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Protein

39S ribosomal protein L11, mitochondrial

Gene

MRPL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L11, mitochondrial
Short name:
L11mt
Short name:
MRP-L11
Gene namesi
Name:MRPL11
ORF Names:CGI-113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14042. MRPL11.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial ribosome Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174547.
PharmGKBiPA30940.

Polymorphism and mutation databases

BioMutaiMRPL11.
DMDMi22001931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030443? – 19239S ribosomal protein L11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9Y3B7.
PaxDbiQ9Y3B7.
PeptideAtlasiQ9Y3B7.
PRIDEiQ9Y3B7.
TopDownProteomicsiQ9Y3B7-1. [Q9Y3B7-1]
Q9Y3B7-2. [Q9Y3B7-2]

PTM databases

iPTMnetiQ9Y3B7.
PhosphoSitePlusiQ9Y3B7.
SwissPalmiQ9Y3B7.

Expressioni

Gene expression databases

BgeeiENSG00000174547.
CleanExiHS_MRPL11.
ExpressionAtlasiQ9Y3B7. baseline and differential.
GenevisibleiQ9Y3B7. HS.

Organism-specific databases

HPAiHPA057685.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122369. 69 interactors.
IntActiQ9Y3B7. 41 interactors.
MINTiMINT-3085719.
STRINGi9606.ENSP00000308897.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni33 – 35Combined sources3
Helixi36 – 39Combined sources4
Turni40 – 43Combined sources4
Helixi47 – 59Combined sources13
Beta strandi74 – 76Combined sources3
Helixi87 – 94Combined sources8
Turni104 – 106Combined sources3
Helixi114 – 125Combined sources12
Beta strandi128 – 130Combined sources3
Helixi137 – 150Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40J1-192[»]
3J9Melectron microscopy3.50J1-192[»]
ProteinModelPortaliQ9Y3B7.
SMRiQ9Y3B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L11P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3257. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000003153.
HOGENOMiHOG000082123.
HOVERGENiHBG036110.
InParanoidiQ9Y3B7.
KOiK02867.
OMAiTYDLKIG.
OrthoDBiEOG090A0CTR.
PhylomeDBiQ9Y3B7.
TreeFamiTF313471.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiView protein in InterPro
IPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiView protein in Pfam
PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
SMARTiView protein in SMART
SM00649. RL11. 1 hit.
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3B7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC
60 70 80 90 100
KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG
110 120 130 140 150
ARQTGKEVAG LVTLKHVYEI ARIKAQDEAF ALQDVPLSSV VRSIIGSARS
160 170 180 190
LGIRVVKDLS SEELAAFQKE RAIFLAAQKE ADLAAQEEAA KK
Length:192
Mass (Da):20,683
Last modified:November 1, 1999 - v1
Checksum:i92506A20044BF278
GO
Isoform 2 (identifier: Q9Y3B7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-41: Missing.

Show »
Length:166
Mass (Da):18,205
Checksum:iA78DA10D323B1D24
GO
Isoform 3 (identifier: Q9Y3B7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV

Note: No experimental confirmation available.Curated
Show »
Length:181
Mass (Da):19,454
Checksum:i578392577167303F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68T → I in BM554886 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q9Y3B7-3)
Sequence conflicti181V → L in BM554886 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04107716 – 41Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_045237158 – 192DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049638 mRNA. Translation: BAB40843.1.
AF151871 mRNA. Translation: AAD34108.1.
AK290084 mRNA. Translation: BAF82773.1.
AP002748 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74528.1.
CH471076 Genomic DNA. Translation: EAW74529.1.
CH471076 Genomic DNA. Translation: EAW74531.1.
BC005002 mRNA. Translation: AAH05002.1.
BC108277 mRNA. Translation: AAI08278.1.
BM554886 mRNA. No translation available.
AB051338 Genomic DNA. Translation: BAB54928.1.
CCDSiCCDS44655.1. [Q9Y3B7-2]
CCDS8139.1. [Q9Y3B7-1]
CCDS8140.1. [Q9Y3B7-3]
RefSeqiNP_057134.1. NM_016050.4. [Q9Y3B7-1]
NP_733934.1. NM_170738.3. [Q9Y3B7-2]
NP_733935.1. NM_170739.3. [Q9Y3B7-3]
UniGeneiHs.418450.

Genome annotation databases

EnsembliENST00000310999; ENSP00000308897; ENSG00000174547. [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547. [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547. [Q9Y3B7-2]
GeneIDi65003.
KEGGihsa:65003.
UCSCiuc001ohy.5. human. [Q9Y3B7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049638 mRNA. Translation: BAB40843.1.
AF151871 mRNA. Translation: AAD34108.1.
AK290084 mRNA. Translation: BAF82773.1.
AP002748 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74528.1.
CH471076 Genomic DNA. Translation: EAW74529.1.
CH471076 Genomic DNA. Translation: EAW74531.1.
BC005002 mRNA. Translation: AAH05002.1.
BC108277 mRNA. Translation: AAI08278.1.
BM554886 mRNA. No translation available.
AB051338 Genomic DNA. Translation: BAB54928.1.
CCDSiCCDS44655.1. [Q9Y3B7-2]
CCDS8139.1. [Q9Y3B7-1]
CCDS8140.1. [Q9Y3B7-3]
RefSeqiNP_057134.1. NM_016050.4. [Q9Y3B7-1]
NP_733934.1. NM_170738.3. [Q9Y3B7-2]
NP_733935.1. NM_170739.3. [Q9Y3B7-3]
UniGeneiHs.418450.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40J1-192[»]
3J9Melectron microscopy3.50J1-192[»]
ProteinModelPortaliQ9Y3B7.
SMRiQ9Y3B7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122369. 69 interactors.
IntActiQ9Y3B7. 41 interactors.
MINTiMINT-3085719.
STRINGi9606.ENSP00000308897.

PTM databases

iPTMnetiQ9Y3B7.
PhosphoSitePlusiQ9Y3B7.
SwissPalmiQ9Y3B7.

Polymorphism and mutation databases

BioMutaiMRPL11.
DMDMi22001931.

Proteomic databases

EPDiQ9Y3B7.
PaxDbiQ9Y3B7.
PeptideAtlasiQ9Y3B7.
PRIDEiQ9Y3B7.
TopDownProteomicsiQ9Y3B7-1. [Q9Y3B7-1]
Q9Y3B7-2. [Q9Y3B7-2]

Protocols and materials databases

DNASUi65003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310999; ENSP00000308897; ENSG00000174547. [Q9Y3B7-1]
ENST00000329819; ENSP00000329630; ENSG00000174547. [Q9Y3B7-3]
ENST00000430466; ENSP00000415356; ENSG00000174547. [Q9Y3B7-2]
GeneIDi65003.
KEGGihsa:65003.
UCSCiuc001ohy.5. human. [Q9Y3B7-1]

Organism-specific databases

CTDi65003.
GeneCardsiMRPL11.
HGNCiHGNC:14042. MRPL11.
HPAiHPA057685.
MIMi611826. gene.
neXtProtiNX_Q9Y3B7.
OpenTargetsiENSG00000174547.
PharmGKBiPA30940.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3257. Eukaryota.
COG0080. LUCA.
GeneTreeiENSGT00390000003153.
HOGENOMiHOG000082123.
HOVERGENiHBG036110.
InParanoidiQ9Y3B7.
KOiK02867.
OMAiTYDLKIG.
OrthoDBiEOG090A0CTR.
PhylomeDBiQ9Y3B7.
TreeFamiTF313471.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL11. human.
GeneWikiiMRPL11.
GenomeRNAii65003.
PROiQ9Y3B7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174547.
CleanExiHS_MRPL11.
ExpressionAtlasiQ9Y3B7. baseline and differential.
GenevisibleiQ9Y3B7. HS.

Family and domain databases

CDDicd00349. Ribosomal_L11. 1 hit.
Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11. 1 hit.
InterProiView protein in InterPro
IPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020784. Ribosomal_L11_N.
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiView protein in Pfam
PF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
SMARTiView protein in SMART
SM00649. RL11. 1 hit.
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B7
Secondary accession number(s): A6NLT0
, A8K219, Q32P46, Q96Q73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: February 15, 2017
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.