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Q9Y3A5

- SBDS_HUMAN

UniProt

Q9Y3A5 - SBDS_HUMAN

Protein

Ribosome maturation protein SBDS

Gene

SBDS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.4 Publications

    GO - Molecular functioni

    1. microtubule binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. ribosome binding Source: UniProtKB
    5. rRNA binding Source: UniProtKB

    GO - Biological processi

    1. bone marrow development Source: UniProtKB
    2. bone mineralization Source: UniProtKB
    3. cell proliferation Source: UniProtKB
    4. inner cell mass cell proliferation Source: Ensembl
    5. leukocyte chemotaxis Source: UniProtKB
    6. mature ribosome assembly Source: UniProtKB
    7. mitotic spindle stabilization Source: UniProtKB
    8. ribosomal large subunit biogenesis Source: RefGenome
    9. rRNA processing Source: UniProtKB

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosome maturation protein SBDS
    Alternative name(s):
    Shwachman-Bodian-Diamond syndrome protein
    Gene namesi
    Name:SBDS
    ORF Names:CGI-97
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:19440. SBDS.

    Subcellular locationi

    Cytoplasm. Nucleusnucleolus. Nucleusnucleoplasm. Cytoplasmcytoskeletonspindle
    Note: Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903).1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleolus Source: UniProtKB
    3. nucleoplasm Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB
    5. spindle pole Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Shwachman-Diamond syndrome (SDS) [MIM:260400]: Autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81N → K in SDS. 1 Publication
    Corresponds to variant rs28942099 [ dbSNP | Ensembl ].
    VAR_015390
    Natural varianti44 – 441E → G in SDS. 1 Publication
    VAR_015391
    Natural varianti67 – 671K → E in SDS. 1 Publication
    VAR_015392
    Natural varianti87 – 871I → S in SDS. 1 Publication
    VAR_015393
    Natural varianti126 – 1261R → T in SDS; strongly reduced release of EIF6 from pre-60S ribosome subunits. 1 Publication
    VAR_015394
    Natural varianti169 – 1691R → C in SDS. 1 Publication
    VAR_015395
    Natural varianti212 – 2121I → T in SDS. 1 Publication
    Corresponds to variant rs79344818 [ dbSNP | Ensembl ].
    VAR_015396

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi151 – 1511K → N: Strongly reduced release of EIF6 from pre-60S ribosome subunits. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi260400. phenotype.
    Orphaneti88. Idiopathic aplastic anemia.
    811. Shwachman-Diamond syndrome.
    PharmGKBiPA134978742.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 250249Ribosome maturation protein SBDSPRO_0000123762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y3A5.
    PaxDbiQ9Y3A5.
    PeptideAtlasiQ9Y3A5.
    PRIDEiQ9Y3A5.

    PTM databases

    PhosphoSiteiQ9Y3A5.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ9Y3A5.
    BgeeiQ9Y3A5.
    CleanExiHS_SBDS.
    GenevestigatoriQ9Y3A5.

    Organism-specific databases

    HPAiHPA028891.

    Interactioni

    Subunit structurei

    Associates with the 60S ribosomal subunit. Interacts with NPM1, RPA1 and PRKDC. May interact with NIP7.3 Publications

    Protein-protein interaction databases

    BioGridi119307. 35 interactions.
    IntActiQ9Y3A5. 1 interaction.
    MINTiMINT-3085538.
    STRINGi9606.ENSP00000246868.

    Structurei

    Secondary structure

    1
    250
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni6 – 83
    Beta strandi14 – 218
    Beta strandi26 – 3510
    Helixi36 – 405
    Helixi47 – 504
    Beta strandi51 – 555
    Beta strandi56 – 594
    Turni60 – 634
    Beta strandi64 – 663
    Helixi68 – 747
    Helixi80 – 8910
    Beta strandi90 – 934
    Beta strandi97 – 1037
    Helixi107 – 11610
    Turni122 – 1254
    Helixi130 – 14011
    Helixi150 – 16415
    Beta strandi168 – 1703
    Beta strandi174 – 1774
    Helixi180 – 1867
    Turni187 – 1893
    Helixi190 – 1934
    Beta strandi196 – 2005
    Beta strandi203 – 2053
    Beta strandi208 – 2103
    Helixi214 – 2163
    Helixi217 – 22711
    Turni228 – 2314
    Beta strandi232 – 2365
    Beta strandi240 – 2423

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KDONMR-A1-250[»]
    2L9NNMR-A1-250[»]
    ProteinModelPortaliQ9Y3A5.
    SMRiQ9Y3A5. Positions 1-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y3A5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SDO1/SBDS family.Curated

    Phylogenomic databases

    eggNOGiCOG1500.
    HOGENOMiHOG000216685.
    HOVERGENiHBG039762.
    InParanoidiQ9Y3A5.
    KOiK14574.
    OMAiRSGIETD.
    OrthoDBiEOG7XWPPD.
    PhylomeDBiQ9Y3A5.
    TreeFamiTF300881.

    Family and domain databases

    Gene3Di3.30.1250.10. 1 hit.
    InterProiIPR018978. Ribosome_mat_SBDS_C.
    IPR018023. Ribosome_mat_SBDS_CS.
    IPR019783. Ribosome_mat_SBDS_N.
    IPR002140. Ribosome_maturation_pr_SBDS.
    [Graphical view]
    PANTHERiPTHR10927. PTHR10927. 1 hit.
    PfamiPF01172. SBDS. 1 hit.
    PF09377. SBDS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF89895. SSF89895. 1 hit.
    TIGRFAMsiTIGR00291. RNA_SBDS. 1 hit.
    PROSITEiPS01267. UPF0023. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y3A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIFTPTNQI RLTNVAVVRM KRAGKRFEIA CYKNKVVGWR SGVEKDLDEV    50
    LQTHSVFVNV SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER 100
    HTQLEQMFRD IATIVADKCV NPETKRPYTV ILIERAMKDI HYSVKTNKST 150
    KQQALEVIKQ LKEKMKIERA HMRLRFILPV NEGKKLKEKL KPLIKVIESE 200
    DYGQQLEIVC LIDPGCFREI DELIKKETKG KGSLEVLNLK DVEEGDEKFE 250
    Length:250
    Mass (Da):28,764
    Last modified:January 23, 2007 - v4
    Checksum:iD35C43003C05F5A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 433SGV → RAW in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti89 – 891T → A in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti105 – 1051E → G in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti114 – 1141I → F in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti126 – 1261R → G in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti143 – 1431S → L in AAD34092. (PubMed:10810093)Curated
    Sequence conflicti146 – 1461T → P in AAD34092. (PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81N → K in SDS. 1 Publication
    Corresponds to variant rs28942099 [ dbSNP | Ensembl ].
    VAR_015390
    Natural varianti44 – 441E → G in SDS. 1 Publication
    VAR_015391
    Natural varianti67 – 671K → E in SDS. 1 Publication
    VAR_015392
    Natural varianti87 – 871I → S in SDS. 1 Publication
    VAR_015393
    Natural varianti126 – 1261R → T in SDS; strongly reduced release of EIF6 from pre-60S ribosome subunits. 1 Publication
    VAR_015394
    Natural varianti169 – 1691R → C in SDS. 1 Publication
    VAR_015395
    Natural varianti212 – 2121I → T in SDS. 1 Publication
    Corresponds to variant rs79344818 [ dbSNP | Ensembl ].
    VAR_015396

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY169963 mRNA. Translation: AAN77490.1.
    AF151855 mRNA. Translation: AAD34092.1.
    AK001779 mRNA. Translation: BAA91905.1.
    AK289609 mRNA. Translation: BAF82298.1.
    CH471140 Genomic DNA. Translation: EAX07906.1.
    BC065700 mRNA. Translation: AAH65700.1.
    CCDSiCCDS5537.1.
    RefSeqiNP_057122.2. NM_016038.2.
    UniGeneiHs.110445.

    Genome annotation databases

    EnsembliENST00000246868; ENSP00000246868; ENSG00000126524.
    GeneIDi51119.
    KEGGihsa:51119.
    UCSCiuc003tvm.1. human.

    Polymorphism databases

    DMDMi28380824.

    Cross-referencesi

    Web resourcesi

    SBDSbase

    SBDS mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY169963 mRNA. Translation: AAN77490.1 .
    AF151855 mRNA. Translation: AAD34092.1 .
    AK001779 mRNA. Translation: BAA91905.1 .
    AK289609 mRNA. Translation: BAF82298.1 .
    CH471140 Genomic DNA. Translation: EAX07906.1 .
    BC065700 mRNA. Translation: AAH65700.1 .
    CCDSi CCDS5537.1.
    RefSeqi NP_057122.2. NM_016038.2.
    UniGenei Hs.110445.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KDO NMR - A 1-250 [» ]
    2L9N NMR - A 1-250 [» ]
    ProteinModelPortali Q9Y3A5.
    SMRi Q9Y3A5. Positions 1-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119307. 35 interactions.
    IntActi Q9Y3A5. 1 interaction.
    MINTi MINT-3085538.
    STRINGi 9606.ENSP00000246868.

    PTM databases

    PhosphoSitei Q9Y3A5.

    Polymorphism databases

    DMDMi 28380824.

    Proteomic databases

    MaxQBi Q9Y3A5.
    PaxDbi Q9Y3A5.
    PeptideAtlasi Q9Y3A5.
    PRIDEi Q9Y3A5.

    Protocols and materials databases

    DNASUi 51119.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246868 ; ENSP00000246868 ; ENSG00000126524 .
    GeneIDi 51119.
    KEGGi hsa:51119.
    UCSCi uc003tvm.1. human.

    Organism-specific databases

    CTDi 51119.
    GeneCardsi GC07M066452.
    GeneReviewsi SBDS.
    HGNCi HGNC:19440. SBDS.
    HPAi HPA028891.
    MIMi 260400. phenotype.
    607444. gene.
    neXtProti NX_Q9Y3A5.
    Orphaneti 88. Idiopathic aplastic anemia.
    811. Shwachman-Diamond syndrome.
    PharmGKBi PA134978742.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1500.
    HOGENOMi HOG000216685.
    HOVERGENi HBG039762.
    InParanoidi Q9Y3A5.
    KOi K14574.
    OMAi RSGIETD.
    OrthoDBi EOG7XWPPD.
    PhylomeDBi Q9Y3A5.
    TreeFami TF300881.

    Miscellaneous databases

    ChiTaRSi SBDS. human.
    EvolutionaryTracei Q9Y3A5.
    GeneWikii SBDS.
    GenomeRNAii 51119.
    NextBioi 53897.
    PROi Q9Y3A5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y3A5.
    Bgeei Q9Y3A5.
    CleanExi HS_SBDS.
    Genevestigatori Q9Y3A5.

    Family and domain databases

    Gene3Di 3.30.1250.10. 1 hit.
    InterProi IPR018978. Ribosome_mat_SBDS_C.
    IPR018023. Ribosome_mat_SBDS_CS.
    IPR019783. Ribosome_mat_SBDS_N.
    IPR002140. Ribosome_maturation_pr_SBDS.
    [Graphical view ]
    PANTHERi PTHR10927. PTHR10927. 1 hit.
    Pfami PF01172. SBDS. 1 hit.
    PF09377. SBDS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89895. SSF89895. 1 hit.
    TIGRFAMsi TIGR00291. RNA_SBDS. 1 hit.
    PROSITEi PS01267. UPF0023. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in SBDS are associated with Shwachman-Diamond syndrome."
      Boocock G.R.B., Morrison J.A., Popovic M., Richards N., Ellis L., Durie P.R., Rommens J.M.
      Nat. Genet. 33:97-101(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SDS LYS-8; GLY-44; GLU-67; SER-87; THR-126; CYS-169 AND THR-212.
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex and Ovarian carcinoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    6. Bienvenut W.V., Claeys D.
      Submitted (NOV-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-19, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Platelet.
    7. "The Shwachman-Diamond SBDS protein localizes to the nucleolus."
      Austin K.M., Leary R.J., Shimamura A.
      Blood 106:1253-1258(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA."
      Ganapathi K.A., Austin K.M., Lee C.S., Dias A., Malsch M.M., Reed R., Shimamura A.
      Blood 110:1458-1465(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NPM1 AND THE 60S RIBOSOMAL SUBUNIT, SUBCELLULAR LOCATION.
    9. "The Shwachman-Bodian-Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels."
      Hesling C., Oliveira C.C., Castilho B.A., Zanchin N.I.
      Exp. Cell Res. 313:4180-4195(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NIP7.
    10. "Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses."
      Ball H.L., Zhang B., Riches J.J., Gandhi R., Li J., Rommens J.M., Myers J.S.
      Hum. Mol. Genet. 18:3684-3695(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA1; PRKDC AND THE 60S RIBOSOME SUBUNIT.
    11. "SBDS expression and localization at the mitotic spindle in human myeloid progenitors."
      Orelio C., Verkuijlen P., Geissler J., van den Berg T.K., Kuijpers T.W.
      PLoS ONE 4:E7084-E7084(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: STRUCTURE BY NMR, RNA-BINDING.
    16. Cited for: STRUCTURE BY NMR, FUNCTION, CHARACTERIZATION OF VARIANT SDS THR-126, MUTAGENESIS OF LYS-151.

    Entry informationi

    Entry nameiSBDS_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3A5
    Secondary accession number(s): A8K0P4, Q96FX0, Q9NV53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3