Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y383

- LC7L2_HUMAN

UniProt

Q9Y383 - LC7L2_HUMAN

Protein

Putative RNA-binding protein Luc7-like 2

Gene

LUC7L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May bind to RNA via its Arg/Ser-rich domain.

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. mRNA binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA splice site selection Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Gene namesi
    Name:LUC7L2
    ORF Names:CGI-59, CGI-74
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21608. LUC7L2.

    Subcellular locationi

    Nucleus speckle By similarity. Nucleusnucleoplasm By similarity
    Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. U1 snRNP Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi266 – 2661K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. 1 Publication
    Mutagenesisi269 – 2691K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. 1 Publication

    Organism-specific databases

    PharmGKBiPA134873425.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Putative RNA-binding protein Luc7-like 2PRO_0000187282Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 26615-hydroxylysine; by JMJD61 Publication
    Modified residuei269 – 26915-hydroxylysine; by JMJD61 Publication

    Keywords - PTMi

    Hydroxylation

    Proteomic databases

    MaxQBiQ9Y383.
    PaxDbiQ9Y383.
    PRIDEiQ9Y383.

    PTM databases

    PhosphoSiteiQ9Y383.

    Miscellaneous databases

    PMAP-CutDBQ9Y383.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y383.
    BgeeiQ9Y383.
    CleanExiHS_LUC7L2.
    GenevestigatoriQ9Y383.

    Interactioni

    Subunit structurei

    Interacts with SCNM1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAP1LC3BQ9GZQ83EBI-352851,EBI-373144
    SRPK1Q96SB42EBI-352851,EBI-539478
    SRPK2P783622EBI-352851,EBI-593303

    Protein-protein interaction databases

    BioGridi119646. 88 interactions.
    DIPiDIP-32513N.
    IntActiQ9Y383. 49 interactions.
    MINTiMINT-5006732.
    STRINGi9606.ENSP00000347005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili102 – 17776Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi239 – 388150Arg/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Luc7 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5200.
    HOVERGENiHBG062167.
    InParanoidiQ9Y383.
    KOiK13212.
    PhylomeDBiQ9Y383.
    TreeFamiTF317607.

    Family and domain databases

    InterProiIPR004882. Luc7-rel.
    [Graphical view]
    PANTHERiPTHR12375. PTHR12375. 1 hit.
    PfamiPF03194. LUC7. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y383-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS    50
    GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR 100
    TEVAKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE 150
    ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH 200
    DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER 250
    EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR 300
    HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR 350
    DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI 392
    Length:392
    Mass (Da):46,514
    Last modified:May 10, 2004 - v2
    Checksum:i1C559CCE0F23F693
    GO
    Isoform 2 (identifier: Q9Y383-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-21: MSAQAQMRAMLDQLMGTSRDG → MPAYLNLQGSVRKAPHSPSR

    Note: No experimental confirmation available.

    Show »
    Length:391
    Mass (Da):46,425
    Checksum:i68FBCFE447A3E0E5
    GO
    Isoform 3 (identifier: Q9Y383-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MSAQAQMRAMLDQLMGTSRD → MVIHSQLKKIQGASERM

    Note: No experimental confirmation available.

    Show »
    Length:389
    Mass (Da):46,229
    Checksum:iA58A74530C83E98E
    GO

    Sequence cautioni

    The sequence AAD34069.1 differs from that shown. Reason: Frameshift at position 388.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271R → Q in BAA91737. (PubMed:14702039)Curated
    Sequence conflicti389 – 3902AG → QR in AAD34054. (PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti361 – 3611D → E.
    Corresponds to variant rs3757435 [ dbSNP | Ensembl ].
    VAR_034067

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2121MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2. 1 PublicationVSP_010217Add
    BLAST
    Alternative sequencei1 – 2020MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3. 1 PublicationVSP_044896Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151817 mRNA. Translation: AAD34054.1.
    AF151832 mRNA. Translation: AAD34069.1. Frameshift.
    AK001476 mRNA. Translation: BAA91713.1.
    AK001519 mRNA. Translation: BAA91737.1.
    AK022895 mRNA. Translation: BAB14297.1.
    AK298166 mRNA. Translation: BAH12736.1.
    BC017163 mRNA. Translation: AAH17163.1.
    BC042625 mRNA. Translation: AAH42625.1.
    BC050708 mRNA. Translation: AAH50708.1.
    BC056886 mRNA. Translation: AAH56886.1.
    CCDSiCCDS43656.1. [Q9Y383-1]
    CCDS59085.1. [Q9Y383-3]
    CCDS59510.1. [Q9Y383-2]
    RefSeqiNP_001231514.1. NM_001244585.1. [Q9Y383-3]
    NP_001257572.1. NM_001270643.1. [Q9Y383-2]
    NP_057103.2. NM_016019.4. [Q9Y383-1]
    UniGeneiHs.731488.

    Genome annotation databases

    GeneIDi51631.
    KEGGihsa:51631.
    UCSCiuc003vux.4. human. [Q9Y383-1]
    uc003vuy.4. human. [Q9Y383-2]
    uc011kqs.2. human.

    Polymorphism databases

    DMDMi47116960.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151817 mRNA. Translation: AAD34054.1 .
    AF151832 mRNA. Translation: AAD34069.1 . Frameshift.
    AK001476 mRNA. Translation: BAA91713.1 .
    AK001519 mRNA. Translation: BAA91737.1 .
    AK022895 mRNA. Translation: BAB14297.1 .
    AK298166 mRNA. Translation: BAH12736.1 .
    BC017163 mRNA. Translation: AAH17163.1 .
    BC042625 mRNA. Translation: AAH42625.1 .
    BC050708 mRNA. Translation: AAH50708.1 .
    BC056886 mRNA. Translation: AAH56886.1 .
    CCDSi CCDS43656.1. [Q9Y383-1 ]
    CCDS59085.1. [Q9Y383-3 ]
    CCDS59510.1. [Q9Y383-2 ]
    RefSeqi NP_001231514.1. NM_001244585.1. [Q9Y383-3 ]
    NP_001257572.1. NM_001270643.1. [Q9Y383-2 ]
    NP_057103.2. NM_016019.4. [Q9Y383-1 ]
    UniGenei Hs.731488.

    3D structure databases

    ProteinModelPortali Q9Y383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119646. 88 interactions.
    DIPi DIP-32513N.
    IntActi Q9Y383. 49 interactions.
    MINTi MINT-5006732.
    STRINGi 9606.ENSP00000347005.

    PTM databases

    PhosphoSitei Q9Y383.

    Polymorphism databases

    DMDMi 47116960.

    Proteomic databases

    MaxQBi Q9Y383.
    PaxDbi Q9Y383.
    PRIDEi Q9Y383.

    Protocols and materials databases

    DNASUi 51631.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 51631.
    KEGGi hsa:51631.
    UCSCi uc003vux.4. human. [Q9Y383-1 ]
    uc003vuy.4. human. [Q9Y383-2 ]
    uc011kqs.2. human.

    Organism-specific databases

    CTDi 51631.
    GeneCardsi GC07P139026.
    GC07P139036.
    HGNCi HGNC:21608. LUC7L2.
    MIMi 613056. gene.
    neXtProti NX_Q9Y383.
    PharmGKBi PA134873425.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5200.
    HOVERGENi HBG062167.
    InParanoidi Q9Y383.
    KOi K13212.
    PhylomeDBi Q9Y383.
    TreeFami TF317607.

    Miscellaneous databases

    ChiTaRSi LUC7L2. human.
    GeneWikii LUC7L2.
    GenomeRNAii 51631.
    NextBioi 55557.
    PMAP-CutDB Q9Y383.
    PROi Q9Y383.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y383.
    Bgeei Q9Y383.
    CleanExi HS_LUC7L2.
    Genevestigatori Q9Y383.

    Family and domain databases

    InterProi IPR004882. Luc7-rel.
    [Graphical view ]
    PANTHERi PTHR12375. PTHR12375. 1 hit.
    Pfami PF03194. LUC7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Skin and Uterus.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: HYDROXYLATION AT LYS-266 AND LYS-269, MUTAGENESIS OF LYS-266 AND LYS-269.

    Entry informationi

    Entry nameiLC7L2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y383
    Secondary accession number(s): B7Z500
    , Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3