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Q9Y399

- RT02_HUMAN

UniProt

Q9Y399 - RT02_HUMAN

Protein

28S ribosomal protein S2, mitochondrial

Gene

MRPS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S2, mitochondrial
    Short name:
    MRP-S2
    Short name:
    S2mt
    Gene namesi
    Name:MRPS2
    ORF Names:CGI-91
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:14495. MRPS2.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. small ribosomal subunit Source: InterPro

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31007.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29629628S ribosomal protein S2, mitochondrialPRO_0000134343Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y399.
    PaxDbiQ9Y399.
    PRIDEiQ9Y399.

    PTM databases

    PhosphoSiteiQ9Y399.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y399.
    BgeeiQ9Y399.
    CleanExiHS_MRPS2.
    GenevestigatoriQ9Y399.

    Organism-specific databases

    HPAiHPA029487.
    HPA057261.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi119304. 14 interactions.
    IntActiQ9Y399. 4 interactions.
    MINTiMINT-3085473.
    STRINGi9606.ENSP00000241600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y399.
    SMRiQ9Y399. Positions 81-249.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S2P family.1 Publication

    Phylogenomic databases

    eggNOGiCOG0052.
    HOGENOMiHOG000071892.
    HOVERGENiHBG028633.
    InParanoidiQ9Y399.
    KOiK02967.
    OrthoDBiEOG7T4MKX.
    PhylomeDBiQ9Y399.
    TreeFamiTF313480.

    Family and domain databases

    HAMAPiMF_00291_B. Ribosomal_S2_B.
    InterProiIPR001865. Ribosomal_S2.
    IPR005706. Ribosomal_S2_bac/mit/plastid.
    IPR018130. Ribosomal_S2_CS.
    IPR023591. Ribosomal_S2_flav_dom.
    [Graphical view]
    PANTHERiPTHR12534. PTHR12534. 1 hit.
    PfamiPF00318. Ribosomal_S2. 2 hits.
    [Graphical view]
    PRINTSiPR00395. RIBOSOMALS2.
    SUPFAMiSSF52313. SSF52313. 1 hit.
    PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y399-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR    50
    ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR 100
    FMEPYIFGSR LDHDIIDLEQ TATHLQLALN FTAHMAYRKG IILFISRNRQ 150
    FSYLIENMAR DCGEYAHTRY FRGGMLTNAR LLFGPTVRLP DLIIFLHTLN 200
    NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND DSPLAVHLYC 250
    RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL 296
    Length:296
    Mass (Da):33,249
    Last modified:November 1, 1999 - v1
    Checksum:iE05A248B09AA1A8B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121D → G.
    Corresponds to variant rs35140806 [ dbSNP | Ensembl ].
    VAR_034479
    Natural varianti158 – 1581M → V.
    Corresponds to variant rs35293407 [ dbSNP | Ensembl ].
    VAR_034480
    Natural varianti294 – 2941H → R.
    Corresponds to variant rs3748199 [ dbSNP | Ensembl ].
    VAR_020128

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055388 mRNA. Translation: BAB62529.1.
    AF151849 mRNA. Translation: AAD34086.1.
    AL161452 Genomic DNA. Translation: CAI14047.1.
    BC004905 mRNA. Translation: AAH04905.2. Sequence problems.
    BC008017 mRNA. Translation: AAH08017.1.
    BC013108 mRNA. Translation: AAH13108.1.
    CCDSiCCDS6990.1.
    RefSeqiNP_057118.1. NM_016034.4.
    UniGeneiHs.382044.

    Genome annotation databases

    EnsembliENST00000241600; ENSP00000241600; ENSG00000122140.
    ENST00000371785; ENSP00000360850; ENSG00000122140.
    GeneIDi51116.
    KEGGihsa:51116.
    UCSCiuc004cfv.5. human.

    Polymorphism databases

    DMDMi24212389.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB055388 mRNA. Translation: BAB62529.1 .
    AF151849 mRNA. Translation: AAD34086.1 .
    AL161452 Genomic DNA. Translation: CAI14047.1 .
    BC004905 mRNA. Translation: AAH04905.2 . Sequence problems.
    BC008017 mRNA. Translation: AAH08017.1 .
    BC013108 mRNA. Translation: AAH13108.1 .
    CCDSi CCDS6990.1.
    RefSeqi NP_057118.1. NM_016034.4.
    UniGenei Hs.382044.

    3D structure databases

    ProteinModelPortali Q9Y399.
    SMRi Q9Y399. Positions 81-249.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119304. 14 interactions.
    IntActi Q9Y399. 4 interactions.
    MINTi MINT-3085473.
    STRINGi 9606.ENSP00000241600.

    PTM databases

    PhosphoSitei Q9Y399.

    Polymorphism databases

    DMDMi 24212389.

    Proteomic databases

    MaxQBi Q9Y399.
    PaxDbi Q9Y399.
    PRIDEi Q9Y399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241600 ; ENSP00000241600 ; ENSG00000122140 .
    ENST00000371785 ; ENSP00000360850 ; ENSG00000122140 .
    GeneIDi 51116.
    KEGGi hsa:51116.
    UCSCi uc004cfv.5. human.

    Organism-specific databases

    CTDi 51116.
    GeneCardsi GC09P138391.
    H-InvDB HIX0035038.
    HGNCi HGNC:14495. MRPS2.
    HPAi HPA029487.
    HPA057261.
    MIMi 611971. gene.
    neXtProti NX_Q9Y399.
    PharmGKBi PA31007.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0052.
    HOGENOMi HOG000071892.
    HOVERGENi HBG028633.
    InParanoidi Q9Y399.
    KOi K02967.
    OrthoDBi EOG7T4MKX.
    PhylomeDBi Q9Y399.
    TreeFami TF313480.

    Miscellaneous databases

    GenomeRNAii 51116.
    NextBioi 53885.
    PROi Q9Y399.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y399.
    Bgeei Q9Y399.
    CleanExi HS_MRPS2.
    Genevestigatori Q9Y399.

    Family and domain databases

    HAMAPi MF_00291_B. Ribosomal_S2_B.
    InterProi IPR001865. Ribosomal_S2.
    IPR005706. Ribosomal_S2_bac/mit/plastid.
    IPR018130. Ribosomal_S2_CS.
    IPR023591. Ribosomal_S2_flav_dom.
    [Graphical view ]
    PANTHERi PTHR12534. PTHR12534. 1 hit.
    Pfami PF00318. Ribosomal_S2. 2 hits.
    [Graphical view ]
    PRINTSi PR00395. RIBOSOMALS2.
    SUPFAMi SSF52313. SSF52313. 1 hit.
    PROSITEi PS00962. RIBOSOMAL_S2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Lung and Skin.
    5. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT02_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y399
    Secondary accession number(s): Q5T899, Q9BSQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3