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Protein

RRP15-like protein

Gene

RRP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
RRP15-like protein
Alternative name(s):
Ribosomal RNA-processing protein 15
Gene namesi
Name:RRP15
Synonyms:KIAA0507
ORF Names:CGI-115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000067533.5
HGNCiHGNC:24255 RRP15
MIMi611193 gene
neXtProtiNX_Q9Y3B9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067533
PharmGKBiPA162402123

Polymorphism and mutation databases

BioMutaiRRP15
DMDMi124053370

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002732132 – 282RRP15-like proteinAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9CitrullineBy similarity1
Modified residuei11PhosphoserineCombined sources1
Modified residuei19PhosphothreonineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei206PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei266PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y3B9
MaxQBiQ9Y3B9
PaxDbiQ9Y3B9
PeptideAtlasiQ9Y3B9
PRIDEiQ9Y3B9

PTM databases

iPTMnetiQ9Y3B9
PhosphoSitePlusiQ9Y3B9

Miscellaneous databases

PMAP-CutDBiQ9Y3B9

Expressioni

Gene expression databases

BgeeiENSG00000067533
CleanExiHS_RRP15
GenevisibleiQ9Y3B9 HS

Organism-specific databases

HPAiHPA024639

Interactioni

Protein-protein interaction databases

BioGridi119224, 36 interactors
IntActiQ9Y3B9, 13 interactors
MINTiQ9Y3B9
STRINGi9606.ENSP00000355899

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 144Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the RRP15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2974 Eukaryota
ENOG4111R78 LUCA
GeneTreeiENSGT00390000001960
HOGENOMiHOG000047445
HOVERGENiHBG056607
InParanoidiQ9Y3B9
OMAiCGSEKDH
OrthoDBiEOG091G0LBN
PhylomeDBiQ9Y3B9
TreeFamiTF106119

Family and domain databases

InterProiView protein in InterPro
IPR012459 Rrp15
PANTHERiPTHR13245 PTHR13245, 1 hit
PfamiView protein in Pfam
PF07890 Rrp15p, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPDSRV SEEENLKKTP KKKMKMVTGA VASVLEDEAT DTSDSEGSCG
60 70 80 90 100
SEKDHFYSDD DAIEADSEGD AEPCDKENEN DGESSVGTNM GWADAMAKVL
110 120 130 140 150
NKKTPESKPT ILVKNKKLEK EKEKLKQERL EKIKQRDKRL EWEMMCRVKP
160 170 180 190 200
DVVQDKETER NLQRIATRGV VQLFNAVQKH QKNVDEKVKE AGSSMRKRAK
210 220 230 240 250
LISTVSKKDF ISVLRGMDGS TNETASSRKK PKAKQTEVKS EEGPGWTILR
260 270 280
DDFMMGASMK DWDKESDGPD DSRPESASDS DT
Length:282
Mass (Da):31,484
Last modified:January 23, 2007 - v2
Checksum:i3FB1E3D861FB938F
GO

Sequence cautioni

The sequence AAD34110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH20641 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23K → N in AAD34110 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05381332A → V. Corresponds to variant dbSNP:rs34358288Ensembl.1
Natural variantiVAR_030112149K → N. Corresponds to variant dbSNP:rs11118075Ensembl.1
Natural variantiVAR_030113230K → R. Corresponds to variant dbSNP:rs3737978Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020641 mRNA Translation: AAH20641.1 Different initiation.
AF151873 mRNA Translation: AAD34110.1 Different initiation.
CCDSiCCDS1520.2
RefSeqiNP_057136.2, NM_016052.3
UniGeneiHs.660109

Genome annotation databases

EnsembliENST00000366932; ENSP00000355899; ENSG00000067533
GeneIDi51018
KEGGihsa:51018
UCSCiuc001hlj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRRP15_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health