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Q9Y3A4

- RRP7A_HUMAN

UniProt

Q9Y3A4 - RRP7A_HUMAN

Protein

Ribosomal RNA-processing protein 7 homolog A

Gene

RRP7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA-processing protein 7 homolog A
    Alternative name(s):
    Gastric cancer antigen Zg14
    Gene namesi
    Name:RRP7A
    ORF Names:CGI-96
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:24286. RRP7A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162402175.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Ribosomal RNA-processing protein 7 homolog APRO_0000082008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y3A4.
    PaxDbiQ9Y3A4.
    PRIDEiQ9Y3A4.

    PTM databases

    PhosphoSiteiQ9Y3A4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y3A4.
    BgeeiQ9Y3A4.
    CleanExiHS_RRP7A.
    GenevestigatoriQ9Y3A4.

    Organism-specific databases

    HPAiHPA001586.

    Interactioni

    Protein-protein interaction databases

    BioGridi118153. 25 interactions.
    IntActiQ9Y3A4. 1 interaction.
    MINTiMINT-2823375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y3A4.
    SMRiQ9Y3A4. Positions 57-140, 237-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 9030RRMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRP7 family.Curated

    Phylogenomic databases

    eggNOGiNOG283081.
    HOVERGENiHBG054483.
    InParanoidiQ9Y3A4.
    KOiK14545.
    OMAiWEEDKAK.
    OrthoDBiEOG71VSTK.
    PhylomeDBiQ9Y3A4.
    TreeFamiTF313949.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR024326. RRP7.
    [Graphical view]
    PANTHERiPTHR13191. PTHR13191. 1 hit.
    PfamiPF12923. RRP7. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y3A4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG    50
    TKSTWPQKRT LFVLNVPPYC TEESLSRLLS TCGLVQSVEL QEKPDLAESP 100
    KESRSKFFHP KPVPGFQVAY VVFQKPSGVS AALALKGPLL VSTESHPVKS 150
    GIHKWISDYA DSVPDPEALR VEVDTFMEAY DQKIAEEEAK AKEEEGVPDE 200
    EGWVKVTRRG RRPVLPRTEA ASLRVLERER RKRSRKELLN FYAWQHRESK 250
    MEHLAQLRKK FEEDKQRIEL LRAQRKFRPY 280
    Length:280
    Mass (Da):32,334
    Last modified:May 24, 2005 - v2
    Checksum:i3625D609B0FF2F76
    GO

    Sequence cautioni

    The sequence AAH31838.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021E → K in BAG37211. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751L → M.
    Corresponds to variant rs8139383 [ dbSNP | Ensembl ].
    VAR_052227
    Natural varianti85 – 851V → I.1 Publication
    Corresponds to variant rs1812240 [ dbSNP | Ensembl ].
    VAR_052228
    Natural varianti88 – 881V → I.
    Corresponds to variant rs11553441 [ dbSNP | Ensembl ].
    VAR_052229

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022316 Genomic DNA. Translation: CAQ10429.1.
    AK314650 mRNA. Translation: BAG37211.1.
    BC031838 mRNA. Translation: AAH31838.1. Different initiation.
    BC041639 mRNA. Translation: AAH41639.1.
    BC042335 mRNA. Translation: AAH42335.1.
    BC063537 mRNA. Translation: AAH63537.1.
    BC073834 mRNA. Translation: AAH73834.1.
    BC121118 mRNA. Translation: AAI21119.1.
    BC121119 mRNA. Translation: AAI21120.1.
    AY039240 mRNA. Translation: AAK68659.1.
    CCDSiCCDS14036.1.
    RefSeqiNP_056518.2. NM_015703.4.
    UniGeneiHs.745006.

    Genome annotation databases

    EnsembliENST00000323013; ENSP00000321449; ENSG00000189306.
    GeneIDi27341.
    KEGGihsa:27341.
    UCSCiuc003bcp.3. human.

    Polymorphism databases

    DMDMi66774227.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL022316 Genomic DNA. Translation: CAQ10429.1 .
    AK314650 mRNA. Translation: BAG37211.1 .
    BC031838 mRNA. Translation: AAH31838.1 . Different initiation.
    BC041639 mRNA. Translation: AAH41639.1 .
    BC042335 mRNA. Translation: AAH42335.1 .
    BC063537 mRNA. Translation: AAH63537.1 .
    BC073834 mRNA. Translation: AAH73834.1 .
    BC121118 mRNA. Translation: AAI21119.1 .
    BC121119 mRNA. Translation: AAI21120.1 .
    AY039240 mRNA. Translation: AAK68659.1 .
    CCDSi CCDS14036.1.
    RefSeqi NP_056518.2. NM_015703.4.
    UniGenei Hs.745006.

    3D structure databases

    ProteinModelPortali Q9Y3A4.
    SMRi Q9Y3A4. Positions 57-140, 237-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118153. 25 interactions.
    IntActi Q9Y3A4. 1 interaction.
    MINTi MINT-2823375.

    PTM databases

    PhosphoSitei Q9Y3A4.

    Polymorphism databases

    DMDMi 66774227.

    Proteomic databases

    MaxQBi Q9Y3A4.
    PaxDbi Q9Y3A4.
    PRIDEi Q9Y3A4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323013 ; ENSP00000321449 ; ENSG00000189306 .
    GeneIDi 27341.
    KEGGi hsa:27341.
    UCSCi uc003bcp.3. human.

    Organism-specific databases

    CTDi 27341.
    GeneCardsi GC22M042905.
    H-InvDB HIX0016543.
    HGNCi HGNC:24286. RRP7A.
    HPAi HPA001586.
    neXtProti NX_Q9Y3A4.
    PharmGKBi PA162402175.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283081.
    HOVERGENi HBG054483.
    InParanoidi Q9Y3A4.
    KOi K14545.
    OMAi WEEDKAK.
    OrthoDBi EOG71VSTK.
    PhylomeDBi Q9Y3A4.
    TreeFami TF313949.

    Miscellaneous databases

    GeneWikii CTA-126B4.3.
    GenomeRNAii 27341.
    NextBioi 50412.
    PROi Q9Y3A4.

    Gene expression databases

    ArrayExpressi Q9Y3A4.
    Bgeei Q9Y3A4.
    CleanExi HS_RRP7A.
    Genevestigatori Q9Y3A4.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR024326. RRP7.
    [Graphical view ]
    PANTHERi PTHR13191. PTHR13191. 1 hit.
    Pfami PF12923. RRP7. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-85.
      Tissue: Brain, Duodenum, Liver, Lymph and Uterus.
    5. "Serological identification and expression analysis of gastric cancer-associated genes."
      Line A., Stengrevics A., Slucka Z., Li G., Jankevics E., Rees R.C.
      Br. J. Cancer 86:1824-1830(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-280.
      Tissue: Gastric adenocarcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiRRP7A_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y3A4
    Secondary accession number(s): A4FTX2
    , B2RBG4, Q0VAD0, Q5JZ94, Q6P4B5, Q8IVR9, Q8IVY0, Q8N5Q3, Q8NEY6, Q9Y3H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3