Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MOB-like protein phocein

Gene

MOB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in membrane trafficking, specifically in membrane budding reactions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92ZincBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi169ZincBy similarity1
Metal bindingi174ZincBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB-like protein phocein
Alternative name(s):
2C4D
Class II mMOB1
Mob1 homolog 3
Short name:
Mob3
Mps one binder kinase activator-like 3
Preimplantation protein 3
Gene namesi
Name:MOB4
Synonyms:MOB3, MOBKL3, PHOCN, PREI3
ORF Names:CGI-95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115540.14
HGNCiHGNC:17261 MOB4
MIMi609361 gene
neXtProtiNX_Q9Y3A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25843
OpenTargetsiENSG00000115540
PharmGKBiPA162396053

Polymorphism and mutation databases

BioMutaiMOB4
DMDMi56749365

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935761 – 225MOB-like protein phoceinAdd BLAST225

Post-translational modificationi

Phosphorylated on serine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3A3
PaxDbiQ9Y3A3
PeptideAtlasiQ9Y3A3
PRIDEiQ9Y3A3

2D gel databases

OGPiQ9Y3A3

PTM databases

iPTMnetiQ9Y3A3
PhosphoSitePlusiQ9Y3A3
SwissPalmiQ9Y3A3

Expressioni

Gene expression databases

BgeeiENSG00000115540
CleanExiHS_MOBKL3
ExpressionAtlasiQ9Y3A3 baseline and differential
GenevisibleiQ9Y3A3 HS

Organism-specific databases

HPAiCAB034082
HPA044125

Interactioni

Subunit structurei

Binds STRN4 (By similarity). Interacts with DNM1 and EPS15 (By similarity). Interacts with nucleoside diphosphate kinase (By similarity). Binds STRN and STRN3. Part of a ternary complex containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.By similarity2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117369, 90 interactors
CORUMiQ9Y3A3
IntActiQ9Y3A3, 78 interactors
STRINGi9606.ENSP00000315702

Structurei

3D structure databases

ProteinModelPortaliQ9Y3A3
SMRiQ9Y3A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1852 Eukaryota
ENOG410XNS1 LUCA
GeneTreeiENSGT00390000012143
HOVERGENiHBG052490
InParanoidiQ9Y3A3
OrthoDBiEOG091G0IDP
PhylomeDBiQ9Y3A3
TreeFamiTF314078

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3A3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD
60 70 80 90 100
CSNIDKILEP PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM
110 120 130 140 150
TATEQWIFLC AAHKTPKECP AIDYTRHTLD GAACLLNSNK YFPSRVSIKE
160 170 180 190 200
SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE YENETFLCHR FTKFVMKYNL
210 220
MSKDNLIVPI LEEEVQNSVS GESEA
Length:225
Mass (Da):26,032
Last modified:November 1, 1999 - v1
Checksum:iD0EF1219711458BA
GO
Isoform 2 (identifier: Q9Y3A3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,318
Checksum:i37E70D59A5437A7A
GO
Isoform 3 (identifier: Q9Y3A3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-40: Missing.

Show »
Length:204
Mass (Da):23,513
Checksum:i52D1517EA742A30C
GO

Sequence cautioni

The sequence AAP97221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB45697 differs from that shown. Reason: Frameshift at position 168.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90S → G in BAB15635 (PubMed:14702039).Curated1
Sequence conflicti135L → P in CAB45697 (PubMed:11230166).Curated1
Sequence conflicti172F → S in BAB15635 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123031 – 32Missing in isoform 2. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_04109120 – 40Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015441 mRNA Translation: BAB19057.1
AF093825 mRNA Translation: AAP97221.1 Different initiation.
AJ580638 mRNA Translation: CAE45270.1
AF151853 mRNA Translation: AAD34090.1
AF250319 mRNA Translation: AAG44567.1
AL080070 mRNA Translation: CAB45697.1 Frameshift.
AK027043 mRNA Translation: BAB15635.1
AK292938 mRNA Translation: BAF85627.1
AK297514 mRNA Translation: BAG59922.1
CR457371 mRNA Translation: CAG33652.1
AC020550 Genomic DNA Translation: AAX93147.1
CH471063 Genomic DNA Translation: EAW70164.1
CH471063 Genomic DNA Translation: EAW70167.1
BC005237 mRNA Translation: AAH05237.1
CCDSiCCDS2321.1 [Q9Y3A3-1]
CCDS2322.1 [Q9Y3A3-2]
CCDS46480.1 [Q9Y3A3-3]
PIRiT12466
RefSeqiNP_001094289.1, NM_001100819.2 [Q9Y3A3-3]
NP_001191023.1, NM_001204094.1 [Q9Y3A3-2]
NP_056202.2, NM_015387.4 [Q9Y3A3-1]
NP_955776.1, NM_199482.3 [Q9Y3A3-2]
UniGeneiHs.633165

Genome annotation databases

EnsembliENST00000233892; ENSP00000233892; ENSG00000115540 [Q9Y3A3-2]
ENST00000323303; ENSP00000315702; ENSG00000115540 [Q9Y3A3-1]
ENST00000409360; ENSP00000387289; ENSG00000115540 [Q9Y3A3-2]
ENST00000448447; ENSP00000405354; ENSG00000115540 [Q9Y3A3-3]
GeneIDi25843
KEGGihsa:25843
UCSCiuc002uum.4 human [Q9Y3A3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHOCN_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A3
Secondary accession number(s): B4DML0
, Q53SE0, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y4T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health