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Q9Y3B7 (RM11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L11, mitochondrial

Short name=L11mt
Short name=MRP-L11
Gene names
Name:MRPL11
ORF Names:CGI-113
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion Ref.1.

Sequence similarities

Belongs to the ribosomal protein L11P family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement Ref.7. Source: UniProtKB

   Cellular_componentmitochondrial ribosome

Non-traceable author statement Ref.7. Source: UniProtKB

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Non-traceable author statement Ref.7. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

gagP045913EBI-5453723,EBI-6179727From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y3B7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y3B7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     16-41: Missing.
Isoform 3 (identifier: Q9Y3B7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 19239S ribosomal protein L11, mitochondrial HAMAP-Rule MF_00736PRO_0000030443

Natural variations

Alternative sequence16 – 4126Missing in isoform 2.
VSP_041077
Alternative sequence158 – 19235DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3.
VSP_045237

Experimental info

Sequence conflict681T → I in BM554886. Ref.6
Isoform 3:
Sequence conflict1811V → L in BM554886. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 92506A20044BF278

FASTA19220,683
        10         20         30         40         50         60 
MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI 

        70         80         90        100        110        120 
KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG ARQTGKEVAG LVTLKHVYEI 

       130        140        150        160        170        180 
ARIKAQDEAF ALQDVPLSSV VRSIIGSARS LGIRVVKDLS SEELAAFQKE RAIFLAAQKE 

       190 
ADLAAQEEAA KK 

« Hide

Isoform 2 [UniParc].

Checksum: A78DA10D323B1D24
Show »

FASTA16618,205
Isoform 3 [UniParc].

Checksum: 578392577167303F
Show »

FASTA18119,454

References

« Hide 'large scale' references
[1]"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Subthalamic nucleus.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Duodenum, Lymph and Melanoma.
[7]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-141 (ISOFORMS 1/2).
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049638 mRNA. Translation: BAB40843.1.
AF151871 mRNA. Translation: AAD34108.1.
AK290084 mRNA. Translation: BAF82773.1.
AP002748 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74528.1.
CH471076 Genomic DNA. Translation: EAW74529.1.
CH471076 Genomic DNA. Translation: EAW74531.1.
BC005002 mRNA. Translation: AAH05002.1.
BC108277 mRNA. Translation: AAI08278.1.
BM554886 mRNA. No translation available.
AB051338 Genomic DNA. Translation: BAB54928.1.
RefSeqNP_057134.1. NM_016050.3.
NP_733934.1. NM_170738.2.
NP_733935.1. NM_170739.2.
UniGeneHs.418450.

3D structure databases

ProteinModelPortalQ9Y3B7.
SMRQ9Y3B7. Positions 20-156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122369. 34 interactions.
IntActQ9Y3B7. 2 interactions.
MINTMINT-3085719.
STRING9606.ENSP00000308897.

PTM databases

PhosphoSiteQ9Y3B7.

Polymorphism databases

DMDM22001931.

Proteomic databases

PaxDbQ9Y3B7.
PRIDEQ9Y3B7.

Protocols and materials databases

DNASU65003.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310999; ENSP00000308897; ENSG00000174547. [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547. [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547. [Q9Y3B7-2]
GeneID65003.
KEGGhsa:65003.
UCSCuc001ohy.4. human.
uc001ohz.4. human. [Q9Y3B7-1]
uc001oia.4. human. [Q9Y3B7-2]

Organism-specific databases

CTD65003.
GeneCardsGC11M066202.
HGNCHGNC:14042. MRPL11.
HPAHPA057685.
MIM611826. gene.
neXtProtNX_Q9Y3B7.
PharmGKBPA30940.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0080.
HOGENOMHOG000082123.
HOVERGENHBG036110.
InParanoidQ9Y3B7.
KOK02867.
OMACKDFNEK.
OrthoDBEOG7HHWTP.
PhylomeDBQ9Y3B7.
TreeFamTF313471.

Gene expression databases

ArrayExpressQ9Y3B7.
BgeeQ9Y3B7.
CleanExHS_MRPL11.
GenevestigatorQ9Y3B7.

Family and domain databases

Gene3D1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPMF_00736. Ribosomal_L11.
InterProIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERPTHR11661. PTHR11661. 1 hit.
PfamPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsTIGR01632. L11_bact. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL11. human.
GeneWikiMRPL11.
GenomeRNAi65003.
NextBio67180.
PROQ9Y3B7.
SOURCESearch...

Entry information

Entry nameRM11_HUMAN
AccessionPrimary (citable) accession number: Q9Y3B7
Secondary accession number(s): A6NLT0 expand/collapse secondary AC list , A8K219, Q32P46, Q96Q73
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM