Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y3C0

- CCD53_HUMAN

UniProt

Q9Y3C0 - CCD53_HUMAN

Protein

WASH complex subunit CCDC53

Gene

CCDC53

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WASH complex subunit CCDC53
    Alternative name(s):
    Coiled-coil domain-containing protein 53
    Gene namesi
    Name:CCDC53
    ORF Names:AD-016, CGI-116, x0009
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24256. CCDC53.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: HPA
    2. intracellular membrane-bounded organelle Source: HPA
    3. WASH complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672169.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194WASH complex subunit CCDC53PRO_0000076201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y3C0.
    PaxDbiQ9Y3C0.
    PRIDEiQ9Y3C0.

    PTM databases

    PhosphoSiteiQ9Y3C0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3C0.
    BgeeiQ9Y3C0.
    CleanExiHS_CCDC53.
    GenevestigatoriQ9Y3C0.

    Organism-specific databases

    HPAiHPA038338.
    HPA038339.

    Interactioni

    Subunit structurei

    Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MCRS1Q96EZ83EBI-712969,EBI-348259
    PBXIP1Q96AQ63EBI-712969,EBI-740845

    Protein-protein interaction databases

    BioGridi119225. 21 interactions.
    IntActiQ9Y3C0. 20 interactions.
    MINTiMINT-1369211.
    STRINGi9606.ENSP00000240079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3C0.
    SMRiQ9Y3C0. Positions 15-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili46 – 7429Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC53 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG261899.
    HOGENOMiHOG000006526.
    HOVERGENiHBG009789.
    InParanoidiQ9Y3C0.
    OMAiHTVRFLN.
    PhylomeDBiQ9Y3C0.
    TreeFamiTF318955.

    Family and domain databases

    InterProiIPR019309. WASH_CCDC53.
    [Graphical view]
    PfamiPF10152. DUF2360. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE    50
    KLADLSLRIQ QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP 100
    EATSEQPQQN STQDSGLQES EVSAENILTV AKDPRYARYL KMVQVGVPVM 150
    AIRNKMISEG LDPDLLERPD APVPDGESEK TVEESSDSES SFSD 194
    Length:194
    Mass (Da):21,173
    Last modified:November 1, 1999 - v1
    Checksum:iB0CCF1AE76CDA6D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811D → G in BAD97059. 1 PublicationCurated
    Sequence conflicti110 – 1101N → S in AAH10889. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155655 mRNA. Translation: AAF67012.1.
    AF151874 mRNA. Translation: AAD34111.1.
    CR457171 mRNA. Translation: CAG33452.1.
    AK223339 mRNA. Translation: BAD97059.1.
    AK314970 mRNA. Translation: BAG37471.1.
    CH471054 Genomic DNA. Translation: EAW97687.1.
    BC010889 mRNA. Translation: AAH10889.1.
    CCDSiCCDS44959.1.
    RefSeqiNP_057137.1. NM_016053.2.
    UniGeneiHs.405692.

    Genome annotation databases

    EnsembliENST00000240079; ENSP00000240079; ENSG00000120860.
    GeneIDi51019.
    KEGGihsa:51019.
    UCSCiuc010svw.2. human.

    Polymorphism databases

    DMDMi6831732.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155655 mRNA. Translation: AAF67012.1 .
    AF151874 mRNA. Translation: AAD34111.1 .
    CR457171 mRNA. Translation: CAG33452.1 .
    AK223339 mRNA. Translation: BAD97059.1 .
    AK314970 mRNA. Translation: BAG37471.1 .
    CH471054 Genomic DNA. Translation: EAW97687.1 .
    BC010889 mRNA. Translation: AAH10889.1 .
    CCDSi CCDS44959.1.
    RefSeqi NP_057137.1. NM_016053.2.
    UniGenei Hs.405692.

    3D structure databases

    ProteinModelPortali Q9Y3C0.
    SMRi Q9Y3C0. Positions 15-67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119225. 21 interactions.
    IntActi Q9Y3C0. 20 interactions.
    MINTi MINT-1369211.
    STRINGi 9606.ENSP00000240079.

    PTM databases

    PhosphoSitei Q9Y3C0.

    Polymorphism databases

    DMDMi 6831732.

    Proteomic databases

    MaxQBi Q9Y3C0.
    PaxDbi Q9Y3C0.
    PRIDEi Q9Y3C0.

    Protocols and materials databases

    DNASUi 51019.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240079 ; ENSP00000240079 ; ENSG00000120860 .
    GeneIDi 51019.
    KEGGi hsa:51019.
    UCSCi uc010svw.2. human.

    Organism-specific databases

    CTDi 51019.
    GeneCardsi GC12M102406.
    HGNCi HGNC:24256. CCDC53.
    HPAi HPA038338.
    HPA038339.
    neXtProti NX_Q9Y3C0.
    PharmGKBi PA142672169.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261899.
    HOGENOMi HOG000006526.
    HOVERGENi HBG009789.
    InParanoidi Q9Y3C0.
    OMAi HTVRFLN.
    PhylomeDBi Q9Y3C0.
    TreeFami TF318955.

    Miscellaneous databases

    ChiTaRSi CCDC53. human.
    GeneWikii CCDC53.
    GenomeRNAii 51019.
    NextBioi 53536.
    PROi Q9Y3C0.

    Gene expression databases

    ArrayExpressi Q9Y3C0.
    Bgeei Q9Y3C0.
    CleanExi HS_CCDC53.
    Genevestigatori Q9Y3C0.

    Family and domain databases

    InterProi IPR019309. WASH_CCDC53.
    [Graphical view ]
    Pfami PF10152. DUF2360. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    8. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."
      Derivery E., Sousa C., Gautier J.J., Lombard B., Loew D., Gautreau A.
      Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE WASH COMPLEX, IDENTIFICATION IN THE WASH COMPLEX.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCCD53_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3C0
    Secondary accession number(s): B2RC74
    , Q53FF0, Q6IAI4, Q96QK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3