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Protein

Putative RNA-binding protein Luc7-like 2

Gene

LUC7L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May bind to RNA via its Arg/Ser-rich domain.

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • mRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein Luc7-like 2
Gene namesi
Name:LUC7L2
ORF Names:CGI-59, CGI-74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21608. LUC7L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi266K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-269. 1 Publication1
Mutagenesisi269K → R: Induces a decrease in lysyl-hydroxylation. Abolishes lysyl-hydroxylation; when associated with R-266. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000146963.
PharmGKBiPA134873425.

Polymorphism and mutation databases

BioMutaiLUC7L2.
DMDMi47116960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872821 – 392Putative RNA-binding protein Luc7-like 2Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei2665-hydroxylysine; by JMJD61 Publication1
Modified residuei2695-hydroxylysine; by JMJD61 Publication1

Keywords - PTMi

Hydroxylation, Phosphoprotein

Proteomic databases

EPDiQ9Y383.
PaxDbiQ9Y383.
PeptideAtlasiQ9Y383.
PRIDEiQ9Y383.

PTM databases

iPTMnetiQ9Y383.
PhosphoSitePlusiQ9Y383.
SwissPalmiQ9Y383.

Miscellaneous databases

PMAP-CutDBQ9Y383.

Expressioni

Gene expression databases

BgeeiENSG00000146963.
CleanExiHS_LUC7L2.
ExpressionAtlasiQ9Y383. baseline and differential.
GenevisibleiQ9Y383. HS.

Organism-specific databases

HPAiHPA051631.

Interactioni

Subunit structurei

Interacts with SCNM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-352851,EBI-743771
MAP1LC3BQ9GZQ83EBI-352851,EBI-373144
NFYAP235113EBI-352851,EBI-389739
SRPK1Q96SB42EBI-352851,EBI-539478
SRPK2P783622EBI-352851,EBI-593303
SRSF6Q132475EBI-352851,EBI-745230
SRSF7Q166293EBI-352851,EBI-398885

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119646. 169 interactors.
DIPiDIP-32513N.
IntActiQ9Y383. 59 interactors.
MINTiMINT-5006732.
STRINGi9606.ENSP00000347005.

Structurei

3D structure databases

ProteinModelPortaliQ9Y383.
SMRiQ9Y383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili102 – 177Sequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi239 – 388Arg/Ser-richAdd BLAST150

Sequence similaritiesi

Belongs to the Luc7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOVERGENiHBG062167.
InParanoidiQ9Y383.
KOiK13212.
OrthoDBiEOG091G0PSO.
PhylomeDBiQ9Y383.
TreeFamiTF317607.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y383-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS
60 70 80 90 100
GTRMDLGECL KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR
110 120 130 140 150
TEVAKKRLAE TQEEISAEVA AKAERVHELN EEIGKLLAKV EQLGAEGNVE
160 170 180 190 200
ESQKVMDEVE KARAKKREAE EVYRNSMPAS SFQQQKLRVC EVCSAYLGLH
210 220 230 240 250
DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN QERLKRREER
260 270 280 290 300
EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
310 320 330 340 350
HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR
360 370 380 390
DRSSRDRSPR DRDRKDKKRS YESANGRSED RRSSEEREAG EI
Length:392
Mass (Da):46,514
Last modified:May 10, 2004 - v2
Checksum:i1C559CCE0F23F693
GO
Isoform 2 (identifier: Q9Y383-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSAQAQMRAMLDQLMGTSRDG → MPAYLNLQGSVRKAPHSPSR

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):46,425
Checksum:i68FBCFE447A3E0E5
GO
Isoform 3 (identifier: Q9Y383-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSAQAQMRAMLDQLMGTSRD → MVIHSQLKKIQGASERM

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):46,229
Checksum:iA58A74530C83E98E
GO

Sequence cautioni

The sequence AAD34069 differs from that shown. Reason: Frameshift at position 388.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27R → Q in BAA91737 (PubMed:14702039).Curated1
Sequence conflicti389 – 390AG → QR in AAD34054 (PubMed:10810093).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034067361D → E.Corresponds to variant rs3757435dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102171 – 21MSAQA…TSRDG → MPAYLNLQGSVRKAPHSPSR in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0448961 – 20MSAQA…GTSRD → MVIHSQLKKIQGASERM in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA. Translation: AAD34054.1.
AF151832 mRNA. Translation: AAD34069.1. Frameshift.
AK001476 mRNA. Translation: BAA91713.1.
AK001519 mRNA. Translation: BAA91737.1.
AK022895 mRNA. Translation: BAB14297.1.
AK298166 mRNA. Translation: BAH12736.1.
BC017163 mRNA. Translation: AAH17163.1.
BC042625 mRNA. Translation: AAH42625.1.
BC050708 mRNA. Translation: AAH50708.1.
BC056886 mRNA. Translation: AAH56886.1.
CCDSiCCDS43656.1. [Q9Y383-1]
CCDS59085.1. [Q9Y383-3]
CCDS59510.1. [Q9Y383-2]
RefSeqiNP_001231514.1. NM_001244585.1. [Q9Y383-3]
NP_001257572.1. NM_001270643.1. [Q9Y383-2]
NP_057103.2. NM_016019.4. [Q9Y383-1]
UniGeneiHs.731488.

Genome annotation databases

EnsembliENST00000263545; ENSP00000263545; ENSG00000146963. [Q9Y383-3]
ENST00000354926; ENSP00000347005; ENSG00000146963. [Q9Y383-1]
ENST00000541170; ENSP00000441604; ENSG00000146963. [Q9Y383-3]
ENST00000619796; ENSP00000483438; ENSG00000146963. [Q9Y383-2]
GeneIDi51631.
KEGGihsa:51631.
UCSCiuc003vux.5. human. [Q9Y383-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151817 mRNA. Translation: AAD34054.1.
AF151832 mRNA. Translation: AAD34069.1. Frameshift.
AK001476 mRNA. Translation: BAA91713.1.
AK001519 mRNA. Translation: BAA91737.1.
AK022895 mRNA. Translation: BAB14297.1.
AK298166 mRNA. Translation: BAH12736.1.
BC017163 mRNA. Translation: AAH17163.1.
BC042625 mRNA. Translation: AAH42625.1.
BC050708 mRNA. Translation: AAH50708.1.
BC056886 mRNA. Translation: AAH56886.1.
CCDSiCCDS43656.1. [Q9Y383-1]
CCDS59085.1. [Q9Y383-3]
CCDS59510.1. [Q9Y383-2]
RefSeqiNP_001231514.1. NM_001244585.1. [Q9Y383-3]
NP_001257572.1. NM_001270643.1. [Q9Y383-2]
NP_057103.2. NM_016019.4. [Q9Y383-1]
UniGeneiHs.731488.

3D structure databases

ProteinModelPortaliQ9Y383.
SMRiQ9Y383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119646. 169 interactors.
DIPiDIP-32513N.
IntActiQ9Y383. 59 interactors.
MINTiMINT-5006732.
STRINGi9606.ENSP00000347005.

PTM databases

iPTMnetiQ9Y383.
PhosphoSitePlusiQ9Y383.
SwissPalmiQ9Y383.

Polymorphism and mutation databases

BioMutaiLUC7L2.
DMDMi47116960.

Proteomic databases

EPDiQ9Y383.
PaxDbiQ9Y383.
PeptideAtlasiQ9Y383.
PRIDEiQ9Y383.

Protocols and materials databases

DNASUi51631.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263545; ENSP00000263545; ENSG00000146963. [Q9Y383-3]
ENST00000354926; ENSP00000347005; ENSG00000146963. [Q9Y383-1]
ENST00000541170; ENSP00000441604; ENSG00000146963. [Q9Y383-3]
ENST00000619796; ENSP00000483438; ENSG00000146963. [Q9Y383-2]
GeneIDi51631.
KEGGihsa:51631.
UCSCiuc003vux.5. human. [Q9Y383-1]

Organism-specific databases

CTDi51631.
GeneCardsiC7orf55-LUC7L2.
LUC7L2.
HGNCiHGNC:21608. LUC7L2.
HPAiHPA051631.
MIMi613056. gene.
neXtProtiNX_Q9Y383.
OpenTargetsiENSG00000146963.
PharmGKBiPA134873425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0796. Eukaryota.
COG5200. LUCA.
GeneTreeiENSGT00730000110670.
HOVERGENiHBG062167.
InParanoidiQ9Y383.
KOiK13212.
OrthoDBiEOG091G0PSO.
PhylomeDBiQ9Y383.
TreeFamiTF317607.

Miscellaneous databases

ChiTaRSiLUC7L2. human.
GeneWikiiLUC7L2.
GenomeRNAii51631.
PMAP-CutDBQ9Y383.
PROiQ9Y383.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146963.
CleanExiHS_LUC7L2.
ExpressionAtlasiQ9Y383. baseline and differential.
GenevisibleiQ9Y383. HS.

Family and domain databases

InterProiIPR004882. Luc7-rel.
[Graphical view]
PANTHERiPTHR12375. PTHR12375. 1 hit.
PfamiPF03194. LUC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLC7L2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y383
Secondary accession number(s): B7Z500
, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.