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Protein

Ribosome maturation protein SBDS

Gene

SBDS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.4 Publications

GO - Molecular functioni

  1. microtubule binding Source: UniProtKB
  2. poly(A) RNA binding Source: UniProtKB
  3. ribosome binding Source: UniProtKB
  4. rRNA binding Source: UniProtKB

GO - Biological processi

  1. bone marrow development Source: UniProtKB
  2. bone mineralization Source: UniProtKB
  3. cell proliferation Source: UniProtKB
  4. inner cell mass cell proliferation Source: Ensembl
  5. leukocyte chemotaxis Source: UniProtKB
  6. mature ribosome assembly Source: UniProtKB
  7. mitotic spindle stabilization Source: UniProtKB
  8. ribosomal large subunit biogenesis Source: GO_Central
  9. rRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SBDS
Alternative name(s):
Shwachman-Bodian-Diamond syndrome protein
Gene namesi
Name:SBDS
ORF Names:CGI-97
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:19440. SBDS.

Subcellular locationi

  1. Cytoplasm
  2. Nucleusnucleolus
  3. Nucleusnucleoplasm
  4. Cytoplasmcytoskeletonspindle

  5. Note: Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleolus Source: UniProtKB
  3. nucleoplasm Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB
  5. spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Shwachman-Diamond syndrome (SDS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.

See also OMIM:260400
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81N → K in SDS. 1 Publication
Corresponds to variant rs28942099 [ dbSNP | Ensembl ].
VAR_015390
Natural varianti33 – 331K → T in SDS. 1 Publication
VAR_071673
Natural varianti44 – 441E → G in SDS. 1 Publication
VAR_015391
Natural varianti67 – 671K → E in SDS. 1 Publication
VAR_015392
Natural varianti87 – 871I → S in SDS. 1 Publication
VAR_015393
Natural varianti126 – 1261R → T in SDS; strongly reduced release of EIF6 from pre-60S ribosome subunits. 2 Publications
VAR_015394
Natural varianti169 – 1691R → C in SDS. 1 Publication
VAR_015395
Natural varianti212 – 2121I → T in SDS. 1 Publication
Corresponds to variant rs79344818 [ dbSNP | Ensembl ].
VAR_015396

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi151 – 1511K → N: Strongly reduced release of EIF6 from pre-60S ribosome subunits. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi260400. phenotype.
Orphaneti88. Idiopathic aplastic anemia.
811. Shwachman-Diamond syndrome.
PharmGKBiPA134978742.

Polymorphism and mutation databases

BioMutaiSBDS.
DMDMi28380824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 250249Ribosome maturation protein SBDSPRO_0000123762Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y3A5.
PaxDbiQ9Y3A5.
PeptideAtlasiQ9Y3A5.
PRIDEiQ9Y3A5.

PTM databases

PhosphoSiteiQ9Y3A5.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9Y3A5.
CleanExiHS_SBDS.
ExpressionAtlasiQ9Y3A5. baseline.
GenevestigatoriQ9Y3A5.

Organism-specific databases

HPAiHPA028891.

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7.3 Publications

Protein-protein interaction databases

BioGridi119307. 38 interactions.
IntActiQ9Y3A5. 1 interaction.
MINTiMINT-3085538.
STRINGi9606.ENSP00000246868.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 83Combined sources
Beta strandi14 – 218Combined sources
Beta strandi26 – 3510Combined sources
Helixi36 – 405Combined sources
Helixi47 – 504Combined sources
Beta strandi51 – 555Combined sources
Beta strandi56 – 594Combined sources
Turni60 – 634Combined sources
Beta strandi64 – 663Combined sources
Helixi68 – 747Combined sources
Helixi80 – 8910Combined sources
Beta strandi90 – 934Combined sources
Beta strandi97 – 1037Combined sources
Helixi107 – 11610Combined sources
Turni122 – 1254Combined sources
Helixi130 – 14011Combined sources
Helixi150 – 16415Combined sources
Beta strandi168 – 1703Combined sources
Beta strandi174 – 1774Combined sources
Helixi180 – 1867Combined sources
Turni187 – 1893Combined sources
Helixi190 – 1934Combined sources
Beta strandi196 – 2005Combined sources
Beta strandi203 – 2053Combined sources
Beta strandi208 – 2103Combined sources
Helixi214 – 2163Combined sources
Helixi217 – 22711Combined sources
Turni228 – 2314Combined sources
Beta strandi232 – 2365Combined sources
Beta strandi240 – 2423Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDONMR-A1-250[»]
2L9NNMR-A1-250[»]
SMRiQ9Y3A5. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

eggNOGiCOG1500.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiQ9Y3A5.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiQ9Y3A5.
TreeFamiTF300881.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Ribosome_maturation_pr_SBDS.
[Graphical view]
PANTHERiPTHR10927. PTHR10927. 1 hit.
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV
60 70 80 90 100
LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER
110 120 130 140 150
HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKTNKST
160 170 180 190 200
KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLIKVIESE
210 220 230 240 250
DYGQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLNLK DVEEGDEKFE
Length:250
Mass (Da):28,764
Last modified:January 23, 2007 - v4
Checksum:iD35C43003C05F5A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 433SGV → RAW in AAD34092 (PubMed:10810093).Curated
Sequence conflicti89 – 891T → A in AAD34092 (PubMed:10810093).Curated
Sequence conflicti105 – 1051E → G in AAD34092 (PubMed:10810093).Curated
Sequence conflicti114 – 1141I → F in AAD34092 (PubMed:10810093).Curated
Sequence conflicti126 – 1261R → G in AAD34092 (PubMed:10810093).Curated
Sequence conflicti143 – 1431S → L in AAD34092 (PubMed:10810093).Curated
Sequence conflicti146 – 1461T → P in AAD34092 (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81N → K in SDS. 1 Publication
Corresponds to variant rs28942099 [ dbSNP | Ensembl ].
VAR_015390
Natural varianti33 – 331K → T in SDS. 1 Publication
VAR_071673
Natural varianti44 – 441E → G in SDS. 1 Publication
VAR_015391
Natural varianti67 – 671K → E in SDS. 1 Publication
VAR_015392
Natural varianti87 – 871I → S in SDS. 1 Publication
VAR_015393
Natural varianti126 – 1261R → T in SDS; strongly reduced release of EIF6 from pre-60S ribosome subunits. 2 Publications
VAR_015394
Natural varianti169 – 1691R → C in SDS. 1 Publication
VAR_015395
Natural varianti212 – 2121I → T in SDS. 1 Publication
Corresponds to variant rs79344818 [ dbSNP | Ensembl ].
VAR_015396

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169963 mRNA. Translation: AAN77490.1.
AF151855 mRNA. Translation: AAD34092.1.
AK001779 mRNA. Translation: BAA91905.1.
AK289609 mRNA. Translation: BAF82298.1.
CH471140 Genomic DNA. Translation: EAX07906.1.
BC065700 mRNA. Translation: AAH65700.1.
CCDSiCCDS5537.1.
RefSeqiNP_057122.2. NM_016038.2.
UniGeneiHs.110445.

Genome annotation databases

EnsembliENST00000246868; ENSP00000246868; ENSG00000126524.
GeneIDi51119.
KEGGihsa:51119.
UCSCiuc003tvm.1. human.

Polymorphism and mutation databases

BioMutaiSBDS.

Cross-referencesi

Web resourcesi

SBDSbase

SBDS mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169963 mRNA. Translation: AAN77490.1.
AF151855 mRNA. Translation: AAD34092.1.
AK001779 mRNA. Translation: BAA91905.1.
AK289609 mRNA. Translation: BAF82298.1.
CH471140 Genomic DNA. Translation: EAX07906.1.
BC065700 mRNA. Translation: AAH65700.1.
CCDSiCCDS5537.1.
RefSeqiNP_057122.2. NM_016038.2.
UniGeneiHs.110445.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KDONMR-A1-250[»]
2L9NNMR-A1-250[»]
SMRiQ9Y3A5. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119307. 38 interactions.
IntActiQ9Y3A5. 1 interaction.
MINTiMINT-3085538.
STRINGi9606.ENSP00000246868.

PTM databases

PhosphoSiteiQ9Y3A5.

Polymorphism and mutation databases

BioMutaiSBDS.
DMDMi28380824.

Proteomic databases

MaxQBiQ9Y3A5.
PaxDbiQ9Y3A5.
PeptideAtlasiQ9Y3A5.
PRIDEiQ9Y3A5.

Protocols and materials databases

DNASUi51119.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246868; ENSP00000246868; ENSG00000126524.
GeneIDi51119.
KEGGihsa:51119.
UCSCiuc003tvm.1. human.

Organism-specific databases

CTDi51119.
GeneCardsiGC07M066452.
GeneReviewsiSBDS.
HGNCiHGNC:19440. SBDS.
HPAiHPA028891.
MIMi260400. phenotype.
607444. gene.
neXtProtiNX_Q9Y3A5.
Orphaneti88. Idiopathic aplastic anemia.
811. Shwachman-Diamond syndrome.
PharmGKBiPA134978742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1500.
GeneTreeiENSGT00390000008135.
HOGENOMiHOG000216685.
HOVERGENiHBG039762.
InParanoidiQ9Y3A5.
KOiK14574.
OMAiTIDSETR.
OrthoDBiEOG7XWPPD.
PhylomeDBiQ9Y3A5.
TreeFamiTF300881.

Miscellaneous databases

ChiTaRSiSBDS. human.
EvolutionaryTraceiQ9Y3A5.
GeneWikiiSBDS.
GenomeRNAii51119.
NextBioi53897.
PROiQ9Y3A5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y3A5.
CleanExiHS_SBDS.
ExpressionAtlasiQ9Y3A5. baseline.
GenevestigatoriQ9Y3A5.

Family and domain databases

Gene3Di3.30.1250.10. 1 hit.
InterProiIPR018978. Ribosome_mat_SBDS_C.
IPR018023. Ribosome_mat_SBDS_CS.
IPR019783. Ribosome_mat_SBDS_N.
IPR002140. Ribosome_maturation_pr_SBDS.
[Graphical view]
PANTHERiPTHR10927. PTHR10927. 1 hit.
PfamiPF01172. SBDS. 1 hit.
PF09377. SBDS_C. 1 hit.
[Graphical view]
SUPFAMiSSF89895. SSF89895. 1 hit.
TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
PROSITEiPS01267. UPF0023. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in SBDS are associated with Shwachman-Diamond syndrome."
    Boocock G.R.B., Morrison J.A., Popovic M., Richards N., Ellis L., Durie P.R., Rommens J.M.
    Nat. Genet. 33:97-101(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SDS LYS-8; GLY-44; GLU-67; SER-87; THR-126; CYS-169 AND THR-212.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex and Ovarian carcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  6. Bienvenut W.V., Claeys D.
    Submitted (NOV-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-19, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  7. "The Shwachman-Diamond SBDS protein localizes to the nucleolus."
    Austin K.M., Leary R.J., Shimamura A.
    Blood 106:1253-1258(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA."
    Ganapathi K.A., Austin K.M., Lee C.S., Dias A., Malsch M.M., Reed R., Shimamura A.
    Blood 110:1458-1465(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NPM1 AND THE 60S RIBOSOMAL SUBUNIT, SUBCELLULAR LOCATION.
  9. "The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels."
    Hesling C., Oliveira C.C., Castilho B.A., Zanchin N.I.
    Exp. Cell Res. 313:4180-4195(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NIP7.
  10. "Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses."
    Ball H.L., Zhang B., Riches J.J., Gandhi R., Li J., Rommens J.M., Myers J.S.
    Hum. Mol. Genet. 18:3684-3695(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA1; PRKDC AND THE 60S RIBOSOME SUBUNIT.
  11. "SBDS expression and localization at the mitotic spindle in human myeloid progenitors."
    Orelio C., Verkuijlen P., Geissler J., van den Berg T.K., Kuijpers T.W.
    PLoS ONE 4:E7084-E7084(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. Cited for: STRUCTURE BY NMR, RNA-BINDING.
  17. Cited for: STRUCTURE BY NMR, FUNCTION, CHARACTERIZATION OF VARIANT SDS THR-126, MUTAGENESIS OF LYS-151.
  18. Cited for: VARIANT SDS THR-33.

Entry informationi

Entry nameiSBDS_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A5
Secondary accession number(s): A8K0P4, Q96FX0, Q9NV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.