Q9Y399 (RT02_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S2, mitochondrial
Short name=MRP-S2
Short name=S2mt

Gene names

Name:	MRPS2
ORF Names:	CGI-91

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.5.
Sequence similarities	Belongs to the ribosomal protein S2P family. Ref.5
Sequence caution	The sequence AAH04905.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	28S ribosomal protein S2, mitochondrial		PRO_0000134343
Natural variations
	Natural variant	112	1	D → G. Corresponds to variant rs35140806 [ dbSNP | Ensembl ].		VAR_034479
	Natural variant	158	1	M → V. Corresponds to variant rs35293407 [ dbSNP | Ensembl ].		VAR_034480
	Natural variant	294	1	H → R. Corresponds to variant rs3748199 [ dbSNP | Ensembl ].		VAR_020128

Sequences

	Sequence		Length	Mass (Da)
	Q9Y399 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E05A248B09AA1A8B	FASTA	296	33,249
	10 20 30 40 50 60 MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR ESEDSTDFND 70 80 90 100 110 120 KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR FMEPYIFGSR LDHDIIDLEQ 130 140 150 160 170 180 TATHLQLALN FTAHMAYRKG IILFISRNRQ FSYLIENMAR DCGEYAHTRY FRGGMLTNAR 190 200 210 220 230 240 LLFGPTVRLP DLIIFLHTLN NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND 250 260 270 280 290 DSPLAVHLYC RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Lung and Skin.
[5]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB055388 mRNA. Translation: BAB62529.1. AF151849 mRNA. Translation: AAD34086.1. AL161452 Genomic DNA. Translation: CAI14047.1. BC004905 mRNA. Translation: AAH04905.2. Sequence problems. BC008017 mRNA. Translation: AAH08017.1. BC013108 mRNA. Translation: AAH13108.1.
IPI	IPI00006970.
RefSeq	NP_057118.1. NM_016034.4.
UniGene	Hs.382044.
3D structure databases
ProteinModelPortal	Q9Y399.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y399. 3 interactions.
STRING	9606.ENSP00000241600.
PTM databases
PhosphoSite	Q9Y399.
Polymorphism databases
DMDM	24212389.
Proteomic databases
PaxDb	Q9Y399.
PRIDE	Q9Y399.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000241600; ENSP00000241600; ENSG00000122140. ENST00000371785; ENSP00000360850; ENSG00000122140.
GeneID	51116.
KEGG	hsa:51116.
UCSC	uc004cfv.4. human.
Organism-specific databases
CTD	51116.
GeneCards	GC09P138391.
H-InvDB	HIX0035038.
HGNC	HGNC:14495. MRPS2.
MIM	611971. gene.
neXtProt	NX_Q9Y399.
PharmGKB	PA31007.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0052.
HOGENOM	HOG000071892.
HOVERGEN	HBG028633.
InParanoid	Q9Y399.
KO	K02967.
OrthoDB	EOG4XWFZM.
PhylomeDB	Q9Y399.
Gene expression databases
ArrayExpress	Q9Y399.
Bgee	Q9Y399.
CleanEx	HS_MRPS2.
Genevestigator	Q9Y399.
GermOnline	ENSG00000122140. Homo sapiens.
Family and domain databases
InterPro	IPR001865. Ribosomal_S2. IPR005706. Ribosomal_S2_bac/mit/plastid. IPR018130. Ribosomal_S2_CS. IPR023591. Ribosomal_S2_flav_dom. [Graphical view]
PANTHER	PTHR12534. PTHR12534. 1 hit.
Pfam	PF00318. Ribosomal_S2. 2 hits. [Graphical view]
PRINTS	PR00395. RIBOSOMALS2.
SUPFAM	SSF52313. Ribosomal_S2. 1 hit.
PROSITE	PS00962. RIBOSOMAL_S2_1. 1 hit. PS00963. RIBOSOMAL_S2_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51116.
NextBio	53885.
SOURCE	Search...

Entry information

Entry name

RT02_HUMAN

Accession

Primary (citable) accession number: Q9Y399
Secondary accession number(s): Q5T899, Q9BSQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.