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Q9Y3B7

- RM11_HUMAN

UniProt

Q9Y3B7 - RM11_HUMAN

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Protein

39S ribosomal protein L11, mitochondrial

Gene

MRPL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L11, mitochondrial
Short name:
L11mt
Short name:
MRP-L11
Gene namesi
Name:MRPL11
ORF Names:CGI-113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14042. MRPL11.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 19239S ribosomal protein L11, mitochondrialPRO_0000030443
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiQ9Y3B7.
PaxDbiQ9Y3B7.
PRIDEiQ9Y3B7.

PTM databases

PhosphoSiteiQ9Y3B7.

Expressioni

Gene expression databases

BgeeiQ9Y3B7.
CleanExiHS_MRPL11.
ExpressionAtlasiQ9Y3B7. baseline and differential.
GenevestigatoriQ9Y3B7.

Organism-specific databases

HPAiHPA057685.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
gagP045913EBI-5453723,EBI-6179727From a different organism.

Protein-protein interaction databases

BioGridi122369. 40 interactions.
IntActiQ9Y3B7. 2 interactions.
MINTiMINT-3085719.
STRINGi9606.ENSP00000308897.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B7.
SMRiQ9Y3B7. Positions 20-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L11P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0080.
GeneTreeiENSGT00390000003153.
HOGENOMiHOG000082123.
HOVERGENiHBG036110.
InParanoidiQ9Y3B7.
KOiK02867.
OMAiTAYGDRT.
OrthoDBiEOG7HHWTP.
PhylomeDBiQ9Y3B7.
TreeFamiTF313471.

Family and domain databases

Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11.
InterProiIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y3B7) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC
60 70 80 90 100
KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG
110 120 130 140 150
ARQTGKEVAG LVTLKHVYEI ARIKAQDEAF ALQDVPLSSV VRSIIGSARS
160 170 180 190
LGIRVVKDLS SEELAAFQKE RAIFLAAQKE ADLAAQEEAA KK
Length:192
Mass (Da):20,683
Last modified:November 1, 1999 - v1
Checksum:i92506A20044BF278
GO
Isoform 2 (identifier: Q9Y3B7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-41: Missing.

Show »
Length:166
Mass (Da):18,205
Checksum:iA78DA10D323B1D24
GO
Isoform 3 (identifier: Q9Y3B7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV

Note: No experimental confirmation available.Curated

Show »
Length:181
Mass (Da):19,454
Checksum:i578392577167303F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681T → I in BM554886. (PubMed:15489334)Curated
Isoform 3 (identifier: Q9Y3B7-3)
Sequence conflicti181 – 1811V → L in BM554886. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 4126Missing in isoform 2. 1 PublicationVSP_041077Add
BLAST
Alternative sequencei158 – 19235DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3. 1 PublicationVSP_045237Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049638 mRNA. Translation: BAB40843.1.
AF151871 mRNA. Translation: AAD34108.1.
AK290084 mRNA. Translation: BAF82773.1.
AP002748 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74528.1.
CH471076 Genomic DNA. Translation: EAW74529.1.
CH471076 Genomic DNA. Translation: EAW74531.1.
BC005002 mRNA. Translation: AAH05002.1.
BC108277 mRNA. Translation: AAI08278.1.
BM554886 mRNA. No translation available.
AB051338 Genomic DNA. Translation: BAB54928.1.
CCDSiCCDS44655.1. [Q9Y3B7-2]
CCDS8139.1. [Q9Y3B7-1]
CCDS8140.1. [Q9Y3B7-3]
RefSeqiNP_057134.1. NM_016050.4. [Q9Y3B7-1]
NP_733934.1. NM_170738.3. [Q9Y3B7-2]
NP_733935.1. NM_170739.3. [Q9Y3B7-3]
XP_006718729.1. XM_006718666.1. [Q9Y3B7-3]
UniGeneiHs.418450.

Genome annotation databases

EnsembliENST00000310999; ENSP00000308897; ENSG00000174547. [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547. [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547. [Q9Y3B7-2]
GeneIDi65003.
KEGGihsa:65003.
UCSCiuc001ohy.4. human.
uc001ohz.4. human. [Q9Y3B7-1]
uc001oia.4. human. [Q9Y3B7-2]

Polymorphism databases

DMDMi22001931.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049638 mRNA. Translation: BAB40843.1 .
AF151871 mRNA. Translation: AAD34108.1 .
AK290084 mRNA. Translation: BAF82773.1 .
AP002748 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74528.1 .
CH471076 Genomic DNA. Translation: EAW74529.1 .
CH471076 Genomic DNA. Translation: EAW74531.1 .
BC005002 mRNA. Translation: AAH05002.1 .
BC108277 mRNA. Translation: AAI08278.1 .
BM554886 mRNA. No translation available.
AB051338 Genomic DNA. Translation: BAB54928.1 .
CCDSi CCDS44655.1. [Q9Y3B7-2 ]
CCDS8139.1. [Q9Y3B7-1 ]
CCDS8140.1. [Q9Y3B7-3 ]
RefSeqi NP_057134.1. NM_016050.4. [Q9Y3B7-1 ]
NP_733934.1. NM_170738.3. [Q9Y3B7-2 ]
NP_733935.1. NM_170739.3. [Q9Y3B7-3 ]
XP_006718729.1. XM_006718666.1. [Q9Y3B7-3 ]
UniGenei Hs.418450.

3D structure databases

ProteinModelPortali Q9Y3B7.
SMRi Q9Y3B7. Positions 20-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122369. 40 interactions.
IntActi Q9Y3B7. 2 interactions.
MINTi MINT-3085719.
STRINGi 9606.ENSP00000308897.

PTM databases

PhosphoSitei Q9Y3B7.

Polymorphism databases

DMDMi 22001931.

Proteomic databases

MaxQBi Q9Y3B7.
PaxDbi Q9Y3B7.
PRIDEi Q9Y3B7.

Protocols and materials databases

DNASUi 65003.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310999 ; ENSP00000308897 ; ENSG00000174547 . [Q9Y3B7-1 ]
ENST00000329819 ; ENSP00000329630 ; ENSG00000174547 . [Q9Y3B7-3 ]
ENST00000430466 ; ENSP00000415356 ; ENSG00000174547 . [Q9Y3B7-2 ]
GeneIDi 65003.
KEGGi hsa:65003.
UCSCi uc001ohy.4. human.
uc001ohz.4. human. [Q9Y3B7-1 ]
uc001oia.4. human. [Q9Y3B7-2 ]

Organism-specific databases

CTDi 65003.
GeneCardsi GC11M066202.
HGNCi HGNC:14042. MRPL11.
HPAi HPA057685.
MIMi 611826. gene.
neXtProti NX_Q9Y3B7.
PharmGKBi PA30940.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0080.
GeneTreei ENSGT00390000003153.
HOGENOMi HOG000082123.
HOVERGENi HBG036110.
InParanoidi Q9Y3B7.
KOi K02867.
OMAi TAYGDRT.
OrthoDBi EOG7HHWTP.
PhylomeDBi Q9Y3B7.
TreeFami TF313471.

Miscellaneous databases

ChiTaRSi MRPL11. human.
GeneWikii MRPL11.
GenomeRNAii 65003.
NextBioi 67180.
PROi Q9Y3B7.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y3B7.
CleanExi HS_MRPL11.
ExpressionAtlasi Q9Y3B7. baseline and differential.
Genevestigatori Q9Y3B7.

Family and domain databases

Gene3Di 1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPi MF_00736. Ribosomal_L11.
InterProi IPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
[Graphical view ]
PANTHERi PTHR11661. PTHR11661. 1 hit.
Pfami PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view ]
SMARTi SM00649. RL11. 1 hit.
[Graphical view ]
SUPFAMi SSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsi TIGR01632. L11_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Subthalamic nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Duodenum, Lymph and Melanoma.
  7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-141 (ISOFORMS 1/2).
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B7
Secondary accession number(s): A6NLT0
, A8K219, Q32P46, Q96Q73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3