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Protein

RRP15-like protein

Gene

RRP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000067533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RRP15-like protein
Alternative name(s):
Ribosomal RNA-processing protein 15
Gene namesi
Name:RRP15
Synonyms:KIAA0507
ORF Names:CGI-115
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24255. RRP15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067533.
PharmGKBiPA162402123.

Polymorphism and mutation databases

BioMutaiRRP15.
DMDMi124053370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002732132 – 282RRP15-like proteinAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9CitrullineBy similarity1
Modified residuei11PhosphoserineCombined sources1
Modified residuei19PhosphothreonineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei266PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y3B9.
MaxQBiQ9Y3B9.
PaxDbiQ9Y3B9.
PeptideAtlasiQ9Y3B9.
PRIDEiQ9Y3B9.

PTM databases

iPTMnetiQ9Y3B9.
PhosphoSitePlusiQ9Y3B9.

Miscellaneous databases

PMAP-CutDBQ9Y3B9.

Expressioni

Gene expression databases

BgeeiENSG00000067533.
CleanExiHS_RRP15.
GenevisibleiQ9Y3B9. HS.

Organism-specific databases

HPAiHPA024639.

Interactioni

Protein-protein interaction databases

BioGridi119224. 29 interactors.
IntActiQ9Y3B9. 12 interactors.
MINTiMINT-3085803.
STRINGi9606.ENSP00000355899.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 144Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the RRP15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2974. Eukaryota.
ENOG4111R78. LUCA.
GeneTreeiENSGT00390000001960.
HOGENOMiHOG000047445.
HOVERGENiHBG056607.
InParanoidiQ9Y3B9.
OMAiGTNMGWA.
OrthoDBiEOG091G0LBN.
PhylomeDBiQ9Y3B9.
TreeFamiTF106119.

Family and domain databases

InterProiIPR012459. Rrp15.
[Graphical view]
PANTHERiPTHR13245. PTHR13245. 1 hit.
PfamiPF07890. Rrp15p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAPDSRV SEEENLKKTP KKKMKMVTGA VASVLEDEAT DTSDSEGSCG
60 70 80 90 100
SEKDHFYSDD DAIEADSEGD AEPCDKENEN DGESSVGTNM GWADAMAKVL
110 120 130 140 150
NKKTPESKPT ILVKNKKLEK EKEKLKQERL EKIKQRDKRL EWEMMCRVKP
160 170 180 190 200
DVVQDKETER NLQRIATRGV VQLFNAVQKH QKNVDEKVKE AGSSMRKRAK
210 220 230 240 250
LISTVSKKDF ISVLRGMDGS TNETASSRKK PKAKQTEVKS EEGPGWTILR
260 270 280
DDFMMGASMK DWDKESDGPD DSRPESASDS DT
Length:282
Mass (Da):31,484
Last modified:January 23, 2007 - v2
Checksum:i3FB1E3D861FB938F
GO

Sequence cautioni

The sequence AAD34110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH20641 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23K → N in AAD34110 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05381332A → V.Corresponds to variant rs34358288dbSNPEnsembl.1
Natural variantiVAR_030112149K → N.Corresponds to variant rs11118075dbSNPEnsembl.1
Natural variantiVAR_030113230K → R.Corresponds to variant rs3737978dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020641 mRNA. Translation: AAH20641.1. Different initiation.
AF151873 mRNA. Translation: AAD34110.1. Different initiation.
CCDSiCCDS1520.2.
RefSeqiNP_057136.2. NM_016052.3.
UniGeneiHs.660109.

Genome annotation databases

EnsembliENST00000366932; ENSP00000355899; ENSG00000067533.
GeneIDi51018.
KEGGihsa:51018.
UCSCiuc001hlj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020641 mRNA. Translation: AAH20641.1. Different initiation.
AF151873 mRNA. Translation: AAD34110.1. Different initiation.
CCDSiCCDS1520.2.
RefSeqiNP_057136.2. NM_016052.3.
UniGeneiHs.660109.

3D structure databases

ProteinModelPortaliQ9Y3B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119224. 29 interactors.
IntActiQ9Y3B9. 12 interactors.
MINTiMINT-3085803.
STRINGi9606.ENSP00000355899.

PTM databases

iPTMnetiQ9Y3B9.
PhosphoSitePlusiQ9Y3B9.

Polymorphism and mutation databases

BioMutaiRRP15.
DMDMi124053370.

Proteomic databases

EPDiQ9Y3B9.
MaxQBiQ9Y3B9.
PaxDbiQ9Y3B9.
PeptideAtlasiQ9Y3B9.
PRIDEiQ9Y3B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366932; ENSP00000355899; ENSG00000067533.
GeneIDi51018.
KEGGihsa:51018.
UCSCiuc001hlj.3. human.

Organism-specific databases

CTDi51018.
GeneCardsiRRP15.
HGNCiHGNC:24255. RRP15.
HPAiHPA024639.
MIMi611193. gene.
neXtProtiNX_Q9Y3B9.
OpenTargetsiENSG00000067533.
PharmGKBiPA162402123.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2974. Eukaryota.
ENOG4111R78. LUCA.
GeneTreeiENSGT00390000001960.
HOGENOMiHOG000047445.
HOVERGENiHBG056607.
InParanoidiQ9Y3B9.
OMAiGTNMGWA.
OrthoDBiEOG091G0LBN.
PhylomeDBiQ9Y3B9.
TreeFamiTF106119.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000067533-MONOMER.

Miscellaneous databases

ChiTaRSiRRP15. human.
GeneWikiiRRP15.
GenomeRNAii51018.
PMAP-CutDBQ9Y3B9.
PROiQ9Y3B9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067533.
CleanExiHS_RRP15.
GenevisibleiQ9Y3B9. HS.

Family and domain databases

InterProiIPR012459. Rrp15.
[Graphical view]
PANTHERiPTHR13245. PTHR13245. 1 hit.
PfamiPF07890. Rrp15p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRP15_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.