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Protein

28S ribosomal protein S2, mitochondrial

Gene

MRPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S2, mitochondrial
Short name:
MRP-S2
Short name:
S2mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS2m1 Publication
Gene namesi
Name:MRPS2
ORF Names:CGI-91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122140.10.
HGNCiHGNC:14495. MRPS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122140.
PharmGKBiPA31007.

Polymorphism and mutation databases

BioMutaiMRPS2.
DMDMi24212389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001343431 – 29628S ribosomal protein S2, mitochondrialAdd BLAST296

Proteomic databases

EPDiQ9Y399.
MaxQBiQ9Y399.
PaxDbiQ9Y399.
PeptideAtlasiQ9Y399.
PRIDEiQ9Y399.

PTM databases

iPTMnetiQ9Y399.
PhosphoSitePlusiQ9Y399.

Expressioni

Gene expression databases

BgeeiENSG00000122140.
CleanExiHS_MRPS2.
ExpressionAtlasiQ9Y399. baseline and differential.
GenevisibleiQ9Y399. HS.

Organism-specific databases

HPAiHPA029487.
HPA057261.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119304. 61 interactors.
CORUMiQ9Y399.
IntActiQ9Y399. 16 interactors.
MINTiMINT-3085473.
STRINGi9606.ENSP00000241600.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AB1-296[»]
ProteinModelPortaliQ9Y399.
SMRiQ9Y399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0832. Eukaryota.
COG0052. LUCA.
GeneTreeiENSGT00390000017382.
HOGENOMiHOG000071892.
HOVERGENiHBG028633.
InParanoidiQ9Y399.
KOiK02967.
OrthoDBiEOG091G0NYD.
PhylomeDBiQ9Y399.
TreeFamiTF313480.

Family and domain databases

CDDicd01425. RPS2. 1 hit.
HAMAPiMF_00291_B. Ribosomal_S2_B. 1 hit.
InterProiView protein in InterPro
IPR001865. Ribosomal_S2.
IPR005706. Ribosomal_S2_bac/mit/plastid.
IPR018130. Ribosomal_S2_CS.
IPR023591. Ribosomal_S2_flav_dom.
PANTHERiPTHR12534. PTHR12534. 1 hit.
PfamiView protein in Pfam
PF00318. Ribosomal_S2. 2 hits.
PRINTSiPR00395. RIBOSOMALS2.
SUPFAMiSSF52313. SSF52313. 1 hit.
PROSITEiView protein in PROSITE
PS00962. RIBOSOMAL_S2_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSAALPR ILGAGARAPS RWLGFLGKAT PRPARPSRRT LGSATALMIR
60 70 80 90 100
ESEDSTDFND KILNEPLKHS DFFNVKELFS VRSLFDARVH LGHKAGCRHR
110 120 130 140 150
FMEPYIFGSR LDHDIIDLEQ TATHLQLALN FTAHMAYRKG IILFISRNRQ
160 170 180 190 200
FSYLIENMAR DCGEYAHTRY FRGGMLTNAR LLFGPTVRLP DLIIFLHTLN
210 220 230 240 250
NIFEPHVAVR DAAKMNIPTV GIVDTNCNPC LITYPVPGND DSPLAVHLYC
260 270 280 290
RLFQTAITRA KEKRQQVEAL YRLQGQKEPG DQGPAHPPGA DMSHSL
Length:296
Mass (Da):33,249
Last modified:November 1, 1999 - v1
Checksum:iE05A248B09AA1A8B
GO

Sequence cautioni

The sequence AAH04905 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034479112D → G. Corresponds to variant dbSNP:rs35140806Ensembl.1
Natural variantiVAR_034480158M → V. Corresponds to variant dbSNP:rs35293407Ensembl.1
Natural variantiVAR_020128294H → R. Corresponds to variant dbSNP:rs3748199Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055388 mRNA. Translation: BAB62529.1.
AF151849 mRNA. Translation: AAD34086.1.
AL161452 Genomic DNA. No translation available.
BC004905 mRNA. Translation: AAH04905.2. Sequence problems.
BC008017 mRNA. Translation: AAH08017.1.
BC013108 mRNA. Translation: AAH13108.1.
CCDSiCCDS6990.1.
RefSeqiNP_057118.1. NM_016034.4.
UniGeneiHs.382044.

Genome annotation databases

EnsembliENST00000241600; ENSP00000241600; ENSG00000122140.
ENST00000371785; ENSP00000360850; ENSG00000122140.
GeneIDi51116.
KEGGihsa:51116.
UCSCiuc004cfv.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT02_HUMAN
AccessioniPrimary (citable) accession number: Q9Y399
Secondary accession number(s): Q5T899, Q9BSQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families