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Q9Y383 (LC7L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative RNA-binding protein Luc7-like 2
Gene names
Name:LUC7L2
ORF Names:CGI-59, CGI-74
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind to RNA via its Arg/Ser-rich domain.

Subunit structure

Interacts with SCNM1 By similarity.

Subcellular location

Nucleus speckle By similarity. Nucleusnucleoplasm By similarity. Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles By similarity.

Sequence similarities

Belongs to the Luc7 family.

Sequence caution

The sequence AAD34069.1 differs from that shown. Reason: Frameshift at position 388.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   PTMHydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA splice site selection

Inferred from electronic annotation. Source: InterPro

   Cellular_componentU1 snRNP

Inferred from electronic annotation. Source: InterPro

nuclear speck

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionenzyme binding

Inferred from physical interaction Ref.6. Source: UniProtKB

mRNA binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y383-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y383-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSAQAQMRAMLDQLMGTSRDG → MPAYLNLQGSVRKAPHSPSR
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9Y383-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRAMLDQLMGTSRD → MVIHSQLKKIQGASERM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Putative RNA-binding protein Luc7-like 2
PRO_0000187282

Regions

Coiled coil102 – 17776 Potential
Compositional bias239 – 388150Arg/Ser-rich

Amino acid modifications

Modified residue26615-hydroxylysine; by JMJD6 Ref.6
Modified residue26915-hydroxylysine; by JMJD6 Ref.6

Natural variations

Alternative sequence1 – 2121MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2.
VSP_010217
Alternative sequence1 – 2020MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3.
VSP_044896
Natural variant3611D → E.
Corresponds to variant rs3757435 [ dbSNP | Ensembl ].
VAR_034067

Experimental info

Mutagenesis2661K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. Ref.6
Mutagenesis2691K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. Ref.6
Sequence conflict271R → Q in BAA91737. Ref.2
Sequence conflict389 – 3902AG → QR in AAD34054. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 1C559CCE0F23F693

FASTA39246,514
        10         20         30         40         50         60 
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS GTRMDLGECL 

        70         80         90        100        110        120 
KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR TEVAKKRLAE TQEEISAEVA 

       130        140        150        160        170        180 
AKAERVHELN EEIGKLLAKV EQLGAEGNVE ESQKVMDEVE KARAKKREAE EVYRNSMPAS 

       190        200        210        220        230        240 
SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN 

       250        260        270        280        290        300 
QERLKRREER EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR 

       310        320        330        340        350        360 
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR DRSSRDRSPR 

       370        380        390 
DRDRKDKKRS YESANGRSED RRSSEEREAG EI 

« Hide

Isoform 2 [UniParc].

Checksum: 68FBCFE447A3E0E5
Show »

FASTA39146,425
Isoform 3 [UniParc].

Checksum: A58A74530C83E98E
Show »

FASTA38946,229

References

« Hide 'large scale' references
[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Skin and Uterus.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing."
Webby C.J., Wolf A., Gromak N., Dreger M., Kramer H., Kessler B., Nielsen M.L., Schmitz C., Butler D.S., Yates J.R. III, Delahunty C.M., Hahn P., Lengeling A., Mann M., Proudfoot N.J., Schofield C.J., Boettger A.
Science 325:90-93(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: HYDROXYLATION AT LYS-266 AND LYS-269, MUTAGENESIS OF LYS-266 AND LYS-269.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151817 mRNA. Translation: AAD34054.1.
AF151832 mRNA. Translation: AAD34069.1. Frameshift.
AK001476 mRNA. Translation: BAA91713.1.
AK001519 mRNA. Translation: BAA91737.1.
AK022895 mRNA. Translation: BAB14297.1.
AK298166 mRNA. Translation: BAH12736.1.
BC017163 mRNA. Translation: AAH17163.1.
BC042625 mRNA. Translation: AAH42625.1.
BC050708 mRNA. Translation: AAH50708.1.
BC056886 mRNA. Translation: AAH56886.1.
RefSeqNP_001231514.1. NM_001244585.1.
NP_001257572.1. NM_001270643.1.
NP_057103.2. NM_016019.4.
UniGeneHs.731488.

3D structure databases

ProteinModelPortalQ9Y383.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119646. 82 interactions.
DIPDIP-32513N.
IntActQ9Y383. 48 interactions.
MINTMINT-5006732.
STRING9606.ENSP00000347005.

PTM databases

PhosphoSiteQ9Y383.

Polymorphism databases

DMDM47116960.

Proteomic databases

PaxDbQ9Y383.
PRIDEQ9Y383.

Protocols and materials databases

DNASU51631.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID51631.
KEGGhsa:51631.
UCSCuc003vux.4. human. [Q9Y383-1]
uc003vuy.4. human. [Q9Y383-2]
uc011kqs.2. human.

Organism-specific databases

CTD51631.
GeneCardsGC07P139026.
GC07P139036.
HGNCHGNC:21608. LUC7L2.
MIM613056. gene.
neXtProtNX_Q9Y383.
PharmGKBPA134873425.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5200.
HOVERGENHBG062167.
InParanoidQ9Y383.
KOK13212.
PhylomeDBQ9Y383.
TreeFamTF317607.

Gene expression databases

ArrayExpressQ9Y383.
BgeeQ9Y383.
CleanExHS_LUC7L2.
GenevestigatorQ9Y383.

Family and domain databases

InterProIPR004882. Luc7-rel.
[Graphical view]
PANTHERPTHR12375. PTHR12375. 1 hit.
PfamPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLUC7L2. human.
GeneWikiLUC7L2.
GenomeRNAi51631.
NextBio55557.
PMAP-CutDBQ9Y383.
PROQ9Y383.
SOURCESearch...

Entry information

Entry nameLC7L2_HUMAN
AccessionPrimary (citable) accession number: Q9Y383
Secondary accession number(s): B7Z500 expand/collapse secondary AC list , Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: April 16, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM