1: The sequence BAG62525 differs from that shown. Reason: Frameshift at position 195.Curated
Q9Y3C1: The sequence EAW85085 differs from that shown. Reason: Frameshift at position 195.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 33PR → RG in AAD34112 (PubMed:10810093).Curated2
Sequence conflicti32 – 33PR → RG in AAF29075 (PubMed:11042152).Curated2
Sequence conflicti178E → D in CAG33450 (Ref. 5) Curated1
Isoform 2 (identifier: Q9Y3C1-2)
Sequence conflicti171C → F in BAG62525 (PubMed:14702039).Combined sourcesCurated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045583132 – 178AMARD…KMEVE → SGKTSSILCRRGRWRWSDWF TSQLPQAEASPGPVKLEPGC KARRCCVAPEELARSHGIRR LHTRAHSPLWGRNCSQRLQF IFIWGFTEKPEPAVFRVGDV NIVCT in isoform 2. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_057393132 – 178AMARD…KMEVE → QSGKTSSILCRRGRWRWSDW FTSQLPQAEASPGPVKLEPG CKARRCCVAPEELARSHGIR RLHTHVHTPRSGEGTVLRGS NLYSSGGSRKSQNLLFSGWV M in isoform 3. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY561704 mRNA. Translation: AAS66977.1.
AF151875 mRNA. Translation: AAD34112.1.
AF161460 mRNA. Translation: AAF29075.1.
AK300883 mRNA. Translation: BAG62525.1. Frameshift.
CR457169 mRNA. Translation: CAG33450.1.
AC138956 Genomic DNA. No translation available.
KF459629 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85084.1.
CH471195 Genomic DNA. Translation: EAW85085.1. Frameshift.
BC019331 mRNA. Translation: AAH19331.1. Frameshift.
BC032424 mRNA. Translation: AAH32424.1.
BC040106 mRNA. Translation: AAH40106.1.
CCDSiCCDS43403.1. [Q9Y3C1-1]
CCDS78091.1. [Q9Y3C1-3]
RefSeqiNP_001243468.2. NM_001256539.3. [Q9Y3C1-3]
NP_001243469.2. NM_001256540.3.
NP_001278234.1. NM_001291305.2.
NP_001278236.1. NM_001291307.2.
NP_001278237.1. NM_001291308.2.
NP_001304904.1. NM_001317975.1.
NP_057475.2. NM_016391.7. [Q9Y3C1-1]
UniGeneiHs.696283.

Genome annotation databases

EnsembliENST00000614830; ENSP00000480832; ENSG00000048162. [Q9Y3C1-1]
ENST00000618911; ENSP00000483001; ENSG00000048162. [Q9Y3C1-3]
GeneIDi51491.
KEGGihsa:51491.
UCSCiuc032vuv.2. human. [Q9Y3C1-1]
uc063jyi.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNOP16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C1
Secondary accession number(s): B4DV13
, D6RGD3, Q05D05, Q6IAI6, Q6PIM0, Q8IXL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 19, 2006
Last modified: September 27, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families