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Q9Y3C0

- CCD53_HUMAN

UniProt

Q9Y3C0 - CCD53_HUMAN

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Protein

WASH complex subunit CCDC53

Gene
CCDC53, AD-016, CGI-116, x0009
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
WASH complex subunit CCDC53
Alternative name(s):
Coiled-coil domain-containing protein 53
Gene namesi
Name:CCDC53
ORF Names:AD-016, CGI-116, x0009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24256. CCDC53.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. intracellular membrane-bounded organelle Source: HPA
  3. WASH complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194WASH complex subunit CCDC53PRO_0000076201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y3C0.
PaxDbiQ9Y3C0.
PRIDEiQ9Y3C0.

PTM databases

PhosphoSiteiQ9Y3C0.

Expressioni

Gene expression databases

ArrayExpressiQ9Y3C0.
BgeeiQ9Y3C0.
CleanExiHS_CCDC53.
GenevestigatoriQ9Y3C0.

Organism-specific databases

HPAiHPA038338.
HPA038339.

Interactioni

Subunit structurei

Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MCRS1Q96EZ83EBI-712969,EBI-348259
PBXIP1Q96AQ63EBI-712969,EBI-740845

Protein-protein interaction databases

BioGridi119225. 21 interactions.
IntActiQ9Y3C0. 20 interactions.
MINTiMINT-1369211.
STRINGi9606.ENSP00000240079.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3C0.
SMRiQ9Y3C0. Positions 15-67.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili46 – 7429 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC53 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG261899.
HOGENOMiHOG000006526.
HOVERGENiHBG009789.
InParanoidiQ9Y3C0.
OMAiHTVRFLN.
PhylomeDBiQ9Y3C0.
TreeFamiTF318955.

Family and domain databases

InterProiIPR019309. WASH_CCDC53.
[Graphical view]
PfamiPF10152. DUF2360. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3C0-1 [UniParc]FASTAAdd to Basket

« Hide

MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE    50
KLADLSLRIQ QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP 100
EATSEQPQQN STQDSGLQES EVSAENILTV AKDPRYARYL KMVQVGVPVM 150
AIRNKMISEG LDPDLLERPD APVPDGESEK TVEESSDSES SFSD 194
Length:194
Mass (Da):21,173
Last modified:November 1, 1999 - v1
Checksum:iB0CCF1AE76CDA6D2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811D → G in BAD97059. 1 Publication
Sequence conflicti110 – 1101N → S in AAH10889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155655 mRNA. Translation: AAF67012.1.
AF151874 mRNA. Translation: AAD34111.1.
CR457171 mRNA. Translation: CAG33452.1.
AK223339 mRNA. Translation: BAD97059.1.
AK314970 mRNA. Translation: BAG37471.1.
CH471054 Genomic DNA. Translation: EAW97687.1.
BC010889 mRNA. Translation: AAH10889.1.
CCDSiCCDS44959.1.
RefSeqiNP_057137.1. NM_016053.2.
UniGeneiHs.405692.

Genome annotation databases

EnsembliENST00000240079; ENSP00000240079; ENSG00000120860.
GeneIDi51019.
KEGGihsa:51019.
UCSCiuc010svw.2. human.

Polymorphism databases

DMDMi6831732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155655 mRNA. Translation: AAF67012.1 .
AF151874 mRNA. Translation: AAD34111.1 .
CR457171 mRNA. Translation: CAG33452.1 .
AK223339 mRNA. Translation: BAD97059.1 .
AK314970 mRNA. Translation: BAG37471.1 .
CH471054 Genomic DNA. Translation: EAW97687.1 .
BC010889 mRNA. Translation: AAH10889.1 .
CCDSi CCDS44959.1.
RefSeqi NP_057137.1. NM_016053.2.
UniGenei Hs.405692.

3D structure databases

ProteinModelPortali Q9Y3C0.
SMRi Q9Y3C0. Positions 15-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119225. 21 interactions.
IntActi Q9Y3C0. 20 interactions.
MINTi MINT-1369211.
STRINGi 9606.ENSP00000240079.

PTM databases

PhosphoSitei Q9Y3C0.

Polymorphism databases

DMDMi 6831732.

Proteomic databases

MaxQBi Q9Y3C0.
PaxDbi Q9Y3C0.
PRIDEi Q9Y3C0.

Protocols and materials databases

DNASUi 51019.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240079 ; ENSP00000240079 ; ENSG00000120860 .
GeneIDi 51019.
KEGGi hsa:51019.
UCSCi uc010svw.2. human.

Organism-specific databases

CTDi 51019.
GeneCardsi GC12M102406.
HGNCi HGNC:24256. CCDC53.
HPAi HPA038338.
HPA038339.
neXtProti NX_Q9Y3C0.
PharmGKBi PA142672169.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG261899.
HOGENOMi HOG000006526.
HOVERGENi HBG009789.
InParanoidi Q9Y3C0.
OMAi HTVRFLN.
PhylomeDBi Q9Y3C0.
TreeFami TF318955.

Miscellaneous databases

ChiTaRSi CCDC53. human.
GeneWikii CCDC53.
GenomeRNAii 51019.
NextBioi 53536.
PROi Q9Y3C0.

Gene expression databases

ArrayExpressi Q9Y3C0.
Bgeei Q9Y3C0.
CleanExi HS_CCDC53.
Genevestigatori Q9Y3C0.

Family and domain databases

InterProi IPR019309. WASH_CCDC53.
[Graphical view ]
Pfami PF10152. DUF2360. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  8. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."
    Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.
    Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE WASH COMPLEX, IDENTIFICATION IN THE WASH COMPLEX.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD53_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3C0
Secondary accession number(s): B2RC74
, Q53FF0, Q6IAI4, Q96QK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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