Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dehydrogenase/reductase SDR family member 7

Gene

DHRS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190SubstrateBy similarity1
Active sitei203Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 78NADBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 4
Short name:
retSDR4
Short chain dehydrogenase/reductase family 34C member 1
Gene namesi
Name:DHRS7
Synonyms:DHRS7A, RETSDR4, SDR34C1
ORF Names:CGI-86, UNQ285/PRO3448
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100612.13
HGNCiHGNC:21524 DHRS7
MIMi612833 gene
neXtProtiNX_Q9Y394

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi51635
OpenTargetsiENSG00000100612
PharmGKBiPA134974539

Polymorphism and mutation databases

BioMutaiDHRS7
DMDMi34395856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003196829 – 339Dehydrogenase/reductase SDR family member 7Add BLAST311

Proteomic databases

EPDiQ9Y394
PaxDbiQ9Y394
PeptideAtlasiQ9Y394
PRIDEiQ9Y394
ProteomicsDBi85986
85987 [Q9Y394-2]

PTM databases

iPTMnetiQ9Y394
PhosphoSitePlusiQ9Y394
SwissPalmiQ9Y394

Expressioni

Gene expression databases

BgeeiENSG00000100612
CleanExiHS_DHRS7
ExpressionAtlasiQ9Y394 baseline and differential
GenevisibleiQ9Y394 HS

Organism-specific databases

HPAiHPA031121

Interactioni

Protein-protein interaction databases

BioGridi119649, 42 interactors
IntActiQ9Y394, 12 interactors
MINTiQ9Y394
STRINGi9606.ENSP00000216500

Structurei

3D structure databases

ProteinModelPortaliQ9Y394
SMRiQ9Y394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUBT Eukaryota
COG0300 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG054346
InParanoidiQ9Y394
KOiK11165
PhylomeDBiQ9Y394
TreeFamiTF354276

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y394-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWELLLWLL VLCALLLLLV QLLRFLRADG DLTLLWAEWQ GRRPEWELTD
60 70 80 90 100
MVVWVTGASS GIGEELAYQL SKLGVSLVLS ARRVHELERV KRRCLENGNL
110 120 130 140 150
KEKDILVLPL DLTDTGSHEA ATKAVLQEFG RIDILVNNGG MSQRSLCMDT
160 170 180 190 200
SLDVYRKLIE LNYLGTVSLT KCVLPHMIER KQGKIVTVNS ILGIISVPLS
210 220 230 240 250
IGYCASKHAL RGFFNGLRTE LATYPGIIVS NICPGPVQSN IVENSLAGEV
260 270 280 290 300
TKTIGNNGDQ SHKMTTSRCV RLMLISMAND LKEVWISEQP FLLVTYLWQY
310 320 330
MPTWAWWITN KMGKKRIENF KSGVDADSSY FKIFKTKHD
Length:339
Mass (Da):38,299
Last modified:November 1, 1999 - v1
Checksum:i7B251CE5894ED70C
GO
Isoform 2 (identifier: Q9Y394-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):32,268
Checksum:i051AF9154FB0DEDF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052319218R → Q. Corresponds to variant dbSNP:rs34583017Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0081031 – 50Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151844 mRNA Translation: AAD34081.1
AF126782 mRNA Translation: AAF06941.1
AY359031 mRNA Translation: AAQ89390.1
AK313285 mRNA Translation: BAG36093.1
AL163853 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80770.1
BC000637 mRNA Translation: AAH00637.1
BC007337 mRNA Translation: AAH07337.1
CCDSiCCDS81810.1 [Q9Y394-2]
CCDS9743.1 [Q9Y394-1]
RefSeqiNP_001309209.1, NM_001322280.1 [Q9Y394-2]
NP_057113.1, NM_016029.3 [Q9Y394-1]
UniGeneiHs.59719

Genome annotation databases

EnsembliENST00000216500; ENSP00000216500; ENSG00000100612 [Q9Y394-1]
ENST00000536410; ENSP00000442993; ENSG00000100612 [Q9Y394-2]
ENST00000557185; ENSP00000451882; ENSG00000100612 [Q9Y394-1]
GeneIDi51635
KEGGihsa:51635
UCSCiuc001xes.5 human [Q9Y394-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDHRS7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y394
Secondary accession number(s): B2R896, Q9UKU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health