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Protein

Putative RNA-binding protein Luc7-like 2

Gene

LUC7L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. mRNA binding Source: InterPro
  3. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA splice site selection Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 2
Gene namesi
Name:LUC7L2
ORF Names:CGI-59, CGI-74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:21608. LUC7L2.

Subcellular locationi

Nucleus speckle By similarity. Nucleusnucleoplasm By similarity
Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.By similarity

GO - Cellular componenti

  1. nuclear speck Source: UniProtKB-SubCell
  2. U1 snRNP Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi266 – 2661K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. 1 Publication
Mutagenesisi269 – 2691K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. 1 Publication

Organism-specific databases

PharmGKBiPA134873425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Putative RNA-binding protein Luc7-like 2PRO_0000187282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 26615-hydroxylysine; by JMJD61 Publication
Modified residuei269 – 26915-hydroxylysine; by JMJD61 Publication

Keywords - PTMi

Hydroxylation

Proteomic databases

MaxQBiQ9Y383.
PaxDbiQ9Y383.
PRIDEiQ9Y383.

PTM databases

PhosphoSiteiQ9Y383.

Miscellaneous databases

PMAP-CutDBQ9Y383.

Expressioni

Gene expression databases

BgeeiQ9Y383.
CleanExiHS_LUC7L2.
ExpressionAtlasiQ9Y383. baseline and differential.
GenevestigatoriQ9Y383.

Organism-specific databases

HPAiHPA051631.

Interactioni

Subunit structurei

Interacts with SCNM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP1LC3BQ9GZQ83EBI-352851,EBI-373144
SRPK1Q96SB42EBI-352851,EBI-539478
SRPK2P783622EBI-352851,EBI-593303

Protein-protein interaction databases

BioGridi119646. 148 interactions.
DIPiDIP-32513N.
IntActiQ9Y383. 49 interactions.
MINTiMINT-5006732.
STRINGi9606.ENSP00000347005.

Structurei

3D structure databases

ProteinModelPortaliQ9Y383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili102 – 17776Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi239 – 388150Arg/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5200.
GeneTreeiENSGT00730000110670.
HOVERGENiHBG062167.
InParanoidiQ9Y383.
KOiK13212.
PhylomeDBiQ9Y383.
TreeFamiTF317607.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y383-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVAKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Length:392
Mass (Da):46,514
Last modified:May 10, 2004 - v2
Checksum:i1C559CCE0F23F693
GO
Isoform 2 (identifier: Q9Y383-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSAQAQMRAMLDQLMGTSRDG → MPAYLNLQGSVRKAPHSPSR

Note: No experimental confirmation available.

Show »
Length:391
Mass (Da):46,425
Checksum:i68FBCFE447A3E0E5
GO
Isoform 3 (identifier: Q9Y383-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRAMLDQLMGTSRD → MVIHSQLKKIQGASERM

Note: No experimental confirmation available.

Show »
Length:389
Mass (Da):46,229
Checksum:iA58A74530C83E98E
GO

Sequence cautioni

The sequence AAD34069.1 differs from that shown. Reason: Frameshift at position 388. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271R → Q in BAA91737 (PubMed:14702039).Curated
Sequence conflicti389 – 3902AG → QR in AAD34054 (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti361 – 3611D → E.
Corresponds to variant rs3757435 [ dbSNP | Ensembl ].
VAR_034067

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2. 1 PublicationVSP_010217Add
BLAST
Alternative sequencei1 – 2020MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3. 1 PublicationVSP_044896Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA. Translation: AAD34054.1.
AF151832 mRNA. Translation: AAD34069.1. Frameshift.
AK001476 mRNA. Translation: BAA91713.1.
AK001519 mRNA. Translation: BAA91737.1.
AK022895 mRNA. Translation: BAB14297.1.
AK298166 mRNA. Translation: BAH12736.1.
BC017163 mRNA. Translation: AAH17163.1.
BC042625 mRNA. Translation: AAH42625.1.
BC050708 mRNA. Translation: AAH50708.1.
BC056886 mRNA. Translation: AAH56886.1.
CCDSiCCDS43656.1. [Q9Y383-1]
CCDS59085.1. [Q9Y383-3]
CCDS59510.1. [Q9Y383-2]
RefSeqiNP_001231514.1. NM_001244585.1. [Q9Y383-3]
NP_001257572.1. NM_001270643.1. [Q9Y383-2]
NP_057103.2. NM_016019.4. [Q9Y383-1]
UniGeneiHs.731488.

Genome annotation databases

GeneIDi51631.
KEGGihsa:51631.
UCSCiuc003vux.4. human. [Q9Y383-1]
uc003vuy.4. human. [Q9Y383-2]
uc011kqs.2. human.

Polymorphism databases

DMDMi47116960.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA. Translation: AAD34054.1.
AF151832 mRNA. Translation: AAD34069.1. Frameshift.
AK001476 mRNA. Translation: BAA91713.1.
AK001519 mRNA. Translation: BAA91737.1.
AK022895 mRNA. Translation: BAB14297.1.
AK298166 mRNA. Translation: BAH12736.1.
BC017163 mRNA. Translation: AAH17163.1.
BC042625 mRNA. Translation: AAH42625.1.
BC050708 mRNA. Translation: AAH50708.1.
BC056886 mRNA. Translation: AAH56886.1.
CCDSiCCDS43656.1. [Q9Y383-1]
CCDS59085.1. [Q9Y383-3]
CCDS59510.1. [Q9Y383-2]
RefSeqiNP_001231514.1. NM_001244585.1. [Q9Y383-3]
NP_001257572.1. NM_001270643.1. [Q9Y383-2]
NP_057103.2. NM_016019.4. [Q9Y383-1]
UniGeneiHs.731488.

3D structure databases

ProteinModelPortaliQ9Y383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119646. 148 interactions.
DIPiDIP-32513N.
IntActiQ9Y383. 49 interactions.
MINTiMINT-5006732.
STRINGi9606.ENSP00000347005.

PTM databases

PhosphoSiteiQ9Y383.

Polymorphism databases

DMDMi47116960.

Proteomic databases

MaxQBiQ9Y383.
PaxDbiQ9Y383.
PRIDEiQ9Y383.

Protocols and materials databases

DNASUi51631.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51631.
KEGGihsa:51631.
UCSCiuc003vux.4. human. [Q9Y383-1]
uc003vuy.4. human. [Q9Y383-2]
uc011kqs.2. human.

Organism-specific databases

CTDi51631.
GeneCardsiGC07P139026.
GC07P139041.
HGNCiHGNC:21608. LUC7L2.
HPAiHPA051631.
MIMi613056. gene.
neXtProtiNX_Q9Y383.
PharmGKBiPA134873425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5200.
GeneTreeiENSGT00730000110670.
HOVERGENiHBG062167.
InParanoidiQ9Y383.
KOiK13212.
PhylomeDBiQ9Y383.
TreeFamiTF317607.

Miscellaneous databases

ChiTaRSiLUC7L2. human.
GeneWikiiLUC7L2.
GenomeRNAii51631.
NextBioi55557.
PMAP-CutDBQ9Y383.
PROiQ9Y383.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y383.
CleanExiHS_LUC7L2.
ExpressionAtlasiQ9Y383. baseline and differential.
GenevestigatoriQ9Y383.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Skin and Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: HYDROXYLATION AT LYS-266 AND LYS-269, MUTAGENESIS OF LYS-266 AND LYS-269.

Entry informationi

Entry nameiLC7L2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y383
Secondary accession number(s): B7Z500
, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: March 4, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.