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Q9Y3B7

- RM11_HUMAN

UniProt

Q9Y3B7 - RM11_HUMAN

Protein

39S ribosomal protein L11, mitochondrial

Gene

MRPL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L11, mitochondrial
    Short name:
    L11mt
    Short name:
    MRP-L11
    Gene namesi
    Name:MRPL11
    ORF Names:CGI-113
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14042. MRPL11.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 19239S ribosomal protein L11, mitochondrialPRO_0000030443
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ9Y3B7.
    PaxDbiQ9Y3B7.
    PRIDEiQ9Y3B7.

    PTM databases

    PhosphoSiteiQ9Y3B7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3B7.
    BgeeiQ9Y3B7.
    CleanExiHS_MRPL11.
    GenevestigatoriQ9Y3B7.

    Organism-specific databases

    HPAiHPA057685.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    gagP045913EBI-5453723,EBI-6179727From a different organism.

    Protein-protein interaction databases

    BioGridi122369. 35 interactions.
    IntActiQ9Y3B7. 2 interactions.
    MINTiMINT-3085719.
    STRINGi9606.ENSP00000308897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3B7.
    SMRiQ9Y3B7. Positions 20-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L11P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0080.
    HOGENOMiHOG000082123.
    HOVERGENiHBG036110.
    InParanoidiQ9Y3B7.
    KOiK02867.
    OMAiTAYGDRT.
    OrthoDBiEOG7HHWTP.
    PhylomeDBiQ9Y3B7.
    TreeFamiTF313471.

    Family and domain databases

    Gene3Di1.10.10.250. 1 hit.
    3.30.1550.10. 1 hit.
    HAMAPiMF_00736. Ribosomal_L11.
    InterProiIPR000911. Ribosomal_L11/L12.
    IPR006519. Ribosomal_L11_bac-typ.
    IPR020783. Ribosomal_L11_C.
    IPR020784. Ribosomal_L11_N.
    [Graphical view]
    PANTHERiPTHR11661. PTHR11661. 1 hit.
    PfamiPF00298. Ribosomal_L11. 1 hit.
    PF03946. Ribosomal_L11_N. 1 hit.
    [Graphical view]
    SMARTiSM00649. RL11. 1 hit.
    [Graphical view]
    SUPFAMiSSF46906. SSF46906. 1 hit.
    SSF54747. SSF54747. 1 hit.
    TIGRFAMsiTIGR01632. L11_bact. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y3B7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC    50
    KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSYF LKAAAGIEKG 100
    ARQTGKEVAG LVTLKHVYEI ARIKAQDEAF ALQDVPLSSV VRSIIGSARS 150
    LGIRVVKDLS SEELAAFQKE RAIFLAAQKE ADLAAQEEAA KK 192
    Length:192
    Mass (Da):20,683
    Last modified:November 1, 1999 - v1
    Checksum:i92506A20044BF278
    GO
    Isoform 2 (identifier: Q9Y3B7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         16-41: Missing.

    Show »
    Length:166
    Mass (Da):18,205
    Checksum:iA78DA10D323B1D24
    GO
    Isoform 3 (identifier: Q9Y3B7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         158-192: DLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK → ERCSANVLRNGKISMKDPSGRSSV

    Note: No experimental confirmation available.Curated

    Show »
    Length:181
    Mass (Da):19,454
    Checksum:i578392577167303F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681T → I in BM554886. (PubMed:15489334)Curated
    Isoform 3 (identifier: Q9Y3B7-3)
    Sequence conflicti181 – 1811V → L in BM554886. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei16 – 4126Missing in isoform 2. 1 PublicationVSP_041077Add
    BLAST
    Alternative sequencei158 – 19235DLSSE…EAAKK → ERCSANVLRNGKISMKDPSG RSSV in isoform 3. 1 PublicationVSP_045237Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049638 mRNA. Translation: BAB40843.1.
    AF151871 mRNA. Translation: AAD34108.1.
    AK290084 mRNA. Translation: BAF82773.1.
    AP002748 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74528.1.
    CH471076 Genomic DNA. Translation: EAW74529.1.
    CH471076 Genomic DNA. Translation: EAW74531.1.
    BC005002 mRNA. Translation: AAH05002.1.
    BC108277 mRNA. Translation: AAI08278.1.
    BM554886 mRNA. No translation available.
    AB051338 Genomic DNA. Translation: BAB54928.1.
    CCDSiCCDS44655.1. [Q9Y3B7-2]
    CCDS8139.1. [Q9Y3B7-1]
    CCDS8140.1. [Q9Y3B7-3]
    RefSeqiNP_057134.1. NM_016050.4. [Q9Y3B7-1]
    NP_733934.1. NM_170738.3. [Q9Y3B7-2]
    NP_733935.1. NM_170739.3. [Q9Y3B7-3]
    XP_006718729.1. XM_006718666.1. [Q9Y3B7-3]
    UniGeneiHs.418450.

    Genome annotation databases

    EnsembliENST00000310999; ENSP00000308897; ENSG00000174547. [Q9Y3B7-1]
    ENST00000329819; ENSP00000329630; ENSG00000174547. [Q9Y3B7-3]
    ENST00000430466; ENSP00000415356; ENSG00000174547. [Q9Y3B7-2]
    GeneIDi65003.
    KEGGihsa:65003.
    UCSCiuc001ohy.4. human.
    uc001ohz.4. human. [Q9Y3B7-1]
    uc001oia.4. human. [Q9Y3B7-2]

    Polymorphism databases

    DMDMi22001931.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049638 mRNA. Translation: BAB40843.1 .
    AF151871 mRNA. Translation: AAD34108.1 .
    AK290084 mRNA. Translation: BAF82773.1 .
    AP002748 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74528.1 .
    CH471076 Genomic DNA. Translation: EAW74529.1 .
    CH471076 Genomic DNA. Translation: EAW74531.1 .
    BC005002 mRNA. Translation: AAH05002.1 .
    BC108277 mRNA. Translation: AAI08278.1 .
    BM554886 mRNA. No translation available.
    AB051338 Genomic DNA. Translation: BAB54928.1 .
    CCDSi CCDS44655.1. [Q9Y3B7-2 ]
    CCDS8139.1. [Q9Y3B7-1 ]
    CCDS8140.1. [Q9Y3B7-3 ]
    RefSeqi NP_057134.1. NM_016050.4. [Q9Y3B7-1 ]
    NP_733934.1. NM_170738.3. [Q9Y3B7-2 ]
    NP_733935.1. NM_170739.3. [Q9Y3B7-3 ]
    XP_006718729.1. XM_006718666.1. [Q9Y3B7-3 ]
    UniGenei Hs.418450.

    3D structure databases

    ProteinModelPortali Q9Y3B7.
    SMRi Q9Y3B7. Positions 20-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122369. 35 interactions.
    IntActi Q9Y3B7. 2 interactions.
    MINTi MINT-3085719.
    STRINGi 9606.ENSP00000308897.

    PTM databases

    PhosphoSitei Q9Y3B7.

    Polymorphism databases

    DMDMi 22001931.

    Proteomic databases

    MaxQBi Q9Y3B7.
    PaxDbi Q9Y3B7.
    PRIDEi Q9Y3B7.

    Protocols and materials databases

    DNASUi 65003.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310999 ; ENSP00000308897 ; ENSG00000174547 . [Q9Y3B7-1 ]
    ENST00000329819 ; ENSP00000329630 ; ENSG00000174547 . [Q9Y3B7-3 ]
    ENST00000430466 ; ENSP00000415356 ; ENSG00000174547 . [Q9Y3B7-2 ]
    GeneIDi 65003.
    KEGGi hsa:65003.
    UCSCi uc001ohy.4. human.
    uc001ohz.4. human. [Q9Y3B7-1 ]
    uc001oia.4. human. [Q9Y3B7-2 ]

    Organism-specific databases

    CTDi 65003.
    GeneCardsi GC11M066202.
    HGNCi HGNC:14042. MRPL11.
    HPAi HPA057685.
    MIMi 611826. gene.
    neXtProti NX_Q9Y3B7.
    PharmGKBi PA30940.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0080.
    HOGENOMi HOG000082123.
    HOVERGENi HBG036110.
    InParanoidi Q9Y3B7.
    KOi K02867.
    OMAi TAYGDRT.
    OrthoDBi EOG7HHWTP.
    PhylomeDBi Q9Y3B7.
    TreeFami TF313471.

    Miscellaneous databases

    ChiTaRSi MRPL11. human.
    GeneWikii MRPL11.
    GenomeRNAii 65003.
    NextBioi 67180.
    PROi Q9Y3B7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3B7.
    Bgeei Q9Y3B7.
    CleanExi HS_MRPL11.
    Genevestigatori Q9Y3B7.

    Family and domain databases

    Gene3Di 1.10.10.250. 1 hit.
    3.30.1550.10. 1 hit.
    HAMAPi MF_00736. Ribosomal_L11.
    InterProi IPR000911. Ribosomal_L11/L12.
    IPR006519. Ribosomal_L11_bac-typ.
    IPR020783. Ribosomal_L11_C.
    IPR020784. Ribosomal_L11_N.
    [Graphical view ]
    PANTHERi PTHR11661. PTHR11661. 1 hit.
    Pfami PF00298. Ribosomal_L11. 1 hit.
    PF03946. Ribosomal_L11_N. 1 hit.
    [Graphical view ]
    SMARTi SM00649. RL11. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46906. SSF46906. 1 hit.
    SSF54747. SSF54747. 1 hit.
    TIGRFAMsi TIGR01632. L11_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Subthalamic nucleus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Duodenum, Lymph and Melanoma.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-141 (ISOFORMS 1/2).
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM11_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3B7
    Secondary accession number(s): A6NLT0
    , A8K219, Q32P46, Q96Q73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3