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Q9Y394

- DHRS7_HUMAN

UniProt

Q9Y394 - DHRS7_HUMAN

Protein

Dehydrogenase/reductase SDR family member 7

Gene

DHRS7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei190 – 1901SubstrateBy similarity
    Active sitei203 – 2031Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 7825NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-)
    Alternative name(s):
    Retinal short-chain dehydrogenase/reductase 4
    Short name:
    retSDR4
    Gene namesi
    Name:DHRS7
    Synonyms:DHRS7A, RETSDR4
    ORF Names:CGI-86, UNQ285/PRO3448
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:21524. DHRS7.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134974539.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 339311Dehydrogenase/reductase SDR family member 7PRO_0000031968Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y394.
    PaxDbiQ9Y394.
    PRIDEiQ9Y394.

    PTM databases

    PhosphoSiteiQ9Y394.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y394.
    BgeeiQ9Y394.
    CleanExiHS_DHRS7.
    GenevestigatoriQ9Y394.

    Organism-specific databases

    HPAiHPA031121.

    Interactioni

    Protein-protein interaction databases

    BioGridi119649. 2 interactions.
    IntActiQ9Y394. 5 interactions.
    STRINGi9606.ENSP00000216500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y394.
    SMRiQ9Y394. Positions 19-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0300.
    HOVERGENiHBG054346.
    KOiK11165.
    OrthoDBiEOG7W6WM5.
    PhylomeDBiQ9Y394.
    TreeFamiTF354276.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y394-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD    50
    MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL 100
    KEKDILVLPL DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT 150
    SLDVYRKLIE LNYLGTVSLT KCVLPHMIER KQGKIVTVNS ILGIISVPLS 200
    IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN IVENSLAGEV 250
    TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY 300
    MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD 339
    Length:339
    Mass (Da):38,299
    Last modified:November 1, 1999 - v1
    Checksum:i7B251CE5894ED70C
    GO
    Isoform 2 (identifier: Q9Y394-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:289
    Mass (Da):32,268
    Checksum:i051AF9154FB0DEDF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181R → Q.
    Corresponds to variant rs34583017 [ dbSNP | Ensembl ].
    VAR_052319

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5050Missing in isoform 2. 1 PublicationVSP_008103Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151844 mRNA. Translation: AAD34081.1.
    AF126782 mRNA. Translation: AAF06941.1.
    AY359031 mRNA. Translation: AAQ89390.1.
    AK313285 mRNA. Translation: BAG36093.1.
    AL163853 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80770.1.
    BC000637 mRNA. Translation: AAH00637.1.
    BC007337 mRNA. Translation: AAH07337.1.
    CCDSiCCDS9743.1. [Q9Y394-1]
    RefSeqiNP_057113.1. NM_016029.2. [Q9Y394-1]
    UniGeneiHs.59719.

    Genome annotation databases

    EnsembliENST00000216500; ENSP00000216500; ENSG00000100612. [Q9Y394-1]
    ENST00000536410; ENSP00000442993; ENSG00000100612. [Q9Y394-2]
    ENST00000557185; ENSP00000451882; ENSG00000100612. [Q9Y394-1]
    GeneIDi51635.
    KEGGihsa:51635.
    UCSCiuc001xes.3. human. [Q9Y394-1]

    Polymorphism databases

    DMDMi34395856.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151844 mRNA. Translation: AAD34081.1 .
    AF126782 mRNA. Translation: AAF06941.1 .
    AY359031 mRNA. Translation: AAQ89390.1 .
    AK313285 mRNA. Translation: BAG36093.1 .
    AL163853 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80770.1 .
    BC000637 mRNA. Translation: AAH00637.1 .
    BC007337 mRNA. Translation: AAH07337.1 .
    CCDSi CCDS9743.1. [Q9Y394-1 ]
    RefSeqi NP_057113.1. NM_016029.2. [Q9Y394-1 ]
    UniGenei Hs.59719.

    3D structure databases

    ProteinModelPortali Q9Y394.
    SMRi Q9Y394. Positions 19-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119649. 2 interactions.
    IntActi Q9Y394. 5 interactions.
    STRINGi 9606.ENSP00000216500.

    PTM databases

    PhosphoSitei Q9Y394.

    Polymorphism databases

    DMDMi 34395856.

    Proteomic databases

    MaxQBi Q9Y394.
    PaxDbi Q9Y394.
    PRIDEi Q9Y394.

    Protocols and materials databases

    DNASUi 51635.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216500 ; ENSP00000216500 ; ENSG00000100612 . [Q9Y394-1 ]
    ENST00000536410 ; ENSP00000442993 ; ENSG00000100612 . [Q9Y394-2 ]
    ENST00000557185 ; ENSP00000451882 ; ENSG00000100612 . [Q9Y394-1 ]
    GeneIDi 51635.
    KEGGi hsa:51635.
    UCSCi uc001xes.3. human. [Q9Y394-1 ]

    Organism-specific databases

    CTDi 51635.
    GeneCardsi GC14M060610.
    H-InvDB HIX0011708.
    HGNCi HGNC:21524. DHRS7.
    HPAi HPA031121.
    MIMi 612833. gene.
    neXtProti NX_Q9Y394.
    PharmGKBi PA134974539.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0300.
    HOVERGENi HBG054346.
    KOi K11165.
    OrthoDBi EOG7W6WM5.
    PhylomeDBi Q9Y394.
    TreeFami TF354276.

    Miscellaneous databases

    GenomeRNAii 51635.
    NextBioi 55569.
    PROi Q9Y394.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y394.
    Bgeei Q9Y394.
    CleanExi HS_DHRS7.
    Genevestigatori Q9Y394.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Short-chain dehydrogenases/reductases in retina."
      Haeseleer F., Palczewski K.
      Methods Enzymol. 316:372-383(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
      Tissue: Retina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Skin.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDHRS7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y394
    Secondary accession number(s): B2R896, Q9UKU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3