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Q9Y399

- RT02_HUMAN

UniProt

Q9Y399 - RT02_HUMAN

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Protein

28S ribosomal protein S2, mitochondrial

Gene
MRPS2, CGI-91
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S2, mitochondrial
Short name:
MRP-S2
Short name:
S2mt
Gene namesi
Name:MRPS2
ORF Names:CGI-91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14495. MRPS2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. small ribosomal subunit Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29629628S ribosomal protein S2, mitochondrialUniRule annotationPRO_0000134343Add
BLAST

Proteomic databases

MaxQBiQ9Y399.
PaxDbiQ9Y399.
PRIDEiQ9Y399.

PTM databases

PhosphoSiteiQ9Y399.

Expressioni

Gene expression databases

ArrayExpressiQ9Y399.
BgeeiQ9Y399.
CleanExiHS_MRPS2.
GenevestigatoriQ9Y399.

Organism-specific databases

HPAiHPA029487.
HPA057261.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119304. 14 interactions.
IntActiQ9Y399. 4 interactions.
MINTiMINT-3085473.
STRINGi9606.ENSP00000241600.

Structurei

3D structure databases

ProteinModelPortaliQ9Y399.
SMRiQ9Y399. Positions 81-249.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0052.
HOGENOMiHOG000071892.
HOVERGENiHBG028633.
InParanoidiQ9Y399.
KOiK02967.
OrthoDBiEOG7T4MKX.
PhylomeDBiQ9Y399.
TreeFamiTF313480.

Family and domain databases

HAMAPiMF_00291_B. Ribosomal_S2_B.
InterProiIPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view]
PANTHERiPTHR12534. PTHR12534. 1 hit.
PfamiPF00318. Ribosomal_S2. 2 hits.
[Graphical view]
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
PROSITEiPS00962. RIBOSOMAL_S2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y399-1 [UniParc]FASTAAdd to Basket

« Hide

MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR    50
ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR 100
FMEPYIFGSR LDHDIIDLEQ TATHLQLALN FTAHMAYRKG IILFISRNRQ 150
FSYLIENMAR DCGEYAHTRY FRGGMLTNAR LLFGPTVRLP DLIIFLHTLN 200
NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND DSPLAVHLYC 250
RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL 296
Length:296
Mass (Da):33,249
Last modified:November 1, 1999 - v1
Checksum:iE05A248B09AA1A8B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121D → G.
Corresponds to variant rs35140806 [ dbSNP | Ensembl ].
VAR_034479
Natural varianti158 – 1581M → V.
Corresponds to variant rs35293407 [ dbSNP | Ensembl ].
VAR_034480
Natural varianti294 – 2941H → R.
Corresponds to variant rs3748199 [ dbSNP | Ensembl ].
VAR_020128

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055388 mRNA. Translation: BAB62529.1.
AF151849 mRNA. Translation: AAD34086.1.
AL161452 Genomic DNA. Translation: CAI14047.1.
BC004905 mRNA. Translation: AAH04905.2. Sequence problems.
BC008017 mRNA. Translation: AAH08017.1.
BC013108 mRNA. Translation: AAH13108.1.
CCDSiCCDS6990.1.
RefSeqiNP_057118.1. NM_016034.4.
UniGeneiHs.382044.

Genome annotation databases

EnsembliENST00000241600; ENSP00000241600; ENSG00000122140.
ENST00000371785; ENSP00000360850; ENSG00000122140.
GeneIDi51116.
KEGGihsa:51116.
UCSCiuc004cfv.5. human.

Polymorphism databases

DMDMi24212389.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB055388 mRNA. Translation: BAB62529.1 .
AF151849 mRNA. Translation: AAD34086.1 .
AL161452 Genomic DNA. Translation: CAI14047.1 .
BC004905 mRNA. Translation: AAH04905.2 . Sequence problems.
BC008017 mRNA. Translation: AAH08017.1 .
BC013108 mRNA. Translation: AAH13108.1 .
CCDSi CCDS6990.1.
RefSeqi NP_057118.1. NM_016034.4.
UniGenei Hs.382044.

3D structure databases

ProteinModelPortali Q9Y399.
SMRi Q9Y399. Positions 81-249.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119304. 14 interactions.
IntActi Q9Y399. 4 interactions.
MINTi MINT-3085473.
STRINGi 9606.ENSP00000241600.

PTM databases

PhosphoSitei Q9Y399.

Polymorphism databases

DMDMi 24212389.

Proteomic databases

MaxQBi Q9Y399.
PaxDbi Q9Y399.
PRIDEi Q9Y399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000241600 ; ENSP00000241600 ; ENSG00000122140 .
ENST00000371785 ; ENSP00000360850 ; ENSG00000122140 .
GeneIDi 51116.
KEGGi hsa:51116.
UCSCi uc004cfv.5. human.

Organism-specific databases

CTDi 51116.
GeneCardsi GC09P138391.
H-InvDB HIX0035038.
HGNCi HGNC:14495. MRPS2.
HPAi HPA029487.
HPA057261.
MIMi 611971. gene.
neXtProti NX_Q9Y399.
PharmGKBi PA31007.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0052.
HOGENOMi HOG000071892.
HOVERGENi HBG028633.
InParanoidi Q9Y399.
KOi K02967.
OrthoDBi EOG7T4MKX.
PhylomeDBi Q9Y399.
TreeFami TF313480.

Miscellaneous databases

GenomeRNAii 51116.
NextBioi 53885.
PROi Q9Y399.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y399.
Bgeei Q9Y399.
CleanExi HS_MRPS2.
Genevestigatori Q9Y399.

Family and domain databases

HAMAPi MF_00291_B. Ribosomal_S2_B.
InterProi IPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
[Graphical view ]
PANTHERi PTHR12534. PTHR12534. 1 hit.
Pfami PF00318. Ribosomal_S2. 2 hits.
[Graphical view ]
PRINTSi PR00395. RIBOSOMALS2.
SUPFAMi SSF52313. SSF52313. 1 hit.
PROSITEi PS00962. RIBOSOMAL_S2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Lung and Skin.
  5. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT02_HUMAN
AccessioniPrimary (citable) accession number: Q9Y399
Secondary accession number(s): Q5T899, Q9BSQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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