Q9Y394 (DHRS7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dehydrogenase/reductase SDR family member 7
EC=1.1.-.-

Alternative name(s):
Retinal short-chain dehydrogenase/reductase 4
Short name=retSDR4

Gene names

Name:	DHRS7
Synonyms:	DHRS7A, RETSDR4
ORF Names:	CGI-86, UNQ285/PRO3448

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y394-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y394-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 339	311	Dehydrogenase/reductase SDR family member 7		PRO_0000031968
Regions
	Nucleotide binding	54 – 78	25	NAD By similarity
Sites
	Active site	203	1	Proton acceptor By similarity
	Binding site	190	1	Substrate By similarity
Natural variations
	Alternative sequence	1 – 50	50	Missing in isoform 2.		VSP_008103
	Natural variant	218	1	R → Q. Corresponds to variant rs34583017 [ dbSNP | Ensembl ].		VAR_052319

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7B251CE5894ED70C	FASTA	339	38,299
	10 20 30 40 50 60 MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD MVVWVTGASS 70 80 90 100 110 120 GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL KEKDILVLPL DLTDTGSHEA 130 140 150 160 170 180 ATKAVLQEFG RIDILVNNGG MSQRSLCMDT SLDVYRKLIE LNYLGTVSLT KCVLPHMIER 190 200 210 220 230 240 KQGKIVTVNS ILGIISVPLS IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN 250 260 270 280 290 300 IVENSLAGEV TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY 310 320 330 MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD
	Isoform 2 [UniParc]. Checksum: 051AF9154FB0DEDF	FASTA	289	32,268
	10 20 30 40 50 60 MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL KEKDILVLPL 70 80 90 100 110 120 DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT SLDVYRKLIE LNYLGTVSLT 130 140 150 160 170 180 KCVLPHMIER KQGKIVTVNS ILGIISVPLS IGYCASKHAL RGFFNGLRTE LATYPGIIVS 190 200 210 220 230 240 NICPGPVQSN IVENSLAGEV TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP 250 260 270 280 FLLVTYLWQY MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Short-chain dehydrogenases/reductases in retina." Haeseleer F., Palczewski K. Methods Enzymol. 316:372-383(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). Tissue: Retina.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skeletal muscle.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Skin.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151844 mRNA. Translation: AAD34081.1. AF126782 mRNA. Translation: AAF06941.1. AY359031 mRNA. Translation: AAQ89390.1. AK313285 mRNA. Translation: BAG36093.1. AL163853 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW80770.1. BC000637 mRNA. Translation: AAH00637.1. BC007337 mRNA. Translation: AAH07337.1.
IPI	IPI00006957. IPI00339238.
RefSeq	NP_057113.1. NM_016029.2.
UniGene	Hs.59719.
3D structure databases
ProteinModelPortal	Q9Y394.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y394. 5 interactions.
STRING	9606.ENSP00000216500.
PTM databases
PhosphoSite	Q9Y394.
Polymorphism databases
DMDM	34395856.
Proteomic databases
PaxDb	Q9Y394.
PRIDE	Q9Y394.
Protocols and materials databases
DNASU	51635.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216500; ENSP00000216500; ENSG00000100612. ENST00000536410; ENSP00000442993; ENSG00000100612. ENST00000557185; ENSP00000451882; ENSG00000100612.
GeneID	51635.
KEGG	hsa:51635.
UCSC	uc001xes.3. human.
Organism-specific databases
CTD	51635.
GeneCards	GC14M060610.
H-InvDB	HIX0011708.
HGNC	HGNC:21524. DHRS7.
HPA	HPA031121.
MIM	612833. gene.
neXtProt	NX_Q9Y394.
PharmGKB	PA134974539.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0300.
HOVERGEN	HBG054346.
KO	K11165.
OrthoDB	EOG47PX6D.
PhylomeDB	Q9Y394.
Gene expression databases
ArrayExpress	Q9Y394.
Bgee	Q9Y394.
CleanEx	HS_DHRS7.
Genevestigator	Q9Y394.
GermOnline	ENSG00000100612. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PIRSF	PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51635.
NextBio	55569.
SOURCE	Search...

Entry information

Entry name

DHRS7_HUMAN

Accession

Primary (citable) accession number: Q9Y394
Secondary accession number(s): B2R896, Q9UKU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.