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Q9Y3A4

- RRP7A_HUMAN

UniProt

Q9Y3A4 - RRP7A_HUMAN

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Protein

Ribosomal RNA-processing protein 7 homolog A

Gene

RRP7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA-processing protein 7 homolog A
Alternative name(s):
Gastric cancer antigen Zg14
Gene namesi
Name:RRP7A
ORF Names:CGI-96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:24286. RRP7A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Ribosomal RNA-processing protein 7 homolog APRO_0000082008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y3A4.
PaxDbiQ9Y3A4.
PRIDEiQ9Y3A4.

PTM databases

PhosphoSiteiQ9Y3A4.

Expressioni

Gene expression databases

BgeeiQ9Y3A4.
CleanExiHS_RRP7A.
ExpressionAtlasiQ9Y3A4. baseline and differential.
GenevestigatoriQ9Y3A4.

Organism-specific databases

HPAiHPA001586.

Interactioni

Protein-protein interaction databases

BioGridi118153. 36 interactions.
IntActiQ9Y3A4. 1 interaction.
MINTiMINT-2823375.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3A4.
SMRiQ9Y3A4. Positions 58-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 9030RRMAdd
BLAST

Sequence similaritiesi

Belongs to the RRP7 family.Curated

Phylogenomic databases

eggNOGiNOG283081.
GeneTreeiENSGT00390000018482.
HOVERGENiHBG054483.
InParanoidiQ9Y3A4.
KOiK14545.
OMAiWEEDKAK.
OrthoDBiEOG71VSTK.
PhylomeDBiQ9Y3A4.
TreeFamiTF313949.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024326. RRP7.
[Graphical view]
PANTHERiPTHR13191. PTHR13191. 1 hit.
PfamiPF12923. RRP7. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y3A4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG
60 70 80 90 100
TKSTWPQKRT LFVLNVPPYC TEESLSRLLS TCGLVQSVEL QEKPDLAESP
110 120 130 140 150
KESRSKFFHP KPVPGFQVAY VVFQKPSGVS AALALKGPLL VSTESHPVKS
160 170 180 190 200
GIHKWISDYA DSVPDPEALR VEVDTFMEAY DQKIAEEEAK AKEEEGVPDE
210 220 230 240 250
EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRSRKELLN FYAWQHRESK
260 270 280
MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY
Length:280
Mass (Da):32,334
Last modified:May 24, 2005 - v2
Checksum:i3625D609B0FF2F76
GO

Sequence cautioni

The sequence AAH31838.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021E → K in BAG37211. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751L → M.
Corresponds to variant rs8139383 [ dbSNP | Ensembl ].
VAR_052227
Natural varianti85 – 851V → I.1 Publication
Corresponds to variant rs1812240 [ dbSNP | Ensembl ].
VAR_052228
Natural varianti88 – 881V → I.
Corresponds to variant rs11553441 [ dbSNP | Ensembl ].
VAR_052229

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022316 Genomic DNA. Translation: CAQ10429.1.
AK314650 mRNA. Translation: BAG37211.1.
BC031838 mRNA. Translation: AAH31838.1. Different initiation.
BC041639 mRNA. Translation: AAH41639.1.
BC042335 mRNA. Translation: AAH42335.1.
BC063537 mRNA. Translation: AAH63537.1.
BC073834 mRNA. Translation: AAH73834.1.
BC121118 mRNA. Translation: AAI21119.1.
BC121119 mRNA. Translation: AAI21120.1.
AY039240 mRNA. Translation: AAK68659.1.
CCDSiCCDS14036.1.
RefSeqiNP_056518.2. NM_015703.4.
UniGeneiHs.745006.

Genome annotation databases

EnsembliENST00000323013; ENSP00000321449; ENSG00000189306.
GeneIDi27341.
KEGGihsa:27341.
UCSCiuc003bcp.3. human.

Polymorphism databases

DMDMi66774227.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022316 Genomic DNA. Translation: CAQ10429.1 .
AK314650 mRNA. Translation: BAG37211.1 .
BC031838 mRNA. Translation: AAH31838.1 . Different initiation.
BC041639 mRNA. Translation: AAH41639.1 .
BC042335 mRNA. Translation: AAH42335.1 .
BC063537 mRNA. Translation: AAH63537.1 .
BC073834 mRNA. Translation: AAH73834.1 .
BC121118 mRNA. Translation: AAI21119.1 .
BC121119 mRNA. Translation: AAI21120.1 .
AY039240 mRNA. Translation: AAK68659.1 .
CCDSi CCDS14036.1.
RefSeqi NP_056518.2. NM_015703.4.
UniGenei Hs.745006.

3D structure databases

ProteinModelPortali Q9Y3A4.
SMRi Q9Y3A4. Positions 58-86.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118153. 36 interactions.
IntActi Q9Y3A4. 1 interaction.
MINTi MINT-2823375.

PTM databases

PhosphoSitei Q9Y3A4.

Polymorphism databases

DMDMi 66774227.

Proteomic databases

MaxQBi Q9Y3A4.
PaxDbi Q9Y3A4.
PRIDEi Q9Y3A4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323013 ; ENSP00000321449 ; ENSG00000189306 .
GeneIDi 27341.
KEGGi hsa:27341.
UCSCi uc003bcp.3. human.

Organism-specific databases

CTDi 27341.
GeneCardsi GC22M042905.
H-InvDB HIX0016543.
HGNCi HGNC:24286. RRP7A.
HPAi HPA001586.
neXtProti NX_Q9Y3A4.
PharmGKBi PA162402175.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283081.
GeneTreei ENSGT00390000018482.
HOVERGENi HBG054483.
InParanoidi Q9Y3A4.
KOi K14545.
OMAi WEEDKAK.
OrthoDBi EOG71VSTK.
PhylomeDBi Q9Y3A4.
TreeFami TF313949.

Miscellaneous databases

GeneWikii CTA-126B4.3.
GenomeRNAii 27341.
NextBioi 50412.
PROi Q9Y3A4.

Gene expression databases

Bgeei Q9Y3A4.
CleanExi HS_RRP7A.
ExpressionAtlasi Q9Y3A4. baseline and differential.
Genevestigatori Q9Y3A4.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024326. RRP7.
[Graphical view ]
PANTHERi PTHR13191. PTHR13191. 1 hit.
Pfami PF12923. RRP7. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-85.
    Tissue: Brain, Duodenum, Liver, Lymph and Uterus.
  5. "Serological identification and expression analysis of gastric cancer-associated genes."
    Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
    Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-280.
    Tissue: Gastric adenocarcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiRRP7A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A4
Secondary accession number(s): A4FTX2
, B2RBG4, Q0VAD0, Q5JZ94, Q6P4B5, Q8IVR9, Q8IVY0, Q8N5Q3, Q8NEY6, Q9Y3H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3