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Protein

Probable U3 small nucleolar RNA-associated protein 11

Gene

UTP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • nervous system development Source: HGNC
  • positive regulation of apoptotic process Source: BHF-UCL
  • ribosomal small subunit biogenesis Source: GO_Central
  • rRNA processing Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable U3 small nucleolar RNA-associated protein 11
Short name:
U3 snoRNA-associated protein 11
Alternative name(s):
UTP11-like protein
Gene namesi
Name:UTP11Imported
Synonyms:UTP11LImported
ORF Names:CGI-94, HDCMB12P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24329. UTP11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • extracellular space Source: BHF-UCL
  • nucleolus Source: BHF-UCL
  • nucleoplasm Source: Reactome
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670630.

Polymorphism and mutation databases

BioMutaiUTP11L.
DMDMi29611911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Probable U3 small nucleolar RNA-associated protein 11PRO_0000211042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphothreonineCombined sources
Cross-linki103 – 103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei241 – 2411PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y3A2.
MaxQBiQ9Y3A2.
PaxDbiQ9Y3A2.
PeptideAtlasiQ9Y3A2.
PRIDEiQ9Y3A2.

PTM databases

iPTMnetiQ9Y3A2.
PhosphoSiteiQ9Y3A2.

Expressioni

Gene expression databases

BgeeiENSG00000183520.
CleanExiHS_UTP11L.
GenevisibleiQ9Y3A2. HS.

Organism-specific databases

HPAiHPA045830.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-2876697,EBI-739624

Protein-protein interaction databases

BioGridi119306. 11 interactions.
IntActiQ9Y3A2. 3 interactions.
MINTiMINT-3085511.
STRINGi9606.ENSP00000362105.

Structurei

3D structure databases

ProteinModelPortaliQ9Y3A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UTP11 family.Curated

Phylogenomic databases

eggNOGiKOG3237. Eukaryota.
COG5223. LUCA.
GeneTreeiENSGT00390000005813.
HOGENOMiHOG000231076.
HOVERGENiHBG057139.
InParanoidiQ9Y3A2.
KOiK14769.
OMAiGFRKHLG.
OrthoDBiEOG091G0H14.
PhylomeDBiQ9Y3A2.
TreeFamiTF314171.

Family and domain databases

InterProiIPR007144. SSU_processome_Utp11.
[Graphical view]
PANTHERiPTHR12838. PTHR12838. 1 hit.
PfamiPF03998. Utp11. 1 hit.
[Graphical view]
PIRSFiPIRSF015952. U3snoRNP11. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y3A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAFRKAAK SRQREHRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY
60 70 80 90 100
LKALRKKALE KNPDEFYYKM TRVKLQDGVH IIKETKEEVT PEQLKLMRTQ
110 120 130 140 150
DVKYIEMKRV AEAKKIERLK SELHLLDFQG KQQNKHVFFF DTKKEVEQFD
160 170 180 190 200
VATHLQTAPE LVDRVFNRPR IETLQKEKVK GVTNQTGLKR IAKERQKQYN
210 220 230 240 250
CLTQRIEREK KLFVIAQKIQ TRKDLMDKTQ KVKVKKETVN SPAIYKFQSR

RKR
Length:253
Mass (Da):30,447
Last modified:April 4, 2003 - v2
Checksum:iD005AD09E96E7FA4
GO
Isoform 2 (identifier: Q9Y3A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-253: VEQFDVATHL...IYKFQSRRKR → ANS

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,869
Checksum:iCCC12EAD8FF3A044
GO

Sequence cautioni

The sequence AAF75562 differs from that shown. Reason: Frameshift at position 14. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211Q → E in AAD34089 (PubMed:10810093).Curated
Sequence conflicti241 – 2411S → F in AAF75562 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 253108VEQFD…SRRKR → ANS in isoform 2. 1 PublicationVSP_056872Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151852 mRNA. Translation: AAD34089.1.
AF067802 mRNA. Translation: AAF75562.1. Frameshift.
AK291900 mRNA. Translation: BAF84589.1.
AK296018 mRNA. Translation: BAG58788.1.
AL603790 Genomic DNA. Translation: CAH69932.1.
CH471059 Genomic DNA. Translation: EAX07299.1.
CH471059 Genomic DNA. Translation: EAX07300.1.
BC005182 mRNA. Translation: AAH05182.1.
CCDSiCCDS429.1. [Q9Y3A2-1]
RefSeqiNP_057121.2. NM_016037.3. [Q9Y3A2-1]
UniGeneiHs.472038.
Hs.637686.

Genome annotation databases

EnsembliENST00000373014; ENSP00000362105; ENSG00000183520. [Q9Y3A2-1]
GeneIDi51118.
KEGGihsa:51118.
UCSCiuc001ccn.5. human. [Q9Y3A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151852 mRNA. Translation: AAD34089.1.
AF067802 mRNA. Translation: AAF75562.1. Frameshift.
AK291900 mRNA. Translation: BAF84589.1.
AK296018 mRNA. Translation: BAG58788.1.
AL603790 Genomic DNA. Translation: CAH69932.1.
CH471059 Genomic DNA. Translation: EAX07299.1.
CH471059 Genomic DNA. Translation: EAX07300.1.
BC005182 mRNA. Translation: AAH05182.1.
CCDSiCCDS429.1. [Q9Y3A2-1]
RefSeqiNP_057121.2. NM_016037.3. [Q9Y3A2-1]
UniGeneiHs.472038.
Hs.637686.

3D structure databases

ProteinModelPortaliQ9Y3A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119306. 11 interactions.
IntActiQ9Y3A2. 3 interactions.
MINTiMINT-3085511.
STRINGi9606.ENSP00000362105.

PTM databases

iPTMnetiQ9Y3A2.
PhosphoSiteiQ9Y3A2.

Polymorphism and mutation databases

BioMutaiUTP11L.
DMDMi29611911.

Proteomic databases

EPDiQ9Y3A2.
MaxQBiQ9Y3A2.
PaxDbiQ9Y3A2.
PeptideAtlasiQ9Y3A2.
PRIDEiQ9Y3A2.

Protocols and materials databases

DNASUi51118.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373014; ENSP00000362105; ENSG00000183520. [Q9Y3A2-1]
GeneIDi51118.
KEGGihsa:51118.
UCSCiuc001ccn.5. human. [Q9Y3A2-1]

Organism-specific databases

CTDi51118.
GeneCardsiUTP11L.
HGNCiHGNC:24329. UTP11.
HPAiHPA045830.
MIMi609440. gene.
neXtProtiNX_Q9Y3A2.
PharmGKBiPA142670630.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3237. Eukaryota.
COG5223. LUCA.
GeneTreeiENSGT00390000005813.
HOGENOMiHOG000231076.
HOVERGENiHBG057139.
InParanoidiQ9Y3A2.
KOiK14769.
OMAiGFRKHLG.
OrthoDBiEOG091G0H14.
PhylomeDBiQ9Y3A2.
TreeFamiTF314171.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiUTP11L. human.
GeneWikiiUTP11L.
GenomeRNAii51118.
PROiQ9Y3A2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183520.
CleanExiHS_UTP11L.
GenevisibleiQ9Y3A2. HS.

Family and domain databases

InterProiIPR007144. SSU_processome_Utp11.
[Graphical view]
PANTHERiPTHR12838. PTHR12838. 1 hit.
PfamiPF03998. Utp11. 1 hit.
[Graphical view]
PIRSFiPIRSF015952. U3snoRNP11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUTP11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3A2
Secondary accession number(s): A8K785
, B4DJC6, D3DPT7, Q5VT93, Q9BS98, Q9NS31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.