Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PRELI domain containing protein 3B

Gene

PRELID3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRELI domain containing protein 3B
Alternative name(s):
Protein slowmo homolog 2
Gene namesi
Name:PRELID3B
Synonyms:C20orf45, SLMO2
ORF Names:CGI-107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15892. PRELID3B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403922.

Polymorphism and mutation databases

BioMutaiSLMO2.
DMDMi26392626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194PRELI domain containing protein 3BPRO_0000079429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3B1.
MaxQBiQ9Y3B1.
PaxDbiQ9Y3B1.
PRIDEiQ9Y3B1.

PTM databases

iPTMnetiQ9Y3B1.
PhosphoSiteiQ9Y3B1.

Expressioni

Gene expression databases

BgeeiQ9Y3B1.
CleanExiHS_SLMO2.
ExpressionAtlasiQ9Y3B1. baseline and differential.
GenevisibleiQ9Y3B1. HS.

Organism-specific databases

HPAiCAB017039.
HPA047721.

Interactioni

Protein-protein interaction databases

BioGridi119219. 2 interactions.
STRINGi9606.ENSP00000348206.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3B1.
SMRiQ9Y3B1. Positions 6-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 172172PRELI/MSF1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the slowmo family.Curated
Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3336. Eukaryota.
ENOG410YBNZ. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000187596.
HOVERGENiHBG009393.
InParanoidiQ9Y3B1.
OMAiPINTAVI.
OrthoDBiEOG72VH7F.
PhylomeDBiQ9Y3B1.
TreeFamiTF312873.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIWTSEHVF DHPWETVTTA AMQKYPNPMN PSVVGVDVLD RHIDPSGKLH
60 70 80 90 100
SHRLLSTEWG LPSIVKSLIG AARTKTYVQE HSVVDPVEKT MELKSTNISF
110 120 130 140 150
TNMVSVDERL IYKPHPQDPE KTVLTQEAII TVKGVSLSSY LEGLMASTIS
160 170 180 190
SNASKGREAM EWVIHKLNAE IEELTASARG TIRTPMAAAA FAEK
Length:194
Mass (Da):21,495
Last modified:December 6, 2002 - v2
Checksum:iDF32EA44992BFA94
GO
Isoform 2 (identifier: Q9Y3B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-97: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,167
Checksum:i1A13B071A410A40A
GO

Sequence cautioni

The sequence AAD34102.1 differs from that shown. Reason: Frameshift at position 192. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 9730Missing in isoform 2. 1 PublicationVSP_044840Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151865 mRNA. Translation: AAD34102.1. Frameshift.
AK002157 mRNA. Translation: BAA92114.1.
AK298135 mRNA. Translation: BAG60414.1.
AL109840 Genomic DNA. Translation: CAC09373.1.
AL109840 Genomic DNA. Translation: CAI42936.1.
CH471077 Genomic DNA. Translation: EAW75442.1.
CH471077 Genomic DNA. Translation: EAW75443.1.
BC010649 mRNA. Translation: AAH10649.1.
BC013969 mRNA. Translation: AAH13969.1.
CCDSiCCDS42893.1. [Q9Y3B1-1]
CCDS58783.1. [Q9Y3B1-2]
RefSeqiNP_001243332.1. NM_001256403.1. [Q9Y3B1-2]
NP_057129.2. NM_016045.2. [Q9Y3B1-1]
UniGeneiHs.656865.

Genome annotation databases

EnsembliENST00000355937; ENSP00000348206; ENSG00000101166. [Q9Y3B1-1]
ENST00000371033; ENSP00000360072; ENSG00000101166. [Q9Y3B1-2]
GeneIDi51012.
KEGGihsa:51012.
UCSCiuc002yam.4. human. [Q9Y3B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151865 mRNA. Translation: AAD34102.1. Frameshift.
AK002157 mRNA. Translation: BAA92114.1.
AK298135 mRNA. Translation: BAG60414.1.
AL109840 Genomic DNA. Translation: CAC09373.1.
AL109840 Genomic DNA. Translation: CAI42936.1.
CH471077 Genomic DNA. Translation: EAW75442.1.
CH471077 Genomic DNA. Translation: EAW75443.1.
BC010649 mRNA. Translation: AAH10649.1.
BC013969 mRNA. Translation: AAH13969.1.
CCDSiCCDS42893.1. [Q9Y3B1-1]
CCDS58783.1. [Q9Y3B1-2]
RefSeqiNP_001243332.1. NM_001256403.1. [Q9Y3B1-2]
NP_057129.2. NM_016045.2. [Q9Y3B1-1]
UniGeneiHs.656865.

3D structure databases

ProteinModelPortaliQ9Y3B1.
SMRiQ9Y3B1. Positions 6-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119219. 2 interactions.
STRINGi9606.ENSP00000348206.

PTM databases

iPTMnetiQ9Y3B1.
PhosphoSiteiQ9Y3B1.

Polymorphism and mutation databases

BioMutaiSLMO2.
DMDMi26392626.

Proteomic databases

EPDiQ9Y3B1.
MaxQBiQ9Y3B1.
PaxDbiQ9Y3B1.
PRIDEiQ9Y3B1.

Protocols and materials databases

DNASUi51012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355937; ENSP00000348206; ENSG00000101166. [Q9Y3B1-1]
ENST00000371033; ENSP00000360072; ENSG00000101166. [Q9Y3B1-2]
GeneIDi51012.
KEGGihsa:51012.
UCSCiuc002yam.4. human. [Q9Y3B1-1]

Organism-specific databases

CTDi51012.
GeneCardsiSLMO2.
HGNCiHGNC:15892. PRELID3B.
HPAiCAB017039.
HPA047721.
neXtProtiNX_Q9Y3B1.
PharmGKBiPA162403922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3336. Eukaryota.
ENOG410YBNZ. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000187596.
HOVERGENiHBG009393.
InParanoidiQ9Y3B1.
OMAiPINTAVI.
OrthoDBiEOG72VH7F.
PhylomeDBiQ9Y3B1.
TreeFamiTF312873.

Miscellaneous databases

GenomeRNAii51012.
NextBioi53504.
PROiQ9Y3B1.

Gene expression databases

BgeeiQ9Y3B1.
CleanExiHS_SLMO2.
ExpressionAtlasiQ9Y3B1. baseline and differential.
GenevisibleiQ9Y3B1. HS.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye and Uterus.

Entry informationi

Entry nameiPLD3B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3B1
Secondary accession number(s): E1P5I8, Q5JX17, Q9NUL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: March 16, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.