Q9Y3B7 (RM11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L11, mitochondrial
Short name=L11mt
Short name=MRP-L11

Gene names

Name:	MRPL11
ORF Names:	CGI-113

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion Ref.1.
Sequence similarities	Belongs to the ribosomal protein L11P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.7. Source: UniProtKB
Cellular_component	mitochondrial ribosome Non-traceable author statement Ref.7. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
gag	P04591	3	EBI-5453723,EBI-6179727	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y3B7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y3B7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     16-41: Missing.

Isoform 3 (identifier: Q9Y3B7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 192		39S ribosomal protein L11, mitochondrial		PRO_0000030443
Natural variations
	Alternative sequence	16 – 41	26	Missing in isoform 2.		VSP_041077
	Alternative sequence	158 – 192	35	DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3.		VSP_045237
Experimental info
	Sequence conflict	68	1	T → I in BM554886. Ref.6
Isoform 3:
	Sequence conflict	181	1	V → L in BM554886. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 92506A20044BF278	FASTA	192	20,683
	10 20 30 40 50 60 MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI 70 80 90 100 110 120 KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG ARQTGKEVAG LVTLKHVYEI 130 140 150 160 170 180 ARIKAQDEAF ALQDVPLSSV VRSIIGSARS LGIRVVKDLS SEELAAFQKE RAIFLAAQKE 190 ADLAAQEEAA KK
	Isoform 2 [UniParc]. Checksum: A78DA10D323B1D24	FASTA	166	18,205
	10 20 30 40 50 60 MSKLGRAARG LRKPERGVSI NQFCKEFNER TKDIKEGIPL PTKILVKPDR TFEIKIGQPT 70 80 90 100 110 120 VSYFLKAAAG IEKGARQTGK EVAGLVTLKH VYEIARIKAQ DEAFALQDVP LSSVVRSIIG 130 140 150 160 SARSLGIRVV KDLSSEELAA FQKERAIFLA AQKEADLAAQ EEAAKK
	Isoform 3 [UniParc]. Checksum: 578392577167303F	FASTA	181	19,454
	10 20 30 40 50 60 MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI 70 80 90 100 110 120 KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG ARQTGKEVAG LVTLKHVYEI 130 140 150 160 170 180 ARIKAQDEAF ALQDVPLSSV VRSIIGSARS LGIRVVKERC SANVLRNGKI SMKDPSGRSS V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Subthalamic nucleus.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Duodenum, Lymph and Melanoma.
[7]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-141 (ISOFORMS 1/2).
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049638 mRNA. Translation: BAB40843.1. AF151871 mRNA. Translation: AAD34108.1. AK290084 mRNA. Translation: BAF82773.1. AP002748 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW74528.1. CH471076 Genomic DNA. Translation: EAW74529.1. CH471076 Genomic DNA. Translation: EAW74531.1. BC005002 mRNA. Translation: AAH05002.1. BC108277 mRNA. Translation: AAI08278.1. BM554886 mRNA. No translation available. AB051338 Genomic DNA. Translation: BAB54928.1.
IPI	IPI00007001. IPI00333848. IPI00377233.
RefSeq	NP_057134.1. NM_016050.3. NP_733934.1. NM_170738.2. NP_733935.1. NM_170739.2.
UniGene	Hs.418450.
3D structure databases
ProteinModelPortal	Q9Y3B7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y3B7. 1 interaction.
MINT	MINT-3085719.
STRING	9606.ENSP00000308897.
PTM databases
PhosphoSite	Q9Y3B7.
Polymorphism databases
DMDM	22001931.
Proteomic databases
PaxDb	Q9Y3B7.
PRIDE	Q9Y3B7.
Protocols and materials databases
DNASU	65003.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310999; ENSP00000308897; ENSG00000174547. ENST00000329819; ENSP00000329630; ENSG00000174547. ENST00000430466; ENSP00000415356; ENSG00000174547.
GeneID	65003.
KEGG	hsa:65003.
UCSC	uc001ohy.4. human. uc001ohz.4. human. uc001oia.4. human.
Organism-specific databases
CTD	65003.
GeneCards	GC11M066202.
HGNC	HGNC:14042. MRPL11.
MIM	611826. gene.
neXtProt	NX_Q9Y3B7.
PharmGKB	PA30940.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0080.
HOGENOM	HOG000082123.
HOVERGEN	HBG036110.
InParanoid	Q9Y3B7.
KO	K02867.
OMA	CKDFNEK.
OrthoDB	EOG46Q6TQ.
PhylomeDB	Q9Y3B7.
Gene expression databases
ArrayExpress	Q9Y3B7.
Bgee	Q9Y3B7.
CleanEx	HS_MRPL11.
Genevestigator	Q9Y3B7.
GermOnline	ENSG00000174547. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.250. 1 hit. 3.30.1550.10. 1 hit.
InterPro	IPR000911. Ribosomal_L11. IPR006519. Ribosomal_L11_bac-typ. IPR020783. Ribosomal_L11_C. IPR020784. Ribosomal_L11_N. [Graphical view]
PANTHER	PTHR11661. PTHR11661. 1 hit.
Pfam	PF00298. Ribosomal_L11. 1 hit. PF03946. Ribosomal_L11_N. 1 hit. [Graphical view]
SMART	SM00649. RL11. 1 hit. [Graphical view]
SUPFAM	SSF46906. Ribosomal_L11. 1 hit. SSF54747. Ribosomal_L11. 1 hit.
TIGRFAMs	TIGR01632. L11_bact. 1 hit.
PROSITE	PS00359. RIBOSOMAL_L11. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL11. human.
GenomeRNAi	65003.
NextBio	67180.
SOURCE	Search...

Entry information

Entry name

RM11_HUMAN

Accession

Primary (citable) accession number: Q9Y3B7
Secondary accession number(s): A6NLT0 , A8K219, Q32P46, Q96Q73

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.