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Protein

28S ribosomal protein S2, mitochondrial

Gene

MRPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • translation Source: GO_Central
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S2, mitochondrial
Short name:
MRP-S2
Short name:
S2mt
Gene namesi
Name:MRPS2
ORF Names:CGI-91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14495. MRPS2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial small ribosomal subunit Source: UniProtKB
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31007.

Polymorphism and mutation databases

BioMutaiMRPS2.
DMDMi24212389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29629628S ribosomal protein S2, mitochondrialPRO_0000134343Add
BLAST

Proteomic databases

EPDiQ9Y399.
MaxQBiQ9Y399.
PaxDbiQ9Y399.
PeptideAtlasiQ9Y399.
PRIDEiQ9Y399.

PTM databases

iPTMnetiQ9Y399.
PhosphoSiteiQ9Y399.

Expressioni

Gene expression databases

BgeeiENSG00000122140.
CleanExiHS_MRPS2.
ExpressionAtlasiQ9Y399. baseline and differential.
GenevisibleiQ9Y399. HS.

Organism-specific databases

HPAiHPA029487.
HPA057261.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119304. 55 interactions.
IntActiQ9Y399. 13 interactions.
MINTiMINT-3085473.
STRINGi9606.ENSP00000241600.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AB1-296[»]
ProteinModelPortaliQ9Y399.
SMRiQ9Y399. Positions 57-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S2P family.1 Publication

Phylogenomic databases

eggNOGiKOG0832. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000017382.
HOGENOMiHOG000071892.
HOVERGENiHBG028633.
InParanoidiQ9Y399.
KOiK02967.
OrthoDBiEOG091G0NYD.
PhylomeDBiQ9Y399.
TreeFamiTF313480.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_00291_B. Ribosomal_S2_B. 1 hit.
InterProiIPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR12534. PTHR12534. 1 hit.
PfamiPF00318. Ribosomal_S2. 2 hits.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR
60 70 80 90 100
ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR
110 120 130 140 150
FMEPYIFGSR LDHDIIDLEQ TATHLQLALN FTAHMAYRKG IILFISRNRQ
160 170 180 190 200
FSYLIENMAR DCGEYAHTRY FRGGMLTNAR LLFGPTVRLP DLIIFLHTLN
210 220 230 240 250
NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND DSPLAVHLYC
260 270 280 290
RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL
Length:296
Mass (Da):33,249
Last modified:November 1, 1999 - v1
Checksum:iE05A248B09AA1A8B
GO

Sequence cautioni

The sequence AAH04905 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121D → G.
Corresponds to variant rs35140806 [ dbSNP | Ensembl ].
VAR_034479
Natural varianti158 – 1581M → V.
Corresponds to variant rs35293407 [ dbSNP | Ensembl ].
VAR_034480
Natural varianti294 – 2941H → R.
Corresponds to variant rs3748199 [ dbSNP | Ensembl ].
VAR_020128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055388 mRNA. Translation: BAB62529.1.
AF151849 mRNA. Translation: AAD34086.1.
AL161452 Genomic DNA. Translation: CAI14047.1.
BC004905 mRNA. Translation: AAH04905.2. Sequence problems.
BC008017 mRNA. Translation: AAH08017.1.
BC013108 mRNA. Translation: AAH13108.1.
CCDSiCCDS6990.1.
RefSeqiNP_057118.1. NM_016034.4.
UniGeneiHs.382044.

Genome annotation databases

EnsembliENST00000241600; ENSP00000241600; ENSG00000122140.
ENST00000371785; ENSP00000360850; ENSG00000122140.
GeneIDi51116.
KEGGihsa:51116.
UCSCiuc004cfv.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055388 mRNA. Translation: BAB62529.1.
AF151849 mRNA. Translation: AAD34086.1.
AL161452 Genomic DNA. Translation: CAI14047.1.
BC004905 mRNA. Translation: AAH04905.2. Sequence problems.
BC008017 mRNA. Translation: AAH08017.1.
BC013108 mRNA. Translation: AAH13108.1.
CCDSiCCDS6990.1.
RefSeqiNP_057118.1. NM_016034.4.
UniGeneiHs.382044.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AB1-296[»]
ProteinModelPortaliQ9Y399.
SMRiQ9Y399. Positions 57-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119304. 55 interactions.
IntActiQ9Y399. 13 interactions.
MINTiMINT-3085473.
STRINGi9606.ENSP00000241600.

PTM databases

iPTMnetiQ9Y399.
PhosphoSiteiQ9Y399.

Polymorphism and mutation databases

BioMutaiMRPS2.
DMDMi24212389.

Proteomic databases

EPDiQ9Y399.
MaxQBiQ9Y399.
PaxDbiQ9Y399.
PeptideAtlasiQ9Y399.
PRIDEiQ9Y399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241600; ENSP00000241600; ENSG00000122140.
ENST00000371785; ENSP00000360850; ENSG00000122140.
GeneIDi51116.
KEGGihsa:51116.
UCSCiuc004cfv.6. human.

Organism-specific databases

CTDi51116.
GeneCardsiMRPS2.
H-InvDBHIX0035038.
HGNCiHGNC:14495. MRPS2.
HPAiHPA029487.
HPA057261.
MIMi611971. gene.
neXtProtiNX_Q9Y399.
PharmGKBiPA31007.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0832. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000017382.
HOGENOMiHOG000071892.
HOVERGENiHBG028633.
InParanoidiQ9Y399.
KOiK02967.
OrthoDBiEOG091G0NYD.
PhylomeDBiQ9Y399.
TreeFamiTF313480.

Miscellaneous databases

ChiTaRSiMRPS2. human.
GenomeRNAii51116.
PROiQ9Y399.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122140.
CleanExiHS_MRPS2.
ExpressionAtlasiQ9Y399. baseline and differential.
GenevisibleiQ9Y399. HS.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_00291_B. Ribosomal_S2_B. 1 hit.
InterProiIPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR12534. PTHR12534. 1 hit.
PfamiPF00318. Ribosomal_S2. 2 hits.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT02_HUMAN
AccessioniPrimary (citable) accession number: Q9Y399
Secondary accession number(s): Q5T899, Q9BSQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.